ATE490253T1 - Synthese von 5-substituierten 7-azaindolen und 7- azaindolinen - Google Patents
Synthese von 5-substituierten 7-azaindolen und 7- azaindolinenInfo
- Publication number
- ATE490253T1 ATE490253T1 AT04717703T AT04717703T ATE490253T1 AT E490253 T1 ATE490253 T1 AT E490253T1 AT 04717703 T AT04717703 T AT 04717703T AT 04717703 T AT04717703 T AT 04717703T AT E490253 T1 ATE490253 T1 AT E490253T1
- Authority
- AT
- Austria
- Prior art keywords
- azaindolines
- substituted
- synthesis
- azaindoline
- novel
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- QDKGOMZIPXGDDJ-UHFFFAOYSA-N 2,3-dihydro-1h-indazole Chemical class C1=CC=C2CNNC2=C1 QDKGOMZIPXGDDJ-UHFFFAOYSA-N 0.000 abstract 2
- -1 5-substituted 7-azaindolines Chemical class 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0305142.2A GB0305142D0 (en) | 2003-03-06 | 2003-03-06 | Synthesis |
| PCT/GB2004/000946 WO2004078757A2 (en) | 2003-03-06 | 2004-03-05 | Synthesis of 5-substituted 7-azaindoles and 7-azaidonines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE490253T1 true ATE490253T1 (de) | 2010-12-15 |
Family
ID=9954241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04717703T ATE490253T1 (de) | 2003-03-06 | 2004-03-05 | Synthese von 5-substituierten 7-azaindolen und 7- azaindolinen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7652137B2 (de) |
| EP (1) | EP1633750B1 (de) |
| JP (1) | JP4711950B2 (de) |
| AT (1) | ATE490253T1 (de) |
| DE (1) | DE602004030334D1 (de) |
| ES (1) | ES2355726T3 (de) |
| GB (1) | GB0305142D0 (de) |
| WO (1) | WO2004078757A2 (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1474420T1 (sl) * | 2002-02-01 | 2012-06-29 | Astrazeneca Ab | Spojine kinazolina |
| DE60316542T2 (de) * | 2002-03-28 | 2008-07-03 | Eisai R&D Management Co., Ltd. | 7-azaindole als inhibitoren c-jun n-terminaler kinasen zur behandlung neurodegenerativer störungen |
| GB0305142D0 (en) | 2003-03-06 | 2003-04-09 | Eisai London Res Lab Ltd | Synthesis |
| US7612086B2 (en) * | 2003-05-16 | 2009-11-03 | Eisai R & D Management Co. Ltd. | JNK inhibitors |
| GB0405055D0 (en) * | 2004-03-05 | 2004-04-07 | Eisai London Res Lab Ltd | JNK inhibitors |
| WO2006015123A1 (en) | 2004-07-27 | 2006-02-09 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
| US7626021B2 (en) | 2004-07-27 | 2009-12-01 | Sgx Pharmaceuticals, Inc. | Fused ring heterocycle kinase modulators |
| CA2573573A1 (en) | 2004-07-27 | 2006-02-09 | Sgx Pharmaceuticals, Inc. | Fused ring heterocycle kinase modulators |
| US7361764B2 (en) | 2004-07-27 | 2008-04-22 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
| GB0516156D0 (en) * | 2005-08-05 | 2005-09-14 | Eisai London Res Lab Ltd | JNK inhibitors |
| WO2007135398A1 (en) * | 2006-05-22 | 2007-11-29 | Astrazeneca Ab | Indole derivatives |
| US8765747B2 (en) | 2009-06-12 | 2014-07-01 | Dana-Farber Cancer Institute, Inc. | Fused 2-aminothiazole compounds |
| WO2011060216A1 (en) | 2009-11-12 | 2011-05-19 | Concert Pharmaceuticals Inc. | Substituted azaindoles |
| WO2011090738A2 (en) * | 2009-12-29 | 2011-07-28 | Dana-Farber Cancer Institute, Inc. | Type ii raf kinase inhibitors |
| WO2011109932A1 (en) * | 2010-03-09 | 2011-09-15 | F.Hoffmann-La Roche Ag | Novel process for the manufacture of 5-halogenated-7-azaindoles |
| EP2576570A1 (de) * | 2010-05-26 | 2013-04-10 | Boehringer Ingelheim International GmbH | 2-oxo-1,2-dihydropyridin-4-ylborsäure-derivate |
| US9382239B2 (en) | 2011-11-17 | 2016-07-05 | Dana-Farber Cancer Institute, Inc. | Inhibitors of c-Jun-N-terminal kinase (JNK) |
| EP2909194A1 (de) | 2012-10-18 | 2015-08-26 | Dana-Farber Cancer Institute, Inc. | Hemmer der cyclinabhängigen kinase 7 (cdk7) |
| WO2014063054A1 (en) | 2012-10-19 | 2014-04-24 | Dana-Farber Cancer Institute, Inc. | Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof |
| USRE48175E1 (en) | 2012-10-19 | 2020-08-25 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged small molecules as inducers of protein degradation |
| SG10201802911RA (en) | 2013-03-15 | 2018-05-30 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
| WO2015058126A1 (en) | 2013-10-18 | 2015-04-23 | Syros Pharmaceuticals, Inc. | Heteroaromatic compounds useful for the treatment of prolferative diseases |
| EP3057956B1 (de) | 2013-10-18 | 2021-05-05 | Dana-Farber Cancer Institute, Inc. | Polycyclische inhibitoren der cyclin-dependent-kinase 7 (cdk7) |
| EA202092627A1 (ru) | 2013-11-18 | 2021-09-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| CN107001354B (zh) * | 2014-04-11 | 2021-06-22 | 台北医学大学 | 组蛋白去乙酰酶抑制剂 |
| US9862688B2 (en) | 2014-04-23 | 2018-01-09 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged janus kinase inhibitors and uses thereof |
| WO2015164614A1 (en) | 2014-04-23 | 2015-10-29 | Dana-Farber Cancer Institute, Inc. | Janus kinase inhibitors and uses thereof |
| CN104478909B (zh) * | 2014-11-19 | 2017-01-04 | 上海泰坦科技股份有限公司 | 杂环硼酸类化合物的合成工艺 |
| JP6854762B2 (ja) | 2014-12-23 | 2021-04-07 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | サイクリン依存性キナーゼ７（ｃｄｋ７）の阻害剤 |
| USRE50776E1 (en) | 2015-03-27 | 2026-02-03 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
| WO2016201370A1 (en) | 2015-06-12 | 2016-12-15 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
| AU2016319125B2 (en) | 2015-09-09 | 2021-04-08 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
| SG11201801856XA (en) | 2015-09-18 | 2018-04-27 | Kaken Pharmaceutical Co Ltd | Biaryl derivative and medicine containing same |
| CN105622605B (zh) * | 2016-03-01 | 2017-10-13 | 苏州艾缇克药物化学有限公司 | 一种5‑溴‑7‑氮杂吲哚的合成方法 |
| CN106188050A (zh) * | 2016-07-20 | 2016-12-07 | 南通雅本化学有限公司 | 一种5‑溴‑7‑氮杂吲哚的生产工艺 |
| CN107033142A (zh) * | 2017-05-15 | 2017-08-11 | 杭州科耀医药科技有限公司 | 一种Venetoclax关键中间体的合成方法 |
| EP3810132A4 (de) | 2018-06-25 | 2022-06-22 | Dana-Farber Cancer Institute, Inc. | Kinaseinhibitoren der taire und ihre verwendungen |
| US12281126B2 (en) | 2018-12-28 | 2025-04-22 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 and uses thereof |
| CN110078726B (zh) * | 2019-06-19 | 2022-05-17 | 陕西师范大学 | 一种全取代2,3-二氢-1H-吡咯并[2,3-b]吡啶衍生物的合成方法 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4719218A (en) * | 1985-12-12 | 1988-01-12 | Smithkline Beckman Corporation | Pyrrolo[1,2-a]imidazole and pyrrolo[1,2-a]pyridine derivatives and their use as 5-lipoxygenase pathway inhibitor |
| JPH0830013B2 (ja) * | 1989-07-28 | 1996-03-27 | 財団法人相模中央化学研究所 | ビアリール化合物の製造方法 |
| GB9026926D0 (en) | 1990-12-12 | 1991-01-30 | Smith Kline French Lab | Novel process |
| ZA919797B (en) | 1990-12-13 | 1992-10-28 | Smithkline Beecham Corp | Bicyclo-5,6-dihydro-7h-pyrrolo-1,20-imidazol-7-ols and 7-ones |
| SE9100920D0 (sv) | 1991-03-27 | 1991-03-27 | Astra Ab | New active compounds |
| JP3119758B2 (ja) | 1993-02-24 | 2000-12-25 | 日清製粉株式会社 | ７−アザインドール誘導体及びこれを有効成分とする抗潰瘍薬 |
| US5705515A (en) * | 1994-04-26 | 1998-01-06 | Merck & Co., Inc. | Substituted sulfonamides as selective β-3 agonists for the treatment of diabetes and obesity |
| FR2732969B1 (fr) * | 1995-04-14 | 1997-05-16 | Adir | Nouveaux composes pyridiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO1998047899A1 (en) | 1997-04-24 | 1998-10-29 | Ortho-Mcneil Corporation, Inc. | Substituted pyrrolopyridines useful in the treatment of inflammatory diseases |
| GB9721437D0 (en) | 1997-10-10 | 1997-12-10 | Glaxo Group Ltd | Heteroaromatic compounds and their use in medicine |
| BR9812944A (pt) | 1997-10-20 | 2000-08-08 | Hoffmann La Roche | Inibidores bicìclicos da cinase |
| WO1999051233A1 (en) | 1998-04-02 | 1999-10-14 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| WO2000026211A1 (en) | 1998-10-30 | 2000-05-11 | Merck & Co., Inc. | Thrombin inhibitors |
| EP1124823A1 (de) * | 1998-10-30 | 2001-08-22 | Merck & Co., Inc. | Thrombin inhibitoren |
| KR20010108024A (ko) | 1998-12-17 | 2001-12-07 | 프리돌린 클라우스너, 롤란드 비. 보레르 | 단백질 키나제 억제제로서의 4,5-피라진옥신돌 |
| CN1136217C (zh) | 1998-12-17 | 2004-01-28 | 霍夫曼-拉罗奇有限公司 | 作为jnk蛋白质激酶抑制剂的4-芳基羟吲哚 |
| US6265403B1 (en) | 1999-01-20 | 2001-07-24 | Merck & Co., Inc. | Angiogenesis inhibitors |
| GB9904933D0 (en) | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
| US6239132B1 (en) | 1999-04-23 | 2001-05-29 | Merck & Co., Inc. | Thrombin inhibitors |
| DE60041763D1 (de) | 1999-04-23 | 2009-04-23 | Vertex Pharma | Inhibitoren von c-jun n-terminal kinasen (jnk) |
| KR20080028516A (ko) | 1999-08-19 | 2008-03-31 | 시그널 파머슈티컬스 인크 | Ｊｎｋ억제제로서의 피라졸로안트론과 그 유도체 및 이를함유하는 조성물 |
| US6642375B2 (en) * | 1999-12-07 | 2003-11-04 | Fuji Photo Film Co., Ltd. | Fluorescent substances |
| WO2001047922A2 (en) | 1999-12-24 | 2001-07-05 | Aventis Pharma Limited | Azaindoles |
| DE60132975T2 (de) | 2000-01-06 | 2009-02-26 | Merck Frosst Canada Inc., Kirkland | Neue substanzen und verbindungen als protease-inhibitoren |
| US6897231B2 (en) | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
| PE20020506A1 (es) | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
| WO2002024648A2 (en) * | 2000-09-20 | 2002-03-28 | Abbott Laboratories | Process for the preparation of cell proliferation inhibitors |
| GB0108770D0 (en) * | 2001-04-06 | 2001-05-30 | Eisai London Res Lab Ltd | Inhibitors |
| GB0115109D0 (en) * | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
| WO2003028724A1 (en) | 2001-10-04 | 2003-04-10 | Smithkline Beecham Corporation | Chk1 kinase inhibitors |
| DE60316542T2 (de) * | 2002-03-28 | 2008-07-03 | Eisai R&D Management Co., Ltd. | 7-azaindole als inhibitoren c-jun n-terminaler kinasen zur behandlung neurodegenerativer störungen |
| WO2003082869A1 (en) | 2002-03-28 | 2003-10-09 | Eisai Co., Ltd. | Azaindoles as inhibitors of c-jun n-terminal kinases |
| SE0202463D0 (sv) | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | Novel compounds |
| EP2295433A3 (de) * | 2003-03-06 | 2011-07-06 | Eisai R&D Management Co., Ltd. | JNK Inhibitoren |
| GB0305142D0 (en) | 2003-03-06 | 2003-04-09 | Eisai London Res Lab Ltd | Synthesis |
| GB0516156D0 (en) * | 2005-08-05 | 2005-09-14 | Eisai London Res Lab Ltd | JNK inhibitors |
-
2003
- 2003-03-06 GB GBGB0305142.2A patent/GB0305142D0/en not_active Ceased
-
2004
- 2004-03-05 ES ES04717703T patent/ES2355726T3/es not_active Expired - Lifetime
- 2004-03-05 WO PCT/GB2004/000946 patent/WO2004078757A2/en not_active Ceased
- 2004-03-05 EP EP04717703A patent/EP1633750B1/de not_active Expired - Lifetime
- 2004-03-05 US US10/548,162 patent/US7652137B2/en not_active Expired - Fee Related
- 2004-03-05 JP JP2006505923A patent/JP4711950B2/ja not_active Expired - Fee Related
- 2004-03-05 AT AT04717703T patent/ATE490253T1/de not_active IP Right Cessation
- 2004-03-05 DE DE602004030334T patent/DE602004030334D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| GB0305142D0 (en) | 2003-04-09 |
| WO2004078757A2 (en) | 2004-09-16 |
| JP4711950B2 (ja) | 2011-06-29 |
| EP1633750B1 (de) | 2010-12-01 |
| US20060235042A1 (en) | 2006-10-19 |
| WO2004078757A3 (en) | 2005-09-01 |
| JP2006520771A (ja) | 2006-09-14 |
| ES2355726T3 (es) | 2011-03-30 |
| DE602004030334D1 (de) | 2011-01-13 |
| US7652137B2 (en) | 2010-01-26 |
| EP1633750A2 (de) | 2006-03-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE490253T1 (de) | Synthese von 5-substituierten 7-azaindolen und 7- azaindolinen | |
| ATE360627T1 (de) | Pyrrolidindion-substituierte piperidin- phthalazone als pde4-inhibitoren | |
| ATE357434T1 (de) | Disubstituierte thiazolylcarboxanilide und ihre verwendung als mikrobizide | |
| EA200500203A1 (ru) | Новый способ синтеза и новая кристаллическая форма агомелатина и фармацевтические композиции, которые её содержат | |
| SE0302811D0 (sv) | Novel compounds | |
| SE0202133D0 (sv) | Novel compounds | |
| DE60236600D1 (de) | Substituierte 1h-dihydropyrazole, ihre herstellung und verwendung | |
| NO20073678L (no) | Nye fremgangsmater for fremstilling av benzofuran | |
| SE0403171D0 (sv) | New compounds | |
| IL178156A0 (en) | Intermediates for the preparation of pramipexole | |
| MXPA05011962A (es) | Oxiarenos substituidos. | |
| DE50202504D1 (de) | Neue 4-aminofuropyrimidine und ihre verwendung | |
| NO20043016L (no) | 6-aminomorfinan-derivater, fremgangsmate for fremstilling og anvendelse derav | |
| SE0303541D0 (sv) | New compounds | |
| SE0103710D0 (sv) | Compounds | |
| DE60316984D1 (de) | Benzoylsulfonamide als antitumor-mittel | |
| ATE399168T1 (de) | Imidazopyridin-derivate und ihre verwendung als induzierbare no-synthase inhibitoren | |
| CY1107101T1 (el) | Μεθοδος συνθεσης παραγωγων της 1,3-διϋδρο-2h-3-βενζαζεπιν-2-ονης και εφαρμογη στη συνθεση της ιβαβραδινης και των αλατων προσθηκης με φαρμακευτικως αποδεκτο οξυ | |
| ATE287403T1 (de) | 6-phenylbenzonaphthyidine | |
| MXPA06003345A (es) | Derivados de aminopiridina como inhibidores de la no-sintasa inducible. | |
| EA200301101A1 (ru) | Производные пиперазина и их применение в качестве ингибиторов pde4 | |
| DK1644385T3 (da) | Siliciumforbindelser og deres anvendelse | |
| EA200600608A1 (ru) | Производные имидазопиридина как ингибиторы индуцируемой no-синтазы | |
| ATE390427T1 (de) | Diazabicylononan - und decanderivate und ihre verwendung als opioid-rezeptorligande | |
| DE50303586D1 (de) | Methylthiophencarboxanilide |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |