UA87856C2 - Алкильные производные как модуляторы метаботропных рецепторов глутамата - Google Patents

Алкильные производные как модуляторы метаботропных рецепторов глутамата

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Publication number
UA87856C2
UA87856C2 UAA200700380A UAA200700380A UA87856C2 UA 87856 C2 UA87856 C2 UA 87856C2 UA A200700380 A UAA200700380 A UA A200700380A UA A200700380 A UAA200700380 A UA A200700380A UA 87856 C2 UA87856 C2 UA 87856C2
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UA
Ukraine
Prior art keywords
modulators
glutamate receptors
alkynyl derivatives
metatropic
receptors
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UAA200700380A
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English (en)
Ukrainian (uk)
Inventor
Анне-Софи Бессис
Христел Болеа
Беатрис Боннет
Марк Эппинг-Джордан
Нихоляс Пойрер
Соня-Мария Поли
Жан-Филип Рохер
Original Assignee
Аддекс Фарма Са
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Application filed by Аддекс Фарма Са filed Critical Аддекс Фарма Са
Publication of UA87856C2 publication Critical patent/UA87856C2/ru

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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  • Chemical & Material Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
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  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Данное изобретение касается новых соединений формулы І, где W, n, X и W' определены в описании; соединения за изобретением представляют собой модуляторы метаботропных рецепторов глутамата - подтип 5 ("mGlu5"), которые являются полезными при лечении расстройств центральной нервной системы, а также других расстройств, модулированных рецепторами mGlu5.
UAA200700380A 2004-06-17 2005-06-17 Алкильные производные как модуляторы метаботропных рецепторов глутамата UA87856C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0413605.7A GB0413605D0 (en) 2004-06-17 2004-06-17 Novel compounds

Publications (1)

Publication Number Publication Date
UA87856C2 true UA87856C2 (ru) 2009-08-25

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ID=32750115

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Application Number Title Priority Date Filing Date
UAA200700380A UA87856C2 (ru) 2004-06-17 2005-06-17 Алкильные производные как модуляторы метаботропных рецепторов глутамата

Country Status (23)

Country Link
US (3) US8101637B2 (ru)
EP (2) EP2426115A3 (ru)
JP (2) JP5053840B2 (ru)
KR (1) KR101200175B1 (ru)
CN (2) CN102993084B (ru)
AU (1) AU2005254808B2 (ru)
BR (1) BRPI0511072B8 (ru)
CA (1) CA2570987C (ru)
CY (1) CY1114582T1 (ru)
DK (1) DK1765795T3 (ru)
EA (2) EA012206B1 (ru)
ES (1) ES2404034T3 (ru)
GB (1) GB0413605D0 (ru)
IL (1) IL179692A (ru)
MX (1) MXPA06014721A (ru)
NO (1) NO339660B1 (ru)
NZ (1) NZ551664A (ru)
PL (1) PL1765795T3 (ru)
PT (1) PT1765795E (ru)
SI (1) SI1765795T1 (ru)
UA (1) UA87856C2 (ru)
WO (1) WO2005123703A2 (ru)
ZA (1) ZA200610023B (ru)

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US8815351B2 (en) * 2005-09-15 2014-08-26 The United States Of America As Represented By The Secretary Of The Air Force Method for attachment of silicon-containing compounds to a surface and for synthesis of hypervalent silicon-compounds
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MX2008012617A (es) * 2006-03-31 2008-10-10 Novartis Ag Compuestos organicos.
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TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
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KR20100065191A (ko) 2007-09-14 2010-06-15 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 １,３-이치환된 ４-(아릴-ｘ-페닐)-１ｈ-피리딘-２-온
CA2696948C (en) 2007-09-14 2013-04-30 Jose Maria Cid-Nunez 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones
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