ATE495172T1 - Neue azabizyklische arylderivate und medizinische verwendung damit - Google Patents

Neue azabizyklische arylderivate und medizinische verwendung damit

Info

Publication number: ATE495172T1
Authority: AT; Austria
Prior art keywords: diseases; disorders; compounds; pyridazinyl; medical use
Prior art date: 2004-10-15

Application number

AT05797020T

Other languages

English (en)

Inventor

Dan Peters

Daniel B Timmermann

Gunnar M Olsen

Elsebet Ystergaard Nielsen

Tino Dyhring Jyrgensen

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-10-15

Filing date

2005-10-14

Publication date

2011-01-15

2005-10-14 Application filed by Neurosearch As filed Critical Neurosearch As

2011-01-15 Application granted granted Critical

2011-01-15 Publication of ATE495172T1 publication Critical patent/ATE495172T1/de

Links

208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 8
201000010099 disease Diseases 0.000 abstract 4
208000035475 disorder Diseases 0.000 abstract 4
210000003169 central nervous system Anatomy 0.000 abstract 2
230000001713 cholinergic effect Effects 0.000 abstract 2
210000001428 peripheral nervous system Anatomy 0.000 abstract 2
108010078791 Carrier Proteins Proteins 0.000 abstract 1
208000017701 Endocrine disease Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
102000019315 Nicotinic acetylcholine receptors Human genes 0.000 abstract 1
108050006807 Nicotinic acetylcholine receptors Proteins 0.000 abstract 1
208000002193 Pain Diseases 0.000 abstract 1
208000007271 Substance Withdrawal Syndrome Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
208000030172 endocrine system disease Diseases 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
230000004770 neurodegeneration Effects 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
125000002098 pyridazinyl group Chemical group 0.000 abstract 1
102000005962 receptors Human genes 0.000 abstract 1
108020003175 receptors Proteins 0.000 abstract 1
230000016160 smooth muscle contraction Effects 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT05797020T 2004-10-15 2005-10-14 Neue azabizyklische arylderivate und medizinische verwendung damit ATE495172T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US61859804P	2004-10-15	2004-10-15
DKPA200401582		2004-10-15
PCT/EP2005/055263 WO2006040352A1 (en)	2004-10-15	2005-10-14	Novel azabicyclic aryl derivatives and their medical use

Publications (1)

Publication Number	Publication Date
ATE495172T1 true ATE495172T1 (de)	2011-01-15

Family

ID=38744785

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05797020T ATE495172T1 (de)	2004-10-15	2005-10-14	Neue azabizyklische arylderivate und medizinische verwendung damit

Country Status (8)

Country	Link
US (1)	US7652010B2 (de)
EP (1)	EP1802616B1 (de)
CN (1)	CN100588657C (de)
AT (1)	ATE495172T1 (de)
AU (1)	AU2005293510A1 (de)
CA (1)	CA2584836A1 (de)
DE (1)	DE602005025902D1 (de)
WO (1)	WO2006040352A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0220581D0 (en)	2002-09-04	2002-10-09	Novartis Ag	Organic Compound
PE20060437A1 (es)	2004-06-18	2006-06-08	Novartis Ag	COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR
GB0415746D0 (en)	2004-07-14	2004-08-18	Novartis Ag	Organic compounds
GB0521508D0 (en)	2005-10-21	2005-11-30	Novartis Ag	Organic compounds
GB0525673D0 (en)	2005-12-16	2006-01-25	Novartis Ag	Organic compounds
GB0525672D0 (en)	2005-12-16	2006-01-25	Novartis Ag	Organic compounds
WO2007093601A1 (en)	2006-02-14	2007-08-23	Neurosearch A/S	3, 9-diazabicyclo(3.3.1)non-3-yl-aryl methanone derivatives as nicotinic acetylcholine receptor agonists
US20100227869A1 (en) *	2006-02-16	2010-09-09	Dan Peters	Enantiopure quinuclidinyloxy pyridazines and their use as nicotinic acetylcholine receptor ligands
US8314119B2 (en) *	2006-11-06	2012-11-20	Abbvie Inc.	Azaadamantane derivatives and methods of use
TWI558398B (zh)	2009-09-22	2016-11-21	諾華公司	菸鹼乙醯膽鹼受體α７活化劑之用途
EP2619205B1 (de)	2010-09-23	2017-05-17	AbbVie Bahamas Ltd.	Monohydrat eines azaadamantanderivates
CA2971413A1 (en)	2014-12-16	2016-06-23	Axovant Sciences Gmbh	Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors
CN107847494A (zh)	2015-06-10	2018-03-27	阿考温特科学股份有限公司	作为α7‑烟碱乙酰胆碱受体激动剂的氨基苯并异噁唑化合物
US10428062B2 (en)	2015-08-12	2019-10-01	Axovant Sciences Gmbh	Geminal substituted aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors
CN109593088B (zh) *	2018-12-27	2022-03-25	华东理工大学	氮杂双环衍生物及其制备和应用
EP4359077A4 (de) *	2021-06-24	2025-07-30	Atacama Therapeutics Inc	Dexmecamylamin und verwendungen davon

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2791678B1 (fr)	1999-03-30	2001-05-04	Synthelabo	Derives de 1,4-diazabicyclo [3.2.2] nonane-4-carboxylates et -carboxamides, leur preparation et leur application en therapeutique
US6492385B2 (en) *	2000-08-18	2002-12-10	Pharmacia & Upjohn Company	Quinuclidine-substituted heteroaryl moieties for treatment of disease
ES2276072T3 (es)	2002-06-10	2007-06-16	Bayer Healthcare Ag	Amidas de acidos 2-heteroarilcarboxilicos.
SE0202430D0 (sv) *	2002-08-14	2002-08-14	Astrazeneca Ab	New Compounds
GB0415746D0 (en)	2004-07-14	2004-08-18	Novartis Ag	Organic compounds

2005
- 2005-10-14 CA CA002584836A patent/CA2584836A1/en not_active Abandoned
- 2005-10-14 AU AU2005293510A patent/AU2005293510A1/en not_active Abandoned
- 2005-10-14 US US11/663,152 patent/US7652010B2/en not_active Expired - Fee Related
- 2005-10-14 DE DE602005025902T patent/DE602005025902D1/de not_active Expired - Lifetime
- 2005-10-14 CN CN200580032356A patent/CN100588657C/zh not_active Expired - Fee Related
- 2005-10-14 AT AT05797020T patent/ATE495172T1/de not_active IP Right Cessation
- 2005-10-14 WO PCT/EP2005/055263 patent/WO2006040352A1/en not_active Ceased
- 2005-10-14 EP EP05797020A patent/EP1802616B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US20070299082A1 (en)	2007-12-27
CN100588657C (zh)	2010-02-10
CA2584836A1 (en)	2006-04-20
WO2006040352A1 (en)	2006-04-20
US7652010B2 (en)	2010-01-26
DE602005025902D1 (de)	2011-02-24
EP1802616B1 (de)	2011-01-12
HK1106513A1 (zh)	2008-03-14
CN101027300A (zh)	2007-08-29
EP1802616A1 (de)	2007-07-04
AU2005293510A1 (en)	2006-04-20

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Legal Events

Date	Code	Title	Description
2011-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties