ATE497762T1 - Verwendung von diindolylmethan-verwandten indolen zur behandlung und prävention von erkrankungen im zusammenhang mit dem respiratory syncytial virus - Google Patents
Verwendung von diindolylmethan-verwandten indolen zur behandlung und prävention von erkrankungen im zusammenhang mit dem respiratory syncytial virusInfo
- Publication number
- ATE497762T1 ATE497762T1 AT05857257T AT05857257T ATE497762T1 AT E497762 T1 ATE497762 T1 AT E497762T1 AT 05857257 T AT05857257 T AT 05857257T AT 05857257 T AT05857257 T AT 05857257T AT E497762 T1 ATE497762 T1 AT E497762T1
- Authority
- AT
- Austria
- Prior art keywords
- diindolylmethane
- prevention
- treatment
- rsv
- syncytial virus
- Prior art date
Links
- 241000725643 Respiratory syncytial virus Species 0.000 title abstract 5
- 230000002265 prevention Effects 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
- VFTRKSBEFQDZKX-UHFFFAOYSA-N 3,3'-diindolylmethane Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4NC=3)=CNC2=C1 VFTRKSBEFQDZKX-UHFFFAOYSA-N 0.000 abstract 3
- 208000015181 infectious disease Diseases 0.000 abstract 3
- 102000001301 EGF receptor Human genes 0.000 abstract 2
- 108060006698 EGF receptor Proteins 0.000 abstract 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 206010006448 Bronchiolitis Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010035664 Pneumonia Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64030104P | 2004-12-30 | 2004-12-30 | |
| PCT/US2005/047537 WO2006083458A2 (en) | 2004-12-30 | 2005-12-30 | Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associates conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE497762T1 true ATE497762T1 (de) | 2011-02-15 |
Family
ID=36777712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05857257T ATE497762T1 (de) | 2004-12-30 | 2005-12-30 | Verwendung von diindolylmethan-verwandten indolen zur behandlung und prävention von erkrankungen im zusammenhang mit dem respiratory syncytial virus |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7989486B2 (de) |
| EP (1) | EP1838303B1 (de) |
| AT (1) | ATE497762T1 (de) |
| CA (1) | CA2593084C (de) |
| DE (1) | DE602005026328D1 (de) |
| WO (1) | WO2006083458A2 (de) |
Families Citing this family (27)
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| WO2006019831A1 (en) | 2004-07-14 | 2006-02-23 | Ptc Therapeutics, Inc. | Methods for treating hepatitis c |
| US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| ATE497762T1 (de) * | 2004-12-30 | 2011-02-15 | Bioresponse Llc | Verwendung von diindolylmethan-verwandten indolen zur behandlung und prävention von erkrankungen im zusammenhang mit dem respiratory syncytial virus |
| US20070059310A1 (en) * | 2005-05-03 | 2007-03-15 | Karel Steven J | Therapeutic combination compositions and methods of using same |
| WO2007016935A1 (en) * | 2005-07-29 | 2007-02-15 | Histogenex Nv | Methods, reagents and instrumentation for preparing impregnated tissue samples suitable for histopathological and molecular studies |
| US8586621B2 (en) * | 2006-10-27 | 2013-11-19 | Michael A. Zeligs | Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles |
| WO2009103755A1 (en) * | 2008-02-19 | 2009-08-27 | Dsm Ip Assets B.V. | Novel use of 3,3'-diindolylmethane |
| US8629153B2 (en) | 2008-09-03 | 2014-01-14 | Boehringer Ingelheim International Gmbh | Use of quinazoline derivatives for the treatment of viral diseases |
| WO2010033198A2 (en) * | 2008-09-17 | 2010-03-25 | Sri International | Analogs of indole-3-carbinol and their use as agents against infection |
| EP2373329A4 (de) * | 2008-12-19 | 2012-07-04 | Univ California | Verwendung von hemmern des epidermalen wachstumsfaktors bei der behandlung von virusinfektionen |
| CN101428016B (zh) * | 2008-12-23 | 2011-06-15 | 南京大学 | 二吲哚甲烷及其衍生物在制备治疗类风湿关节炎的药物中的应用 |
| WO2010118339A2 (en) * | 2009-04-09 | 2010-10-14 | University Of Kansas | Formulations of indole-3-carbinol derived antitumor agents with increased oral bioavailability |
| GB201004761D0 (en) * | 2010-03-22 | 2010-05-05 | Medical Res Council | Method |
| CN102133210A (zh) * | 2010-04-28 | 2011-07-27 | 重庆医科大学附属儿童医院 | 白藜芦醇在制备预防和治疗呼吸道合胞病毒感染的药物中的应用 |
| RU2013111465A (ru) * | 2010-08-18 | 2014-09-27 | Клиэфарма Индастриз Лтд. | Функциональные пищевые композиции и способы |
| GB201105050D0 (en) | 2011-03-25 | 2011-05-11 | Iiaa Ltd | Pharmaceutical agent |
| CA2827214C (en) * | 2011-04-01 | 2017-07-18 | Sri International | Lipoxygenase inhibitors |
| WO2014043442A1 (en) * | 2012-09-14 | 2014-03-20 | Children's Medical Center Corporation | Inhibition of viral infection-triggered asthma with c-kit inhibitor |
| CN105272900B (zh) * | 2015-01-21 | 2018-06-19 | 南通大学 | 双吲哚类衍生物及其制备方法与应用 |
| EP3280398B1 (de) | 2015-04-10 | 2026-02-25 | Bioresponse LLC | Selbstemulgierende formulierungen aus dim-assoziierten indolen |
| CN105030766A (zh) * | 2015-06-24 | 2015-11-11 | 安徽四正医药科技有限公司 | 吲哚-3-甲醇、二吲哚甲烷及其衍生物用于治疗过敏性咽炎药物的应用 |
| WO2017001979A1 (en) * | 2015-06-27 | 2017-01-05 | Reform Bio Inc. | Diindolyl methane compositions, formulations and use thereof |
| CN110074978A (zh) * | 2019-03-13 | 2019-08-02 | 安庆瑄宇医药科技有限公司 | 一种缬更昔洛韦组合片剂及其制备方法 |
| RU2740377C1 (ru) * | 2020-03-18 | 2021-01-13 | Всеволод Иванович Киселёв | Способ лечения эндометриоза и сопутствующего спаечного процесса лекарственным средством на основе 3,3'-дииндолилметана в комплексе с B-циклодекстрином |
| EP4157271A1 (de) | 2020-05-29 | 2023-04-05 | Boulder Bioscience LLC | Verfahren zur verbesserten endovaskulären thrombektomie mit 3,3'-diindolylmethan |
| CA3268510A1 (en) | 2022-09-30 | 2024-04-04 | Boulder Bioscience Llc | Compositions containing 3,3'-diindolmythane for treating a closed, non-bleeding head wound |
| CN116585321B (zh) * | 2023-02-21 | 2024-04-26 | 华中科技大学同济医学院附属协和医院 | 更昔洛韦在制备治疗过敏性鼻炎药物中的应用 |
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| FR2676927B1 (fr) | 1991-05-29 | 1995-06-23 | Ibf | Microspheres utilisables pour les occlusions vasculaires therapeutiques et solutions injectables les contenant. |
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| EP0656786B2 (de) | 1992-05-19 | 2014-04-23 | Novogen Research Pty Ltd | Verwendung von isoflavon phyto-östrogen extrakten von soja oder klee |
| DE69536015D1 (de) | 1995-03-30 | 2009-12-10 | Pfizer Prod Inc | Chinazolinone Derivate |
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| US5948808A (en) | 1997-03-07 | 1999-09-07 | The Texas A&M University System | Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens |
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| BRPI0510717B8 (pt) | 2004-05-06 | 2021-05-25 | Bioresponse Llc | uso de 3,3' diindolilmetano (dim) ou 2-(indol-3-ilmetil)-3,3´-diindolilmetano (ltr) |
| WO2006047716A2 (en) | 2004-10-26 | 2006-05-04 | Bioresponse Llc | Use of diindolylmethane-related indoles and growth factor receptor inhibitors for the treatment of human cytomegalovirus associated disease |
| US20060100264A1 (en) * | 2004-11-06 | 2006-05-11 | Bjeldanes Leonard F | 3,3'-Diindolylmethane immune activating compositions |
| ATE497762T1 (de) * | 2004-12-30 | 2011-02-15 | Bioresponse Llc | Verwendung von diindolylmethan-verwandten indolen zur behandlung und prävention von erkrankungen im zusammenhang mit dem respiratory syncytial virus |
| US20060229355A1 (en) | 2005-04-08 | 2006-10-12 | The Regents Of The University Of California | 3.3'-Diindolylmethane compositions inhibit angiogenesis |
-
2005
- 2005-12-30 AT AT05857257T patent/ATE497762T1/de not_active IP Right Cessation
- 2005-12-30 US US11/322,803 patent/US7989486B2/en not_active Expired - Fee Related
- 2005-12-30 WO PCT/US2005/047537 patent/WO2006083458A2/en not_active Ceased
- 2005-12-30 EP EP05857257A patent/EP1838303B1/de not_active Expired - Lifetime
- 2005-12-30 CA CA2593084A patent/CA2593084C/en not_active Expired - Fee Related
- 2005-12-30 DE DE602005026328T patent/DE602005026328D1/de not_active Expired - Lifetime
-
2011
- 2011-06-20 US US13/164,488 patent/US8552052B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2593084A1 (en) | 2006-08-10 |
| EP1838303A4 (de) | 2008-06-18 |
| DE602005026328D1 (de) | 2011-03-24 |
| US20080103114A1 (en) | 2008-05-01 |
| WO2006083458A3 (en) | 2007-10-04 |
| EP1838303A2 (de) | 2007-10-03 |
| US20110250267A1 (en) | 2011-10-13 |
| US8552052B2 (en) | 2013-10-08 |
| WO2006083458A2 (en) | 2006-08-10 |
| CA2593084C (en) | 2014-03-18 |
| US7989486B2 (en) | 2011-08-02 |
| EP1838303B1 (de) | 2011-02-09 |
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