ATE492811T1 - System zur zellbasierten reihenuntersuchun mit hoher durchlaufleistung - Google Patents

System zur zellbasierten reihenuntersuchun mit hoher durchlaufleistung

Info

Publication number
ATE492811T1
ATE492811T1 AT07722969T AT07722969T ATE492811T1 AT E492811 T1 ATE492811 T1 AT E492811T1 AT 07722969 T AT07722969 T AT 07722969T AT 07722969 T AT07722969 T AT 07722969T AT E492811 T1 ATE492811 T1 AT E492811T1
Authority
AT
Austria
Prior art keywords
flow
test solutions
immobilisation
array
points
Prior art date
Application number
AT07722969T
Other languages
English (en)
Inventor
Livia Seemann
Frauke Greve
Jan Lichtenberg
Original Assignee
Eth Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eth Zuerich filed Critical Eth Zuerich
Application granted granted Critical
Publication of ATE492811T1 publication Critical patent/ATE492811T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/432—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Engine Equipment That Uses Special Cycles (AREA)
AT07722969T 2006-03-01 2007-02-28 System zur zellbasierten reihenuntersuchun mit hoher durchlaufleistung ATE492811T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06004090A EP1830186A1 (de) 2006-03-01 2006-03-01 Vorrichtung für Hochdurchsatzanalyse auf Zellbasis
PCT/EP2007/001716 WO2007098933A1 (en) 2006-03-01 2007-02-28 High-throughput cell-based screening system

Publications (1)

Publication Number Publication Date
ATE492811T1 true ATE492811T1 (de) 2011-01-15

Family

ID=36675175

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07722969T ATE492811T1 (de) 2006-03-01 2007-02-28 System zur zellbasierten reihenuntersuchun mit hoher durchlaufleistung

Country Status (5)

Country Link
US (1) US20090305901A1 (de)
EP (2) EP1830186A1 (de)
AT (1) ATE492811T1 (de)
DE (1) DE602007011403D1 (de)
WO (1) WO2007098933A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9494557B2 (en) 2011-04-05 2016-11-15 Purdue Research Foundation Micro-fluidic system using micro-apertures for high throughput detection of cells
US9116145B2 (en) * 2011-12-14 2015-08-25 The George Washington University Flexible IC/microfluidic integration and packaging
WO2014138203A2 (en) * 2013-03-05 2014-09-12 Board Of Regents, The University Of Texas System Microfluidic devices for the rapid and automated processing of sample populations
JP2017518752A (ja) * 2014-06-12 2017-07-13 ウエハージェン インコーポレイテッド 捕捉用重合体膜を用いた単細胞捕捉
US11213824B2 (en) 2017-03-29 2022-01-04 The Research Foundation For The State University Of New York Microfluidic device and methods
CN115253845B (zh) * 2022-07-29 2024-05-10 苏州福斯特光伏材料有限公司 一种用于多组分混合液的自动配料装置以及自动配料方法

Family Cites Families (16)

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US2496173A (en) * 1948-06-01 1950-01-31 Chad A Peebles Adjustable appliance plug
US4713393A (en) * 1985-04-25 1987-12-15 Merck & Co., Inc. Phenylpropyl-2,3-dihydrobenzofurans useful as anti-inflammatory agents
DE19540304C2 (de) * 1995-10-28 1998-07-30 Braun Ag Gerätestecker für Elektrogeräte
US6429025B1 (en) * 1996-06-28 2002-08-06 Caliper Technologies Corp. High-throughput screening assay systems in microscale fluidic devices
US6887693B2 (en) * 1998-12-24 2005-05-03 Cepheid Device and method for lysing cells, spores, or microorganisms
GB2366087B (en) * 2000-08-09 2004-05-26 Chiu-Shan Lee Universal electric adapter
WO2002022264A2 (en) * 2000-09-18 2002-03-21 President And Fellows Of Harvard College Method and apparatus for gradient generation
TW519330U (en) * 2001-09-04 2003-01-21 Delta Electronics Inc Rotating plug
US7560267B2 (en) * 2002-03-18 2009-07-14 City University Of Hong Kong Apparatus and methods for on-chip monitoring of cellular reactions
US20040061257A1 (en) * 2002-09-27 2004-04-01 The Regents Of The University Of Michigan Packaging technique for elastomeric microfluidic chips and microfluidic device prepared thereby
GB0300098D0 (en) * 2003-01-03 2003-02-05 Modern Sense Ltd Electrical adaptor
WO2005089253A2 (en) * 2004-03-12 2005-09-29 The Regents Of The University Of California Methods and apparatus for integrated cell handling and measurements
US20060068608A1 (en) * 2004-09-30 2006-03-30 Mcfadden Orrin H Rotatable outlet adaptor
US7001196B1 (en) * 2005-03-07 2006-02-21 Cheng Uei Precision Industry Co., Ltd. Rotatable plug with an arcing resistant mechanism
TWM273876U (en) * 2005-03-14 2005-08-21 Cheng Uei Prec Ind Co Ltd Rotatable plug
TWI273752B (en) * 2006-02-07 2007-02-11 Leader Electronics Inc Power source plug with changeable direction

Also Published As

Publication number Publication date
WO2007098933A1 (en) 2007-09-07
EP1989545B1 (de) 2010-12-22
EP1989545A1 (de) 2008-11-12
US20090305901A1 (en) 2009-12-10
DE602007011403D1 (de) 2011-02-03
EP1830186A1 (de) 2007-09-05

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