ATE552238T1 - 2-methylen-(20s,25s)-19,27-dinor-(22e)-vitamin- - analoga - Google Patents

2-methylen-(20s,25s)-19,27-dinor-(22e)-vitamin- - analoga

Info

Publication number: ATE552238T1
Authority: AT; Austria
Prior art keywords: dinor; methylene; skin; compound; vitamin
Prior art date: 2006-09-28

Application number

AT07843117T

Other languages

English (en)

Inventor

Hector F Deluca

Margaret Clagett-Dame

Lori A Plum

Grazia Chiellini

Pawel Grzywacz

Original Assignee

Wisconsin Alumni Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-09-28

Filing date

2007-09-25

Publication date

2012-04-15

2007-09-25 Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found

2012-04-15 Application granted granted Critical

2012-04-15 Publication of ATE552238T1 publication Critical patent/ATE552238T1/de

Links

229940088594 vitamin Drugs 0.000 title 1
239000011782 vitamin Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
208000023275 Autoimmune disease Diseases 0.000 abstract 1
208000013725 Chronic Kidney Disease-Mineral and Bone disease Diseases 0.000 abstract 1
206010013786 Dry skin Diseases 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
201000004681 Psoriasis Diseases 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
208000037979 autoimmune inflammatory disease Diseases 0.000 abstract 1
230000000125 calcaemic effect Effects 0.000 abstract 1
239000011612 calcitriol Substances 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
230000004069 differentiation Effects 0.000 abstract 1
230000037336 dry skin Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000001939 inductive effect Effects 0.000 abstract 1
210000001616 monocyte Anatomy 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1
201000006409 renal osteodystrophy Diseases 0.000 abstract 1
210000002374 sebum Anatomy 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1
208000017520 skin disease Diseases 0.000 abstract 1
239000011710 vitamin D Substances 0.000 abstract 1
229940046008 vitamin d Drugs 0.000 abstract 1
230000037303 wrinkles Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Diabetes (AREA)
Hematology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Obesity (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Oncology (AREA)
Neurosurgery (AREA)
Child & Adolescent Psychology (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Emergency Medicine (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT07843117T 2006-09-28 2007-09-25 2-methylen-(20s,25s)-19,27-dinor-(22e)-vitamin- - analoga ATE552238T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US84880506P	2006-09-28	2006-09-28
PCT/US2007/079381 WO2008039751A2 (en)	2006-09-28	2007-09-25	2-methylene-(20s,25s)-19,27-dinor-(22e)-vitamin d analogs

Publications (1)

Publication Number	Publication Date
ATE552238T1 true ATE552238T1 (de)	2012-04-15

Family

ID=39172159

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07843117T ATE552238T1 (de)	2006-09-28	2007-09-25	2-methylen-(20s,25s)-19,27-dinor-(22e)-vitamin- - analoga

Country Status (9)

Country	Link
US (1)	US8114859B2 (de)
EP (1)	EP2069296B1 (de)
JP (1)	JP2010504994A (de)
AT (1)	ATE552238T1 (de)
AU (1)	AU2007300211A1 (de)
CA (1)	CA2662864A1 (de)
MX (1)	MX2009002944A (de)
NZ (1)	NZ575159A (de)
WO (1)	WO2008039751A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8399439B2 (en)	2008-07-10	2013-03-19	Wisconsin Alumni Research Foundation	2-methylene-19,26-dinor-(20S,22E,25R)-vitamin D analogs
MX2012003883A (es) *	2009-10-02	2012-06-27	Wisconsin Alumni Res Found	Analogos de (20s,22e)-2-metileno-19-nor-22-ene-1a,25-dihidroxovita mina d3.
US8993547B2 (en) *	2011-06-14	2015-03-31	Wisconsin Alumni Research Foundation	3-desoxy-2-methylene-19-nor-vitamin D analogs and their uses
US9545302B2 (en)	2013-11-20	2017-01-17	Dermagenesis Llc	Skin printing and auto-grafting
US20150140058A1 (en) *	2013-11-20	2015-05-21	Dermagenesis Llc	Skin printing and auto-grafting

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4486333A (en) *	1981-04-10	1984-12-04	Felix Sebba	Preparation of biliquid foam compositions
US4666634A (en)	1984-12-05	1987-05-19	Chugai Seiyaku Kabushiki Kaisha	vitamin D3 derivatives having a substituent at 2-position
US5086191A (en)	1991-05-28	1992-02-04	Wisconsin Alumni Research Foundation	Intermediates for the synthesis of 19-nor vitamin D compounds
JP2898882B2 (ja)	1993-04-05	1999-06-02	ウイスコンシンアラムナイリサーチフオンデーシヨン	２−位に置換基を有する１９−ノル−ビタミンｄ３化合物
US5945410A (en)	1997-03-17	1999-08-31	Wisconsin Alumni Research Foundation	2-alkyl-19-nor-vitamin D compounds
US5843928A (en)	1997-03-17	1998-12-01	Wisconsin Alumni Research Foundation	2-alkylidene-19-nor-vitamin D compounds
CN1173703C (zh) *	1999-04-23	2004-11-03	里奥药物制品有限公司	药物组合物
ES2309069T3 (es)	2000-05-31	2008-12-16	Wisconsin Alumni Research Foundation	Compuestos de 2-etil y 2-etiliden-19-nor-vitamina d.
EP1305946A1 (de)	2000-07-21	2003-05-02	Koninklijke Philips Electronics N.V.	Verfahren und system zur bestimmung eines benutzerprofils
BR0113703A (pt)	2000-09-08	2003-07-22	Wisconsin Alumni Researcg Foun	Compostos e métodos de tratamento de psorìase, leucemia, câncer do cólon, do seio ou da próstata, osteodistrofia renal, de doenças auto-imune, inflamatória e de condição de pele
US6627622B2 (en)	2002-02-18	2003-09-30	Wisconsin Alumni Research Foundation	(20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses
US6566352B1 (en)	2002-02-18	2003-05-20	Wisconsin Alumni Research Foudation	1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses
US20050009792A1 (en)	2003-07-08	2005-01-13	Deluca Hector F.	(20S)-1alpha-hydroxy-2-methylene-19-nor-vitamin D3 and its uses
CA2544502A1 (en)	2003-11-25	2005-06-09	Wisconsin Alumni Research Foundation	Vitamin d analogs for obesity prevention and treatment
WO2006057884A2 (en)	2004-11-22	2006-06-01	Wisconsin Alumni Research Foundation	2α-METHYL AND 2ß-METHYL ANALOGS OF 19,26,27-TRINOR-(20S)-1α-HYDROXYVITAMIN D3 AND THEIR USES
US7528122B2 (en) *	2006-02-02	2009-05-05	Wisconsin Alumni Research Foundation	Vitamin D analog—NEL, methods and uses thereof
MX2008012673A (es)	2006-04-06	2008-10-15	Wisconsin Alumni Res Found	Analogos de 2-metilen-1a-hidroxi-19, 21-dinorvitamina d3 y sus usos.

2007
- 2007-09-25 CA CA002662864A patent/CA2662864A1/en not_active Abandoned
- 2007-09-25 EP EP07843117A patent/EP2069296B1/de not_active Not-in-force
- 2007-09-25 AU AU2007300211A patent/AU2007300211A1/en not_active Abandoned
- 2007-09-25 MX MX2009002944A patent/MX2009002944A/es not_active Application Discontinuation
- 2007-09-25 JP JP2009530553A patent/JP2010504994A/ja active Pending
- 2007-09-25 AT AT07843117T patent/ATE552238T1/de active
- 2007-09-25 WO PCT/US2007/079381 patent/WO2008039751A2/en not_active Ceased
- 2007-09-25 US US11/860,863 patent/US8114859B2/en not_active Expired - Fee Related
- 2007-09-25 NZ NZ575159A patent/NZ575159A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO2008039751A3 (en)	2008-05-22
MX2009002944A (es)	2009-04-02
US20080081799A1 (en)	2008-04-03
AU2007300211A1 (en)	2008-04-03
NZ575159A (en)	2012-04-27
EP2069296B1 (de)	2012-04-04
JP2010504994A (ja)	2010-02-18
CA2662864A1 (en)	2008-04-03
WO2008039751A2 (en)	2008-04-03
US8114859B2 (en)	2012-02-14
EP2069296A2 (de)	2009-06-17

