ATE496917T1 - Haptene, immunogene, antikörper und konjugate für 2-oxo-3-hydroxy lsd - Google Patents

Haptene, immunogene, antikörper und konjugate für 2-oxo-3-hydroxy lsd

Info

Publication number
ATE496917T1
ATE496917T1 AT02080687T AT02080687T ATE496917T1 AT E496917 T1 ATE496917 T1 AT E496917T1 AT 02080687 T AT02080687 T AT 02080687T AT 02080687 T AT02080687 T AT 02080687T AT E496917 T1 ATE496917 T1 AT E496917T1
Authority
AT
Austria
Prior art keywords
lsd
oxo
present
hydroxy
antibodies
Prior art date
Application number
AT02080687T
Other languages
English (en)
Inventor
Robert Ivan Mcconnell
El Ouard Benchikh
Stephen Peter Fitzgerald
John Victor Lamont
Original Assignee
Randox Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Randox Lab Ltd filed Critical Randox Lab Ltd
Application granted granted Critical
Publication of ATE496917T1 publication Critical patent/ATE496917T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D457/00Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06Lysergic acid amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/946CNS-stimulants, e.g. cocaine, amphetamines
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/811Test for named disease, body condition or organ function
    • Y10S436/814Pregnancy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT02080687T 2001-12-20 2002-12-17 Haptene, immunogene, antikörper und konjugate für 2-oxo-3-hydroxy lsd ATE496917T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01205057 2001-12-20

Publications (1)

Publication Number Publication Date
ATE496917T1 true ATE496917T1 (de) 2011-02-15

Family

ID=27589058

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02080687T ATE496917T1 (de) 2001-12-20 2002-12-17 Haptene, immunogene, antikörper und konjugate für 2-oxo-3-hydroxy lsd

Country Status (6)

Country Link
US (1) US7115718B2 (de)
EP (1) EP1321466B1 (de)
CN (1) CN1300139C (de)
AT (1) ATE496917T1 (de)
DE (1) DE60239042D1 (de)
ES (1) ES2361907T3 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794496B2 (en) * 2000-04-07 2004-09-21 Roche Diagnostics Corporation Immunoassay for LSD and 2-oxo-3-hydroxy-LSD
JP4696079B2 (ja) 2003-12-17 2011-06-08 ヤンセン アルツハイマー イミュノセラピー Aβ免疫原性ペプチド担体結合物およびそれの製造方法
US20060223998A1 (en) * 2005-03-30 2006-10-05 Fang-Jie Zhang Synthetic LSD metabolite for preparing haptens used in an LSD metabolite immunoassay
JP4057046B2 (ja) * 2006-02-23 2008-03-05 独立行政法人科学技術振興機構 ハプテン化合物および抗体
CN102707047A (zh) * 2012-06-05 2012-10-03 南通市产品质量监督检验所 快速检测麦角生物碱的胶体金检测卡及其制备方法
CN102707046A (zh) * 2012-07-13 2012-10-03 江苏省苏微微生物研究有限公司 一种麦角生物碱多残留分析的酶联免疫分析测试盒及其检测方法
GB201217938D0 (en) * 2012-10-08 2012-11-21 Randox Lab Ltd Immunoassays for meperidine and metabolites
CA3066026A1 (en) 2017-06-14 2018-12-20 Virometix Ag Cyclic peptides for protection against respiratory syncytial virus
JP7550762B2 (ja) 2018-12-20 2024-09-13 ヴァイロメティックス アーゲー リポペプチドビルディングブロックおよび合成ウイルス様粒子
CN110187094A (zh) * 2019-06-27 2019-08-30 贵州盛世康生物科技有限公司 一种5-羟基吲哚乙酸测定试剂
US12240813B2 (en) 2020-05-19 2025-03-04 Cybin Irl Limited Deuterated tryptamine derivatives and methods of use
EP4216992A1 (de) 2020-09-28 2023-08-02 DBV Technologies Partikel mit einem rsv-f-protein zur verwendung bei der rsv-impfung
CN112924665B (zh) * 2021-02-19 2023-10-03 山东莱博生物科技有限公司 一种抗体辣根过氧化物酶标记物及其制备与应用
EP4329759A4 (de) 2021-04-30 2025-07-16 Mind Medicine Inc Lsd-salzkristallformen
US12611399B2 (en) 2021-05-04 2026-04-28 Definium Therapeutics US, Inc. Movement disorders
JP7846211B2 (ja) 2021-08-19 2026-04-14 デフィニウム セラピューティクス ユーエス, インコーポレイテッド 治療適用のためのd-リゼルグ酸ジエチルアミドの即時放出製剤
WO2024249820A2 (en) * 2023-05-31 2024-12-05 Cacti, Inc. Neuroplastigen modulators for the treatment of pain, itch and nerve injury
CN121693342A (zh) 2023-07-12 2026-03-17 维罗迈科斯股份公司 肺炎球菌抗原的组合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207396B1 (en) * 1995-11-20 2001-03-27 Microgenics Corporation Immunoassay reagents and methods for determination of LSD and LSD metabolites
US6063908A (en) * 1996-07-02 2000-05-16 Roche Diagnostics Corporation Reagents for lysergic acid diethylamide immunoassay
US6306616B1 (en) * 1998-03-27 2001-10-23 Microgenics Corporation Adsorption type confirmatory assays
US6794496B2 (en) * 2000-04-07 2004-09-21 Roche Diagnostics Corporation Immunoassay for LSD and 2-oxo-3-hydroxy-LSD

Also Published As

Publication number Publication date
US7115718B2 (en) 2006-10-03
CN1450065A (zh) 2003-10-22
US20030143655A1 (en) 2003-07-31
EP1321466B1 (de) 2011-01-26
CN1300139C (zh) 2007-02-14
EP1321466A1 (de) 2003-06-25
DE60239042D1 (de) 2011-03-10
ES2361907T3 (es) 2011-06-24

Similar Documents

Publication Publication Date Title
ATE496917T1 (de) Haptene, immunogene, antikörper und konjugate für 2-oxo-3-hydroxy lsd
ATE492565T1 (de) Immunogene, antikörper und konjugate für ketamin und dessen metaboliten
ATE205602T1 (de) Verfahren und gerät zum nachweis und zur quantifizierung von glukose in körperflüssigkeiten
ATE400813T1 (de) Tumormarker für frühes krebsstadium
BRPI9910394B8 (pt) molÉculas de ligaÇço especÍfica para cintigrafia e conjugados contendo as mesmas
DE69121844D1 (de) Immunotest für Cyclosporin
EE200300128A (et) Meetod allergeeniga seostuva immunoglobuliini detekteerimiseks proovis, patsiendi allergiate in vitro diagnoosimeetod, mikromaatrikskiip ja komplekt
DE59406903D1 (de) Homobidentale, trifunktionelle Maleinimid-Linker, und ihre Verwendung in immunologisch aktiven Konjugaten
ATE408843T1 (de) Verfahren und kit zum nachweis oder zur bestimmung von 3,4-methylendioxymethamphetamin
DE69604920D1 (de) Verwendung einer phycobiliprotein-peptidkomplexverbindung als fluoreszenzlabel
DE60207016D1 (de) Verfahren und Kit zur Quantifizierung von Beta-Laktam Penizillinen
WO2003106649A3 (en) CONJUGATE TEST AND USES THEREOF
AU2002311679A1 (en) A differential labelling method
DK1173766T3 (da) Isoform af tenascin-C som markör for neoplasier
DE69928888D1 (de) Reduziertes Cortisolkonjugat
ATE52251T1 (de) Histamin-derivate, immunogen-konjugate und dadurch induzierte antikoerper.
DE60332479D1 (de) Holo-transcobalamin bindungspartner und ihre verwendung in cobalamintest
DE59911588D1 (de) Brunnenrohr
DE69922680D1 (de) Detektion und quantifikation von vancomycin in den biologischen flüssigkeiten
DE602005023784D1 (de) Blockierter enzymsondenkomplex
DE50214566D1 (de) Bioanalytische Messverfahren zur Bestimmung von Katalasen und Peroxidasen, deren Konjugaten, Substraten, Aktivatoren, und Inhibitoren
NO970130D0 (no) Oligomere bærermolekyler med definerte, innebygde markörgrupper og haptener
ES2151491T3 (es) Reactivos y procedimientos de cuantificacion de la imipramina o de la desipramina en fluidos biologicos.
DE10158713A8 (de) Träger mit immobilisierten Antigenen oder Antikörpern und Verfahren zu dessen Herstellen
DE3751543D1 (de) Lektinkomplex, sowie verfahren und sonde zu dessen herstellung.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties