ATE455848T1 - Mutante glucose-dehydrogenase - Google Patents
Mutante glucose-dehydrogenaseInfo
- Publication number
- ATE455848T1 ATE455848T1 AT06757259T AT06757259T ATE455848T1 AT E455848 T1 ATE455848 T1 AT E455848T1 AT 06757259 T AT06757259 T AT 06757259T AT 06757259 T AT06757259 T AT 06757259T AT E455848 T1 ATE455848 T1 AT E455848T1
- Authority
- AT
- Austria
- Prior art keywords
- amino acid
- glucose dehydrogenase
- mutant glucose
- acid sequence
- acid residue
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01049—Glucose-6-phosphate dehydrogenase (1.1.1.49)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Plant Pathology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005179231 | 2005-06-20 | ||
| JP2006011774 | 2006-06-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE455848T1 true ATE455848T1 (de) | 2010-02-15 |
Family
ID=37570313
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06757259T ATE455848T1 (de) | 2005-06-20 | 2006-06-12 | Mutante glucose-dehydrogenase |
| AT09004339T ATE520771T1 (de) | 2005-06-20 | 2006-06-12 | Mutierte glucose-dehydrogenase |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT09004339T ATE520771T1 (de) | 2005-06-20 | 2006-06-12 | Mutierte glucose-dehydrogenase |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7604969B2 (de) |
| EP (2) | EP1860183B1 (de) |
| JP (1) | JP5341312B2 (de) |
| KR (2) | KR101387240B1 (de) |
| CN (1) | CN101107353B (de) |
| AT (2) | ATE455848T1 (de) |
| DE (1) | DE602006011858D1 (de) |
| TW (2) | TWI485249B (de) |
| WO (1) | WO2006137283A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4494978B2 (ja) | 2002-12-24 | 2010-06-30 | 池田食研株式会社 | 補酵素結合型グルコース脱水素酵素 |
| EP1661516B1 (de) * | 2003-09-02 | 2012-08-15 | Koji Sode | Glukosesensor und glukosespiegel-messgerät |
| EP2368987A1 (de) | 2005-03-25 | 2011-09-28 | Ikeda Food Research Co. Ltd. | Coenzym-verknüpfte glucose-dehydrogenase und dafür codierendes polynucleotid |
| EP2241621B1 (de) * | 2007-12-28 | 2012-08-15 | Ikeda Food Research Co. Ltd. | Modifiziertes glucosedehydrogenasegen |
| CA2759911A1 (en) * | 2009-04-30 | 2010-11-04 | Ikeda Food Research Co. Ltd. | Protein electron mediator |
| JP5803081B2 (ja) * | 2009-10-09 | 2015-11-04 | 東洋紡株式会社 | Ｆａｄジヌクレオチド依存性グルコースデヒドロゲナーゼの温度依存性を改善する方法 |
| WO2012010308A1 (en) * | 2010-07-23 | 2012-01-26 | Roche Diagnostics Gmbh | Zwitterion buffer containing compositions and uses in electroanalytical devices and methods |
| JP5824205B2 (ja) * | 2010-10-27 | 2015-11-25 | アークレイ株式会社 | 変異グルコース脱水素酵素 |
| CN102559624B (zh) * | 2012-03-05 | 2013-10-16 | 浙江德清汇宁生物科技有限公司 | 一种吡咯喹啉醌依赖型葡萄糖脱氢酶的热稳定性突变体及其高通量筛选方法 |
| US10487348B2 (en) * | 2014-08-12 | 2019-11-26 | Pharmazell Gmbh | 3-alpha-hydroxysteroid dehydrogenase mutants and process for the preparation of ursodeoxycholic acid |
| WO2016087937A2 (en) * | 2014-12-04 | 2016-06-09 | Smartzyme Innovation Ltd. | Compositions and methods for measuring blood glucose levels |
| CN106349392A (zh) * | 2015-07-14 | 2017-01-25 | 达尔生技股份有限公司 | 一种融合多肽 |
| EP3325615A4 (de) | 2015-07-23 | 2019-06-05 | Smartzyme Biopharma Ltd. | Zusammensetzungen und verfahren zur messung des blutzuckerspiegels |
| JP6856344B2 (ja) * | 2015-10-29 | 2021-04-07 | アークレイ株式会社 | 変異グルコース脱水素酵素およびその利用 |
| EP3249050B1 (de) | 2016-05-23 | 2019-01-23 | ARKRAY, Inc. | Enzymelektrode und biosensor mit verwendung davon |
| JP7339723B2 (ja) * | 2017-07-04 | 2023-09-06 | アークレイ株式会社 | 変異型シトクロムタンパク質およびその利用 |
| CN109425643B (zh) | 2017-08-25 | 2022-10-25 | 爱科来株式会社 | 基于酶电化学阻抗测量法的新型生物传感技术 |
| CN108486027A (zh) * | 2018-04-04 | 2018-09-04 | 江南大学 | 一种fad为辅基的葡萄糖脱氢酶的生产、纯化方法 |
| EP3578665B1 (de) | 2018-05-22 | 2024-02-21 | ARKRAY, Inc. | Biosensing-verfahren |
| US11293921B2 (en) | 2018-10-03 | 2022-04-05 | Arkray, Inc. | Direct electron transfer-type oxidoreductase-modified molecular recognition element |
| CN113614514B (zh) * | 2020-01-07 | 2022-11-25 | 北京九强生物技术股份有限公司 | 6-磷酸葡萄糖脱氢酶突变体及其在制备检测试剂中的用途 |
| CN115125221A (zh) | 2021-03-29 | 2022-09-30 | 北卡罗来纳大学教堂山分校 | 具有改善的热稳定性的突变体葡萄糖脱氢酶及其应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10243786A (ja) | 1997-03-03 | 1998-09-14 | Koji Hayade | 改変型グルコース脱水素酵素 |
| JP2000312588A (ja) * | 1999-04-30 | 2000-11-14 | Koji Hayade | グルコース脱水素酵素 |
| JP2001197888A (ja) | 2000-01-18 | 2001-07-24 | Koji Hayade | 基質特異性に優れたグルコース脱水素酵素 |
| TWI224136B (en) * | 1999-04-30 | 2004-11-21 | Koji Sode | Glucose dehydrogenase |
| PL205561B1 (pl) * | 2000-10-27 | 2010-05-31 | Hoffmann La Roche | Zmutowane białko zależnej od pirolochinolinochinonu rozpuszczalnej dehydrogenazy glukozowej, wyizolowany polinukleotyd kodujący to białko, wektor ekspresyjny, komórka gospodarza, sposób wytwarzania wariantów s-GDH, sposób wykrywania, oznaczania lub pomiaru glukozy i urządzenie do wykrywania lub pomiaru glukozy |
| CA2427031C (en) | 2000-10-31 | 2016-02-09 | Koji Sode | Novel glucose dehydrogenase and method for producing the dehydrogenase |
| JP4036667B2 (ja) | 2002-03-25 | 2008-01-23 | 広司 早出 | 新規グルコース脱水素酵素及びそれをコードする遺伝子 |
| JP4107389B2 (ja) | 2002-04-26 | 2008-06-25 | 広司 早出 | グルコース脱水素酵素βサブユニット及びそれをコードするＤＮＡ |
| JP2004344145A (ja) | 2002-05-27 | 2004-12-09 | Toyobo Co Ltd | 基質特異性または安定性に優れたピロロキノリンキノン（ｐｑｑ）依存性グルコースデヒドロゲナーゼ改変体 |
| US7476525B2 (en) * | 2002-05-27 | 2009-01-13 | Toyo Boseki Kabushiki Kaisha | Modified pyrroloquinoline quinone (PQQ) dependent glucose dehydrogenase with superior substrate specificity and stability |
