NO20002132L - Heteroaryldiazasykloalkaner som kolinerge ligander i nikotinsyreacetylkolinreseptorer - Google Patents

Heteroaryldiazasykloalkaner som kolinerge ligander i nikotinsyreacetylkolinreseptorer

Info

Publication number: NO20002132L
Authority: NO; Norway
Prior art keywords: alkyl; alkoxy; cycloalkylalkyl; cycloalkyl; alkynoxy
Prior art date: 1997-10-27

Application number

NO20002132A

Other languages

English (en)

Other versions

NO317094B1 (no

NO20002132D0 (no

Inventor

Dan Peters

Gunnar M Olsen

Simon Feldbaek Nielsen

Elsebet Istergaard Nielsen

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-27

Filing date

2000-04-26

Publication date

2000-04-26

2000-04-26 Application filed by Neurosearch As filed Critical Neurosearch As

2000-04-26 Publication of NO20002132D0 publication Critical patent/NO20002132D0/no

2000-04-26 Publication of NO20002132L publication Critical patent/NO20002132L/no

2004-08-09 Publication of NO317094B1 publication Critical patent/NO317094B1/no

Links

108010009685 Cholinergic Receptors Proteins 0.000 title abstract 2
102000034337 acetylcholine receptors Human genes 0.000 title abstract 2
239000003446 ligand Substances 0.000 title abstract 2
QFBCQOXKGBYUSU-UHFFFAOYSA-M 2-acetyloxyethyl(trimethyl)azanium;pyridine-3-carboxylate Chemical compound [O-]C(=O)C1=CC=CN=C1.CC(=O)OCC[N+](C)(C)C QFBCQOXKGBYUSU-UHFFFAOYSA-M 0.000 title 1
230000001713 cholinergic effect Effects 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 10
125000003545 alkoxy group Chemical group 0.000 abstract 9
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 9
125000000753 cycloalkyl group Chemical group 0.000 abstract 9
125000003342 alkenyl group Chemical group 0.000 abstract 8
125000000304 alkynyl group Chemical group 0.000 abstract 8
125000000000 cycloalkoxy group Chemical group 0.000 abstract 8
125000001475 halogen functional group Chemical group 0.000 abstract 8
-1 methylenedioxy Chemical group 0.000 abstract 8
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 7
125000000623 heterocyclic group Chemical group 0.000 abstract 3
125000002950 monocyclic group Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 2
125000001072 heteroaryl group Chemical group 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
102000019315 Nicotinic acetylcholine receptors Human genes 0.000 abstract 1
108050006807 Nicotinic acetylcholine receptors Proteins 0.000 abstract 1
CPQPJKVLRWQDJS-WLHGVMLRSA-N OC(=O)\C=C\C(O)=O.N1=C(Cl)C(OC)=CC(N2CCNCCC2)=C1 Chemical compound OC(=O)\C=C\C(O)=O.N1=C(Cl)C(OC)=CC(N2CCNCCC2)=C1 CPQPJKVLRWQDJS-WLHGVMLRSA-N 0.000 abstract 1
125000005083 alkoxyalkoxy group Chemical group 0.000 abstract 1
125000005036 alkoxyphenyl group Chemical group 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
230000000202 analgesic effect Effects 0.000 abstract 1
230000003257 anti-anginal effect Effects 0.000 abstract 1
230000001088 anti-asthma Effects 0.000 abstract 1
230000001773 anti-convulsant effect Effects 0.000 abstract 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
230000002460 anti-migrenic effect Effects 0.000 abstract 1
230000002738 anti-smoking effect Effects 0.000 abstract 1
239000000924 antiasthmatic agent Substances 0.000 abstract 1
239000001961 anticonvulsive agent Substances 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
229940005513 antidepressants Drugs 0.000 abstract 1
229960003965 antiepileptics Drugs 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229940027564 cytisine Drugs 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000004464 hydroxyphenyl group Chemical group 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000003176 neuroleptic agent Substances 0.000 abstract 1
230000000701 neuroleptic effect Effects 0.000 abstract 1
230000000324 neuroprotective effect Effects 0.000 abstract 1
125000006501 nitrophenyl group Chemical group 0.000 abstract 1
230000001777 nootropic effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000005309 thioalkoxy group Chemical group 0.000 abstract 1
229940125725 tranquilizer Drugs 0.000 abstract 1
239000003204 tranquilizing agent Substances 0.000 abstract 1
230000002936 tranquilizing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/22—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing two or more pyridine rings directly linked together, e.g. bipyridyl
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Psychiatry (AREA)
Psychology (AREA)
Addiction (AREA)
Orthopedic Medicine & Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO20002132A 1997-10-27 2000-04-26 Heteroaryldiazasykloalkaner som kolinerge ligander i nikotinsyreacetylkolinreseptorer NO317094B1 (no)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DK122597		1997-10-27
DK40998		1998-03-24
DK79698		1998-06-19
PCT/DK1998/000465 WO1999021834A1 (en)	1997-10-27	1998-10-27	Heteroaryl diazacycloalkanes as cholinergic ligands at nicotinic acetylcholine receptors

Publications (3)

Publication Number	Publication Date
NO20002132D0 NO20002132D0 (no)	2000-04-26
NO20002132L true NO20002132L (no)	2000-04-26
NO317094B1 NO317094B1 (no)	2004-08-09

Family

ID=27220661

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20002132A NO317094B1 (no)	1997-10-27	2000-04-26	Heteroaryldiazasykloalkaner som kolinerge ligander i nikotinsyreacetylkolinreseptorer

Country Status (25)

Country	Link
US (2)	US6825189B1 (no)
EP (2)	EP1491532B1 (no)
JP (1)	JP4570773B2 (no)
KR (1)	KR100607838B1 (no)
CN (1)	CN1131211C (no)
AT (2)	ATE278670T1 (no)
AU (1)	AU744539B2 (no)
BR (1)	BR9813279B1 (no)
CA (1)	CA2306093C (no)
CZ (1)	CZ299499B6 (no)
DE (2)	DE69842058D1 (no)
DK (1)	DK1027336T3 (no)
EE (1)	EE04588B1 (no)
ES (1)	ES2230723T3 (no)
HU (1)	HU226859B1 (no)
IL (2)	IL135108A0 (no)
IS (1)	IS5420A (no)
NO (1)	NO317094B1 (no)
NZ (1)	NZ503520A (no)
PL (1)	PL203140B1 (no)
PT (1)	PT1027336E (no)
RU (1)	RU2205179C2 (no)
SK (1)	SK285198B6 (no)
TR (1)	TR200001171T2 (no)
WO (1)	WO1999021834A1 (no)

Families Citing this family (65)

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AU744539B2 (en) *	1997-10-27	2002-02-28	Neurosearch A/S	Heteroaryl diazacycloalkanes as cholinergic ligands at nicotinic acetylcholine receptors
WO2000064885A1 (en) *	1999-04-26	2000-11-02	Neurosearch A/S	Heteroaryl diazacycloalkanes, their preparation and use
NZ513575A (en) *	1999-05-04	2003-07-25	Neurosearch As	Heteroaryl diazabicycloalkanes useful for treating or preventing a disease or a disorder responsive to the activity of nAChR modulators
GB9914026D0 (en) *	1999-06-17	1999-08-18	Zeneca Ltd	Chemical compounds
WO2001044243A2 (en) *	1999-12-14	2001-06-21	Neurosearch A/S	Novel heteroaryl-diazabicycloalkanes
MY137020A (en) *	2000-04-27	2008-12-31	Abbott Lab	Diazabicyclic central nervous system active agents
US6809105B2 (en)	2000-04-27	2004-10-26	Abbott Laboratories	Diazabicyclic central nervous system active agents
DE60122015T2 (de)	2000-10-13	2006-11-23	Neurosearch A/S	Behandlung affektiver störungen durch kombinierte wirkung eines nikotinischen rezeptoragonisten und einer monoaminergischen substanz
CA2341952A1 (en)	2001-03-23	2002-09-23	Universite Laval	Nicotinic receptor agonists for the treatment of inflammatory pulmonary diseases
US8039459B2 (en)	2004-07-15	2011-10-18	Universite Laval	Nicotinic receptor agonists for the treatment of inflammatory diseases
US8557804B2 (en)	2002-03-25	2013-10-15	Universite Laval	Nicotinic receptor agonists for the treatment of inflammatory diseases
EA009789B1 (ru)	2002-07-05	2008-04-28	Таргасепт, Инк.	N-арилдиазаспирациклические соединения и способы их получения и применения
AU2003254016A1 (en)	2002-07-19	2004-02-09	Catholic Healthcare West	Methods and compositions relating to chimeric nicotinic receptor subunits
US7098331B2 (en)	2003-03-05	2006-08-29	Targacept, Inc.	Arylvinylazacycloalkane compounds and methods of preparation and use thereof
GB0316915D0 (en)	2003-07-18	2003-08-20	Glaxo Group Ltd	Compounds
EP1678172B1 (en)	2003-10-15	2009-12-09	Targacept, Inc.	Azabicyclic compounds for relieving pain and treating central nervous system disorders
US20070191815A1 (en)	2004-09-13	2007-08-16	Chrono Therapeutics, Inc.	Biosynchronous transdermal drug delivery
CN101044134A (zh)	2004-09-20	2007-09-26	塔加西普特公司	具有烟碱性胆碱能受体活性的氮杂螺烯和氮杂螺烷化合物
EP2289510A1 (en)	2004-09-20	2011-03-02	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
MX2007003332A (es)	2004-09-20	2007-06-05	Xenon Pharmaceuticals Inc	Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa.
US20080167321A1 (en) *	2004-09-20	2008-07-10	Xenon Pharmaceuticals Inc.	Pyridine Derivatives For Inhibiting Human Stearoyl-Coa-Desaturase
EP2269610A3 (en)	2004-09-20	2011-03-09	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
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- 1998-10-27 AT AT98951286T patent/ATE278670T1/de active
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Publication number	Publication date
EP1491532B1 (en)	2010-12-15
US6825189B1 (en)	2004-11-30
PL203140B1 (pl)	2009-08-31
JP4570773B2 (ja)	2010-10-27
US20040072823A1 (en)	2004-04-15
SK6142000A3 (en)	2000-09-12
PL340224A1 (en)	2001-01-15
EP1491532A1 (en)	2004-12-29
CZ20001507A3 (cs)	2000-08-16
US6897219B2 (en)	2005-05-24
NO317094B1 (no)	2004-08-09
DE69826883D1 (de)	2004-11-11
IL135108A (en)	2006-12-31
IS5420A (is)	2000-03-28
HUP0100426A3 (en)	2002-03-28
DE69826883T2 (de)	2005-02-03
CZ299499B6 (cs)	2008-08-13
DK1027336T3 (da)	2005-01-24
AU744539B2 (en)	2002-02-28
TR200001171T2 (tr)	2000-10-23
HK1031378A1 (en)	2001-06-15
HUP0100426A2 (hu)	2002-02-28
EP1027336B1 (en)	2004-10-06
EP1027336A1 (en)	2000-08-16
CN1131211C (zh)	2003-12-17
KR100607838B1 (ko)	2006-08-04
IL135108A0 (en)	2001-05-20
HU226859B1 (en)	2009-12-28
JP2001521025A (ja)	2001-11-06
KR20010031461A (ko)	2001-04-16
EE200000178A (et)	2001-04-16
NO20002132D0 (no)	2000-04-26
SK285198B6 (sk)	2006-08-03
ATE491689T1 (de)	2011-01-15
NZ503520A (en)	2002-08-28
BR9813279A (pt)	2000-08-22
ATE278670T1 (de)	2004-10-15
DE69842058D1 (de)	2011-01-27
ES2230723T3 (es)	2005-05-01
CA2306093A1 (en)	1999-05-06
EE04588B1 (et)	2006-02-15
BR9813279B1 (pt)	2010-11-16
PT1027336E (pt)	2005-01-31
WO1999021834A1 (en)	1999-05-06
RU2205179C2 (ru)	2003-05-27
CA2306093C (en)	2011-01-04
AU9736898A (en)	1999-05-17
CN1277604A (zh)	2000-12-20

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