ATE488766T1 - Diagnostik und screening-methode und kit in verbindung mit proteolytischer aktivität - Google Patents
Diagnostik und screening-methode und kit in verbindung mit proteolytischer aktivitätInfo
- Publication number
- ATE488766T1 ATE488766T1 AT05762260T AT05762260T ATE488766T1 AT E488766 T1 ATE488766 T1 AT E488766T1 AT 05762260 T AT05762260 T AT 05762260T AT 05762260 T AT05762260 T AT 05762260T AT E488766 T1 ATE488766 T1 AT E488766T1
- Authority
- AT
- Austria
- Prior art keywords
- ubiquitin
- signal
- animal
- diagnostics
- disease
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000002797 proteolythic effect Effects 0.000 title 1
- 238000012216 screening Methods 0.000 title 1
- 241001465754 Metazoa Species 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 3
- 102000044159 Ubiquitin Human genes 0.000 abstract 2
- 108090000848 Ubiquitin Proteins 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 230000004927 fusion Effects 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000001890 transfection Methods 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58090004P | 2004-06-21 | 2004-06-21 | |
| PCT/US2005/021819 WO2006002100A2 (en) | 2004-06-21 | 2005-06-21 | Diagnostic and screening methods and kits associated with proteolytic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE488766T1 true ATE488766T1 (de) | 2010-12-15 |
Family
ID=35782279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05762260T ATE488766T1 (de) | 2004-06-21 | 2005-06-21 | Diagnostik und screening-methode und kit in verbindung mit proteolytischer aktivität |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7842460B2 (de) |
| EP (1) | EP1792181B1 (de) |
| JP (1) | JP5031560B2 (de) |
| KR (1) | KR20070051257A (de) |
| CN (1) | CN1989411B (de) |
| AT (1) | ATE488766T1 (de) |
| AU (1) | AU2005258000B2 (de) |
| CA (1) | CA2570959C (de) |
| DE (1) | DE602005024833D1 (de) |
| IL (1) | IL180201A (de) |
| WO (1) | WO2006002100A2 (de) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002346008A1 (en) * | 2001-06-28 | 2003-03-03 | Dermtech International | Method for detection of melanoma |
| US8133733B2 (en) | 2003-10-24 | 2012-03-13 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to target tissues |
| US20090123468A1 (en) | 2003-10-24 | 2009-05-14 | Gencia Corporation | Transducible polypeptides for modifying metabolism |
| US8507277B2 (en) | 2003-10-24 | 2013-08-13 | Gencia Corporation | Nonviral vectors for delivering polynucleotides |
| US8062891B2 (en) | 2003-10-24 | 2011-11-22 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to plants |
| CA2543257C (en) | 2003-10-24 | 2013-12-31 | Gencia Corporation | Methods and compositions for delivering polynucleotides |
| WO2006002453A2 (en) * | 2004-07-07 | 2006-01-12 | Biodevelops Pharma Entwicklung Gmbh | Use of a deubiquitinating compound for enhancing the expression of membrane proteins on the cell surface |
| US20100048480A1 (en) * | 2006-11-22 | 2010-02-25 | Bettina Bommarius | Production of anti-microbial peptides |
| US8642067B2 (en) | 2007-04-02 | 2014-02-04 | Allergen, Inc. | Methods and compositions for intraocular administration to treat ocular conditions |
| EP2152911A4 (de) * | 2007-05-04 | 2010-05-19 | Dermtech Int | Melanomdiagnose mittels nukleinsäureanalyse |
| DE102007031708A1 (de) * | 2007-07-06 | 2009-01-08 | Dade Behring Marburg Gmbh | Bestimmung der von Willebrand Faktor-Aktivität in Abwesenheit von Ristocetin |
| WO2009009773A1 (en) * | 2007-07-11 | 2009-01-15 | The Johns Hopkins University | Use of otubain enzyme to cleave lysine-48-linked polyubiquitin |
| US20090092502A1 (en) * | 2007-10-08 | 2009-04-09 | Emerson Climate Technologies, Inc. | Compressor having a power factor correction system and method |
| WO2009064843A1 (en) * | 2007-11-13 | 2009-05-22 | Bayer Healthcare Llc | Method to measure amino acid concentrations |
| CN102089444A (zh) | 2008-05-14 | 2011-06-08 | 德玛泰克国际公司 | 利用核酸分析方法来诊断黑素瘤和太阳能雀斑 |
| CA2734521A1 (en) * | 2008-08-28 | 2010-03-04 | Dermtech International | Determining age ranges of skin samples |
| EP2182073B1 (de) * | 2008-10-30 | 2014-04-16 | Les Laboratoires Servier | Ubiquitinspezifische Proteasen für die MCL-1-Stabilität und Verwendungen davon |
| WO2011042874A1 (en) * | 2009-10-06 | 2011-04-14 | Ecole Polytechnique Federale De Lausanne (Epfl) | Visualization of proprotein convertase activity in living cells and tissues |
| US8518660B2 (en) | 2010-06-24 | 2013-08-27 | Lifesensors, Inc. | Di- and poly-ubiquitin deubiquitinase substrates and uses thereof |
| WO2013040433A1 (en) * | 2011-09-15 | 2013-03-21 | Genentech, Inc. | Methods of promoting differentiation |
| CN102558310A (zh) * | 2012-02-24 | 2012-07-11 | 李兵辉 | 实时监测蛋白水解酶活性的指示剂的制备方法及应用方法 |
| KR101533345B1 (ko) * | 2013-08-08 | 2015-07-22 | 아주대학교산학협력단 | 자가저해 단백질을 이용한 프로테아제 활성 측정용 센서, 및 이를 이용한 프로테아제의 활성 측정 방법 |
| CN103468822B (zh) * | 2013-09-30 | 2015-08-26 | 吴南 | 一种腰椎间盘退变相关snp的检测试剂盒 |
| GB201318728D0 (en) * | 2013-10-23 | 2013-12-04 | Mologic Ltd | Detection of cleavage activity of an enzyme |
| WO2015148566A1 (en) * | 2014-03-24 | 2015-10-01 | Duke University | Screening targets and compositions and methods for treatment of ciliopathy disorders |
| US10709428B2 (en) | 2015-05-01 | 2020-07-14 | Dermtech, Inc. | Non-invasive skin collection system |
| CN105542013A (zh) * | 2015-06-17 | 2016-05-04 | 吉林大学 | 融合蛋白sumo3-pla2及制备方法和医用用途 |
| CN105542012A (zh) * | 2015-06-17 | 2016-05-04 | 吉林大学 | 融合蛋白sumo1-pla2及制备方法和医用用途 |
| CN105886595A (zh) * | 2016-04-28 | 2016-08-24 | 夏云 | 一种快速检测人体粪便中蛋白质水解细菌的方法 |
| CN106636366A (zh) * | 2016-11-25 | 2017-05-10 | 苏州首度基因科技有限责任公司 | 预测胃癌转移的基因检测试剂盒及其使用方法 |
| LT3483164T (lt) | 2017-03-20 | 2020-05-11 | Forma Therapeutics, Inc. | Pirolpirolo kompozicijos kaip piruvato kinazės (pkr) aktyvatoriai |
| CN108004247A (zh) * | 2017-12-06 | 2018-05-08 | 吉林大学 | 一种类泛素底物融合蛋白及制备方法和医用用途 |
| CA3090785A1 (en) | 2018-02-14 | 2019-08-22 | John Daniel Dobak Iii | Novel gene classifiers and uses thereof in non-melanoma skin cancers |
| GB201804285D0 (en) * | 2018-03-16 | 2018-05-02 | Univ Dundee | Ligase screening assay |
| EP3852791B1 (de) | 2018-09-19 | 2024-07-03 | Novo Nordisk Health Care AG | Aktivierung von pyruvatkinase r |
| EP3853206B1 (de) | 2018-09-19 | 2024-04-10 | Novo Nordisk Health Care AG | Behandlung von sichelzellanämie mit einer pyruvatkinase-r-aktivierenden verbindung |
| JP2022524641A (ja) | 2019-03-26 | 2022-05-09 | ダームテック，インク． | 皮膚癌における新規な遺伝子分類子とその使用 |
| CN110004228B (zh) * | 2019-04-03 | 2023-05-23 | 清华大学深圳研究生院 | 一种与乳腺癌分子分型相关的诊断标志物及其用途 |
| CN110412004A (zh) * | 2019-08-29 | 2019-11-05 | 苏州新格诺康生物技术有限公司 | 一种去泛素化酶的活性检测方法 |
| HRP20251148T1 (hr) | 2019-09-19 | 2025-11-21 | Novo Nordisk Health Care Ag | Pripravci koji aktiviraju piruvat-kinazu r (pkr) |
| US11170872B2 (en) | 2019-11-05 | 2021-11-09 | Apeel Technology, Inc. | Prediction of latent infection in plant products |
| JP2023542867A (ja) * | 2020-09-11 | 2023-10-12 | グリンプス バイオ， インコーポレイテッド | 疾患の検出／診断、病期分類、モニタリング及び処置のための生体外でのプロテアーゼ活性検出 |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
| JPWO2022259904A1 (de) * | 2021-06-07 | 2022-12-15 | ||
| WO2025019414A1 (en) * | 2023-07-14 | 2025-01-23 | Zeteo Tech, Inc. | Substrate-based probes for monitoring protease activity using maldi-tofms |
| CN116994672B (zh) * | 2023-07-24 | 2025-06-24 | 清华大学 | 筛选方法、装置、计算机设备、存储介质和程序产品 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5503977A (en) * | 1994-04-22 | 1996-04-02 | California Institute Of Technology | Split ubiquitin protein sensor |
| US6127116A (en) * | 1995-08-29 | 2000-10-03 | Washington University | Functional DNA clone for hepatitis C virus (HCV) and uses thereof |
| WO2002027020A1 (en) | 2000-09-29 | 2002-04-04 | Universität Zürich | Method and kit for detecting membrane protein - protein interactions |
| CN1164752C (zh) * | 2002-01-16 | 2004-09-01 | 北京大学 | 拟南芥的AT4g10590基因的用途 |
| DE10211063A1 (de) * | 2002-03-13 | 2003-10-09 | Axaron Bioscience Ag | Neue Verfahren zur Detektion und Analyse von Protein-Interaktionen in vivo |
| KR100910844B1 (ko) | 2002-07-19 | 2009-08-06 | 주식회사 파라 | 모노-필라멘트를 포함하는 보강용 지지체를 가지는기체분리 및 수처리용 외압식 중공사막, 그 제조방법 및제조장치 |
| US20040053324A1 (en) * | 2002-08-30 | 2004-03-18 | Brian Wong | Assays and compositions for identifying agents that modulate the activity of deubiquitinating agents |
| DE10318048A1 (de) * | 2003-04-17 | 2004-11-04 | Axaron Bioscience Ag | Nicht fluoreszierende, durch Proteolyse zur Fluoreszenz aktivierbare Reporterproteine und ihre Verwendung zur Detektion Protease-abhängiger Ereignisse |
-
2005
- 2005-06-21 AT AT05762260T patent/ATE488766T1/de not_active IP Right Cessation
- 2005-06-21 DE DE602005024833T patent/DE602005024833D1/de not_active Expired - Lifetime
- 2005-06-21 KR KR1020077001581A patent/KR20070051257A/ko not_active Withdrawn
- 2005-06-21 EP EP05762260A patent/EP1792181B1/de not_active Expired - Lifetime
- 2005-06-21 WO PCT/US2005/021819 patent/WO2006002100A2/en not_active Ceased
- 2005-06-21 CN CN200580025067XA patent/CN1989411B/zh not_active Expired - Fee Related
- 2005-06-21 CA CA2570959A patent/CA2570959C/en not_active Expired - Fee Related
- 2005-06-21 AU AU2005258000A patent/AU2005258000B2/en not_active Ceased
- 2005-06-21 US US11/156,707 patent/US7842460B2/en not_active Expired - Fee Related
- 2005-06-21 JP JP2007516825A patent/JP5031560B2/ja not_active Expired - Fee Related
-
2006
- 2006-12-20 IL IL180201A patent/IL180201A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20070051257A (ko) | 2007-05-17 |
| CN1989411B (zh) | 2012-06-27 |
| EP1792181B1 (de) | 2010-11-17 |
| WO2006002100A3 (en) | 2006-04-20 |
| IL180201A0 (en) | 2007-07-04 |
| AU2005258000A1 (en) | 2006-01-05 |
| CA2570959A1 (en) | 2006-01-05 |
| DE602005024833D1 (de) | 2010-12-30 |
| CA2570959C (en) | 2014-09-30 |
| WO2006002100A2 (en) | 2006-01-05 |
| IL180201A (en) | 2012-08-30 |
| EP1792181A2 (de) | 2007-06-06 |
| JP5031560B2 (ja) | 2012-09-19 |
| CN1989411A (zh) | 2007-06-27 |
| JP2008503219A (ja) | 2008-02-07 |
| US20060040335A1 (en) | 2006-02-23 |
| EP1792181A4 (de) | 2008-02-20 |
| US7842460B2 (en) | 2010-11-30 |
| AU2005258000B2 (en) | 2011-02-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |