ATE488252T1 - Erhöhte transduktion mit abc- transportersubstratenhemmern - Google Patents

Erhöhte transduktion mit abc- transportersubstratenhemmern

Info

Publication number
ATE488252T1
ATE488252T1 AT04760720T AT04760720T ATE488252T1 AT E488252 T1 ATE488252 T1 AT E488252T1 AT 04760720 T AT04760720 T AT 04760720T AT 04760720 T AT04760720 T AT 04760720T AT E488252 T1 ATE488252 T1 AT E488252T1
Authority
AT
Austria
Prior art keywords
increased transduction
abc transporter
transporter substrate
substrate inhibitors
substrate
Prior art date
Application number
AT04760720T
Other languages
English (en)
Inventor
Brian Davis
Laurent Humeau
Boro Dropulic
Original Assignee
Virxsys Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virxsys Corp filed Critical Virxsys Corp
Application granted granted Critical
Publication of ATE488252T1 publication Critical patent/ATE488252T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT04760720T 2003-05-05 2004-05-04 Erhöhte transduktion mit abc- transportersubstratenhemmern ATE488252T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46820703P 2003-05-05 2003-05-05
PCT/US2004/013968 WO2004098531A2 (en) 2003-05-05 2004-05-04 Increased transduction using abc transporter substrates and/or inhibitors

Publications (1)

Publication Number Publication Date
ATE488252T1 true ATE488252T1 (de) 2010-12-15

Family

ID=33435167

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04760720T ATE488252T1 (de) 2003-05-05 2004-05-04 Erhöhte transduktion mit abc- transportersubstratenhemmern

Country Status (5)

Country Link
US (1) US20050123514A1 (de)
EP (1) EP1624899B1 (de)
AT (1) ATE488252T1 (de)
DE (1) DE602004030105D1 (de)
WO (1) WO2004098531A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004104022A2 (en) * 2003-05-16 2004-12-02 The General Hospital Corporation Compositions comprising pathogen elicited epithelial chemoattractant (eicosanoid hepoxilin a3), inhibitors thereof and methods of use thereof
WO2009142767A1 (en) * 2008-05-22 2009-11-26 Lentigen Corporation Lentivector-based protein production
EP3192874B1 (de) * 2008-06-18 2019-10-16 Oxford BioMedica (UK) Limited Virusreinigung
KR102011532B1 (ko) * 2011-09-30 2019-08-16 블루버드 바이오, 인코포레이티드. 개선된 바이러스 형질도입을 위한 화합물
EP2943203A4 (de) * 2013-01-11 2016-08-24 Scripps Research Inst Verfahren und zusammensetzungen zur erhöhung der transduktionseffizienz retroviraler vektoren
EP3036325A4 (de) * 2013-08-23 2017-04-19 The Scripps Research Institute Erhöhung der effizienz einer retroviralen transduktion von wirtszellen
GB201407322D0 (en) 2014-04-25 2014-06-11 Ospedale San Raffaele Gene therapy
JP6754761B2 (ja) * 2014-07-11 2020-09-16 セルジーン コーポレイション Ｔリンパ球へのベクター導入効率の改善方法
RU2744603C2 (ru) 2016-02-12 2021-03-11 Блубёрд Био, Инк. Композиции, повышающие число копий вектора (чкв), и способы их применения
US11326183B2 (en) 2016-02-12 2022-05-10 Bluebird Bio, Inc. VCN enhancer compositions and methods of using the same
GB201706394D0 (en) 2017-04-21 2017-06-07 Ospedale San Raffaele Srl Gene Therapy
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections
AU2021202658A1 (en) 2021-04-28 2022-11-17 Fondazione Telethon Gene therapy
GB202206346D0 (en) 2022-04-29 2022-06-15 Ospedale San Raffaele Srl Gene therapy

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5512421A (en) * 1991-02-19 1996-04-30 The Regents Of The University Of California Generation, concentration and efficient transfer of VSV-G pseudotyped retroviral vectors
AU3635695A (en) * 1994-09-19 1996-04-09 Board Of Trustees Of The Leland Stanford Junior University Methods for genetically modifying hematopoietic stem cells
US6818439B1 (en) * 1994-12-30 2004-11-16 Chiron Corporation Methods for administration of recombinant gene delivery vehicles for treatment of hemophilia and other disorders
US5885806A (en) 1995-11-28 1999-03-23 The Johns Hopkins University School Of Medicine Methods to prepare conditionally replicating viral vectors
US5739018A (en) 1996-08-07 1998-04-14 The Regents Of The University Of California Packaging cell lines for pseudotyped retroviral vectors
US5814500A (en) * 1996-10-31 1998-09-29 The Johns Hopkins University School Of Medicine Delivery construct for antisense nucleic acids and methods of use
FR2762843B1 (fr) * 1997-04-30 1999-12-10 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
US6251629B1 (en) * 1997-10-07 2001-06-26 Smithkline Beecham Corporation ABC transporter
US6218181B1 (en) * 1998-03-18 2001-04-17 The Salk Institute For Biological Studies Retroviral packaging cell line
WO1999061589A2 (en) * 1998-05-28 1999-12-02 St. Jude Children's Research Hospital Expansion of hematopoietic stem cells transduced with mdr-1 and methods of use thereof
WO2002012285A2 (en) * 2000-08-10 2002-02-14 Board Of Regents, The University Of Texas System The tumor suppressor car-1
AU2002343458B2 (en) * 2001-10-02 2008-03-20 Institut Clayton De La Recherche Methods and compositions relating to restricted expression lentiviral vectors and their applications
US20050163760A1 (en) * 2001-12-06 2005-07-28 Nathalie Cartier-Lacave Use of cd34+ hematopoietic progenitor cells for the treatment of cns disorders

Also Published As

Publication number Publication date
WO2004098531A3 (en) 2005-04-28
EP1624899A2 (de) 2006-02-15
EP1624899B1 (de) 2010-11-17
EP1624899A4 (de) 2006-05-10
DE602004030105D1 (de) 2010-12-30
US20050123514A1 (en) 2005-06-09
WO2004098531A2 (en) 2004-11-18

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