ATE494061T1 - Mikrofluidische vorrichtung, mischverfahren und verwendung der vorrichtung - Google Patents

Mikrofluidische vorrichtung, mischverfahren und verwendung der vorrichtung

Info

Publication number
ATE494061T1
ATE494061T1 AT07013434T AT07013434T ATE494061T1 AT E494061 T1 ATE494061 T1 AT E494061T1 AT 07013434 T AT07013434 T AT 07013434T AT 07013434 T AT07013434 T AT 07013434T AT E494061 T1 ATE494061 T1 AT E494061T1
Authority
AT
Austria
Prior art keywords
chamber
liquid
hydrophilic
chambers
correspondence
Prior art date
Application number
AT07013434T
Other languages
English (en)
Inventor
Mario Curcio
Micheal Glauser
Carlo Effenhauser
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE494061T1 publication Critical patent/ATE494061T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3035—Micromixers using surface tension to mix, move or hold the fluids
    • B01F33/30351—Micromixers using surface tension to mix, move or hold the fluids using hydrophilic/hydrophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3017—Mixing chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
    • B01F33/3021—Micromixers the materials to be mixed flowing in the form of droplets the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00833—Plastic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00837—Materials of construction comprising coatings other than catalytically active coatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00858—Aspects relating to the size of the reactor
    • B01J2219/0086—Dimensions of the flow channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0694—Valves, specific forms thereof vents used to stop and induce flow, backpressure valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/088—Passive control of flow resistance by specific surface properties

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
AT07013434T 2007-07-10 2007-07-10 Mikrofluidische vorrichtung, mischverfahren und verwendung der vorrichtung ATE494061T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07013434A EP2016997B1 (de) 2007-07-10 2007-07-10 Mikrofluidische Vorrichtung, Mischverfahren und Verwendung der Vorrichtung

Publications (1)

Publication Number Publication Date
ATE494061T1 true ATE494061T1 (de) 2011-01-15

Family

ID=38752765

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07013434T ATE494061T1 (de) 2007-07-10 2007-07-10 Mikrofluidische vorrichtung, mischverfahren und verwendung der vorrichtung

Country Status (5)

Country Link
US (1) US8911683B2 (de)
EP (1) EP2016997B1 (de)
JP (1) JP5027070B2 (de)
AT (1) ATE494061T1 (de)
DE (1) DE602007011745D1 (de)

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US20070047388A1 (en) * 2005-08-25 2007-03-01 Rockwell Scientific Licensing, Llc Fluidic mixing structure, method for fabricating same, and mixing method
US8053191B2 (en) 2006-08-31 2011-11-08 Westend Asset Clearinghouse Company, Llc Iterative nucleic acid assembly using activation of vector-encoded traits
EP2213364A1 (de) * 2009-01-30 2010-08-04 Albert-Ludwigs-Universität Freiburg Phasenleitermuster für Flüssigkeitsmanipulation
US10207240B2 (en) 2009-11-03 2019-02-19 Gen9, Inc. Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly
US9216414B2 (en) 2009-11-25 2015-12-22 Gen9, Inc. Microfluidic devices and methods for gene synthesis
US9217144B2 (en) 2010-01-07 2015-12-22 Gen9, Inc. Assembly of high fidelity polynucleotides
US8204172B1 (en) 2010-03-17 2012-06-19 General Electric Company System and method of prior image constrained image reconstruction using short scan image data and objective function minimization
US20140147346A1 (en) * 2010-08-20 2014-05-29 Girish Chitnis Laser treatment of a medium for microfluids and various other applications
US10457935B2 (en) 2010-11-12 2019-10-29 Gen9, Inc. Protein arrays and methods of using and making the same
US9295965B2 (en) 2010-11-12 2016-03-29 Gen9, Inc. Methods and devices for nucleic acid synthesis
CN103597203B (zh) * 2011-06-09 2016-10-12 Pp能源有限责任公司 用于连接风力涡轮机的两个转子叶片段的升降装置
ES2737957T3 (es) 2011-08-26 2020-01-17 Gen9 Inc Composiciones y métodos para el ensamblaje de alta fidelidad de ácidos nucleicos
US9150853B2 (en) 2012-03-21 2015-10-06 Gen9, Inc. Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
EP2841601B1 (de) 2012-04-24 2019-03-06 Gen9, Inc. Verfahren zum sortieren von nukleinsäuren und zur multiplexierten, vorbereitenden in-vitro-klonung
CA2877823A1 (en) 2012-06-25 2014-01-03 Gen9, Inc. Methods for nucleic acid assembly and high throughput sequencing
US20150225771A1 (en) * 2012-09-19 2015-08-13 Nec Corporation Analysis chip and analysis device
FR2996544B1 (fr) * 2012-10-08 2015-03-13 Ecole Polytech Circuit microfluidique permettant la mise en contact de gouttes de plusieurs fluides, et procede microfluidique correspondant.
US10037382B2 (en) * 2012-10-29 2018-07-31 Kyocera Corporation Surface acoustic wave sensor
JP5839526B1 (ja) * 2015-02-06 2016-01-06 秋田県 微小液滴を形成する反応デバイス及びこれを用いた電界撹拌方法
US9604209B2 (en) 2015-03-19 2017-03-28 International Business Machines Corporation Microfluidic device with anti-wetting, venting areas
WO2019117102A1 (ja) * 2017-12-11 2019-06-20 デンカ株式会社 液体試料検査キット用膜担体、液体試料検査キット、液体試料検査キットの製造方法、液体試料の検査方法及び膜担体
GB201801019D0 (en) * 2018-01-22 2018-03-07 Q Linea Ab Sample holder
EP3953044A4 (de) * 2019-04-08 2022-06-01 Technion Research & Development Foundation Limited Multiplexiertes array von vorrichtungen für nanoliter-tröpfchen-arrays
CN114096855A (zh) * 2019-07-08 2022-02-25 积水化学工业株式会社 送液方法以及检测芯片
JP7561041B2 (ja) * 2020-04-28 2024-10-03 デクセリアルズ株式会社 検査チップ、及びその製造方法
CN113804658B (zh) * 2020-06-11 2023-06-06 京东方科技集团股份有限公司 微流控流道结构、检测系统及其使用方法
JP2023544985A (ja) 2020-09-23 2023-10-26 エフ． ホフマン－ラ ロシュ アーゲー 電極上の金属ナノ粒子の支援により分析物を検出するための方法
KR102919524B1 (ko) * 2021-11-26 2026-02-02 한국기계연구원 개폐형 디지털 유전자 증폭 키트 어셈블리
EP4638006A1 (de) 2022-12-19 2025-10-29 Anchorline Biolabs, Inc. Mikrofluidik zur kapillarpartitionierung
CN116687084B (zh) * 2023-04-13 2025-08-05 青岛大学 一种湿度可控的口罩及口罩湿度的控制方法

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US5904824A (en) * 1997-03-07 1999-05-18 Beckman Instruments, Inc. Microfluidic electrophoresis device
CN1188702C (zh) * 1997-03-12 2005-02-09 株式会社京都第一科学 分析样液的测试装置
DE10002500A1 (de) 2000-01-21 2001-07-26 Univ Albert Ludwigs Freiburg Kapillarkraftmischer
CA2430651C (en) * 2001-02-09 2010-10-12 Wisconsin Alumni Research Foundation Method and structure for microfluidic flow guiding
EP1643231A1 (de) * 2003-07-09 2006-04-05 Olympus Corporation Vorrichtung und verfahren zum tragen und zur behandlung von flüssigkeit
US20070047388A1 (en) * 2005-08-25 2007-03-01 Rockwell Scientific Licensing, Llc Fluidic mixing structure, method for fabricating same, and mixing method
DE502006007372D1 (de) * 2006-05-22 2010-08-19 Micronas Gmbh Vorrichtung zum Mischen von Mikrotröpfchen

Also Published As

Publication number Publication date
US20090016932A1 (en) 2009-01-15
US8911683B2 (en) 2014-12-16
JP5027070B2 (ja) 2012-09-19
JP2009025301A (ja) 2009-02-05
EP2016997A1 (de) 2009-01-21
DE602007011745D1 (de) 2011-02-17
EP2016997B1 (de) 2011-01-05

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