ATE455848T1 - Mutante glucose-dehydrogenase - Google Patents
Mutante glucose-dehydrogenaseInfo
- Publication number
- ATE455848T1 ATE455848T1 AT06757259T AT06757259T ATE455848T1 AT E455848 T1 ATE455848 T1 AT E455848T1 AT 06757259 T AT06757259 T AT 06757259T AT 06757259 T AT06757259 T AT 06757259T AT E455848 T1 ATE455848 T1 AT E455848T1
- Authority
- AT
- Austria
- Prior art keywords
- amino acid
- glucose dehydrogenase
- mutant glucose
- acid sequence
- acid residue
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01049—Glucose-6-phosphate dehydrogenase (1.1.1.49)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Botany (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005179231 | 2005-06-20 | ||
| JP2006011774 | 2006-06-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE455848T1 true ATE455848T1 (de) | 2010-02-15 |
Family
ID=37570313
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT09004339T ATE520771T1 (de) | 2005-06-20 | 2006-06-12 | Mutierte glucose-dehydrogenase |
| AT06757259T ATE455848T1 (de) | 2005-06-20 | 2006-06-12 | Mutante glucose-dehydrogenase |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT09004339T ATE520771T1 (de) | 2005-06-20 | 2006-06-12 | Mutierte glucose-dehydrogenase |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7604969B2 (de) |
| EP (2) | EP2077321B1 (de) |
| JP (1) | JP5341312B2 (de) |
| KR (2) | KR101399727B1 (de) |
| CN (1) | CN101107353B (de) |
| AT (2) | ATE520771T1 (de) |
| DE (1) | DE602006011858D1 (de) |
| TW (2) | TWI485249B (de) |
| WO (1) | WO2006137283A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2511656A1 (en) | 2002-12-24 | 2004-07-15 | Ikeda Food Research Co., Ltd. | Coenzyme-binding glucose dehydrogenase |
| EP1661516B1 (de) * | 2003-09-02 | 2012-08-15 | Koji Sode | Glukosesensor und glukosespiegel-messgerät |
| EP2365073A1 (de) | 2005-03-25 | 2011-09-14 | Ikeda Food Research Co. Ltd. | Coenzym-verknüpfte glucose-dehydrogenase und dafür codierendes polynucleotid |
| EP2241621B1 (de) * | 2007-12-28 | 2012-08-15 | Ikeda Food Research Co. Ltd. | Modifiziertes glucosedehydrogenasegen |
| EP2426200A4 (de) * | 2009-04-30 | 2012-11-14 | Ikeda Food Res Co Ltd | Protein-elektronenmediator |
| JP5803081B2 (ja) * | 2009-10-09 | 2015-11-04 | 東洋紡株式会社 | Ｆａｄジヌクレオチド依存性グルコースデヒドロゲナーゼの温度依存性を改善する方法 |
| ES2568464T3 (es) | 2010-07-23 | 2016-04-29 | F. Hoffmann-La Roche Ag | Composiciones que contienen tampón zwiteriónico y usos en dispositivos y métodos electroanalíticos |
| JP5824205B2 (ja) | 2010-10-27 | 2015-11-25 | アークレイ株式会社 | 変異グルコース脱水素酵素 |
| CN102559624B (zh) * | 2012-03-05 | 2013-10-16 | 浙江德清汇宁生物科技有限公司 | 一种吡咯喹啉醌依赖型葡萄糖脱氢酶的热稳定性突变体及其高通量筛选方法 |
| WO2016023933A1 (de) * | 2014-08-12 | 2016-02-18 | Pharmazell Gmbh | 3alpha-hydroxysteroid dehydrogenase-mutanten und verfahren zur herstellung von ursodesoxycholsäure |
| US10689626B2 (en) | 2014-12-04 | 2020-06-23 | SmartZyme Innovations Ltd. | Compositions and methods for measuring blood glucose levels |
| CN106349392A (zh) * | 2015-07-14 | 2017-01-25 | 达尔生技股份有限公司 | 一种融合多肽 |
| CA2993600A1 (en) | 2015-07-23 | 2017-01-26 | Smartzyme Biopharma Ltd. | Compositions and methods for measuring blood glucose levels |
| JP6856344B2 (ja) * | 2015-10-29 | 2021-04-07 | アークレイ株式会社 | 変異グルコース脱水素酵素およびその利用 |
| EP3249050B1 (de) | 2016-05-23 | 2019-01-23 | ARKRAY, Inc. | Enzymelektrode und biosensor mit verwendung davon |
| JP7339723B2 (ja) * | 2017-07-04 | 2023-09-06 | アークレイ株式会社 | 変異型シトクロムタンパク質およびその利用 |
| CN109425643B (zh) | 2017-08-25 | 2022-10-25 | 爱科来株式会社 | 基于酶电化学阻抗测量法的新型生物传感技术 |
| CN108486027A (zh) * | 2018-04-04 | 2018-09-04 | 江南大学 | 一种fad为辅基的葡萄糖脱氢酶的生产、纯化方法 |
| US11608515B2 (en) | 2018-05-22 | 2023-03-21 | Arkray, Inc. | Biosensing method |
| US11293921B2 (en) | 2018-10-03 | 2022-04-05 | Arkray, Inc. | Direct electron transfer-type oxidoreductase-modified molecular recognition element |
| US12517120B2 (en) * | 2020-01-07 | 2026-01-06 | Beijing Strong Biotechnologies, Inc. | Glucose-6-phosphate dehydrogenase mutant and use thereof in preparing detection reagent |
| EP4067483A1 (de) | 2021-03-29 | 2022-10-05 | The University of North Carolina at Chapel Hill | Mutante glucose-dehydrogenase mit verbesserter thermischer stabilität und deren verwendung |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10243786A (ja) * | 1997-03-03 | 1998-09-14 | Koji Hayade | 改変型グルコース脱水素酵素 |
| TWI224136B (en) | 1999-04-30 | 2004-11-21 | Koji Sode | Glucose dehydrogenase |
| JP2000312588A (ja) * | 1999-04-30 | 2000-11-14 | Koji Hayade | グルコース脱水素酵素 |
| JP2001197888A (ja) | 2000-01-18 | 2001-07-24 | Koji Hayade | 基質特異性に優れたグルコース脱水素酵素 |
| AU1596602A (en) | 2000-10-27 | 2002-05-06 | Peter Kratzsch | Variants of soluble pyrroloquinoline quinone-dependent glucose dehydrogenase |
| KR100753747B1 (ko) | 2000-10-31 | 2007-08-31 | 고지 소데 | 신규 글루코오스 탈수소효소 및 해당 탈수소효소의제조방법 |
| JP4036667B2 (ja) * | 2002-03-25 | 2008-01-23 | 広司 早出 | 新規グルコース脱水素酵素及びそれをコードする遺伝子 |
| WO2003091430A1 (fr) | 2002-04-26 | 2003-11-06 | Koji Sode | SOUS-UNITE ss DE LA GLUCOSE DESHYDROGENASE ET ADN LA CODANT |
| JP2004344145A (ja) | 2002-05-27 | 2004-12-09 | Toyobo Co Ltd | 基質特異性または安定性に優れたピロロキノリンキノン（ｐｑｑ）依存性グルコースデヒドロゲナーゼ改変体 |
| EP1367120A3 (de) | 2002-05-27 | 2004-06-02 | Toyo Boseki Kabushiki Kaisha | Modifizierte pyrroloquinolin quinon-abhängigen glukose Dehydrogenase mit höher Substratspezifität und Stabilität |
| JP4102138B2 (ja) * | 2002-08-30 | 2008-06-18 | 広司 早出 | グルコース脱水素酵素の製造方法 |
| JP2004173538A (ja) | 2002-11-25 | 2004-06-24 | Amano Enzyme Inc | ピロロキノリンキノン依存性グルコース脱水素酵素 |
| JP4029346B2 (ja) | 2003-03-24 | 2008-01-09 | 東洋紡績株式会社 | 基質特異性または安定性に優れたピロロキノリンキノン（ｐｑｑ）依存性グルコースデヒドロゲナーゼ改変体 |
| JP4332794B2 (ja) | 2003-03-24 | 2009-09-16 | 東洋紡績株式会社 | 基質特異性または安定性に優れたピロロキノリンキノン（ｐｑｑ）依存性グルコースデヒドロゲナーゼ改変体 |
| ATE490316T1 (de) * | 2004-04-23 | 2010-12-15 | Arkray Inc | Mutierte glucosedehydrogenase |
| EP1600503A1 (de) | 2004-05-14 | 2005-11-30 | Amano Enzyme Inc. | Modifizierte pyrroloquinolin quinon-abhängige Glukose Dehydrogenase |
-
2006
- 2006-06-12 EP EP09004339A patent/EP2077321B1/de not_active Not-in-force
- 2006-06-12 WO PCT/JP2006/311774 patent/WO2006137283A1/ja not_active Ceased
- 2006-06-12 AT AT09004339T patent/ATE520771T1/de not_active IP Right Cessation
- 2006-06-12 DE DE602006011858T patent/DE602006011858D1/de active Active
- 2006-06-12 AT AT06757259T patent/ATE455848T1/de not_active IP Right Cessation
- 2006-06-12 JP JP2006541525A patent/JP5341312B2/ja not_active Expired - Fee Related
- 2006-06-12 CN CN200680002834.XA patent/CN101107353B/zh not_active Expired - Fee Related
- 2006-06-12 KR KR1020077012683A patent/KR101399727B1/ko not_active Expired - Fee Related
- 2006-06-12 US US11/665,296 patent/US7604969B2/en active Active
- 2006-06-12 EP EP06757259A patent/EP1860183B1/de not_active Ceased
- 2006-06-12 KR KR1020127033835A patent/KR101387240B1/ko not_active Expired - Fee Related
- 2006-06-20 TW TW101140993A patent/TWI485249B/zh not_active IP Right Cessation
- 2006-06-20 TW TW095122108A patent/TWI403584B/zh not_active IP Right Cessation
-
2009
- 2009-09-09 US US12/556,142 patent/US7776575B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP5341312B2 (ja) | 2013-11-13 |
| EP1860183A4 (de) | 2008-10-15 |
| TWI403584B (zh) | 2013-08-01 |
| TWI485249B (zh) | 2015-05-21 |
| CN101107353B (zh) | 2015-07-29 |
| US7604969B2 (en) | 2009-10-20 |
| EP2077321A3 (de) | 2009-10-07 |
| TW200726842A (en) | 2007-07-16 |
| TW201307562A (zh) | 2013-02-16 |
| EP1860183B1 (de) | 2010-01-20 |
| EP2077321B1 (de) | 2011-08-17 |
| ATE520771T1 (de) | 2011-09-15 |
| EP2077321A2 (de) | 2009-07-08 |
| KR101399727B1 (ko) | 2014-05-29 |
| KR20130018336A (ko) | 2013-02-20 |
| KR101387240B1 (ko) | 2014-04-21 |
| KR20080028834A (ko) | 2008-04-01 |
| CN101107353A (zh) | 2008-01-16 |
| JPWO2006137283A1 (ja) | 2009-01-15 |
| DE602006011858D1 (de) | 2010-03-11 |
| EP1860183A1 (de) | 2007-11-28 |
| US20080206833A1 (en) | 2008-08-28 |
| WO2006137283A1 (ja) | 2006-12-28 |
| US7776575B2 (en) | 2010-08-17 |
| US20100086989A1 (en) | 2010-04-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |