ATE496885T1 - 1-alpha-hydroxy-2-(3'-hydroxypropyliden)-19-nor vitamin-d-verbindungen mit einer 1,1- dimethylpropyl-seitenkette - Google Patents

1-alpha-hydroxy-2-(3'-hydroxypropyliden)-19-nor vitamin-d-verbindungen mit einer 1,1- dimethylpropyl-seitenkette

Info

Publication number: ATE496885T1
Authority: AT; Austria
Prior art keywords: compounds; skin; hydroxypropylidene; dimethylpropyl; vitamin
Prior art date: 2006-04-10

Application number

AT07825740T

Other languages

English (en)

Inventor

Hector Deluca

Angieszka Glebocka

Rafal Sicinski

Lori Plum

Margaret Clagett-Dame

Original Assignee

Wisconsin Alumni Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-04-10

Filing date

2007-04-06

Publication date

2011-02-15

2007-04-06 Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found

2011-02-15 Application granted granted Critical

2011-02-15 Publication of ATE496885T1 publication Critical patent/ATE496885T1/de

Links

-1 1,1-DIMETHYLPROPYL SIDE CHAIN Chemical group 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
208000023275 Autoimmune disease Diseases 0.000 abstract 1
208000013725 Chronic Kidney Disease-Mineral and Bone disease Diseases 0.000 abstract 1
206010013786 Dry skin Diseases 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
201000004681 Psoriasis Diseases 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
208000037979 autoimmune inflammatory disease Diseases 0.000 abstract 1
230000000125 calcaemic effect Effects 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
230000004069 differentiation Effects 0.000 abstract 1
230000037336 dry skin Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000001939 inductive effect Effects 0.000 abstract 1
210000001616 monocyte Anatomy 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1
201000006409 renal osteodystrophy Diseases 0.000 abstract 1
210000002374 sebum Anatomy 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1
208000017520 skin disease Diseases 0.000 abstract 1
125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
230000037303 wrinkles Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Dermatology (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Rheumatology (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Obesity (AREA)
Transplantation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT07825740T 2006-04-10 2007-04-06 1-alpha-hydroxy-2-(3'-hydroxypropyliden)-19-nor vitamin-d-verbindungen mit einer 1,1- dimethylpropyl-seitenkette ATE496885T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US79148706P	2006-04-10	2006-04-10
PCT/IB2007/003643 WO2008023278A2 (en)	2006-04-10	2007-04-06	1alpha-hydroxy-2- (3 ' -hydroxypropylidene) -19-n0r- vitamin d compounds with a 1,1-dimethylpropyl side chain

Publications (1)

Publication Number	Publication Date
ATE496885T1 true ATE496885T1 (de)	2011-02-15

Family

ID=39032111

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07825740T ATE496885T1 (de)	2006-04-10	2007-04-06	1-alpha-hydroxy-2-(3'-hydroxypropyliden)-19-nor vitamin-d-verbindungen mit einer 1,1- dimethylpropyl-seitenkette

Country Status (10)

Country	Link
US (1)	US7763598B2 (de)
EP (1)	EP2004597B1 (de)
JP (1)	JP2009533418A (de)
AT (1)	ATE496885T1 (de)
AU (1)	AU2007287263A1 (de)
CA (1)	CA2648521A1 (de)
DE (1)	DE602007012216D1 (de)
MX (1)	MX2008012674A (de)
NZ (1)	NZ570816A (de)
WO (1)	WO2008023278A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8404667B2 (en) *	2006-12-29	2013-03-26	Wisconsin Alumni Research Foundation	Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog
US8217023B2 (en) *	2009-10-02	2012-07-10	Wisconsin Alumni Research Foundation	19-nor-vitamin D analogs with 1,2- or 3,2-cyclopentene ring

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4188345A (en)	1978-07-26	1980-02-12	Wisconsin Alumni Research Foundation	Fluorovitamin D compounds and processes for their preparation
US4411833A (en)	1982-05-26	1983-10-25	Wisconsin Alumni Research Foundation	Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol
US4666634A (en)	1984-12-05	1987-05-19	Chugai Seiyaku Kabushiki Kaisha	vitamin D3 derivatives having a substituent at 2-position
US4970203A (en)	1988-12-09	1990-11-13	Deluca Hector F	Method for improving reproductive functions in mammals
US5086191A (en)	1991-05-28	1992-02-04	Wisconsin Alumni Research Foundation	Intermediates for the synthesis of 19-nor vitamin D compounds
DE4141746A1 (de) *	1991-12-13	1993-06-17	Schering Ag	20-methyl-substituierte vitamin d-derivate
DE69400495T2 (de)	1993-04-05	1997-04-30	Wisconsin Alumni Res Found	19-Nor-vitamin-D3-Verbindung mit einem Substituent an die 2. Stelle
US5880114A (en)	1993-06-16	1999-03-09	Wisconsin Alumni Research Foundation	Treatment of immune deficiency with vitamin D compounds
US6291444B1 (en)	1993-06-16	2001-09-18	Wisconsin Alumni Research Foundation	Treatment of t-cell immunodeficiencies with vitamin D compounds
US5552392A (en)	1993-11-03	1996-09-03	Wisconsin Alumni Research Foundation	Method of treating hypoparathyroidism with (20S) vitamin D compounds
US5825133A (en) *	1996-09-25	1998-10-20	Rockwell International	Resonant inverter for hot cathode fluorescent lamps
US6306844B1 (en)	1997-03-17	2001-10-23	Wisconsin Alumni Research Foundation	Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength
US6392071B1 (en)	1997-03-17	2002-05-21	Wisconsin Alumni: Research Foundation	26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds
US5843928A (en)	1997-03-17	1998-12-01	Wisconsin Alumni Research Foundation	2-alkylidene-19-nor-vitamin D compounds
US5945410A (en)	1997-03-17	1999-08-31	Wisconsin Alumni Research Foundation	2-alkyl-19-nor-vitamin D compounds
AU758792B2 (en) *	1998-10-23	2003-03-27	Teijin Limited	Vitamin D3 derivatives and remedies for inflammatory respiratory diseases containing the same
US6382071B1 (en)	2000-08-07	2002-05-07	Gilbert A. Bertani	Bola capturing apparatus
WO2002020021A1 (en)	2000-09-08	2002-03-14	Wisconsin Alumni Research Foundation	1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol and its therapeutic applications
US20030018017A1 (en)	2001-01-25	2003-01-23	Deluca Hector F.	Method of treatment of type I diabetes
US6627622B2 (en)	2002-02-18	2003-09-30	Wisconsin Alumni Research Foundation	(20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses
US6566352B1 (en)	2002-02-18	2003-05-20	Wisconsin Alumni Research Foudation	1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses
US6846811B2 (en)	2002-04-22	2005-01-25	Wisconsin Alumni Research Foundation	(20S) 1α-hydroxy-2α-methyl and 2β-methyl-19-nor-vitamin D3 and their uses
AR041696A1 (es) *	2002-10-23	2005-05-26	Leo Pharm Prod Ltd	Compuestos analogos de vitamina d, composiciones que comprenden dichos compuestos analogos y su uso
BRPI0409194A (pt)	2003-04-10	2006-04-11	Wisconsin Alumni Res Found	compostos, composição farmacêutica e método de tratamento de doença metabólica do osso, da psorìase, da leucemia, cáncer do cólon, cáncer da mama, cáncer da pele ou cáncer da próstata, de doença auto-imune, de doença inflamatória do intestino e de aumento da resistência do osso
US7053075B2 (en)	2003-11-25	2006-05-30	Deluca Hector F	Methods for reducing body fat using vitamin D compounds
CA2544502A1 (en)	2003-11-25	2005-06-09	Wisconsin Alumni Research Foundation	Vitamin d analogs for obesity prevention and treatment
US7528122B2 (en)	2006-02-02	2009-05-05	Wisconsin Alumni Research Foundation	Vitamin D analog—NEL, methods and uses thereof
US7803789B2 (en)	2006-02-02	2010-09-28	Wisconsin Alumni Research Foundation	Vitamin D analog—RAK, methods and uses thereof

2007
- 2007-04-06 DE DE602007012216T patent/DE602007012216D1/de active Active
- 2007-04-06 NZ NZ570816A patent/NZ570816A/en not_active IP Right Cessation
- 2007-04-06 MX MX2008012674A patent/MX2008012674A/es active IP Right Grant
- 2007-04-06 EP EP07825740A patent/EP2004597B1/de not_active Not-in-force
- 2007-04-06 US US11/697,430 patent/US7763598B2/en not_active Expired - Fee Related
- 2007-04-06 AT AT07825740T patent/ATE496885T1/de not_active IP Right Cessation
- 2007-04-06 WO PCT/IB2007/003643 patent/WO2008023278A2/en not_active Ceased
- 2007-04-06 JP JP2009504860A patent/JP2009533418A/ja active Pending
- 2007-04-06 CA CA002648521A patent/CA2648521A1/en not_active Abandoned
- 2007-04-06 AU AU2007287263A patent/AU2007287263A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO2008023278A2 (en)	2008-02-28
MX2008012674A (es)	2008-10-15
NZ570816A (en)	2011-07-29
DE602007012216D1 (de)	2011-03-10
WO2008023278A8 (en)	2008-12-31
WO2008023278A3 (en)	2008-07-17
US20070238703A1 (en)	2007-10-11
AU2007287263A1 (en)	2008-02-28
EP2004597A2 (de)	2008-12-24
US7763598B2 (en)	2010-07-27
JP2009533418A (ja)	2009-09-17
CA2648521A1 (en)	2008-02-28
EP2004597B1 (de)	2011-01-26

Legal Events

Date	Code	Title	Description
2011-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE341330T1 (de)	2006-10-15	Alpha-hydroxy-2-methylen-10-nor-pregnacalcifero und seine anwendungen
WO2006057884A3 (en)	2006-10-05	2α-METHYL AND 2ß-METHYL ANALOGS OF 19,26,27-TRINOR-(20S)-1α-HYDROXYVITAMIN D3 AND THEIR USES
PT1315504E (pt)	2004-12-31	1-alfa-hidroxi-2-metileno-19-nor-homopregnacalciferol e suas aplicacoes terapeuticas
ATE552239T1 (de)	2012-04-15	2-methylen-20-methyl-19,24,25,26,27-pentanor- vitamin-d-analoga
WO2006057899A3 (en)	2006-07-06	2alpha-methyl-19-nor-(20s)-1alpha-hydroxy-bishomopregnacalciferol and its uses
MX2009003241A (es)	2009-05-05	Analogos de 2-metilen-(20r,25s)-19,27-dinor-(22e)-vitamina d.
DE602005021245D1 (de)	2010-06-24	2-methylen-19,26,27-trinor-(20s)-1-alpha-hydroxyvitamin d3 and dessen verwendungen
WO2006057901A3 (en)	2006-07-13	2-METHYLENE-19-NOR-1α-HYDROXY-17-ENE-HOMOPREGNACALCIFEROL AND ITS USES
DE60229430D1 (de)	2008-11-27	(20s)-1 alpha-hydroxy-2-methylen-19-nor-bishomopregnacalciferol und ihre verwendungen
MX2010007264A (es)	2011-03-15	Análogos de vitamina d 2-metilen-(20s, 25r)-19, 26-dinor.
ATE552238T1 (de)	2012-04-15	2-methylen-(20s,25s)-19,27-dinor-(22e)-vitamin- - analoga
DE602005022098D1 (de)	2010-08-12	2-methylen-18,19-dinor-1alfa-hydroxy-homopregnacalciferol und dessen verwendungen
ATE496885T1 (de)	2011-02-15	1-alpha-hydroxy-2-(3'-hydroxypropyliden)-19-nor vitamin-d-verbindungen mit einer 1,1- dimethylpropyl-seitenkette
WO2006057902A3 (en)	2006-07-13	2alpha-methyl-19-nor-1alpha-hydroxy-homopregnacalciferol and its uses
WO2009086439A3 (en)	2009-08-27	2-methylene-(20s,25s)-19,26-dinor-vitamin d analogs
WO2010006172A3 (en)	2010-04-08	2-methylene-20(21)-dehydro-19-nor-vitamin d analogs