Publication	Publication Date	Title
MX2007006263A (es)	2007-07-10	Analogos 2a-metil y 2??-metil de 19,26,27-trinor-(20s)-1a- hidroxivitamina d3 y sus usos.
EP1482951B8 (de)	2007-02-28	1-alpha-hydroxy-2-methylen-19-nor-pregnacalciferol und seine anwendungen
PT1315504E (pt)	2004-12-31	1-alfa-hidroxi-2-metileno-19-nor-homopregnacalciferol e suas aplicacoes terapeuticas
ATE552239T1 (de)	2012-04-15	2-methylen-20-methyl-19,24,25,26,27-pentanor- vitamin-d-analoga
WO2006057899A3 (en)	2006-07-06	2alpha-methyl-19-nor-(20s)-1alpha-hydroxy-bishomopregnacalciferol and its uses
MX2009003241A (es)	2009-05-05	Analogos de 2-metilen-(20r,25s)-19,27-dinor-(22e)-vitamina d.
DE602005021245D1 (de)	2010-06-24	2-methylen-19,26,27-trinor-(20s)-1-alpha-hydroxyvitamin d3 and dessen verwendungen
WO2006057885A3 (en)	2006-06-29	17,20(e)-dehydro vitamin d analogs and their uses
MX2010007264A (es)	2011-03-15	Análogos de vitamina d 2-metilen-(20s, 25r)-19, 26-dinor.
MX2009002944A (es)	2009-04-02	Analogos de 2-metilen-(20s,25s)-19,27-dinor-(22e)-vitamina d.
DK1453798T3 (da)	2009-02-16	(20S)-1alfa-hydroxy-2-methylen-19-nor-bishomopregnacalciferol og anvendelser deraf
WO2010006169A3 (en)	2010-04-15	2-methylene-19, 26-dinor-(20s, 22e, 25r)-vitamin d analogs
WO2010006125A3 (en)	2010-04-01	2-methylene-19,26-dinor-(20r,22e,25r)-vitamin d analogs
DE602005022098D1 (de)	2010-08-12	2-methylen-18,19-dinor-1alfa-hydroxy-homopregnacalciferol und dessen verwendungen
WO2009086439A3 (en)	2009-08-27	2-methylene-(20s,25s)-19,26-dinor-vitamin d analogs
WO2010006172A3 (en)	2010-04-08	2-methylene-20(21)-dehydro-19-nor-vitamin d analogs
WO2006057902A3 (en)	2006-07-13	2alpha-methyl-19-nor-1alpha-hydroxy-homopregnacalciferol and its uses
WO2010006162A3 (en)	2010-05-20	2-methylene-(20e)-20(22)-dehydro-19-nor-vitamin d analogs
WO2010006135A3 (en)	2010-04-15	2-methylene-(17z)-17(20)-dehydro-19,21-dinor-vitamin d analogs
ATE496885T1 (de)	2011-02-15	1-alpha-hydroxy-2-(3'-hydroxypropyliden)-19-nor vitamin-d-verbindungen mit einer 1,1- dimethylpropyl-seitenkette
WO2010006129A3 (en)	2010-04-29	2-methylene-(22e)-25-(1-methylene-hexyl)-26,27-cyclo-22-dehydro-19-nor-vitamin d analogs