ATE489368T1 - Pyrimidinonverbindungen als calcilytica - Google Patents
Pyrimidinonverbindungen als calcilyticaInfo
- Publication number
- ATE489368T1 ATE489368T1 AT04749814T AT04749814T ATE489368T1 AT E489368 T1 ATE489368 T1 AT E489368T1 AT 04749814 T AT04749814 T AT 04749814T AT 04749814 T AT04749814 T AT 04749814T AT E489368 T1 ATE489368 T1 AT E489368T1
- Authority
- AT
- Austria
- Prior art keywords
- calcilytics
- pyrimidinone compounds
- pyrimidinone
- compounds
- disclosed
- Prior art date
Links
- VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical class OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 title abstract 3
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46085903P | 2003-04-07 | 2003-04-07 | |
| US47932303P | 2003-06-18 | 2003-06-18 | |
| PCT/US2004/010638 WO2004092120A2 (en) | 2003-04-07 | 2004-04-07 | Pyrimidinone compounds as calcilytics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE489368T1 true ATE489368T1 (de) | 2010-12-15 |
Family
ID=33303030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04749814T ATE489368T1 (de) | 2003-04-07 | 2004-04-07 | Pyrimidinonverbindungen als calcilytica |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7491728B2 (de) |
| EP (2) | EP1613606A4 (de) |
| JP (2) | JP2006522159A (de) |
| AT (1) | ATE489368T1 (de) |
| AU (1) | AU2004230903A1 (de) |
| CA (1) | CA2521129A1 (de) |
| DE (1) | DE602004030231D1 (de) |
| WO (2) | WO2004092121A2 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI316511B (en) | 2002-11-26 | 2009-11-01 | Smithkline Beecham Corp | Calcilytic compounds |
| EP1613606A4 (de) * | 2003-04-07 | 2008-12-03 | Nps Pharma Inc | Verfahren zur herstellung von 2,3,5,6-substituierten 3h-pyrimidin-4-onen |
| JP2007536239A (ja) * | 2004-05-06 | 2007-12-13 | スミスクライン・ビーチャム・コーポレイション | カルシウム受容体アンタゴニスト化合物 |
| CA2630117A1 (en) * | 2005-11-22 | 2007-05-31 | Smithkline Beecham Corporation | Calcilytic compounds |
| EP2079739A2 (de) * | 2006-10-04 | 2009-07-22 | Pfizer Products Inc. | Pyrido[4,3-d]pyrimidin-4(3h)-onderivate als kalziumrezeptorantagonisten |
| CN105980366B (zh) * | 2013-12-16 | 2018-12-14 | 拜耳作物科学股份公司 | 作为害虫防治剂的六元c-n-连接的芳基硫醚衍生物和芳基亚砜衍生物 |
| EP4626878A1 (de) | 2022-12-02 | 2025-10-08 | Neumora Therapeutics, Inc. | Verfahren zur behandlung neurologischer erkrankungen |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3185689A (en) * | 1965-05-25 | Tolyl-x-(jh)-pyrimidones | ||
| JPS4826020B1 (de) * | 1970-06-09 | 1973-08-03 | ||
| RU2026295C1 (ru) * | 1991-06-18 | 1995-01-09 | Новосибирский институт органической химии СО РАН | Способ получения хлоразинов, содержащих о-гидроксифенильную группу |
| JPH0687835A (ja) * | 1992-07-17 | 1994-03-29 | Rohm & Haas Co | 除草性２−アリール−５，６−縮合環−ピリミジン |
| US5726124A (en) * | 1992-07-17 | 1998-03-10 | Rohm And Haas Company | 2-arylpyrimidines and herbicidal use thereof |
| ATE144500T1 (de) * | 1992-07-17 | 1996-11-15 | Rohm & Haas | 2-substituierte pyrimidine und ihre verwendung als herbizide |
| US5300477A (en) * | 1992-07-17 | 1994-04-05 | Rohm And Haas Company | 2-arylpyrimidines and herbicidal use thereof |
| US5948775A (en) * | 1997-03-19 | 1999-09-07 | American Home Products Corporation | 2- or 3-(substitutedaminoalkoxyphenyl)quinazolin-4-ones |
| EP1613606A4 (de) | 2003-04-07 | 2008-12-03 | Nps Pharma Inc | Verfahren zur herstellung von 2,3,5,6-substituierten 3h-pyrimidin-4-onen |
-
2004
- 2004-04-07 EP EP04749815A patent/EP1613606A4/de not_active Withdrawn
- 2004-04-07 CA CA002521129A patent/CA2521129A1/en not_active Abandoned
- 2004-04-07 JP JP2006509758A patent/JP2006522159A/ja active Pending
- 2004-04-07 WO PCT/US2004/010639 patent/WO2004092121A2/en not_active Ceased
- 2004-04-07 EP EP04749814A patent/EP1615897B1/de not_active Expired - Lifetime
- 2004-04-07 AU AU2004230903A patent/AU2004230903A1/en not_active Abandoned
- 2004-04-07 AT AT04749814T patent/ATE489368T1/de not_active IP Right Cessation
- 2004-04-07 JP JP2006509759A patent/JP2006522160A/ja active Pending
- 2004-04-07 DE DE602004030231T patent/DE602004030231D1/de not_active Expired - Fee Related
- 2004-04-07 US US10/552,363 patent/US7491728B2/en not_active Expired - Fee Related
- 2004-04-07 WO PCT/US2004/010638 patent/WO2004092120A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004092120A3 (en) | 2005-04-14 |
| WO2004092120A2 (en) | 2004-10-28 |
| JP2006522159A (ja) | 2006-09-28 |
| JP2006522160A (ja) | 2006-09-28 |
| EP1613606A2 (de) | 2006-01-11 |
| WO2004092121A2 (en) | 2004-10-28 |
| DE602004030231D1 (de) | 2011-01-05 |
| EP1615897A2 (de) | 2006-01-18 |
| EP1615897B1 (de) | 2010-11-24 |
| EP1613606A4 (de) | 2008-12-03 |
| CA2521129A1 (en) | 2004-10-28 |
| AU2004230903A1 (en) | 2004-10-28 |
| US20070197555A1 (en) | 2007-08-23 |
| WO2004092121A3 (en) | 2005-04-14 |
| US7491728B2 (en) | 2009-02-17 |
| EP1615897A4 (de) | 2008-07-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |