ATE491704T1 - 4-ä2-(cycloalkylamino)pyrimidin-4-ylü- (phenyl)imidazolin-2-onderivate als inhibitoren der p38-map-kinase zur behandlung von entzündlichen krankheiten - Google Patents
4-ä2-(cycloalkylamino)pyrimidin-4-ylü- (phenyl)imidazolin-2-onderivate als inhibitoren der p38-map-kinase zur behandlung von entzündlichen krankheitenInfo
- Publication number
- ATE491704T1 ATE491704T1 AT05738662T AT05738662T ATE491704T1 AT E491704 T1 ATE491704 T1 AT E491704T1 AT 05738662 T AT05738662 T AT 05738662T AT 05738662 T AT05738662 T AT 05738662T AT E491704 T1 ATE491704 T1 AT E491704T1
- Authority
- AT
- Austria
- Prior art keywords
- map kinase
- ylü
- cycloalkylamino
- imidazoline
- pyrimidine
- Prior art date
Links
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 title abstract 2
- 108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 title abstract 2
- 208000027866 inflammatory disease Diseases 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- -1 2-oxo-4-imidazolin-3,4-diyl Chemical group 0.000 abstract 1
- 229940122696 MAP kinase inhibitor Drugs 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004133204 | 2004-04-28 | ||
| US56608904P | 2004-04-29 | 2004-04-29 | |
| JP2005007832 | 2005-01-14 | ||
| PCT/JP2005/008564 WO2005105790A1 (en) | 2004-04-28 | 2005-04-28 | 4- 2- (cycloalkylamino) pyrimidin-4-yl ! - (phenyl) - imidazolin-2- one derivatives as p38 map- kinase inhibitors for the treatment of inflammatory diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE491704T1 true ATE491704T1 (de) | 2011-01-15 |
Family
ID=43384198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05738662T ATE491704T1 (de) | 2004-04-28 | 2005-04-28 | 4-ä2-(cycloalkylamino)pyrimidin-4-ylü- (phenyl)imidazolin-2-onderivate als inhibitoren der p38-map-kinase zur behandlung von entzündlichen krankheiten |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7700771B2 (de) |
| EP (1) | EP1740578B1 (de) |
| JP (1) | JP2007535476A (de) |
| AT (1) | ATE491704T1 (de) |
| AU (1) | AU2005238390C1 (de) |
| BR (1) | BRPI0510335A (de) |
| CA (1) | CA2563042C (de) |
| DE (1) | DE602005025332D1 (de) |
| MY (1) | MY143245A (de) |
| NO (1) | NO20064175L (de) |
| TW (1) | TWI326282B (de) |
| WO (1) | WO2005105790A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100113481A1 (en) * | 2003-12-17 | 2010-05-06 | Alcon Research, Ltd. | Use of serum amyloid a gene in diagnosis and treatment of glaucoma and identification of anti-glaucoma agents |
| ES2600460T3 (es) | 2005-05-10 | 2017-02-09 | Intermune, Inc. | Derivados de piridona-2-ona como moduladores del sistema de proteína cinasa activada por estrés |
| EP1992344A1 (de) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 Alpha als therapeutisches Target für Erkrankungen, die mit einer FGFR3- Mutation assoziiert sind |
| CN102099036B (zh) | 2008-06-03 | 2015-05-27 | 英特芒尼公司 | 用于治疗炎性疾患和纤维化疾患的化合物和方法 |
| DE102009043260A1 (de) | 2009-09-28 | 2011-04-28 | Merck Patent Gmbh | Pyridinyl-imidazolonderivate |
| DE102009049679A1 (de) | 2009-10-19 | 2011-04-21 | Merck Patent Gmbh | Pyrazolopyrimidinderivate |
| DE102010049595A1 (de) | 2010-10-26 | 2012-04-26 | Merck Patent Gmbh | Chinazolinderivate |
| JP6211522B2 (ja) * | 2011-10-06 | 2017-10-11 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | ヘテロシクリルピリ（ミ）ジニルピラゾール |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| MX382781B (es) | 2014-04-02 | 2025-03-13 | Intermune Inc | Piridinonas anti-fibroticas. |
| BR112020018094A2 (pt) | 2018-03-08 | 2020-12-22 | Incyte Corporation | Compostos de aminopirazina diol como inibidores de pi3k-¿ |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| WO2022204046A1 (en) * | 2021-03-23 | 2022-09-29 | Gen1E Lifesciences Inc. | Substituted naphthyl p38alpha mitogen-activated protein kinase inhibitors |
| US12084453B2 (en) | 2021-12-10 | 2024-09-10 | Incyte Corporation | Bicyclic amines as CDK12 inhibitors |
| EP4626878A1 (de) | 2022-12-02 | 2025-10-08 | Neumora Therapeutics, Inc. | Verfahren zur behandlung neurologischer erkrankungen |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL118544A (en) * | 1995-06-07 | 2001-08-08 | Smithkline Beecham Corp | History of imidazole, the process for their preparation and the pharmaceutical preparations containing them |
| AR016294A1 (es) * | 1997-07-02 | 2001-07-04 | Smithkline Beecham Corp | Compuesto de imidazol sustituido, composicion farmaceutica que la contiene, su uso en la fabricacion de un medicamento y procedimiento para supreparacion |
| EP1021173A1 (de) | 1997-10-10 | 2000-07-26 | Imperial College Innovations Limited | Verwendung von cytokin-unterdrückenden verbindungen (csaid) zur behandlung von gebärmutterkontraktionen |
| CO5170501A1 (es) * | 1999-04-14 | 2002-06-27 | Novartis Ag | AZOLES SUSTITUIDOS UTILES PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR TNFa eIL-1 Y ENFERMEDADES DEL METABOLISMO OSEO |
| US6492516B1 (en) * | 1999-05-14 | 2002-12-10 | Merck & Co., Inc. | Compounds having cytokine inhibitory activity |
| BR0013551A (pt) * | 1999-08-13 | 2003-06-17 | Vertex Pharma | Inibidores de cinases n-terminal cjun (jnk) e outras cinases de proteìnas |
| WO2001091749A1 (en) | 2000-06-01 | 2001-12-06 | Merck & Co., Inc. | Use of (di-substituted-phenyl)-pyrimidinyl-imidazole derivatives as jnk-inhibitors |
| PE20020506A1 (es) * | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
| ATE550332T1 (de) | 2001-10-22 | 2012-04-15 | Mitsubishi Tanabe Pharma Corp | 4-imidazolin-2-onverbindungen als p38-map- kinaseinhibitors |
| TW200400960A (en) * | 2002-06-05 | 2004-01-16 | Pharmacia Corp | Novel pyrazoles and their use as P38 kinase inhibitors |
| AU2003242873A1 (en) | 2002-06-06 | 2003-12-22 | Koninklijke Philips Electronics N.V. | Quad flat non-leaded package comprising a semiconductor device |
| CA2526285A1 (en) * | 2003-05-15 | 2004-12-23 | Arqule, Inc. | Inhibitors of p38 and methods of using the same |
-
2005
- 2005-04-27 TW TW094113384A patent/TWI326282B/zh not_active IP Right Cessation
- 2005-04-27 MY MYPI20051847A patent/MY143245A/en unknown
- 2005-04-28 US US11/587,498 patent/US7700771B2/en not_active Expired - Fee Related
- 2005-04-28 WO PCT/JP2005/008564 patent/WO2005105790A1/en not_active Ceased
- 2005-04-28 EP EP05738662A patent/EP1740578B1/de not_active Expired - Lifetime
- 2005-04-28 DE DE602005025332T patent/DE602005025332D1/de not_active Expired - Lifetime
- 2005-04-28 AT AT05738662T patent/ATE491704T1/de not_active IP Right Cessation
- 2005-04-28 CA CA2563042A patent/CA2563042C/en not_active Expired - Fee Related
- 2005-04-28 BR BRPI0510335-5A patent/BRPI0510335A/pt not_active IP Right Cessation
- 2005-04-28 JP JP2006519531A patent/JP2007535476A/ja not_active Ceased
- 2005-04-28 AU AU2005238390A patent/AU2005238390C1/en not_active Ceased
-
2006
- 2006-09-15 NO NO20064175A patent/NO20064175L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005238390B2 (en) | 2009-01-08 |
| AU2005238390A1 (en) | 2005-11-10 |
| EP1740578B1 (de) | 2010-12-15 |
| WO2005105790A1 (en) | 2005-11-10 |
| JP2007535476A (ja) | 2007-12-06 |
| BRPI0510335A (pt) | 2007-10-23 |
| CA2563042A1 (en) | 2005-11-10 |
| US7700771B2 (en) | 2010-04-20 |
| EP1740578A1 (de) | 2007-01-10 |
| US20070185326A1 (en) | 2007-08-09 |
| DE602005025332D1 (de) | 2011-01-27 |
| CA2563042C (en) | 2010-04-27 |
| MY143245A (en) | 2011-04-15 |
| AU2005238390C1 (en) | 2009-06-25 |
| TW200536843A (en) | 2005-11-16 |
| TWI326282B (en) | 2010-06-21 |
| NO20064175L (no) | 2006-12-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |