ATE488766T1 - Diagnostik und screening-methode und kit in verbindung mit proteolytischer aktivität - Google Patents

Diagnostik und screening-methode und kit in verbindung mit proteolytischer aktivität

Info

Publication number
ATE488766T1
ATE488766T1 AT05762260T AT05762260T ATE488766T1 AT E488766 T1 ATE488766 T1 AT E488766T1 AT 05762260 T AT05762260 T AT 05762260T AT 05762260 T AT05762260 T AT 05762260T AT E488766 T1 ATE488766 T1 AT E488766T1
Authority
AT
Austria
Prior art keywords
ubiquitin
signal
animal
diagnostics
disease
Prior art date
Application number
AT05762260T
Other languages
English (en)
Inventor
Tauseef R Butt
Alejandro Bernal
Original Assignee
Progenra Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Progenra Inc filed Critical Progenra Inc
Application granted granted Critical
Publication of ATE488766T1 publication Critical patent/ATE488766T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
AT05762260T 2004-06-21 2005-06-21 Diagnostik und screening-methode und kit in verbindung mit proteolytischer aktivität ATE488766T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58090004P 2004-06-21 2004-06-21
PCT/US2005/021819 WO2006002100A2 (en) 2004-06-21 2005-06-21 Diagnostic and screening methods and kits associated with proteolytic activity

Publications (1)

Publication Number Publication Date
ATE488766T1 true ATE488766T1 (de) 2010-12-15

Family

ID=35782279

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05762260T ATE488766T1 (de) 2004-06-21 2005-06-21 Diagnostik und screening-methode und kit in verbindung mit proteolytischer aktivität

Country Status (11)

