ATE488249T1 - Immunologisch bedeutende herpes-simplex-virus- antigene und verfahren für ihre verwendung - Google Patents

Immunologisch bedeutende herpes-simplex-virus- antigene und verfahren für ihre verwendung

Info

Publication number: ATE488249T1
Authority: AT; Austria
Prior art keywords: hsv; herpes simplex; simplex virus; amino acids; fragment
Prior art date: 2001-07-31

Application number

AT02748276T

Other languages

English (en)

Inventor

David Koelle

Nancy Hosken

Christine Posavad

Hongbo Chen

Patrick Mcgowan

Original Assignee

Univ Washington

Corixa Corp

Hutchinson Fred Cancer Res

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-31

Filing date

2002-07-31

Publication date

2010-12-15

2002-07-31 Application filed by Univ Washington, Corixa Corp, Hutchinson Fred Cancer Res filed Critical Univ Washington

2010-12-15 Application granted granted Critical

2010-12-15 Publication of ATE488249T1 publication Critical patent/ATE488249T1/de

Links

241000700584 Simplexvirus Species 0.000 title abstract 3
239000000427 antigen Substances 0.000 title 1
102000036639 antigens Human genes 0.000 title 1
108091007433 antigens Proteins 0.000 title 1
239000012634 fragment Substances 0.000 abstract 4
150000001413 amino acids Chemical class 0.000 abstract 3
JSNNHGHYGYMVCK-XVKPBYJWSA-N Gly-Glu-Val Chemical compound [H]NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(O)=O JSNNHGHYGYMVCK-XVKPBYJWSA-N 0.000 abstract 2
241000700588 Human alphaherpesvirus 1 Species 0.000 abstract 2
241000701074 Human alphaherpesvirus 2 Species 0.000 abstract 2
108010009111 arginyl-glycyl-glutamic acid Proteins 0.000 abstract 2
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
GIVWETPOBCRTND-DCAQKATOSA-N Arg-Gln-Arg Chemical compound NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O GIVWETPOBCRTND-DCAQKATOSA-N 0.000 abstract 1
UGZUVYDKAYNCII-ULQDDVLXSA-N Arg-Phe-Leu Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(O)=O UGZUVYDKAYNCII-ULQDDVLXSA-N 0.000 abstract 1
SLQQPJBDBVPVQV-JYJNAYRXSA-N Arg-Phe-Val Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(O)=O SLQQPJBDBVPVQV-JYJNAYRXSA-N 0.000 abstract 1
WKPXXXUSUHAXDE-SRVKXCTJSA-N Arg-Pro-Arg Chemical compound NC(N)=NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O WKPXXXUSUHAXDE-SRVKXCTJSA-N 0.000 abstract 1
101710188313 Protein U Proteins 0.000 abstract 1
230000024932 T cell mediated immunity Effects 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
230000001747 exhibiting effect Effects 0.000 abstract 1
108020001507 fusion proteins Proteins 0.000 abstract 1
102000037865 fusion proteins Human genes 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Virology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT02748276T 2001-07-31 2002-07-31 Immunologisch bedeutende herpes-simplex-virus- antigene und verfahren für ihre verwendung ATE488249T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US30892301P	2001-07-31	2001-07-31
US30942801P	2001-08-01	2001-08-01
PCT/US2002/024306 WO2003011893A2 (en)	2001-07-31	2002-07-31	Immunologically significant herpes simplex virus antigens and methods for using same

Publications (1)

Publication Number	Publication Date
ATE488249T1 true ATE488249T1 (de)	2010-12-15

Family

ID=26976523

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02748276T ATE488249T1 (de)	2001-07-31	2002-07-31	Immunologisch bedeutende herpes-simplex-virus- antigene und verfahren für ihre verwendung

Country Status (8)

Country	Link
US (2)	US6814969B2 (de)
EP (2)	EP1420821B8 (de)
JP (1)	JP4519461B2 (de)
AT (1)	ATE488249T1 (de)
AU (1)	AU2002317604A1 (de)
CA (1)	CA2454750C (de)
DE (1)	DE60238330D1 (de)
WO (1)	WO2003011893A2 (de)

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* Cited by examiner, † Cited by third party
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DK1523582T3 (da)	2002-07-18	2009-03-02	Univ Washington	Hurtig, effektiv rensning af HSV-specifikke T-lymfocytter samt HSV-antigener identificeret derved
CA2538794C (en)	2003-09-12	2016-04-19	Antigenics, Inc.	Vaccine for treatment and prevention of herpes simplex virus infection
JP5118018B2 (ja)	2005-04-15	2013-01-16	ヒューマンマトリックスサイエンシーズ、エルエルシー	植物由来のエラスチン結合タンパク質リガンドおよびその使用方法
CA2523032A1 (en)	2005-10-07	2007-04-07	Immunovaccine Technologies Inc.	Vaccines for cancer therapy
CA2658484A1 (en) *	2006-07-20	2008-01-24	Vical Incorporated	Compositions and methods for vaccinating against hsv-2
EP2185145A1 (de)	2007-04-04	2010-05-19	Board of Trustees of the University of Arkansas	Nichtspezifische verzögerte überempfindlichkeitsantwort zur behandlung von infektionen mit dem herpes simplex virus
CN106310293A (zh)	2007-09-27	2017-01-11	免疫疫苗技术有限公司	在包括连续疏水相的载体中的脂质体在体内输送多核苷酸中的应用
US20100209452A1 (en) *	2007-10-03	2010-08-19	Immunovaccine Technologies, Inc	Compositions comprising an antigen, an amphipathic compound and a hydrophobic carrier, and uses thereof
WO2009146523A1 (en) *	2008-06-05	2009-12-10	Immunovaccine Technologies Inc.	Compositions comprising liposomes, an antigen, a polynucleotide and a carrier comprising a continuous phase of a hydrophobic substance
US8460674B2 (en)	2009-02-07	2013-06-11	University Of Washington	HSV-1 epitopes and methods for using same
US9044447B2 (en)	2009-04-03	2015-06-02	University Of Washington	Antigenic peptide of HSV-2 and methods for using same
EP3756684A1 (de)	2009-05-22	2020-12-30	Genocea Biosciences, Inc.	Impfstoffe gegen herpes-simplex-virus typ 2: zusammensetzungen und verfahren zur auslösung einer immunantwort
WO2012061637A2 (en) *	2010-11-03	2012-05-10	University Of Washington	Hsv-1 epitopes and methods for using same
JP6055776B2 (ja)	2010-11-24	2016-12-27	ジェノセアバイオサイエンシーズ，インコーポレイテッド	単純ヘルペスウイルス２型に対するワクチン：免疫応答を誘発する組成物及び方法
CN113876945A (zh)	2011-10-06	2022-01-04	免疫疫苗技术有限公司	包括激活或增加tlr2活性的佐剂的脂质体组合物及其应用
AU2012340712B2 (en)	2011-11-23	2017-09-14	Genocea Biosciences, Inc.	Nucleic acid vaccines against Herpes Simplex Virus type 2: compositions and methods for eliciting an immune response
HRP20181102T1 (hr)	2012-05-16	2018-09-07	Immune Design Corp	Cjepiva za hsv-2
CN107427540A (zh)	2015-02-26	2017-12-01	斯垮瑞斯有限责任公司	用于治疗单纯疱疹病毒感染的非特异性延迟型过敏反应
CN118949021A (zh) *	2016-03-14	2024-11-15	雷德生物科技股份公司	用于治疗hsv的手段和方法
US10350288B2 (en)	2016-09-28	2019-07-16	Genocea Biosciences, Inc.	Methods and compositions for treating herpes
WO2019018796A1 (en) *	2017-07-21	2019-01-24	Fred Hutchinson Cancer Research Center	VACCINE EPITOPES AGAINST HERPES SIMPLEX VIRUS RECOGNIZED SPECIFICALLY BY MEMORY T LYMPHOCYTES RESIDING IN FABRICS
CN112710849A (zh) *	2020-12-24	2021-04-27	首都医科大学附属北京友谊医院	一种鉴定抗EBV免疫活性的ELISpot试剂盒、制备方法及应用

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US4859587A (en)	1984-06-04	1989-08-22	Institut Merieux	Recombinant herpes simplex viruses, vaccines and methods
US4683202A (en)	1985-03-28	1987-07-28	Cetus Corporation	Process for amplifying nucleic acid sequences
CA2088600C (en)	1990-08-02	1999-11-16	Rae L. Burke	Herpes simplex virus vp16 vaccines
CA2090295A1 (en)	1992-02-03	1993-08-04	Anthony B. Nesburn	Process for the expression of herpes simplex virus type 1 glycoprotein e and methods of use
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ATE365808T1 (de)	1995-07-28	2007-07-15	Marie Curie Cancer Care	Transportproteine und deren verwendungen
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US6375952B1 (en) *	1998-08-07	2002-04-23	University Of Washington	Immunological herpes simplex virus antigens and methods for use thereof
EP1222281B1 (de) *	1999-09-30	2006-11-15	University of Washington	Immunologisch relevante antigene aus herpes simplexvirus
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2002
- 2002-07-31 AT AT02748276T patent/ATE488249T1/de not_active IP Right Cessation
- 2002-07-31 DE DE60238330T patent/DE60238330D1/de not_active Expired - Lifetime
- 2002-07-31 AU AU2002317604A patent/AU2002317604A1/en not_active Abandoned
- 2002-07-31 EP EP02748276A patent/EP1420821B8/de not_active Expired - Lifetime
- 2002-07-31 JP JP2003517084A patent/JP4519461B2/ja not_active Expired - Fee Related
- 2002-07-31 WO PCT/US2002/024306 patent/WO2003011893A2/en not_active Ceased
- 2002-07-31 CA CA2454750A patent/CA2454750C/en not_active Expired - Fee Related
- 2002-07-31 EP EP10151241A patent/EP2191845A1/de not_active Withdrawn
- 2002-07-31 US US10/210,428 patent/US6814969B2/en not_active Expired - Fee Related
2004
- 2004-06-30 US US10/882,074 patent/US7037509B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2454750C (en)	2012-09-18
DE60238330D1 (de)	2010-12-30
JP2004537308A (ja)	2004-12-16
JP4519461B2 (ja)	2010-08-04
EP1420821A4 (de)	2006-08-30
WO2003011893A3 (en)	2003-09-12
US6814969B2 (en)	2004-11-09
EP2191845A1 (de)	2010-06-02
US20030190324A1 (en)	2003-10-09
US7037509B2 (en)	2006-05-02
EP1420821B8 (de)	2011-02-02
CA2454750A1 (en)	2003-02-13
WO2003011893A2 (en)	2003-02-13
US20040241182A1 (en)	2004-12-02
AU2002317604A1 (en)	2003-02-17
EP1420821B1 (de)	2010-11-17
EP1420821A2 (de)	2004-05-26

Legal Events

Date	Code	Title	Description
2011-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE488249T1 (de)	2010-12-15	Immunologisch bedeutende herpes-simplex-virus- antigene und verfahren für ihre verwendung
EP2011510A3 (de)	2009-04-08	Pharmazeutische Zusammensetzungen, die immunologisch aktive Herpes simplex Virus Proteinfragmente enthalten
MX9702714A (es)	1997-06-28	Produccion de peptidos en plantas como fusiones de proteinas con revestimiento viral.
BG102983A (en)	2000-05-31	Extramembrane protein 106 polypeptide of moraxella catarrhalis, its gene sequence and application
DE69434413D1 (de)	2005-08-04	Fusionsproteine zwischen antigene aminosäuresequenzen und beta - 2- mikroglobulin
CA2111645A1 (en)	1994-06-18	Fibrinogen fragment e peptides and antibodies thereto
EP0965637A4 (de)	2002-09-25	Fas ANTIGEN-DERIVATE
IL135688A0 (en)	2001-05-20	Human checkpoint kinase, hcds1, compositions and methods
PT1417222E (pt)	2010-10-12	Polipéptidos isolados baseados no epítopo neutralizante da proteína p17 de vih, úteis como vacinas, e anticorpos antip17 neutralizantes que reconhecem especificamente o referido polipéptido neutralizante
DE69233311D1 (de)	2004-04-01	Weidelgraspollen-allergen
FI930626A0 (fi)	1993-02-12	Proteinstruktur hos vaexttoxingelonin
PT635025E (pt)	2003-03-31	Processo para preparar proteinas modificadas
DE69128039D1 (de)	1997-11-27	Allergene aus roggenspreupollen
AU1444699A (en)	1999-07-05	Single-chain polypeptides comprising troponin i and troponin
ATE108802T1 (de)	1994-08-15	Polypeptidhemmer für virale replikation.
ATE312923T1 (de)	2005-12-15	Moraxella catarrhalis basb034 polypeptide und verwendungen davon
GB2357507A (en)	2001-06-27	Peptide fragments of cholera toxin B or enterotoxin B as vaccine adjuvants
ATE234358T1 (de)	2003-03-15	Peptide des pferdearteritisvirus, antikörper und ihre verwendung in einem diagnostischen test
AU6393990A (en)	1991-04-18	Hiv related peptides
WO2000034294A3 (en)	2000-10-26	Tumor necrosis factor receptor homologue-1 ('trh1')
DE69827880D1 (de)	2005-01-05	Iga1-protease fragment als trägerpeptid
WO2001070774B1 (en)	2002-03-28	Human t cell response to mhc-binding motif clusters
NZ606260A (en)	2014-10-31	Novel polypeptides involved in immune response
MY106940A (en)	1995-08-30	Allelic variants of plasmodium falciparum merozoite surface antigen.
WO2002000832A3 (fr)	2002-04-18	Nouveau polypeptide, proteine p80-coiline 8.8, et polynucleotide codant ce polypeptide