ATE496999T1 - Auf einem modifizierten alphahelikalen bereich von ubiquitin beruhende künstliche bindungsproteine - Google Patents

Auf einem modifizierten alphahelikalen bereich von ubiquitin beruhende künstliche bindungsproteine

Info

Publication number
ATE496999T1
ATE496999T1 AT07847173T AT07847173T ATE496999T1 AT E496999 T1 ATE496999 T1 AT E496999T1 AT 07847173 T AT07847173 T AT 07847173T AT 07847173 T AT07847173 T AT 07847173T AT E496999 T1 ATE496999 T1 AT E496999T1
Authority
AT
Austria
Prior art keywords
ubiquitin
protein
alphahelical
modified
area
Prior art date
Application number
AT07847173T
Other languages
English (en)
Inventor
Michael Schraeml
Erik Fiedler
Original Assignee
Scil Proteins Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scil Proteins Gmbh filed Critical Scil Proteins Gmbh
Application granted granted Critical
Publication of ATE496999T1 publication Critical patent/ATE496999T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Materials For Medical Uses (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Inorganic Insulating Materials (AREA)
AT07847173T 2006-11-15 2007-11-15 Auf einem modifizierten alphahelikalen bereich von ubiquitin beruhende künstliche bindungsproteine ATE496999T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06124137A EP1925664A1 (de) 2006-11-15 2006-11-15 Künstliche Bindungsproteine auf Grundlage einer modifizierten alpha-Helix Region von Ubiquitin
PCT/EP2007/062375 WO2008059011A1 (en) 2006-11-15 2007-11-15 Artificial binding proteins based on a modified alpha helical region of ubiquitin

Publications (1)

Publication Number Publication Date
ATE496999T1 true ATE496999T1 (de) 2011-02-15

Family

ID=38024317

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07847173T ATE496999T1 (de) 2006-11-15 2007-11-15 Auf einem modifizierten alphahelikalen bereich von ubiquitin beruhende künstliche bindungsproteine

Country Status (8)

Country Link
US (1) US8592179B2 (de)
EP (2) EP1925664A1 (de)
CN (1) CN101563456A (de)
AT (1) ATE496999T1 (de)
DE (1) DE602007012303D1 (de)
DK (1) DK2094845T3 (de)
ES (1) ES2358856T3 (de)
WO (1) WO2008059011A1 (de)

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DE19932688B4 (de) 1999-07-13 2009-10-08 Scil Proteins Gmbh Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen
US6639684B1 (en) * 2000-09-13 2003-10-28 Nextengine, Inc. Digitizer using intensity gradient to image features of three-dimensional objects
DE10324447A1 (de) * 2003-05-28 2004-12-30 Scil Proteins Gmbh Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin
EP1925664A1 (de) 2006-11-15 2008-05-28 Scil proteins GmbH Künstliche Bindungsproteine auf Grundlage einer modifizierten alpha-Helix Region von Ubiquitin
KR101436222B1 (ko) * 2009-12-14 2014-09-01 쉴 프로테인즈 게엠베하 리간드 결합능력을 가진 헤테로-다량체 변형 유비퀴틴 단백질을 확인하는 방법
EP2719707A3 (de) 2010-08-10 2014-09-10 The Governing Council Of The University Of Toronto Spezifische Hemmer des aktiven Zentrums von Enzymen oder substratbindenden Partnern sowie Herstellungsverfahren dafür
EP2721152B1 (de) 2011-06-15 2019-03-27 Navigo Proteins GmbH Dimere bindeproteine auf basis modifizierter ubiquitine
US10373702B2 (en) * 2014-03-27 2019-08-06 Massachusetts Institute Of Technology Water-soluble trans-membrane proteins and methods for the preparation and use thereof
EP3253785B1 (de) * 2015-02-06 2019-04-10 Navigo Proteins Gmbh Neuartige egfr-bindende proteine
GB201505393D0 (en) * 2015-03-30 2015-05-13 Secr Defence Antimicrobal peptide formulations
CN107922483B (zh) 2015-07-16 2021-07-30 纳维格蛋白质有限公司 新型免疫球蛋白结合蛋白及其在亲和纯化中的用途
WO2017013136A1 (en) 2015-07-20 2017-01-26 Scil Proteins Gmbh Novel binding proteins based on di-ubiquitin muteins and methods for generation
AU2017260274A1 (en) 2016-05-04 2018-11-01 Navigo Proteins Gmbh Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker
CA3030208A1 (en) 2016-08-11 2018-02-15 Navigo Proteins Gmbh Novel alkaline stable immunoglobulin binding proteins
US11414466B2 (en) 2017-11-07 2022-08-16 Navigo Proteins Gmbh Fusion proteins with specificity for ED-B and long serum half-life for diagnosis or treatment of cancer
CA3123986A1 (en) 2018-12-18 2020-06-25 Navigo Proteins Gmbh Novel folr1 specific binding proteins for cancer diagnosis and treatment
CN110025766B (zh) * 2019-04-22 2022-03-08 南京医科大学 丝束蛋白t的医药用途
CN111733162A (zh) * 2020-07-01 2020-10-02 江苏莱森生物科技研究院有限公司 一种经基因修饰的cd47蛋白及其单克隆抗体和应用

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KR20090008467A (ko) 2006-05-08 2009-01-21 필로겐 에스.피.에이. 치료용의 항체­표적 사이토카인
EP1892248A1 (de) 2006-08-21 2008-02-27 Eidgenössische Technische Hochschule Zürich Bindeproteine mit spezifischer und hoher Affinität enthaltend modifizierte SH3-Domänen von FYN-Kinasen
EP1925664A1 (de) 2006-11-15 2008-05-28 Scil proteins GmbH Künstliche Bindungsproteine auf Grundlage einer modifizierten alpha-Helix Region von Ubiquitin
EP1955712A1 (de) 2007-02-09 2008-08-13 Scil proteins GmbH Multimeres Konjugat
KR101436222B1 (ko) 2009-12-14 2014-09-01 쉴 프로테인즈 게엠베하 리간드 결합능력을 가진 헤테로-다량체 변형 유비퀴틴 단백질을 확인하는 방법

Also Published As

Publication number Publication date
ES2358856T3 (es) 2011-05-16
CN101563456A (zh) 2009-10-21
US8592179B2 (en) 2013-11-26
WO2008059011A1 (en) 2008-05-22
DK2094845T3 (da) 2011-03-21
EP1925664A1 (de) 2008-05-28
DE602007012303D1 (de) 2011-03-10
EP2094845B1 (de) 2011-01-26
US20100130720A1 (en) 2010-05-27
EP2094845A1 (de) 2009-09-02

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