Country Link
US (1) US7842460B2 (de)
EP (1) EP1792181B1 (de)
JP (1) JP5031560B2 (de)
KR (1) KR20070051257A (de)
CN (1) CN1989411B (de)
AT (1) ATE488766T1 (de)
AU (1) AU2005258000B2 (de)
CA (1) CA2570959C (de)
DE (1) DE602005024833D1 (de)
IL (1) IL180201A (de)
WO (1) WO2006002100A2 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002346008A1 (en) * 2001-06-28 2003-03-03 Dermtech International Method for detection of melanoma
US8062891B2 (en) 2003-10-24 2011-11-22 Gencia Corporation Nonviral vectors for delivering polynucleotides to plants
US8039587B2 (en) 2003-10-24 2011-10-18 Gencia Corporation Methods and compositions for delivering polynucleotides
US8133733B2 (en) 2003-10-24 2012-03-13 Gencia Corporation Nonviral vectors for delivering polynucleotides to target tissues
US20090123468A1 (en) 2003-10-24 2009-05-14 Gencia Corporation Transducible polypeptides for modifying metabolism
US8507277B2 (en) 2003-10-24 2013-08-13 Gencia Corporation Nonviral vectors for delivering polynucleotides
EP1771194A2 (de) * 2004-07-07 2007-04-11 Biodevelops Pharma Entwicklung GmbH Verwendung einer deubiquitinierenden verbindung zur steigerung der expression von membranproteinen auf der zelloberfläche
WO2008140582A2 (en) * 2006-11-22 2008-11-20 Emory University Production of anti-microbial peptides
US8642067B2 (en) 2007-04-02 2014-02-04 Allergen, Inc. Methods and compositions for intraocular administration to treat ocular conditions
CA2686212A1 (en) * 2007-05-04 2008-11-13 Dermtech International Diagnosis of melanoma by nucleic acid analysis
DE102007031708A1 (de) 2007-07-06 2009-01-08 Dade Behring Marburg Gmbh Bestimmung der von Willebrand Faktor-Aktivität in Abwesenheit von Ristocetin
WO2009009773A1 (en) * 2007-07-11 2009-01-15 The Johns Hopkins University Use of otubain enzyme to cleave lysine-48-linked polyubiquitin
US20090092502A1 (en) * 2007-10-08 2009-04-09 Emerson Climate Technologies, Inc. Compressor having a power factor correction system and method
WO2009064843A1 (en) * 2007-11-13 2009-05-22 Bayer Healthcare Llc Method to measure amino acid concentrations
EP2294216A4 (de) 2008-05-14 2011-11-23 Dermtech Int Diagnose von melanom und sonnenpigmentflecken mittels nukleinsäureanalyse
EP2331707A4 (de) * 2008-08-28 2012-06-06 Dermtech Int Bestimmung des alterbereiches von hautproben
EP2182073B1 (de) * 2008-10-30 2014-04-16 Les Laboratoires Servier Ubiquitinspezifische Proteasen für die MCL-1-Stabilität und Verwendungen davon
WO2011042874A1 (en) * 2009-10-06 2011-04-14 Ecole Polytechnique Federale De Lausanne (Epfl) Visualization of proprotein convertase activity in living cells and tissues
US8518660B2 (en) 2010-06-24 2013-08-27 Lifesensors, Inc. Di- and poly-ubiquitin deubiquitinase substrates and uses thereof
BR112014005720A2 (pt) * 2011-09-15 2017-12-12 Genentech Inc método de seleção e/ou identificação de um antagonista de usp1, antagonista de uaf1 e/ou um antagonista de id que promove uma alteração no destino celular do dito método
CN102558310A (zh) * 2012-02-24 2012-07-11 李兵辉 实时监测蛋白水解酶活性的指示剂的制备方法及应用方法
KR101533345B1 (ko) * 2013-08-08 2015-07-22 아주대학교산학협력단 자가저해 단백질을 이용한 프로테아제 활성 측정용 센서, 및 이를 이용한 프로테아제의 활성 측정 방법
CN103468822B (zh) * 2013-09-30 2015-08-26 吴南 一种腰椎间盘退变相关snp的检测试剂盒
GB201318728D0 (en) * 2013-10-23 2013-12-04 Mologic Ltd Detection of cleavage activity of an enzyme
WO2015148566A1 (en) * 2014-03-24 2015-10-01 Duke University Screening targets and compositions and methods for treatment of ciliopathy disorders
US10709428B2 (en) 2015-05-01 2020-07-14 Dermtech, Inc. Non-invasive skin collection system
CN105542012A (zh) * 2015-06-17 2016-05-04 吉林大学 融合蛋白sumo1-pla2及制备方法和医用用途
CN105542013A (zh) * 2015-06-17 2016-05-04 吉林大学 融合蛋白sumo3-pla2及制备方法和医用用途
CN105886595A (zh) * 2016-04-28 2016-08-24 夏云 一种快速检测人体粪便中蛋白质水解细菌的方法
CN106636366A (zh) * 2016-11-25 2017-05-10 苏州首度基因科技有限责任公司 预测胃癌转移的基因检测试剂盒及其使用方法
MA45614B1 (fr) 2017-03-20 2020-04-30 Forma Therapeutics Inc Compositions de pyrrolopyrrole en tant qu'activateurs de la pyruvate kinase (pkr)
CN108004247A (zh) * 2017-12-06 2018-05-08 吉林大学 一种类泛素底物融合蛋白及制备方法和医用用途
EP3752645A4 (de) 2018-02-14 2022-04-13 Dermtech, Inc. Neue gen-klassifikatoren und deren verwendung bei nicht-melanom-hautkrebs
GB201804285D0 (en) * 2018-03-16 2018-05-02 Univ Dundee Ligase screening assay
EP3852791B1 (de) 2018-09-19 2024-07-03 Novo Nordisk Health Care AG Aktivierung von pyruvatkinase r
CN113166060B (zh) 2018-09-19 2024-01-09 诺沃挪第克健康护理股份公司 用丙酮酸激酶激活化合物治疗镰状细胞病
AU2020247911A1 (en) 2019-03-26 2021-11-11 Dermtech, Llc Novel gene classifiers and uses thereof in skin cancers
CN110004228B (zh) * 2019-04-03 2023-05-23 清华大学深圳研究生院 一种与乳腺癌分子分型相关的诊断标志物及其用途
CN110412004A (zh) * 2019-08-29 2019-11-05 苏州新格诺康生物技术有限公司 一种去泛素化酶的活性检测方法
CA3151612A1 (en) 2019-09-19 2021-03-25 George P. Luke Pyruvate kinase r (pkr) activating compositions
US11170872B2 (en) 2019-11-05 2021-11-09 Apeel Technology, Inc. Prediction of latent infection in plant products
JP2023542867A (ja) * 2020-09-11 2023-10-12 グリンプス バイオ， インコーポレイテッド 疾患の検出／診断、病期分類、モニタリング及び処置のための生体外でのプロテアーゼ活性検出
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R
JPWO2022259904A1 (de) * 2021-06-07 2022-12-15
WO2025019414A1 (en) * 2023-07-14 2025-01-23 Zeteo Tech, Inc. Substrate-based probes for monitoring protease activity using maldi-tofms
CN116994672B (zh) * 2023-07-24 2025-06-24 清华大学 筛选方法、装置、计算机设备、存储介质和程序产品

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5503977A (en) * 1994-04-22 1996-04-02 California Institute Of Technology Split ubiquitin protein sensor
US6127116A (en) * 1995-08-29 2000-10-03 Washington University Functional DNA clone for hepatitis C virus (HCV) and uses thereof
AU2000274004A1 (en) 2000-09-29 2002-04-08 Universitat Zurich Method and kit for detecting membrane protein - protein interactions
CN1164752C (zh) * 2002-01-16 2004-09-01 北京大学 拟南芥的AT4g10590基因的用途
DE10211063A1 (de) * 2002-03-13 2003-10-09 Axaron Bioscience Ag Neue Verfahren zur Detektion und Analyse von Protein-Interaktionen in vivo
KR100910844B1 (ko) 2002-07-19 2009-08-06 주식회사 파라 모노-필라멘트를 포함하는 보강용 지지체를 가지는기체분리 및 수처리용 외압식 중공사막, 그 제조방법 및제조장치
US20040053324A1 (en) * 2002-08-30 2004-03-18 Brian Wong Assays and compositions for identifying agents that modulate the activity of deubiquitinating agents
DE10318048A1 (de) 2003-04-17 2004-11-04 Axaron Bioscience Ag Nicht fluoreszierende, durch Proteolyse zur Fluoreszenz aktivierbare Reporterproteine und ihre Verwendung zur Detektion Protease-abhängiger Ereignisse

Also Published As

Publication number Publication date
KR20070051257A (ko) 2007-05-17
CA2570959A1 (en) 2006-01-05
WO2006002100A3 (en) 2006-04-20
JP2008503219A (ja) 2008-02-07
CA2570959C (en) 2014-09-30
AU2005258000B2 (en) 2011-02-03
AU2005258000A1 (en) 2006-01-05
CN1989411A (zh) 2007-06-27
EP1792181A4 (de) 2008-02-20
IL180201A (en) 2012-08-30
WO2006002100A2 (en) 2006-01-05
US20060040335A1 (en) 2006-02-23
IL180201A0 (en) 2007-07-04
JP5031560B2 (ja) 2012-09-19
EP1792181B1 (de) 2010-11-17
EP1792181A2 (de) 2007-06-06
US7842460B2 (en) 2010-11-30
CN1989411B (zh) 2012-06-27
DE602005024833D1 (de) 2010-12-30

Similar Documents

Publication Publication Date Title
ATE488766T1 (de) Diagnostik und screening-methode und kit in verbindung mit proteolytischer aktivität
Singh et al. Botulinum neurotoxin: where are we with detection technologies?
Soares et al. The integration of sociality, monoamines and stress neuroendocrinology in fish models: applications in the neurosciences
Tabuchi et al. Pheromone responsiveness threshold depends on temporal integration by antennal lobe projection neurons
ATE412905T1 (de) Diagnoseverfahren für lebersteatose unter verwendung biochemischer marker
EP1725573A4 (de) Verfahren und materialien unter anwendung von signalsonden
Novak et al. Revisiting the role of NAG across the continuum of kidney disease
BRPI0509419A (pt) método de ensaio imunossorvente ligado por enzimas, anticorpos, hibridoma e kit de imunoensaio
RU2684404C2 (ru) Способы повышения специфического захвата ботулиновых нейротоксинов клетками
Dillingham et al. Modular‐extramodular organization in developing multisensory shell regions of the mouse inferior colliculus
JP2009538122A5 (de)
Alpoim-Moreira et al. Collagen type III as a possible blood biomarker of fibrosis in equine endometrium
Al-Hawary et al. Poly (amino acids) towards sensing pathogenic bacteria: A review
WO2007109514A3 (en) Detection of lethality gene for improved fertility in mammals
WO2008147206A3 (en) Means and methods for classifying samples of multiple sclerosis patients
Pan et al. Immunohistochemical characterization of the chemosensory pulmonary neuroepithelial bodies in the naked mole-rat reveals a unique adaptive phenotype
Ferhat et al. Excessive self-grooming of Shank3 mutant mice is associated with gene dysregulation and imbalance between the striosome and matrix compartments in the striatum
BRPI0519060A2 (pt) kit de teste rÁpido para a detecÇço e a localizaÇço de élceras nos eqÜinos e seu mÉtodo de produÇço
DK1644485T3 (da) Udskilte proteiner som markører for celledifferentiering
CA2523466A1 (en) Probes for detection and quantification of lipid second messengers and a method for detecting and quantifying lipid second messengers
Okal et al. Droplet microfluidic screening to engineer angiotensin-converting enzyme 2 (ACE2) catalytic activity
Minter et al. Trisomy of human chromosome 21 orthologs mapping to mouse chromosome 10 cause age and sex-specific learning differences: relevance to down syndrome
CA2497818A1 (en) Glyt1 transgenic mice
RU2004120003A (ru) Способ биохимической оценки адаптации сердечной деятельности у новорожденных детей
WO2006026808A8 (en) Method of diagnosing and/or predicting the development of an allergic disorder

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties