DK1633697T3 - Fremgangsmåde til fremstilling af substituerede 3-aryl-butyl-aminforbindelser - Google Patents

Fremgangsmåde til fremstilling af substituerede 3-aryl-butyl-aminforbindelser

Info

Publication number: DK1633697T3
Authority: DK; Denmark
Prior art keywords: aryl; substituted; butyl; preparation; amine compounds
Prior art date: 2003-06-06

Application number

DK04739583T

Other languages

English (en)

Inventor

Wolfgang Hell

Markus Kegel

Bernhard Akteries

Helmut Buschmann

Hartmut Loebermann

Stefan Gladow

D Heller

H J Drexler

Joerg Holenz

Original Assignee

Gruenenthal Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-06

Filing date

2004-06-04

Publication date

2009-06-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33494923&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1633697(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-06-04 Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh

2009-06-02 Application granted granted Critical

2009-06-02 Publication of DK1633697T3 publication Critical patent/DK1633697T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
- C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
- C07C217/72—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
- C07C209/70—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by reduction of unsaturated amines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/28—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by unsaturated carbon chains
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/56—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
- C07C215/58—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
- C07C215/62—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain the chain having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK04739583T 2003-06-06 2004-06-04 Fremgangsmåde til fremstilling af substituerede 3-aryl-butyl-aminforbindelser DK1633697T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10326097A DE10326097A1 (de)	2003-06-06	2003-06-06	Verfahren zur Herstellung von Dimethyl-(3-aryl-butyl)-aminverbindungen
PCT/EP2004/006027 WO2004108658A1 (de)	2003-06-06	2004-06-04	Verfahren zur herstellung substituierter 3-aryl-butyl-aminverbindungen

Publications (1)

Publication Number	Publication Date
DK1633697T3 true DK1633697T3 (da)	2009-06-02

Family

ID=33494923

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04739583T DK1633697T3 (da)	2003-06-06	2004-06-04	Fremgangsmåde til fremstilling af substituerede 3-aryl-butyl-aminforbindelser

Country Status (25)

Country	Link
US (1)	US7417170B2 (da)
EP (1)	EP1633697B1 (da)
JP (1)	JP4848268B2 (da)
KR (1)	KR101146205B1 (da)
CN (1)	CN1829681B (da)
AT (1)	ATE425136T1 (da)
AU (1)	AU2004245223C1 (da)
BR (1)	BRPI0411268C8 (da)
CA (1)	CA2528087C (da)
CY (1)	CY1109088T1 (da)
DE (2)	DE10326097A1 (da)
DK (1)	DK1633697T3 (da)
EC (1)	ECSP056218A (da)
ES (1)	ES2323870T3 (da)
HR (1)	HRP20090333T1 (da)
IL (1)	IL172357A (da)
MX (1)	MXPA05013193A (da)
NO (1)	NO335587B1 (da)
NZ (1)	NZ544231A (da)
PL (1)	PL1633697T3 (da)
PT (1)	PT1633697E (da)
RU (1)	RU2380355C2 (da)
SI (1)	SI1633697T1 (da)
WO (1)	WO2004108658A1 (da)
ZA (1)	ZA200600109B (da)

Families Citing this family (37)

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DE10328316A1 (de)	2003-06-23	2005-01-20	Grünenthal GmbH	Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe
DE102005052588A1 (de)	2005-11-02	2007-05-10	Grünenthal GmbH	Verfahren zur Herstellung substituierter Dimethyl-(3-aryl-butyl)-amin-Verbindungen mittels homogener Katalyse
WO2008012283A1 (en)	2006-07-24	2008-01-31	Janssen Pharmaceutica Nv	Preparation of (2r,3r)-3-(3-methoxyphenyl)-n,n,2-trimethylpentanamine
TWI496762B (zh) *	2006-07-24	2015-08-21		製備（１ｒ，２ｒ）-３-（３-二甲胺基-１-乙基-２-甲基-丙基）-酚之方法
TWI401237B (zh)	2006-07-24	2013-07-11		３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備
WO2009071310A1 (de) *	2007-12-07	2009-06-11	Grünenthal GmbH	Kristalline modifikationen von (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol
WO2010100477A2 (en) *	2009-03-03	2010-09-10	Shire Llc	Amino acid and peptide carbamate prodrugs of tapentadol and uses thereof
CN102002065B (zh) *	2009-09-02	2014-09-10	上海特化医药科技有限公司	他喷他多的制备方法及其中间体
US8288592B2 (en)	2009-09-22	2012-10-16	Actavis Group Ptc Ehf	Solid state forms of tapentadol salts
IT1397189B1 (it) *	2009-12-01	2013-01-04	Archimica Srl	Nuovo processo per la preparazione di tapentadol e suoi intermedi.
ES2627682T3 (es)	2009-12-29	2017-07-31	Mapi Pharma Limited	Compuestos intermedios y procesos para la preparación de tapentadol y compuestos relacionados
WO2011092719A2 (en) *	2010-02-01	2011-08-04	Ind-Swift Laboratories Limited	Process for the preparation of l-phenyl-3-dimethylaminopropane derivatives
US20130096346A1 (en)	2010-03-05	2013-04-18	Actavis Group Ptc Ehf	Resolution methods for isolating desired enantiomers of tapentadol intermediates and use thereof for the preparation of tapentadol
US20130096347A1 (en)	2010-04-05	2013-04-18	Actavis Group Ptc Ehf	Novel process for preparing highly pure tapentadol or a pharmaceutically acceptable salt thereof
ITMI20100924A1 (it) *	2010-05-21	2011-11-22	Fidia Farmaceutici	Nuovo metodo di sintesi delle due forme enantiomeriche del tapentadol
US8669399B2 (en) *	2010-06-15	2014-03-11	Grünenthal GmbH	Process for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds
IT1401109B1 (it)	2010-07-02	2013-07-12	Archimica Srl	Nuovo processo per la preparazione di tapentadol e suoi intermedi.
EP3597628A1 (en) *	2010-07-23	2020-01-22	Grünenthal GmbH	Salts or co-crystals of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol
EP2606030B1 (en)	2010-08-16	2016-05-18	Indoco Remedies Limited	Process for the preparation of tapentadol
EP2619174A4 (en) *	2010-09-20	2014-05-14	Ind Swift Lab Ltd	PROCESS FOR THE PREPARATION OF L-PHENYL-3-DIMETHYLAMINOPROPANE DERIVATIVES
CN102477016B (zh) *	2010-11-26	2014-12-17	中国医学科学院药物研究所	他喷他多的中间体的合成与应用
CZ2010998A3 (cs) *	2010-12-30	2012-02-08	Zentiva, K.S.	Zpusob výroby (2R,3R)-N,N-dimethyl-3-(3-hydroxyfenyl)-2-methylpentylaminu (tapentadolu)
CZ302992B6 (cs) *	2010-12-30	2012-02-08	Zentiva, K.S.	Zpusob výroby (2R,3R)-N,N-dimethyl-3-(3-hydroxyfenyl)-2-methylpentylaminu (tapentadolu)
WO2012089181A1 (en) *	2010-12-30	2012-07-05	Zentiva, K.S.	O-substituted (2r,3r)-3-(3-hydroxyphenyl)-2-methyl-4-pentenoic acids and a method of obtaining the same
WO2012146978A2 (en)	2011-04-28	2012-11-01	Actavis Group Ptc Ehf	A novel process for the preparation of tapentadol or a pharmaceutically acceptable salt thereof
EP2530072A1 (en)	2011-06-03	2012-12-05	Lacer, S.A.	New compounds, synthesis and use thereof in the treatment of pain
US8853393B2 (en)	2011-07-29	2014-10-07	Anhui New Star Pharmaceutical Development Co., Ltd.	Intermediate for preparing tapentadol or analogues thereof
WO2013105109A1 (en)	2011-11-09	2013-07-18	Indoco Remedies Limited	Process for the preparation of tapentadol
US20130150622A1 (en)	2011-12-12	2013-06-13	Boehringer Ingelheim International Gmbh	Stereoselective synthesis of tapentadol and its salts
WO2013120466A1 (en)	2012-02-17	2013-08-22	Zentiva, K.S.	A new solid form of tapentadol and a method of its preparation
EP2674414A1 (en)	2012-06-15	2013-12-18	Siegfried AG	Method for the preparation of 1-aryl-1-alkyl-3-dialkylaminopropane compounds
CN103159633B (zh) *	2012-07-06	2015-08-12	江苏恩华药业股份有限公司	他喷他多的制备方法及用于制备他喷他多的化合物
WO2015075678A1 (en)	2013-11-21	2015-05-28	Unimark Remedies Ltd.	A novel process for the preparation of 1-phenyl-3-aminopropane derivatives
WO2015091068A1 (en)	2013-12-16	2015-06-25	Farma Grs, D.O.O.	Crystalline forms of tapentadol intermediate
CZ307492B6 (cs)	2014-02-04	2018-10-17	Zentiva, K.S.	Pevná forma maleátu tapentadolu a způsob její přípravy
DK3319941T3 (da)	2015-07-10	2022-03-14	SpecGx LLC	Totrinsfremgangsmåde til fremstilling af 3-substituerede phenylalkylaminer
EP4269384A1 (en)	2022-04-26	2023-11-01	KRKA, d.d., Novo mesto	Method for crystallizing tapentadol intermediate, tapentadol intermediate of high purity, method of making tapentadol and tapentadol of high purity

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US3978129A (en) *	1972-01-28	1976-08-31	A. H. Robins Company, Incorporated	Alkenyl- and alkanylamines
DE4426245A1 (de) *	1994-07-23	1996-02-22	Gruenenthal Gmbh	1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
DE19609847A1 (de) *	1996-03-13	1997-09-18	Gruenenthal Gmbh	Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe
DE19857475A1 (de) *	1998-12-14	2000-06-15	Gruenenthal Gmbh	Substituierte Cycloheptene, deren Herstellung und Verwendung
DE19933421A1 (de) *	1999-07-16	2001-01-25	Gruenenthal Gmbh	2-Benzyl-3-dimethylamino-1-phenyl-propanderi- vate
DE10000311A1 (de) *	2000-01-05	2001-07-12	Gruenenthal Gmbh	Aminomethyl-Phonyl-Cyclohexanonderivate

2003
- 2003-06-06 DE DE10326097A patent/DE10326097A1/de not_active Withdrawn
2004
- 2004-06-04 EP EP04739583A patent/EP1633697B1/de not_active Expired - Lifetime
- 2004-06-04 CA CA2528087A patent/CA2528087C/en not_active Expired - Lifetime
- 2004-06-04 AT AT04739583T patent/ATE425136T1/de active
- 2004-06-04 KR KR1020057023464A patent/KR101146205B1/ko not_active Expired - Lifetime
- 2004-06-04 CN CN2004800218627A patent/CN1829681B/zh not_active Expired - Lifetime
- 2004-06-04 HR HR20090333T patent/HRP20090333T1/xx unknown
- 2004-06-04 RU RU2005141518/04A patent/RU2380355C2/ru active
- 2004-06-04 BR BRPI0411268A patent/BRPI0411268C8/pt not_active IP Right Cessation
- 2004-06-04 DE DE502004009142T patent/DE502004009142D1/de not_active Expired - Lifetime
- 2004-06-04 SI SI200431114T patent/SI1633697T1/sl unknown
- 2004-06-04 JP JP2006508271A patent/JP4848268B2/ja not_active Expired - Lifetime
- 2004-06-04 MX MXPA05013193A patent/MXPA05013193A/es active IP Right Grant
- 2004-06-04 AU AU2004245223A patent/AU2004245223C1/en not_active Expired
- 2004-06-04 PL PL04739583T patent/PL1633697T3/pl unknown
- 2004-06-04 PT PT04739583T patent/PT1633697E/pt unknown
- 2004-06-04 NZ NZ544231A patent/NZ544231A/en not_active IP Right Cessation
- 2004-06-04 WO PCT/EP2004/006027 patent/WO2004108658A1/de not_active Ceased
- 2004-06-04 ES ES04739583T patent/ES2323870T3/es not_active Expired - Lifetime
- 2004-06-04 DK DK04739583T patent/DK1633697T3/da active
2005
- 2005-12-05 IL IL172357A patent/IL172357A/en not_active IP Right Cessation
- 2005-12-06 US US11/294,449 patent/US7417170B2/en not_active Expired - Lifetime
- 2005-12-13 EC EC2005006218A patent/ECSP056218A/es unknown
2006
- 2006-01-04 NO NO20060044A patent/NO335587B1/no unknown
- 2006-01-05 ZA ZA200600109A patent/ZA200600109B/en unknown
2009
- 2009-05-21 CY CY20091100536T patent/CY1109088T1/el unknown

Also Published As

Publication number	Publication date
US20060194988A1 (en)	2006-08-31
BRPI0411268B8 (pt)	2021-01-19
CA2528087A1 (en)	2004-12-16
AU2004245223A1 (en)	2004-12-16
KR20060036923A (ko)	2006-05-02
ATE425136T1 (de)	2009-03-15
RU2380355C2 (ru)	2010-01-27
PT1633697E (pt)	2009-06-04
ZA200600109B (en)	2007-01-31
US7417170B2 (en)	2008-08-26
KR101146205B1 (ko)	2012-05-25
AU2004245223B2 (en)	2010-01-28
DE502004009142D1 (de)	2009-04-23
EP1633697B1 (de)	2009-03-11
IL172357A (en)	2014-09-30
BRPI0411268C8 (pt)	2021-11-16
AU2004245223C1 (en)	2010-06-10
HRP20090333T1 (hr)	2009-07-31
CY1109088T1 (el)	2014-07-02
SI1633697T1 (sl)	2009-08-31
HK1088597A1 (zh)	2006-11-10
JP4848268B2 (ja)	2011-12-28
NO335587B1 (no)	2015-01-05
PL1633697T3 (pl)	2009-08-31
EP1633697A1 (de)	2006-03-15
NO20060044L (no)	2006-01-04
WO2004108658A1 (de)	2004-12-16
CN1829681B (zh)	2013-02-06
ECSP056218A (es)	2006-04-19
CN1829681A (zh)	2006-09-06
ES2323870T3 (es)	2009-07-27
NZ544231A (en)	2009-06-26
DE10326097A1 (de)	2005-01-05
IL172357A0 (en)	2009-02-11
RU2005141518A (ru)	2007-07-20
BRPI0411268A (pt)	2006-08-01
BRPI0411268C1 (pt)	2021-05-25
BRPI0411268B1 (pt)	2020-11-03
MXPA05013193A (es)	2006-03-09
CA2528087C (en)	2012-05-01
JP2006527178A (ja)	2006-11-30

Publication	Publication Date	Title
DK1633697T3 (da)	2009-06-02	Fremgangsmåde til fremstilling af substituerede 3-aryl-butyl-aminforbindelser
DK1682530T3 (da)	2007-07-16	Pyrrolsubstituerede indoler som inhibitorer af PAI-1
DK1828164T3 (da)	2008-12-08	Fremgangsmåde til fremstilling af N-phenylpyrazol-1-carboxamider
NO20071309L (no)	2007-05-10	Fremgangsmate for ekspansjon
UY33981A (es)	2013-10-31	?método para preparar compuestos macrocíclicos inhibidores de serina proteasas de hepatitis c?.
DK1611108T3 (da)	2011-10-10	Fremgangsmåde til fremstilling af telmisartan
ES2338590T3 (es)	2010-05-10	Procedimiento regioselectivo de preparacion de benzoimidazoltiofenos.
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