ATE491689T1 - Heteroaryl diazacycloalkane als cholinergische ligande für nikotin-acetylcholin-rezeptoren - Google Patents

Heteroaryl diazacycloalkane als cholinergische ligande für nikotin-acetylcholin-rezeptoren

Info

Publication number: ATE491689T1
Authority: AT; Austria
Prior art keywords: alkyl; alkoxy; cycloalkylalkyl; cycloalkyl; alkynoxy
Prior art date: 1997-10-27

Application number

AT04102866T

Other languages

English (en)

Inventor

Dan Peters

Gunnar Olsen

Simon Nielsen

Elsebet Nielsen

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-27

Filing date

1998-10-27

Publication date

2011-01-15

1998-10-27 Application filed by Neurosearch As filed Critical Neurosearch As

2011-01-15 Application granted granted Critical

2011-01-15 Publication of ATE491689T1 publication Critical patent/ATE491689T1/de

Links

239000003446 ligand Substances 0.000 title abstract 2
230000001713 cholinergic effect Effects 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 10
125000003545 alkoxy group Chemical group 0.000 abstract 9
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 9
125000000753 cycloalkyl group Chemical group 0.000 abstract 9
125000003342 alkenyl group Chemical group 0.000 abstract 8
125000000304 alkynyl group Chemical group 0.000 abstract 8
125000000000 cycloalkoxy group Chemical group 0.000 abstract 8
125000001475 halogen functional group Chemical group 0.000 abstract 8
-1 methylenedioxy Chemical group 0.000 abstract 8
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 7
125000000623 heterocyclic group Chemical group 0.000 abstract 3
125000002950 monocyclic group Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 2
125000001072 heteroaryl group Chemical group 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
108010009685 Cholinergic Receptors Proteins 0.000 abstract 1
102000019315 Nicotinic acetylcholine receptors Human genes 0.000 abstract 1
108050006807 Nicotinic acetylcholine receptors Proteins 0.000 abstract 1
CPQPJKVLRWQDJS-WLHGVMLRSA-N OC(=O)\C=C\C(O)=O.N1=C(Cl)C(OC)=CC(N2CCNCCC2)=C1 Chemical compound OC(=O)\C=C\C(O)=O.N1=C(Cl)C(OC)=CC(N2CCNCCC2)=C1 CPQPJKVLRWQDJS-WLHGVMLRSA-N 0.000 abstract 1
102000034337 acetylcholine receptors Human genes 0.000 abstract 1
125000005083 alkoxyalkoxy group Chemical group 0.000 abstract 1
125000005036 alkoxyphenyl group Chemical group 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
230000000202 analgesic effect Effects 0.000 abstract 1
230000003257 anti-anginal effect Effects 0.000 abstract 1
230000001088 anti-asthma Effects 0.000 abstract 1
230000001773 anti-convulsant effect Effects 0.000 abstract 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
230000002460 anti-migrenic effect Effects 0.000 abstract 1
230000002738 anti-smoking effect Effects 0.000 abstract 1
239000000924 antiasthmatic agent Substances 0.000 abstract 1
239000001961 anticonvulsive agent Substances 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
229940005513 antidepressants Drugs 0.000 abstract 1
229960003965 antiepileptics Drugs 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229940027564 cytisine Drugs 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000004464 hydroxyphenyl group Chemical group 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000003176 neuroleptic agent Substances 0.000 abstract 1
230000000701 neuroleptic effect Effects 0.000 abstract 1
230000000324 neuroprotective effect Effects 0.000 abstract 1
125000006501 nitrophenyl group Chemical group 0.000 abstract 1
230000001777 nootropic effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000005309 thioalkoxy group Chemical group 0.000 abstract 1
229940125725 tranquilizer Drugs 0.000 abstract 1
239000003204 tranquilizing agent Substances 0.000 abstract 1
230000002936 tranquilizing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/22—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing two or more pyridine rings directly linked together, e.g. bipyridyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
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- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Pulmonology (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Cardiology (AREA)
Addiction (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT04102866T 1997-10-27 1998-10-27 Heteroaryl diazacycloalkane als cholinergische ligande für nikotin-acetylcholin-rezeptoren ATE491689T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK122597		1997-10-27
DK40998		1998-03-24
DK79698		1998-06-19

Publications (1)

Publication Number	Publication Date
ATE491689T1 true ATE491689T1 (de)	2011-01-15

Family

ID=27220661

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT04102866T ATE491689T1 (de)	1997-10-27	1998-10-27	Heteroaryl diazacycloalkane als cholinergische ligande für nikotin-acetylcholin-rezeptoren
AT98951286T ATE278670T1 (de)	1997-10-27	1998-10-27	Heteroaryl diazacycloalkane als cholinergische ligande für nikotin-acetylcholin-rezeptoren

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT98951286T ATE278670T1 (de)	1997-10-27	1998-10-27	Heteroaryl diazacycloalkane als cholinergische ligande für nikotin-acetylcholin-rezeptoren

Country Status (25)

Country	Link
US (2)	US6825189B1 (de)
EP (2)	EP1491532B1 (de)
JP (1)	JP4570773B2 (de)
KR (1)	KR100607838B1 (de)
CN (1)	CN1131211C (de)
AT (2)	ATE491689T1 (de)
AU (1)	AU744539B2 (de)
BR (1)	BR9813279B1 (de)
CA (1)	CA2306093C (de)
CZ (1)	CZ299499B6 (de)
DE (2)	DE69842058D1 (de)
DK (1)	DK1027336T3 (de)
EE (1)	EE04588B1 (de)
ES (1)	ES2230723T3 (de)
HU (1)	HU226859B1 (de)
IL (2)	IL135108A0 (de)
IS (1)	IS5420A (de)
NO (1)	NO317094B1 (de)
NZ (1)	NZ503520A (de)
PL (1)	PL203140B1 (de)
PT (1)	PT1027336E (de)
RU (1)	RU2205179C2 (de)
SK (1)	SK285198B6 (de)
TR (1)	TR200001171T2 (de)
WO (1)	WO1999021834A1 (de)

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ATE491689T1 (de) *	1997-10-27	2011-01-15	Neurosearch As	Heteroaryl diazacycloalkane als cholinergische ligande für nikotin-acetylcholin-rezeptoren
CA2367695A1 (en) *	1999-04-26	2000-11-02	Neurosearch A/S	Heteroaryl diazacycloalkanes, their preparation and use
EP1177196B1 (de) *	1999-05-04	2004-03-10	Neurosearch A/S	Heteroaryl diazabicycloalkene, deren herstellung und verwendung
GB9914026D0 (en) *	1999-06-17	1999-08-18	Zeneca Ltd	Chemical compounds
MXPA02005884A (es)	1999-12-14	2002-10-23	Neurosearch As	Heteroaril-diazabicicloalcanos novedosos.
US6809105B2 (en)	2000-04-27	2004-10-26	Abbott Laboratories	Diazabicyclic central nervous system active agents
MY137020A (en) *	2000-04-27	2008-12-31	Abbott Lab	Diazabicyclic central nervous system active agents
JP4312456B2 (ja) *	2000-10-13	2009-08-12	ニューロサーチ、アクティーゼルスカブ	ニコチン性レセプターアゴニスト及びモノアミン作動性物質の組み合わせ作用による情動障害の治療法
CA2341952A1 (en)	2001-03-23	2002-09-23	Universite Laval	Nicotinic receptor agonists for the treatment of inflammatory pulmonary diseases
US8039459B2 (en)	2004-07-15	2011-10-18	Universite Laval	Nicotinic receptor agonists for the treatment of inflammatory diseases
US8557804B2 (en)	2002-03-25	2013-10-15	Universite Laval	Nicotinic receptor agonists for the treatment of inflammatory diseases
WO2004005293A2 (en)	2002-07-05	2004-01-15	Targacept, Inc.	N-aryl diazaspiracyclic compounds and methods of preparation and use thereof
AU2003254016A1 (en)	2002-07-19	2004-02-09	Catholic Healthcare West	Methods and compositions relating to chimeric nicotinic receptor subunits
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GB0316915D0 (en)	2003-07-18	2003-08-20	Glaxo Group Ltd	Compounds
AU2004282201A1 (en)	2003-10-15	2005-04-28	Targacept, Inc.	Azabicycyclic compounds for relieving pain and treating central nervous system disorders
JP5254616B2 (ja)	2004-09-13	2013-08-07	クロノセラピューティクス、インコーポレイテッド	生物学的同調性（ｂｉｏｓｙｎｃｈｒｏｎｏｕｓ）経皮的薬物送達
US7829712B2 (en)	2004-09-20	2010-11-09	Xenon Pharmaceuticals Inc.	Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase
AR051091A1 (es)	2004-09-20	2006-12-20	Xenon Pharmaceuticals Inc	Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
AU2005286648A1 (en)	2004-09-20	2006-03-30	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
EP2289510A1 (de)	2004-09-20	2011-03-02	Xenon Pharmaceuticals Inc.	Heterozyklische Derivate zur Behandlung von durch Stearoyl-Coa-Desaturase-Enzyme verursachten Krankheiten
CA2580857A1 (en)	2004-09-20	2006-09-28	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
EP1827438B2 (de) *	2004-09-20	2014-12-10	Xenon Pharmaceuticals Inc.	Piperazine derivate zur hemmung der menschlichen stearoyl-coa-desaturase
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DE69826883D1 (de)	2004-11-11
JP2001521025A (ja)	2001-11-06
PL340224A1 (en)	2001-01-15
ATE278670T1 (de)	2004-10-15
KR100607838B1 (ko)	2006-08-04
CN1131211C (zh)	2003-12-17
NO20002132L (no)	2000-04-26
IL135108A0 (en)	2001-05-20
US6897219B2 (en)	2005-05-24
HUP0100426A3 (en)	2002-03-28
NO20002132D0 (no)	2000-04-26
US20040072823A1 (en)	2004-04-15
SK285198B6 (sk)	2006-08-03
US6825189B1 (en)	2004-11-30
RU2205179C2 (ru)	2003-05-27
AU9736898A (en)	1999-05-17
PL203140B1 (pl)	2009-08-31
HUP0100426A2 (hu)	2002-02-28
BR9813279B1 (pt)	2010-11-16
ES2230723T3 (es)	2005-05-01
CZ20001507A3 (cs)	2000-08-16
TR200001171T2 (tr)	2000-10-23
CN1277604A (zh)	2000-12-20
CA2306093A1 (en)	1999-05-06
JP4570773B2 (ja)	2010-10-27
NZ503520A (en)	2002-08-28
NO317094B1 (no)	2004-08-09
AU744539B2 (en)	2002-02-28
EE200000178A (et)	2001-04-16
EP1027336B1 (de)	2004-10-06
DE69826883T2 (de)	2005-02-03
BR9813279A (pt)	2000-08-22
PT1027336E (pt)	2005-01-31
IS5420A (is)	2000-03-28
SK6142000A3 (en)	2000-09-12
EP1491532B1 (de)	2010-12-15
EP1027336A1 (de)	2000-08-16
CA2306093C (en)	2011-01-04
HU226859B1 (en)	2009-12-28
EE04588B1 (et)	2006-02-15
WO1999021834A1 (en)	1999-05-06
IL135108A (en)	2006-12-31
HK1031378A1 (en)	2001-06-15
DK1027336T3 (da)	2005-01-24
CZ299499B6 (cs)	2008-08-13
KR20010031461A (ko)	2001-04-16
EP1491532A1 (de)	2004-12-29
DE69842058D1 (de)	2011-01-27

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