ATE490316T1 - Mutierte glucosedehydrogenase - Google Patents
Mutierte glucosedehydrogenaseInfo
- Publication number
- ATE490316T1 ATE490316T1 AT05734575T AT05734575T ATE490316T1 AT E490316 T1 ATE490316 T1 AT E490316T1 AT 05734575 T AT05734575 T AT 05734575T AT 05734575 T AT05734575 T AT 05734575T AT E490316 T1 ATE490316 T1 AT E490316T1
- Authority
- AT
- Austria
- Prior art keywords
- glucose dehydrogenase
- mutated glucose
- amino acid
- acid residue
- mutated
- Prior art date
Links
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 title abstract 2
- 125000000539 amino acid group Chemical group 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004128165 | 2004-04-23 | ||
| PCT/JP2005/007687 WO2005103248A1 (ja) | 2004-04-23 | 2005-04-22 | 変異グルコース脱水素酵素 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE490316T1 true ATE490316T1 (de) | 2010-12-15 |
Family
ID=35196974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05734575T ATE490316T1 (de) | 2004-04-23 | 2005-04-22 | Mutierte glucosedehydrogenase |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7803592B2 (de) |
| EP (1) | EP1739174B1 (de) |
| JP (1) | JP4639302B2 (de) |
| KR (1) | KR101186718B1 (de) |
| CN (1) | CN1973036B (de) |
| AT (1) | ATE490316T1 (de) |
| DE (1) | DE602005025104D1 (de) |
| WO (1) | WO2005103248A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2511656A1 (en) | 2002-12-24 | 2004-07-15 | Ikeda Food Research Co., Ltd. | Coenzyme-binding glucose dehydrogenase |
| EP1661516B1 (de) * | 2003-09-02 | 2012-08-15 | Koji Sode | Glukosesensor und glukosespiegel-messgerät |
| JP5020070B2 (ja) | 2005-03-25 | 2012-09-05 | 池田食研株式会社 | 補酵素結合型グルコース脱水素酵素をコードするポリヌクレオチド |
| ATE520771T1 (de) * | 2005-06-20 | 2011-09-15 | Arkray Inc | Mutierte glucose-dehydrogenase |
| WO2008001903A1 (fr) | 2006-06-29 | 2008-01-03 | Ikeda Food Research Co., Ltd. | Gène de la glucose-déshydrogénase conjuguée au fad |
| DE602007012130D1 (de) * | 2006-11-14 | 2011-03-03 | Toyo Boseki | Modifizierte flavin-adenin-dinucleotid-abhängige glucose-dehydrogenase |
| WO2009084616A1 (ja) * | 2007-12-28 | 2009-07-09 | Ikeda Food Research Co., Ltd. | 改変型グルコース脱水素酵素遺伝子 |
| JP5803081B2 (ja) * | 2009-10-09 | 2015-11-04 | 東洋紡株式会社 | Ｆａｄジヌクレオチド依存性グルコースデヒドロゲナーゼの温度依存性を改善する方法 |
| JP5824205B2 (ja) * | 2010-10-27 | 2015-11-25 | アークレイ株式会社 | 変異グルコース脱水素酵素 |
| CN102559624B (zh) * | 2012-03-05 | 2013-10-16 | 浙江德清汇宁生物科技有限公司 | 一种吡咯喹啉醌依赖型葡萄糖脱氢酶的热稳定性突变体及其高通量筛选方法 |
| EP2636733A1 (de) | 2012-03-08 | 2013-09-11 | Universität für Bodenkultur Wien | Mutierte Cellobiose-Dehydrogenase mit erhöhter Substratspezifität |
| WO2016087937A2 (en) * | 2014-12-04 | 2016-06-09 | Smartzyme Innovation Ltd. | Compositions and methods for measuring blood glucose levels |
| CN107532152A (zh) * | 2014-12-04 | 2018-01-02 | 智慧酶生物医药有限公司 | 用于测量血糖水平的组合物和方法 |
| CN106349392A (zh) * | 2015-07-14 | 2017-01-25 | 达尔生技股份有限公司 | 一种融合多肽 |
| EP3325615A4 (de) | 2015-07-23 | 2019-06-05 | Smartzyme Biopharma Ltd. | Zusammensetzungen und verfahren zur messung des blutzuckerspiegels |
| EP3249050B1 (de) | 2016-05-23 | 2019-01-23 | ARKRAY, Inc. | Enzymelektrode und biosensor mit verwendung davon |
| CN108251391A (zh) * | 2017-08-18 | 2018-07-06 | 青岛蔚蓝生物集团有限公司 | 新型葡萄糖氧化酶突变体 |
| CN109425643B (zh) | 2017-08-25 | 2022-10-25 | 爱科来株式会社 | 基于酶电化学阻抗测量法的新型生物传感技术 |
| CN108486027A (zh) * | 2018-04-04 | 2018-09-04 | 江南大学 | 一种fad为辅基的葡萄糖脱氢酶的生产、纯化方法 |
| US11608515B2 (en) | 2018-05-22 | 2023-03-21 | Arkray, Inc. | Biosensing method |
| EP3640344B1 (de) | 2018-10-03 | 2024-03-13 | ARKRAY, Inc. | Direkt-elektronen-transfer-oxidoreduktase-modifiziertes molekulares erkennungselement |
| CN111593030B (zh) * | 2020-04-17 | 2022-11-08 | 华东理工大学 | 化学耐受性的葡萄糖脱氢酶突变体及其在辅酶再生中的应用 |
| EP4067483A1 (de) | 2021-03-29 | 2022-10-05 | The University of North Carolina at Chapel Hill | Mutante glucose-dehydrogenase mit verbesserter thermischer stabilität und deren verwendung |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10243786A (ja) * | 1997-03-03 | 1998-09-14 | Koji Hayade | 改変型グルコース脱水素酵素 |
| JP2000312588A (ja) | 1999-04-30 | 2000-11-14 | Koji Hayade | グルコース脱水素酵素 |
| TWI224136B (en) | 1999-04-30 | 2004-11-21 | Koji Sode | Glucose dehydrogenase |
| AU2002210991B2 (en) | 2000-10-31 | 2006-08-10 | Koji Sode | Novel glucose dehydrogenase and process for producing the dehydrogenase |
| JP4036667B2 (ja) | 2002-03-25 | 2008-01-23 | 広司 早出 | 新規グルコース脱水素酵素及びそれをコードする遺伝子 |
| ATE373706T1 (de) | 2002-04-26 | 2007-10-15 | Koji Sode | Beta-untereinheit von glucosedehydrogenase und diese kodierende dna |
| EP1367120A3 (de) * | 2002-05-27 | 2004-06-02 | Toyo Boseki Kabushiki Kaisha | Modifizierte pyrroloquinolin quinon-abhängigen glukose Dehydrogenase mit höher Substratspezifität und Stabilität |
| WO2004022732A1 (ja) | 2002-08-30 | 2004-03-18 | Arkray, Inc. | タンパク質およびグルコース脱水素酵素の精製方法 |
| JP4102138B2 (ja) | 2002-08-30 | 2008-06-18 | 広司 早出 | グルコース脱水素酵素の製造方法 |
-
2005
- 2005-04-22 DE DE602005025104T patent/DE602005025104D1/de not_active Expired - Lifetime
- 2005-04-22 CN CN200580020531.6A patent/CN1973036B/zh not_active Expired - Fee Related
- 2005-04-22 US US11/587,333 patent/US7803592B2/en active Active
- 2005-04-22 EP EP05734575A patent/EP1739174B1/de not_active Expired - Lifetime
- 2005-04-22 KR KR1020067024473A patent/KR101186718B1/ko not_active Expired - Fee Related
- 2005-04-22 WO PCT/JP2005/007687 patent/WO2005103248A1/ja not_active Ceased
- 2005-04-22 JP JP2006512597A patent/JP4639302B2/ja not_active Expired - Fee Related
- 2005-04-22 AT AT05734575T patent/ATE490316T1/de not_active IP Right Cessation
-
2010
- 2010-08-23 US US12/861,734 patent/US8012729B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR20070006921A (ko) | 2007-01-11 |
| EP1739174A1 (de) | 2007-01-03 |
| US8012729B2 (en) | 2011-09-06 |
| CN1973036B (zh) | 2014-07-23 |
| KR101186718B1 (ko) | 2012-09-27 |
| DE602005025104D1 (de) | 2011-01-13 |
| EP1739174A4 (de) | 2008-01-09 |
| EP1739174B1 (de) | 2010-12-01 |
| US20110076707A1 (en) | 2011-03-31 |
| US7803592B2 (en) | 2010-09-28 |
| US20080280312A1 (en) | 2008-11-13 |
| CN1973036A (zh) | 2007-05-30 |
| JPWO2005103248A1 (ja) | 2008-03-13 |
| WO2005103248A1 (ja) | 2005-11-03 |
| JP4639302B2 (ja) | 2011-02-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |