ATE492565T1 - Immunogene, antikörper und konjugate für ketamin und dessen metaboliten - Google Patents

Immunogene, antikörper und konjugate für ketamin und dessen metaboliten

Info

Publication number
ATE492565T1
ATE492565T1 AT03075218T AT03075218T ATE492565T1 AT E492565 T1 ATE492565 T1 AT E492565T1 AT 03075218 T AT03075218 T AT 03075218T AT 03075218 T AT03075218 T AT 03075218T AT E492565 T1 ATE492565 T1 AT E492565T1
Authority
AT
Austria
Prior art keywords
haptens
conjugates
antibodies
ketamine
immunogenics
Prior art date
Application number
AT03075218T
Other languages
English (en)
Inventor
Robert Ivan Mcconnell
El Ouard Benchikh
Stephen Peter Fitzgerald
John Victor Lamont
Original Assignee
Randox Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Randox Lab Ltd filed Critical Randox Lab Ltd
Application granted granted Critical
Publication of ATE492565T1 publication Critical patent/ATE492565T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/823—Immunogenic carrier or carrier per se
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/807—Hapten conjugated with peptide or protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/13—Tracers or tags
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/17—Nitrogen containing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT03075218T 2002-01-31 2003-01-23 Immunogene, antikörper und konjugate für ketamin und dessen metaboliten ATE492565T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02075445 2002-01-31

Publications (1)

Publication Number Publication Date
ATE492565T1 true ATE492565T1 (de) 2011-01-15

Family

ID=29558350

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03075218T ATE492565T1 (de) 2002-01-31 2003-01-23 Immunogene, antikörper und konjugate für ketamin und dessen metaboliten

Country Status (6)

Country Link
US (1) US7371829B2 (de)
EP (1) EP1333023B1 (de)
CN (1) CN100519513C (de)
AT (1) ATE492565T1 (de)
DE (1) DE60335428D1 (de)
ES (1) ES2358737T3 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
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US7632929B2 (en) * 2000-04-20 2009-12-15 The Board Of Trustees Of The University Of Arkansas Methamphetamine-like hapten compounds, linkers, carriers and compositions and uses thereof
US20040242848A1 (en) * 2003-04-21 2004-12-02 Owens S. Michael Mouse/human chimeric anti-phencyclidine antibody and uses thereof
EP2140263B1 (de) * 2007-04-20 2017-01-04 The Board of Trustees of The University of Arkansas Haptenverbindungen und zusammensetzungen sowie ihre verwendung
CN101308139B (zh) * 2008-06-30 2012-12-12 江苏省苏微微生物研究有限公司 一种去甲氯胺酮金标检测试纸盒及其制备方法
CN101413947A (zh) * 2008-11-08 2009-04-22 江苏省苏微微生物研究有限公司 一种检测三聚氰胺的酶联免疫测试盒及其制备及检测方法
US9035068B2 (en) 2010-09-24 2015-05-19 The Rockefeller University Phosphohistidine analogs
GB201021909D0 (en) * 2010-12-23 2011-02-02 Randox Lab Ltd Multi-analyte microarrays using tag-specific antibodies and tag-anchored antibodies
CN102627696B (zh) * 2012-04-11 2013-09-25 杭州博林生物技术有限公司 一种苯环利定人工抗原的制备方法
JP6450314B2 (ja) * 2012-08-21 2019-01-09 ヤンセン ファーマシューティカ エヌ．ベー． クエチアピンハプテンに対する抗体及びその使用
JP2015527365A (ja) 2012-08-21 2015-09-17 オルソ−クリニカル ダイアグノスティクス，インコーポレイティド パリペリドンに対する抗体及びその使用
ES2691092T3 (es) 2012-08-21 2018-11-23 Janssen Pharmaceutica Nv Anticuerpos contra la risperidona y uso de los mismos
CN104837838A (zh) * 2012-08-21 2015-08-12 詹森药业有限公司 帕潘立酮半抗原
JP2015529199A (ja) 2012-08-21 2015-10-05 オルソ−クリニカル ダイアグノスティクス，インコーポレイティド パリペリドンハプテンに対する抗体及びその使用
EP2888284B1 (de) 2012-08-21 2022-07-06 Janssen Pharmaceutica NV Antikörper gegen risperidon-haptene und verwendungen davon
JP6389176B2 (ja) * 2012-08-21 2018-09-12 ヤンセン ファーマシューティカ エヌ．ベー． アリピプラゾールハプテンに対する抗体及びその使用
HK1212673A1 (zh) 2012-10-08 2016-06-17 奥克兰服务有限公司 氯胺酮衍生物
US9023353B2 (en) 2013-03-13 2015-05-05 The Board Of Trustees Of The University Of Arkansas Anti-(+)—methamphetamine monoclonal antibodies
CN104558140A (zh) * 2013-10-29 2015-04-29 艾博生物医药(杭州)有限公司 一种氯胺酮人工抗原的制备方法
CN103698524A (zh) * 2013-12-19 2014-04-02 杭州南开日新生物技术有限公司 一种快速检测五氯酚钠的免疫胶体金试剂板及其制备方法
GB201502226D0 (en) * 2015-02-11 2015-03-25 Randox Lab Ltd AH-7921 detection
GB201511725D0 (en) * 2015-07-03 2015-08-19 Randox Lab Ltd Assay
EP3390449A1 (de) 2015-12-17 2018-10-24 Janssen Pharmaceutica N.V. Antikörper gegen risperidon und verwendung davon
GB201702907D0 (en) * 2017-02-23 2017-04-12 Randox Laboratories Ltd Immunoassay
CA3102387A1 (en) * 2018-06-04 2019-12-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Process for synthesis and purification of (2r,6r)-hydroxynorketamine
CN110981949B (zh) * 2019-11-26 2020-11-06 杭州隆基生物技术有限公司 一种氯胺酮抗原的制备方法
CN114014772A (zh) * 2021-10-20 2022-02-08 上海义守生物科技有限公司 一种氟胺酮半抗原化合物及其制备方法和用途
CN114181108B (zh) * 2021-11-17 2024-01-16 浙江工商大学 一种树枝状多重半抗原、人工抗原及制备方法
WO2024163666A2 (en) * 2023-01-31 2024-08-08 Emory University Labeling primary amides in peptides, antibodies, peptide coated cells, or compounds

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US4533493A (en) * 1981-08-27 1985-08-06 Miles Laboratories, Inc. Theophylline immunogens, antibodies, labeled conjugates, and related derivatives
US4446065A (en) * 1981-12-22 1984-05-01 Syva Company Phencyclidine compounds and assays for its determination
US4469797A (en) * 1982-09-23 1984-09-04 Miles Laboratories, Inc. Digoxigenin immunogens, antibodies, labeled conjugates, and related derivatives
US5155212A (en) * 1986-05-21 1992-10-13 Abbott Laboratories Phencyclidine and phencyclidine metabolites assay, tracers, immunogens, antibodies and reagent kit
US5051361A (en) * 1988-10-19 1991-09-24 Sigma Chemical Company AZT immunoassays, derivatives, conjugates and antibodies
US5262333A (en) * 1988-10-28 1993-11-16 Abbott Laboratories Method and reagents for detecting amphetamine and/or D-methamphetamine in biological samples
US5096838A (en) * 1989-11-27 1992-03-17 Abbott Laboratories Barbiturate assay compositions and methods
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US5939332A (en) * 1998-02-27 1999-08-17 Roche Diagnostics Corp. Phencyclidine analogs for immunoassay
RU2181297C2 (ru) * 2000-06-20 2002-04-20 Эпштейн Олег Ильич Способ лечения патологического синдрома и лекарственное средство

Also Published As

Publication number Publication date
EP1333023A1 (de) 2003-08-06
CN1496974A (zh) 2004-05-19
US20030224447A1 (en) 2003-12-04
ES2358737T3 (es) 2011-05-13
EP1333023B1 (de) 2010-12-22
DE60335428D1 (de) 2011-02-03
US7371829B2 (en) 2008-05-13
CN100519513C (zh) 2009-07-29

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