ATE496051T1 - Pyrazolotetrahydropyridinderivate als orexinrezeptorantagonisten - Google Patents

Pyrazolotetrahydropyridinderivate als orexinrezeptorantagonisten

Info

Publication number
ATE496051T1
ATE496051T1 AT07735643T AT07735643T ATE496051T1 AT E496051 T1 ATE496051 T1 AT E496051T1 AT 07735643 T AT07735643 T AT 07735643T AT 07735643 T AT07735643 T AT 07735643T AT E496051 T1 ATE496051 T1 AT E496051T1
Authority
AT
Austria
Prior art keywords
receptor antagonists
pyrazolotetrahydropyridine
derivatives
orexin receptor
orexin
Prior art date
Application number
AT07735643T
Other languages
German (de)
English (en)
Inventor
Hamed Aissaoui
Christoph Boss
Markus Gude
Ralf Koberstein
Thierry Sifferlen
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Application granted granted Critical
Publication of ATE496051T1 publication Critical patent/ATE496051T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)
AT07735643T 2006-04-26 2007-04-25 Pyrazolotetrahydropyridinderivate als orexinrezeptorantagonisten ATE496051T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2006051300 2006-04-26
PCT/IB2007/051522 WO2007122591A2 (fr) 2006-04-26 2007-04-25 Nouveaux dérivés de pyrazolo-tétrahydropyridine

Publications (1)

Publication Number Publication Date
ATE496051T1 true ATE496051T1 (de) 2011-02-15

Family

ID=38541955

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07735643T ATE496051T1 (de) 2006-04-26 2007-04-25 Pyrazolotetrahydropyridinderivate als orexinrezeptorantagonisten

Country Status (8)

Country Link
US (1) US7834028B2 (fr)
EP (1) EP2013209B1 (fr)
JP (1) JP2009535324A (fr)
CN (1) CN101432285A (fr)
AT (1) ATE496051T1 (fr)
CA (1) CA2647077A1 (fr)
DE (1) DE602007012072D1 (fr)
WO (1) WO2007122591A2 (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1751111T3 (en) 2004-03-01 2015-02-09 Actelion Pharmaceuticals Ltd SUBSTITUTED 1,2,3,4-tetrahydroisoquinoline derivatives
ATE458740T1 (de) * 2006-08-28 2010-03-15 Actelion Pharmaceuticals Ltd 1,4,5,6,7,8-hexahydro-1,2,5-triaza-azulen- derivate als orexinrezeptor-antagonisten
RU2009127842A (ru) 2006-12-22 2011-01-27 Актелион Фармасьютиклз Лтд (Ch) ПРОИЗВОДНЫЕ 5,6,7,8-ТЕТРАГИДРОИМИДАЗО[1.5-а]ПИРАЗИНА
AU2008235528B2 (en) * 2007-04-04 2012-11-08 F. Hoffmann-La Roche Ag Heterocycles as orexin antagonists
MX2009012579A (es) 2007-05-23 2009-12-08 Merck & Co Inc Antagonistas piridil piperidina del receptor de orexina.
EP2025674A1 (fr) 2007-08-15 2009-02-18 sanofi-aventis Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament
WO2009083903A1 (fr) 2007-12-28 2009-07-09 Actelion Pharmaceuticals Ltd Composé 3,4-dihydro-1h-isoquinoléine trisubstituée, méthode de préparation, et son utilisation
JP5346043B2 (ja) * 2008-02-12 2013-11-20 エフ．ホフマン−ラ ロシュ アーゲー ピペリジンスルホンアミド誘導体
MX2010008993A (es) * 2008-02-21 2010-09-07 Actelion Pharmaceuticals Ltd Derivados de 2-aza-biciclo-[2.2.1]heptano.
ME02437B (fr) 2009-10-23 2016-09-20 Janssen Pharmaceutica Nv Octahydropyrrolo[3,4-c]pyrroles disubstitués en tant que modulateurs de récepteur d'orexine
JP2013515032A (ja) * 2009-12-21 2013-05-02 ノバルティス アーゲー 二置換ヘテロアリール縮合ピリジン類
WO2012114252A1 (fr) 2011-02-21 2012-08-30 Actelion Pharmaceuticals Ltd Nouveaux amides d'indole et de pyrrolopyridine
WO2012120056A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine tétra-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
WO2012120053A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine ramifiés, procédé pour leur préparation, utilisation en tant que médicament, agents pharmaceutiques contenant ces dérivés et leur utilisation
EP2683705B1 (fr) 2011-03-08 2015-04-22 Sanofi Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
EP2683699B1 (fr) 2011-03-08 2015-06-24 Sanofi Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
WO2012120052A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés d'oxathiazine substitués par des carbocycles ou des hétérocycles, leur procédé de préparation, médicaments contenant ces composés et leur utilisation
EP2508511A1 (fr) 2011-04-07 2012-10-10 Laboratoire Biodim Inhibiteurs de la réplication virale, leur procédé de préparation et leurs utilisations thérapeutiques
AR088352A1 (es) 2011-10-19 2014-05-28 Merck Sharp & Dohme Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
KR20140124398A (ko) 2012-02-07 2014-10-24 이올라스 테라퓨틱스, 인코포레이티드 오렉신 수용체 길항제로서 치환된 프롤린 / 피페리딘
GB201308236D0 (en) * 2013-05-08 2013-06-12 Givaudan Sa Improvements in or relating to organic compounds
WO2014205782A1 (fr) 2013-06-28 2014-12-31 Givaudan Sa Composés organiques
UY36272A (es) 2014-08-13 2016-02-29 Eolas Therapeutics Inc Difluoropirrolidinas como moduladores de los receptores de orexinas
MX2017005862A (es) 2014-11-10 2017-06-26 Givaudan Sa Mejoras en o que se relacionan con compuestos organicos.
WO2016074696A1 (fr) * 2014-11-10 2016-05-19 Givaudan Ag Ingrédients de parfum et préparations de parfum contenant ces derniers
CA3013927C (fr) 2016-02-12 2024-02-13 Astrazeneca Ab Piperidines halosubstituees en tant que modulateurs de recepteur des orexines
EA201891930A1 (ru) 2016-03-10 2019-02-28 Янссен Фармацевтика Нв Способы лечения депрессии с использованием антагонистов орексиновых рецепторов-2
EP3454857A1 (fr) 2016-05-10 2019-03-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques pour le traitement de maladies inflammatoires auto-immunes
CN111494376A (zh) * 2020-06-15 2020-08-07 牡丹江医学院 一种用于治疗牙龈炎的药物及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2234840T3 (es) 2000-03-14 2005-07-01 Actelion Pharmaceuticals Ltd. Derivados de 1,2,3,4- tetrahidroisoquinolina.
CA2408343A1 (fr) * 2000-05-11 2002-11-07 Banyu Pharmaceutical Co., Ltd. Derives n-acyltetrahydroisoquinoline
WO2002051232A2 (fr) 2000-12-27 2002-07-04 Actelion Pharmaceuticals Ltd. Nouvelles benzazepines et derives heterocycliques associes
KR100681585B1 (ko) 2002-04-26 2007-02-09 에프. 호프만-라 로슈 아게 아이소퀴놀린 유도체
US6709392B1 (en) * 2002-10-10 2004-03-23 Koninklijke Philips Electronics N.V. Imaging ultrasound transducer temperature control system and method using feedback
BRPI0408681A (pt) * 2003-03-26 2006-03-28 Actelion Pharmaceuticals Ltd compostos, composições farmacêuticas, uso de um derivado da 1,2,3,4-tetraidroisoquinolina, método para tratar ou prevenir doenças, processo para a manufatura de composições farmacêuticas, e, uso de um ou mais compostos
DK1751111T3 (en) * 2004-03-01 2015-02-09 Actelion Pharmaceuticals Ltd SUBSTITUTED 1,2,3,4-tetrahydroisoquinoline derivatives
FR2874011B1 (fr) 2004-08-03 2007-06-15 Sanofi Synthelabo Derives de sulfonamides, leur preparation et leur application en therapeutique
JP4582722B2 (ja) * 2006-03-15 2010-11-17 アクテリオン ファーマシューティカルズ リミテッド 記憶機能を向上させるテトラヒドロイソキノリン誘導体

Also Published As

Publication number Publication date
EP2013209B1 (fr) 2011-01-19
JP2009535324A (ja) 2009-10-01
US7834028B2 (en) 2010-11-16
US20090099228A1 (en) 2009-04-16
CA2647077A1 (fr) 2007-11-01
EP2013209A2 (fr) 2009-01-14
WO2007122591A3 (fr) 2008-01-10
DE602007012072D1 (de) 2011-03-03
WO2007122591A2 (fr) 2007-11-01
CN101432285A (zh) 2009-05-13

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