EA200301101A1 - Производные пиперазина и их применение в качестве ингибиторов pde4 - Google Patents

Производные пиперазина и их применение в качестве ингибиторов pde4

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Publication number
EA200301101A1
EA200301101A1 EA200301101A EA200301101A EA200301101A1 EA 200301101 A1 EA200301101 A1 EA 200301101A1 EA 200301101 A EA200301101 A EA 200301101A EA 200301101 A EA200301101 A EA 200301101A EA 200301101 A1 EA200301101 A1 EA 200301101A1
Authority
EA
Eurasian Patent Office
Prior art keywords
application
piperazine
derivatives
pde4 inhibitors
pde4
Prior art date
Application number
EA200301101A
Other languages
English (en)
Inventor
Армин Хатцельманн
Даниела Бундшу
Иоганнес Барзиг
Ханс-Петер Клей
Герхард Грундлер
Беате Шмидт
Герт Ян Стерк
Original Assignee
Алтана Фарма Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Алтана Фарма Аг filed Critical Алтана Фарма Аг
Publication of EA200301101A1 publication Critical patent/EA200301101A1/ru

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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract

В заявке описаны соединения формулы I, в которых R1, R2, R3, A, X, s и R9 имеют значения, указанные в описании заявки, причем указанные соединения являются новыми эффективными ингибиторами PDE4.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200301101A 2001-04-25 2002-04-24 Производные пиперазина и их применение в качестве ингибиторов pde4 EA200301101A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01110227 2001-04-25
PCT/EP2002/004494 WO2002085885A1 (en) 2001-04-25 2002-04-24 Piperazino-derivatives and their use as pde4 inhibitor

Publications (1)

Publication Number Publication Date
EA200301101A1 true EA200301101A1 (ru) 2004-04-29

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ID=8177248

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200301101A EA200301101A1 (ru) 2001-04-25 2002-04-24 Производные пиперазина и их применение в качестве ингибиторов pde4

Country Status (22)

Country Link
US (1) US7022696B2 (ru)
EP (1) EP1385838A1 (ru)
JP (2) JP4021329B2 (ru)
KR (1) KR20030089723A (ru)
CN (1) CN1505624A (ru)
AU (1) AU2002315311B2 (ru)
BG (1) BG108187A (ru)
BR (1) BR0209076A (ru)
CA (1) CA2445236A1 (ru)
CZ (1) CZ20033205A3 (ru)
EA (1) EA200301101A1 (ru)
EE (1) EE200300513A (ru)
HR (1) HRP20030869A2 (ru)
HU (1) HUP0303469A3 (ru)
IL (1) IL157870A0 (ru)
MX (1) MXPA03009806A (ru)
NO (1) NO20034804L (ru)
NZ (1) NZ529363A (ru)
PL (1) PL363544A1 (ru)
SK (1) SK14352003A3 (ru)
WO (1) WO2002085885A1 (ru)
ZA (1) ZA200308931B (ru)

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HRP20030636B1 (en) 2001-02-15 2012-05-31 Nycomed Gmbh Phthalayinone-piperidino-derivatives as pde4 inhibitors
KR100974901B1 (ko) * 2001-12-28 2010-08-10 아카디아 파마슈티칼스 인코포레이티드 모노아민 수용체 조정자로서의 스피로아자사이클릭 화합물
CA2494650A1 (en) * 2002-08-10 2004-03-04 Altana Pharma Ag Pyridazinone-derivatives as pde4 inhibitors
HRP20050197A2 (en) * 2002-08-10 2006-06-30 Altana Pharma Ag Piperidine-n-oxide-derivatives
JP2005538140A (ja) * 2002-08-10 2005-12-15 アルタナ　ファルマ　アクチエンゲゼルシャフト Ｐｄｅ４インヒビターとしてのピペリジン−ピリダゾン及びフタラゾン
US20080227790A1 (en) * 2004-02-04 2008-09-18 Altana Pharma Ag Pyridazinone Derivatives and their Use as Pde4 Inhibitors
AU2005210042B2 (en) 2004-02-04 2011-04-21 Takeda Gmbh 2-(piperidin-4-yl) -4, 5-dihydro-2H-pyridazin-3-one derivatives as PDE4 inhibitors
CN101163681A (zh) * 2005-04-21 2008-04-16 日本新药株式会社 2,3-二氮杂萘酮衍生物及其医药品
WO2007070506A2 (en) 2005-12-14 2007-06-21 Amgen Inc. Diaza heterocyclic sulfonamide derivatives and their uses
KR100843352B1 (ko) * 2007-01-30 2008-07-03 한국과학기술연구원 세로토닌 수용체 5-ＨＴ2ａ 또는 5-ＨＴ2ｃ의 길항제로활성을 갖는 1,2-다이하이드로-1-옥소프탈라지닐 피페라진화합물 및 이의 제조방법
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use

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BR9307570A (pt) 1992-12-02 1999-05-25 Pfizer Diéteres de catecol como inibidores seletivos de pdeiv
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EE200300514A (et) * 2001-04-25 2004-02-16 Altana Pharma Ag Ftalasinoonid, nende kasutamine hingamisteede haigusnähte leevendavate ravimite valmistamiseks ningneid sisaldavad ravimid

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AU2002315311B2 (en) 2007-12-06
BR0209076A (pt) 2004-08-10
PL363544A1 (en) 2004-11-29
ZA200308931B (en) 2004-06-09
JP2006096766A (ja) 2006-04-13
JP4021329B2 (ja) 2007-12-12
CZ20033205A3 (en) 2004-03-17
JP2004526785A (ja) 2004-09-02
SK14352003A3 (sk) 2004-04-06
HRP20030869A2 (en) 2005-08-31
CA2445236A1 (en) 2002-10-31
WO2002085885A1 (en) 2002-10-31
EE200300513A (et) 2004-02-16
KR20030089723A (ko) 2003-11-22
EP1385838A1 (en) 2004-02-04
NO20034804D0 (no) 2003-10-27
IL157870A0 (en) 2004-03-28
CN1505624A (zh) 2004-06-16
NO20034804L (no) 2003-12-29
US7022696B2 (en) 2006-04-04
HUP0303469A2 (hu) 2004-03-01
HUP0303469A3 (en) 2004-04-28
US20040132721A1 (en) 2004-07-08
BG108187A (bg) 2004-09-30
NZ529363A (en) 2005-08-26
MXPA03009806A (es) 2004-01-29

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