ATE287888T1 - Aryl- und heteroaryldiazabicycloalkane, deren zubereitung und verwendung - Google Patents

Aryl- und heteroaryldiazabicycloalkane, deren zubereitung und verwendung

Info

Publication number: ATE287888T1
Authority: AT; Austria
Prior art keywords: diseases; disorders; nervous system; disorders related; cholinergic
Prior art date: 2000-07-04

Application number

AT01943186T

Other languages

English (en)

Inventor

Dan Peters

Gunnar M Olsen

Elsebet Ostergaard Nielsen

Philip K Ahring

Simon Feldbaek Nielsen

Tino Dyhring Jorgensen

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-04

Filing date

2001-06-20

Publication date

2005-02-15

2001-06-20 Application filed by Neurosearch As filed Critical Neurosearch As

2005-02-15 Application granted granted Critical

2005-02-15 Publication of ATE287888T1 publication Critical patent/ATE287888T1/de

Links

208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 8
201000010099 disease Diseases 0.000 abstract 4
208000035475 disorder Diseases 0.000 abstract 4
210000003169 central nervous system Anatomy 0.000 abstract 2
230000001713 cholinergic effect Effects 0.000 abstract 2
210000001428 peripheral nervous system Anatomy 0.000 abstract 2
108010078791 Carrier Proteins Proteins 0.000 abstract 1
208000017701 Endocrine disease Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
102000019315 Nicotinic acetylcholine receptors Human genes 0.000 abstract 1
108050006807 Nicotinic acetylcholine receptors Proteins 0.000 abstract 1
208000002193 Pain Diseases 0.000 abstract 1
208000007271 Substance Withdrawal Syndrome Diseases 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
208000030172 endocrine system disease Diseases 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
230000004770 neurodegeneration Effects 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
102000005962 receptors Human genes 0.000 abstract 1
108020003175 receptors Proteins 0.000 abstract 1
230000016160 smooth muscle contraction Effects 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Psychology (AREA)
Pulmonology (AREA)
Physical Education & Sports Medicine (AREA)
Hospice & Palliative Care (AREA)
Anesthesiology (AREA)
Ophthalmology & Optometry (AREA)
Rheumatology (AREA)
Child & Adolescent Psychology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Obesity (AREA)
Dermatology (AREA)
Gynecology & Obstetrics (AREA)
Urology & Nephrology (AREA)

AT01943186T 2000-07-04 2001-06-20 Aryl- und heteroaryldiazabicycloalkane, deren zubereitung und verwendung ATE287888T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DKPA200001037		2000-07-04
PCT/DK2001/000432 WO2002002564A1 (en)	2000-07-04	2001-06-20	Aryl and heteroaryl diazabicycloalkanes, their preparation and use

Publications (1)

Publication Number	Publication Date
ATE287888T1 true ATE287888T1 (de)	2005-02-15

Family

ID=8159596

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01943186T ATE287888T1 (de)	2000-07-04	2001-06-20	Aryl- und heteroaryldiazabicycloalkane, deren zubereitung und verwendung

Country Status (11)

Country	Link
US (1)	US7060699B2 (de)
EP (1)	EP1301514B1 (de)
JP (1)	JP2004502692A (de)
CN (1)	CN1185233C (de)
AT (1)	ATE287888T1 (de)
AU (2)	AU6583101A (de)
CA (1)	CA2410945A1 (de)
DE (1)	DE60108639T2 (de)
MX (1)	MXPA03000053A (de)
NZ (1)	NZ522793A (de)
WO (1)	WO2002002564A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE60203007T2 (de) *	2001-06-01	2005-07-07	Neurosearch A/S	Heteroaryl-diazabicycloalkanderivaten als cns-modulatoren
JP4750421B2 (ja) *	2002-12-06	2011-08-17	ノースショア−ロングアイランドジュ−イッシュリサ−チインスティチュ−ト	α７受容体結合コリン作動性アゴニストを用いる炎症の阻害
US7238715B2 (en) *	2002-12-06	2007-07-03	The Feinstein Institute For Medical Research	Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists
JP2007504229A (ja) *	2003-09-02	2007-03-01	メルク　エンド　カムパニー　インコーポレーテッド	代謝調節型グルタミン酸受容体−５のモジュレーターとしてのビピリジルアミン類およびエーテル類
US7399765B2 (en)	2003-09-19	2008-07-15	Abbott Laboratories	Substituted diazabicycloalkane derivatives
US20050065178A1 (en) *	2003-09-19	2005-03-24	Anwer Basha	Substituted diazabicycloakane derivatives
US7365193B2 (en)	2004-02-04	2008-04-29	Abbott Laboratories	Amino-substituted tricyclic derivatives and methods of use
US20050171079A1 (en) *	2004-02-04	2005-08-04	Schrimpf Michael R.	Amino-substituted tricyclic derivatives and methods of use
CA2581454A1 (en) *	2004-09-23	2006-03-30	Reddy Us Therapeutics, Inc.	Novel pyrimidine compounds, process for their preparation and compositions containing them
WO2006087306A2 (en) *	2005-02-16	2006-08-24	Neurosearch A/S	Diazabicyclic aryl derivatives and their use as cholinergic ligands at the nicotinic acetylcholine receptors
US7662812B2 (en)	2005-02-16	2010-02-16	Neurosearch A/S	Diazabicyclic aryl derivatives and their use as chinolinergic ligands at nicotinic acetylcholine receptors
JP5214096B2 (ja) *	2005-06-17	2013-06-19	富士フイルムファインケミカルズ株式会社	新規なビピリジン誘導体
US7897766B2 (en) *	2005-09-23	2011-03-01	Abbott Laboratories	Amino-aza-adamantane derivatives and methods of use
US8316104B2 (en)	2005-11-15	2012-11-20	California Institute Of Technology	Method and apparatus for collaborative system
ATE473978T1 (de) *	2005-12-06	2010-07-15	Neurosearch As	Neue diazabicyclische arylderivate und medizinische verwendung dafür
WO2007090888A1 (en)	2006-02-10	2007-08-16	Neurosearch A/S	3-heteroaryl- 3,9-diazabicyclo[3.3.1]nonane derivatives as nicotinic acetylcholine receptor agonists
CN101379063A (zh)	2006-02-10	2009-03-04	神经研究公司	3,9-二氮杂双环[3.3.1]壬烷衍生物及其作为单胺神经递质再摄取抑制剂的用途
AU2007213670A1 (en) *	2006-02-10	2007-08-16	Neurosearch A/S	3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2007135121A1 (en)	2006-05-23	2007-11-29	Neurosearch A/S	Novel 8,10-diaza-bicyclo[4.3.1]decane derivatives and their medical use
US8314119B2 (en)	2006-11-06	2012-11-20	Abbvie Inc.	Azaadamantane derivatives and methods of use
BRPI0818658A2 (pt) *	2007-10-09	2015-04-14	Merck Patent Ges Mit Beschränkter Haftung	Derivados de piridina úteis como ativadores de glicoquinase
EP2288609A2 (de) *	2008-06-10	2011-03-02	NeuroSearch A/S	Indolyl-pyridazinyl-diazabicyclononan-derivative in etikettierter und unetikettierter form sowie ihre verwendung in diagnoseverfahren
TW201031664A (en)	2009-01-26	2010-09-01	Targacept Inc	Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
PE20131394A1 (es)	2010-09-23	2014-01-11	Abbvie Inc	Monohidrato de derivados de aza-adamantano
EP3362819A4 (de)	2015-10-14	2019-06-05	Shenzhen Xpectvision Technology Co., Ltd.	Röntgendetektoren zur begrenzung der diffusion von ladungsträgern
KR102668690B1 (ko) *	2016-08-02	2024-05-28	삼성디스플레이 주식회사	헤테로고리 화합물 및 이를 포함한 유기 발광 소자

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT403803B (de)	1996-04-19	1998-05-25	Sanochemia Ltd	Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
KR100589872B1 (ko)	1997-05-30	2006-06-15	뉴로서치 에이/에스	8-아자비사이클로(3,2,1)옥트-2-엔 유도체 및 이의 제조방법
WO1998054182A1 (en) *	1997-05-30	1998-12-03	Neurosearch A/S	9-AZABICYCLO(3.3.1)NON-2-ENE AND NONANE DERIVATIVES AS CHOLINERGIC LIGANDS AT NICOTINIC ACh RECEPTORS
US7265115B2 (en) *	1999-01-29	2007-09-04	Abbott Laboratories	Diazabicyclic CNS active agents
ES2305373T3 (es) *	1999-01-29	2008-11-01	Abbott Laboratories	Derivados diazabiciclicos como ligandos del receptor nicotinico de la acetilcolina.
NZ513575A (en) *	1999-05-04	2003-07-25	Neurosearch As	Heteroaryl diazabicycloalkanes useful for treating or preventing a disease or a disorder responsive to the activity of nAChR modulators

2001
- 2001-06-20 NZ NZ522793A patent/NZ522793A/en unknown
- 2001-06-20 JP JP2002507816A patent/JP2004502692A/ja not_active Withdrawn
- 2001-06-20 AU AU6583101A patent/AU6583101A/xx active Pending
- 2001-06-20 DE DE60108639T patent/DE60108639T2/de not_active Expired - Lifetime
- 2001-06-20 US US10/276,160 patent/US7060699B2/en not_active Expired - Fee Related
- 2001-06-20 WO PCT/DK2001/000432 patent/WO2002002564A1/en not_active Ceased
- 2001-06-20 EP EP01943186A patent/EP1301514B1/de not_active Expired - Lifetime
- 2001-06-20 CN CNB018121004A patent/CN1185233C/zh not_active Expired - Fee Related
- 2001-06-20 MX MXPA03000053A patent/MXPA03000053A/es active IP Right Grant
- 2001-06-20 AU AU2001265831A patent/AU2001265831B9/en not_active Ceased
- 2001-06-20 CA CA002410945A patent/CA2410945A1/en not_active Abandoned
- 2001-06-20 AT AT01943186T patent/ATE287888T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP1301514A1 (de)	2003-04-16
AU2001265831B9 (en)	2006-08-31
DE60108639D1 (de)	2005-03-03
DE60108639T2 (de)	2005-07-07
HK1057550A1 (en)	2004-04-08
JP2004502692A (ja)	2004-01-29
WO2002002564A1 (en)	2002-01-10
CN1185233C (zh)	2005-01-19
NZ522793A (en)	2005-02-25
CA2410945A1 (en)	2002-01-10
CN1440411A (zh)	2003-09-03
MXPA03000053A (es)	2003-09-25
US20030176416A1 (en)	2003-09-18
AU2001265831B2 (en)	2006-07-27
AU6583101A (en)	2002-01-14
EP1301514B1 (de)	2005-01-26
US7060699B2 (en)	2006-06-13

Legal Events

Date	Code	Title	Description
2005-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60108639D1 (de)	2005-03-03	Aryl- und heteroaryldiazabicycloalkane, deren zubereitung und verwendung
ATE385497T1 (de)	2008-02-15	3-substituierte quinuclidin-derivate und deren verwendung als nikotinischen agonisten
DK1551835T3 (da)	2007-06-04	Hidtil ukendte 1,4-diazabicycloalkanderivater, deres fremstilling og anvendelse
DE60310548D1 (de)	2007-02-01	Diazabicyclische biarylderivate
ATE384720T1 (de)	2008-02-15	Chinucledin - derivate und deren verwendung
ATE289310T1 (de)	2005-03-15	Heteroaryl-diazabicycloalkanderivaten als cns- modulatoren
DK1562945T3 (da)	2007-03-05	Hidtil ukendte diazebicykliske biarylderivater
DE60215172D1 (de)	2006-11-16	Neue verbindungen, deren herstellung und verwendung
MXPA05006861A (es)	2005-12-12	Derivados arildiazabiciclicos novedosos.
MX2007004269A (es)	2007-06-15	Derivados de arilo diazabiciclico nuevos y su uso medico.
WO2006087306A3 (en)	2006-11-23	Diazabicyclic aryl derivatives and their use as cholinergic ligands at the nicotinic acetylcholine receptors
ATE437880T1 (de)	2009-08-15	Dimere azacyclische verbindungen und deren verwendung
DE60307102D1 (de)	2006-09-07	3-substituierte chinuklidine und deren verwendung
ATE401334T1 (de)	2008-08-15	Neue azacyclische ethinylderivate
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