| JP4102138B2 (ja) * | 2002-08-30 | 2008-06-18 | 広司 早出 | グルコース脱水素酵素の製造方法 |
| JP2004173538A (ja) | 2002-11-25 | 2004-06-24 | Amano Enzyme Inc | ピロロキノリンキノン依存性グルコース脱水素酵素 |
| JP4332794B2 (ja) | 2003-03-24 | 2009-09-16 | 東洋紡績株式会社 | 基質特異性または安定性に優れたピロロキノリンキノン（ｐｑｑ）依存性グルコースデヒドロゲナーゼ改変体 |
| JP4029346B2 (ja) | 2003-03-24 | 2008-01-09 | 東洋紡績株式会社 | 基質特異性または安定性に優れたピロロキノリンキノン（ｐｑｑ）依存性グルコースデヒドロゲナーゼ改変体 |
| US7803592B2 (en) * | 2004-04-23 | 2010-09-28 | Arkray, Inc. | Mutant glucose dehydrogenase |
| EP1600503A1 (de) * | 2004-05-14 | 2005-11-30 | Amano Enzyme Inc. | Modifizierte pyrroloquinolin quinon-abhängige Glukose Dehydrogenase |
-
2006
- 2006-06-12 AT AT06757259T patent/ATE455848T1/de not_active IP Right Cessation
- 2006-06-12 EP EP06757259A patent/EP1860183B1/de not_active Ceased
- 2006-06-12 US US11/665,296 patent/US7604969B2/en active Active
- 2006-06-12 JP JP2006541525A patent/JP5341312B2/ja not_active Expired - Fee Related
- 2006-06-12 DE DE602006011858T patent/DE602006011858D1/de active Active
- 2006-06-12 CN CN200680002834.XA patent/CN101107353B/zh not_active Expired - Fee Related
- 2006-06-12 EP EP09004339A patent/EP2077321B1/de not_active Not-in-force
- 2006-06-12 KR KR1020127033835A patent/KR101387240B1/ko not_active Expired - Fee Related
- 2006-06-12 KR KR1020077012683A patent/KR101399727B1/ko not_active Expired - Fee Related
- 2006-06-12 WO PCT/JP2006/311774 patent/WO2006137283A1/ja not_active Ceased
- 2006-06-12 AT AT09004339T patent/ATE520771T1/de not_active IP Right Cessation
- 2006-06-20 TW TW101140993A patent/TWI485249B/zh not_active IP Right Cessation
- 2006-06-20 TW TW095122108A patent/TWI403584B/zh not_active IP Right Cessation
-
2009
- 2009-09-09 US US12/556,142 patent/US7776575B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP5341312B2 (ja) | 2013-11-13 |
| CN101107353A (zh) | 2008-01-16 |
| KR20080028834A (ko) | 2008-04-01 |
| JPWO2006137283A1 (ja) | 2009-01-15 |
| US20080206833A1 (en) | 2008-08-28 |
| EP2077321A2 (de) | 2009-07-08 |
| EP2077321B1 (de) | 2011-08-17 |
| EP1860183A1 (de) | 2007-11-28 |
| TW200726842A (en) | 2007-07-16 |
| WO2006137283A1 (ja) | 2006-12-28 |
| KR101387240B1 (ko) | 2014-04-21 |
| KR101399727B1 (ko) | 2014-05-29 |
| TW201307562A (zh) | 2013-02-16 |
| EP1860183A4 (de) | 2008-10-15 |
| DE602006011858D1 (de) | 2010-03-11 |
| US20100086989A1 (en) | 2010-04-08 |
| ATE520771T1 (de) | 2011-09-15 |
| TWI485249B (zh) | 2015-05-21 |
| TWI403584B (zh) | 2013-08-01 |
| KR20130018336A (ko) | 2013-02-20 |
| US7604969B2 (en) | 2009-10-20 |
| CN101107353B (zh) | 2015-07-29 |
| EP1860183B1 (de) | 2010-01-20 |
| EP2077321A3 (de) | 2009-10-07 |
| US7776575B2 (en) | 2010-08-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |