ATE502692T1 - Mikrofluidische vorrichtung und verfahren für reaktionen nicht mischbarer flüssigkeiten - Google Patents

Mikrofluidische vorrichtung und verfahren für reaktionen nicht mischbarer flüssigkeiten

Info

Publication number
ATE502692T1
ATE502692T1 AT07301224T AT07301224T ATE502692T1 AT E502692 T1 ATE502692 T1 AT E502692T1 AT 07301224 T AT07301224 T AT 07301224T AT 07301224 T AT07301224 T AT 07301224T AT E502692 T1 ATE502692 T1 AT E502692T1
Authority
AT
Austria
Prior art keywords
chamber
channels
width
microfluidic device
immisicable
Prior art date
Application number
AT07301224T
Other languages
English (en)
Inventor
Berengere Chevalier
Clemens Horn
Maxime Moreno
Pierre Woehl
Original Assignee
Corning Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corning Inc filed Critical Corning Inc
Application granted granted Critical
Publication of ATE502692T1 publication Critical patent/ATE502692T1/de

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/80—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/421—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions by moving the components in a convoluted or labyrinthine path
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4331—Mixers with bended, curved, coiled, wounded mixing tubes or comprising elements for bending the flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/304—Micromixers the mixing being performed in a mixing chamber where the products are brought into contact
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
    • B01F33/811—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles in two or more consecutive, i.e. successive, mixing receptacles or being consecutively arranged
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0418—Geometrical information
    • B01F2215/0431—Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/90—Heating or cooling systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00824—Ceramic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00831—Glass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00858—Aspects relating to the size of the reactor
    • B01J2219/00862—Dimensions of the reaction cavity itself
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00925—Irradiation
    • B01J2219/0093—Electric or magnetic energy
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00925—Irradiation
    • B01J2219/00932—Sonic or ultrasonic vibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00925—Irradiation
    • B01J2219/00934—Electromagnetic waves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00968—Type of sensors
    • B01J2219/0097—Optical sensors
    • B01J2219/00975—Ultraviolet light

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
AT07301224T 2007-05-15 2007-07-11 Mikrofluidische vorrichtung und verfahren für reaktionen nicht mischbarer flüssigkeiten ATE502692T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07301042A EP1992403B1 (de) 2007-05-15 2007-05-15 Mikrofluidische und selbstverzögernde oszillierende Mischer sowie Vorrichtungen und Verfahren zu deren Verwendung

Publications (1)

Publication Number Publication Date
ATE502692T1 true ATE502692T1 (de) 2011-04-15

Family

ID=38537743

Family Applications (2)

Application Number Title Priority Date Filing Date
AT07301042T ATE500884T1 (de) 2007-05-15 2007-05-15 Mikrofluidische und selbstverzögernde oszillierende mischer sowie vorrichtungen und verfahren zu deren verwendung
AT07301224T ATE502692T1 (de) 2007-05-15 2007-07-11 Mikrofluidische vorrichtung und verfahren für reaktionen nicht mischbarer flüssigkeiten

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT07301042T ATE500884T1 (de) 2007-05-15 2007-05-15 Mikrofluidische und selbstverzögernde oszillierende mischer sowie vorrichtungen und verfahren zu deren verwendung

Country Status (9)

Country Link
US (1) US20100182868A1 (de)
EP (1) EP1992403B1 (de)
JP (1) JP2011504221A (de)
KR (1) KR20100017806A (de)
CN (1) CN101678293B (de)
AT (2) ATE500884T1 (de)
DE (2) DE602007013010D1 (de)
TW (1) TW200946217A (de)
WO (1) WO2008143923A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2955508B1 (fr) * 2010-01-25 2012-03-30 Corning Inc Microreacteurs avec dispositif microfluidique plan et systeme d'application d'ultrasons ; mise en oeuvre de reactions chimiques en leur sein
US8475738B2 (en) * 2010-05-04 2013-07-02 Electronics And Telecommunications Research Institute Photocatalytic apparatus and method for injecting microfluidic volumes
DE112012001473B4 (de) * 2011-03-28 2016-08-25 Kake Educational Institution Verfahren zum Messen einer Probenlösungs-Konzentration und Vorrichtung zum Messen einer Probenlösungs-Konzentration
US9138714B2 (en) 2011-10-31 2015-09-22 General Electric Company Microfluidic chip and a related method thereof
TWI426951B (zh) * 2011-11-07 2014-02-21 Univ Nat Pingtung Sci & Tech 流體混合裝置
EP3439773B1 (de) * 2016-04-08 2022-11-09 Universidade do Minho Modularer oszillierender strömungsplattenreaktor
BR112019025104A2 (pt) 2017-05-30 2020-06-23 Glaxosmithkline Biologicals S.A. Método de fabricar um sistema de entrega não viral, sistema de entrega não viral, e, composição
CN108636308A (zh) * 2018-05-02 2018-10-12 侯建华 一种管式通用型氯化微反应器
BE1026312B1 (nl) * 2018-05-25 2019-12-23 Ajinomoto Omnichem Doorstroomreactor en gebruik ervan
EP3886901A1 (de) 2018-11-29 2021-10-06 GlaxoSmithKline Biologicals S.A. Verfahren zur herstellung eines adjuvans
US20220032247A1 (en) * 2018-12-06 2022-02-03 Glaxosmithkline Biologicals Sa Microfluidic devices
CN109531851B (zh) * 2019-01-16 2023-08-01 浙江富士特硅橡胶材料有限公司 一种婴童用品用加成型液体硅橡胶混料装置
EP4021407A1 (de) 2019-08-30 2022-07-06 GlaxoSmithKline Biologicals S.A. Strahlmischherstellungsverfahren zum herstellung für lipid-nanopartikel
WO2021133765A1 (en) * 2019-12-23 2021-07-01 Nutcracker Therapeutics, Inc. Microfluidic apparatus and methods of use thereof
CN111939856B (zh) * 2020-07-02 2022-12-30 山东豪迈机械制造有限公司 一种振动反应器及板式反应器
CN114471217A (zh) * 2022-04-02 2022-05-13 深圳市瑞吉生物科技有限公司 一种用于脂质体合成的对冲流混合装置及方法
CN116908435A (zh) * 2023-06-08 2023-10-20 中国人民解放军联勤保障部队第九〇〇医院 一种化学发光免疫分析试剂盒

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3926373A (en) * 1974-07-26 1975-12-16 Us Air Force Thrust augmentation system with oscillating jet nozzles
DE60215546T2 (de) 2001-09-10 2007-05-24 International Business Machines Corp. Datenspeicherungslaufwerke in einer automatischen datenspeicherungsbibliothek
SE0103110D0 (sv) * 2001-09-18 2001-09-18 Aamic Ab Microscale fluid handling system
FR2830206B1 (fr) 2001-09-28 2004-07-23 Corning Inc Dispositif microfluidique et sa fabrication
US20050129580A1 (en) * 2003-02-26 2005-06-16 Swinehart Philip R. Microfluidic chemical reactor for the manufacture of chemically-produced nanoparticles
US7435391B2 (en) * 2003-05-23 2008-10-14 Lucent Technologies Inc. Light-mediated micro-chemical reactors
EP1604733A1 (de) 2004-06-11 2005-12-14 Corning Incorporated Mikrostrukturentwurf zur Optimisierung der Mischung und des Druckabfalls
CN100427194C (zh) * 2004-08-27 2008-10-22 中国科学院长春光学精密机械与物理研究所 芯片内微流体动态混合器、混合池模具及其驱动方法
KR100634525B1 (ko) * 2004-11-23 2006-10-16 삼성전자주식회사 복수 개의 전자석이 배치되어 있는 마이크로채널을포함하는 미세유동 장치, 그를 이용하여 시료를 혼합하는방법 및 세포를 용해하는 방법
EP1679115A1 (de) 2005-01-07 2006-07-12 Corning Incorporated Hochleistungsmikroreaktor
ATE477220T1 (de) 2007-02-28 2010-08-15 Corning Inc Verfahren zur herstellung von mikrofluidischen vorrichtungen

Also Published As

Publication number Publication date
KR20100017806A (ko) 2010-02-16
WO2008143923A1 (en) 2008-11-27
EP1992403B1 (de) 2011-03-09
DE602007013365D1 (de) 2011-05-05
JP2011504221A (ja) 2011-02-03
EP1992403A1 (de) 2008-11-19
CN101678293B (zh) 2012-11-07
TW200946217A (en) 2009-11-16
DE602007013010D1 (de) 2011-04-21
CN101678293A (zh) 2010-03-24
ATE500884T1 (de) 2011-03-15
US20100182868A1 (en) 2010-07-22

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