ATE495172T1 - Neue azabizyklische arylderivate und medizinische verwendung damit - Google Patents

Neue azabizyklische arylderivate und medizinische verwendung damit

Info

Publication number: ATE495172T1
Authority: AT; Austria
Prior art keywords: diseases; disorders; compounds; pyridazinyl; medical use
Prior art date: 2004-10-15

Application number

AT05797020T

Other languages

English (en)

Inventor

Dan Peters

Daniel B Timmermann

Gunnar M Olsen

Elsebet Ystergaard Nielsen

Tino Dyhring Jyrgensen

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-10-15

Filing date

2005-10-14

Publication date

2011-01-15

2005-10-14 Application filed by Neurosearch As filed Critical Neurosearch As

2011-01-15 Application granted granted Critical

2011-01-15 Publication of ATE495172T1 publication Critical patent/ATE495172T1/de

Links

208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 8
201000010099 disease Diseases 0.000 abstract 4
208000035475 disorder Diseases 0.000 abstract 4
210000003169 central nervous system Anatomy 0.000 abstract 2
230000001713 cholinergic effect Effects 0.000 abstract 2
210000001428 peripheral nervous system Anatomy 0.000 abstract 2
108010078791 Carrier Proteins Proteins 0.000 abstract 1
208000017701 Endocrine disease Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
102000019315 Nicotinic acetylcholine receptors Human genes 0.000 abstract 1
108050006807 Nicotinic acetylcholine receptors Proteins 0.000 abstract 1
208000002193 Pain Diseases 0.000 abstract 1
208000007271 Substance Withdrawal Syndrome Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
208000030172 endocrine system disease Diseases 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
230000004770 neurodegeneration Effects 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
125000002098 pyridazinyl group Chemical group 0.000 abstract 1
102000005962 receptors Human genes 0.000 abstract 1
108020003175 receptors Proteins 0.000 abstract 1
230000016160 smooth muscle contraction Effects 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AT05797020T 2004-10-15 2005-10-14 Neue azabizyklische arylderivate und medizinische verwendung damit ATE495172T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US61859804P	2004-10-15	2004-10-15
DKPA200401582		2004-10-15
PCT/EP2005/055263 WO2006040352A1 (en)	2004-10-15	2005-10-14	Novel azabicyclic aryl derivatives and their medical use

Publications (1)

Publication Number	Publication Date
ATE495172T1 true ATE495172T1 (de)	2011-01-15

Family

ID=38744785

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05797020T ATE495172T1 (de)	2004-10-15	2005-10-14	Neue azabizyklische arylderivate und medizinische verwendung damit

Country Status (8)

Country	Link
US (1)	US7652010B2 (de)
EP (1)	EP1802616B1 (de)
CN (1)	CN100588657C (de)
AT (1)	ATE495172T1 (de)
AU (1)	AU2005293510A1 (de)
CA (1)	CA2584836A1 (de)
DE (1)	DE602005025902D1 (de)
WO (1)	WO2006040352A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0220581D0 (en)	2002-09-04	2002-10-09	Novartis Ag	Organic Compound
AR049401A1 (es)	2004-06-18	2006-07-26	Novartis Ag	Aza-biciclononanos
GB0415746D0 (en)	2004-07-14	2004-08-18	Novartis Ag	Organic compounds
GB0521508D0 (en)	2005-10-21	2005-11-30	Novartis Ag	Organic compounds
GB0525673D0 (en)	2005-12-16	2006-01-25	Novartis Ag	Organic compounds
GB0525672D0 (en)	2005-12-16	2006-01-25	Novartis Ag	Organic compounds
EP1987032A1 (de)	2006-02-14	2008-11-05	NeuroSearch A/S	3, 9-diazabicyclo(3.3.1)non-3-yl-arylmethanon-derivate als nikotin-acetylcholin-rezeptoragonisten
EP1987029B1 (de) *	2006-02-16	2010-01-13	Neurosearch A/S	Enantiomerenreine chinuclidinyloxy-pyridazine und ihre verwendung als nikotin-acetylcholin-rezeptorliganden
US8314119B2 (en) *	2006-11-06	2012-11-20	Abbvie Inc.	Azaadamantane derivatives and methods of use
JO3250B1 (ar)	2009-09-22	2018-09-16	Novartis Ag	إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
PE20131394A1 (es)	2010-09-23	2014-01-11	Abbvie Inc	Monohidrato de derivados de aza-adamantano
EP3623371A1 (de)	2014-12-16	2020-03-18	Axovant Sciences GmbH	Geminale substituierte chinuklidinamidverbindungen als agonisten von alpha-7-nikotinischen acetylcholinrezeptoren
CN107847494A (zh)	2015-06-10	2018-03-27	阿考温特科学股份有限公司	作为α7‑烟碱乙酰胆碱受体激动剂的氨基苯并异噁唑化合物
JP2018523707A (ja)	2015-08-12	2018-08-23	アクソバントサイエンシズゲーエムベーハー	α７−ニコチン性アセチルコリン受容体のアゴニストとしてのジェミナル置換アミノベンゾイソオキサゾール化合物
CN109593088B (zh) *	2018-12-27	2022-03-25	华东理工大学	氮杂双环衍生物及其制备和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2791678B1 (fr)	1999-03-30	2001-05-04	Synthelabo	Derives de 1,4-diazabicyclo [3.2.2] nonane-4-carboxylates et -carboxamides, leur preparation et leur application en therapeutique
US6492385B2 (en)	2000-08-18	2002-12-10	Pharmacia & Upjohn Company	Quinuclidine-substituted heteroaryl moieties for treatment of disease
MXPA04012439A (es)	2002-06-10	2005-04-19	Bayer Healthcare Ag	Amidas de acidos 2-heteroarilcarboxilicos.
SE0202430D0 (sv) *	2002-08-14	2002-08-14	Astrazeneca Ab	New Compounds
GB0415746D0 (en)	2004-07-14	2004-08-18	Novartis Ag	Organic compounds

2005
- 2005-10-14 DE DE602005025902T patent/DE602005025902D1/de not_active Expired - Lifetime
- 2005-10-14 AT AT05797020T patent/ATE495172T1/de not_active IP Right Cessation
- 2005-10-14 CA CA002584836A patent/CA2584836A1/en not_active Abandoned
- 2005-10-14 EP EP05797020A patent/EP1802616B1/de not_active Expired - Lifetime
- 2005-10-14 AU AU2005293510A patent/AU2005293510A1/en not_active Abandoned
- 2005-10-14 US US11/663,152 patent/US7652010B2/en not_active Expired - Fee Related
- 2005-10-14 CN CN200580032356A patent/CN100588657C/zh not_active Expired - Fee Related
- 2005-10-14 WO PCT/EP2005/055263 patent/WO2006040352A1/en not_active Ceased

Also Published As

Publication number	Publication date
HK1106513A1 (zh)	2008-03-14
EP1802616B1 (de)	2011-01-12
WO2006040352A1 (en)	2006-04-20
US7652010B2 (en)	2010-01-26
US20070299082A1 (en)	2007-12-27
CN101027300A (zh)	2007-08-29
AU2005293510A1 (en)	2006-04-20
CA2584836A1 (en)	2006-04-20
EP1802616A1 (de)	2007-07-04
CN100588657C (zh)	2010-02-10
DE602005025902D1 (de)	2011-02-24

Legal Events

Date	Code	Title	Description
2011-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE385497T1 (de)	2008-02-15	3-substituierte quinuclidin-derivate und deren verwendung als nikotinischen agonisten
ATE477253T1 (de)	2010-08-15	Neuartige oxadiazol-derivate und deren medizinische verwendung
ATE481407T1 (de)	2010-10-15	Neue diazabicyclische arylderivate und medizinische verwendung dafür
ATE493415T1 (de)	2011-01-15	Neue diazabizyklische arylderivate und medizinische verwendung dafür
DE602007004307D1 (de)	2010-03-04	Enantiomerenreine chinuclidinyloxy-pyridazine und ihre verwendung als nikotin-acetylcholin-rezeptorliganden
ATE287888T1 (de)	2005-02-15	Aryl- und heteroaryldiazabicycloalkane, deren zubereitung und verwendung
DE60310548D1 (de)	2007-02-01	Diazabicyclische biarylderivate
ATE495172T1 (de)	2011-01-15	Neue azabizyklische arylderivate und medizinische verwendung damit
ATE450263T1 (de)	2009-12-15	Diazabicyclische aryl-derivate als cholinerge rezeptor-modulatoren
ATE345342T1 (de)	2006-12-15	1,4-dizabicyclo(3,2,2)nonane derivative, verfahren zur ihre herstellung und therapeutical verwendung
ATE445618T1 (de)	2009-10-15	Neue diazabicyclische arylderivate
DE60215172D1 (de)	2006-11-16	Neue verbindungen, deren herstellung und verwendung
ATE473978T1 (de)	2010-07-15	Neue diazabicyclische arylderivate und medizinische verwendung dafür
ATE437880T1 (de)	2009-08-15	Dimere azacyclische verbindungen und deren verwendung
ATE334129T1 (de)	2006-08-15	3-substituierte chinuklidine und deren verwendung
ATE401334T1 (de)	2008-08-15	Neue azacyclische ethinylderivate
ATE460416T1 (de)	2010-03-15	Neuartige 1,4-diazabicycloä3.2.2ünonan-derivate und deren medizinische verwendung
MX2007003331A (es)	2007-06-05	Nuevos derivados de arilo diazabiciclico.
DE602006019561D1 (de)	2011-02-24	Diazabicyclische arylderivate und ihre verwendung als chinolinergische liganden an nikotin-acetylcholin-rezeptoren
DE602004031124D1 (de)	2011-03-03	Neue chinuklidinderivative und deren pharmazeutische verwendung
ATE478869T1 (de)	2010-09-15	Diazabicycloalkan-derivate und ihre medizinische verwendung
MX2007004245A (es)	2007-06-12	Nuevos derivados de arilo azabiciclicos y su uso medico.