ATE277010T1 - Bis-indolederivate und ihre verwendung als entzündungshemmende mittel - Google Patents

Bis-indolederivate und ihre verwendung als entzündungshemmende mittel

Info

Publication number: ATE277010T1
Authority: AT; Austria
Prior art keywords: bis; inflammatory agents; compounds; indole derivatives; disclosed
Prior art date: 1998-07-08

Application number

AT99933759T

Other languages

English (en)

Inventor

Amy E Wright

Ralph Mattern

Robert S Jacobs

Original Assignee

Harbor Branch Oceanographic

Univ California

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-08

Filing date

1999-07-08

Publication date

2004-10-15

1999-07-08 Application filed by Harbor Branch Oceanographic, Univ California filed Critical Harbor Branch Oceanographic

2004-10-15 Application granted granted Critical

2004-10-15 Publication of ATE277010T1 publication Critical patent/ATE277010T1/de

Links

229940121363 anti-inflammatory agent Drugs 0.000 title 1
239000002260 anti-inflammatory agent Substances 0.000 title 1
229940054051 antipsychotic indole derivative Drugs 0.000 title 1
TYGUTURXHKSOBP-UHFFFAOYSA-N 10-bromo-5,12-dihydroindolo[2,3-g]carbazole-2,3-diol Chemical class C1=C(Br)C=C2NC3=C(C4=C(C=C(C(=C4)O)O)N4)C4=CC=C3C2=C1 TYGUTURXHKSOBP-UHFFFAOYSA-N 0.000 abstract 1
230000000676 anti-immunogenic effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000002757 inflammatory effect Effects 0.000 abstract 1
230000001272 neurogenic effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT99933759T 1998-07-08 1999-07-08 Bis-indolederivate und ihre verwendung als entzündungshemmende mittel ATE277010T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US9199198P	1998-07-08	1998-07-08
PCT/US1999/015376 WO2000002857A1 (en)	1998-07-08	1999-07-08	Bis-indole derivatives and their use as antiinflammatory agents

Publications (1)

Publication Number	Publication Date
ATE277010T1 true ATE277010T1 (de)	2004-10-15

Family

ID=22230663

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99933759T ATE277010T1 (de)	1998-07-08	1999-07-08	Bis-indolederivate und ihre verwendung als entzündungshemmende mittel

Country Status (8)

Country	Link
US (2)	US6323233B1 (de)
EP (1)	EP1093455B1 (de)
JP (1)	JP2002520315A (de)
AT (1)	ATE277010T1 (de)
CA (1)	CA2335254A1 (de)
DE (1)	DE69920455T2 (de)
ES (1)	ES2229736T3 (de)
WO (1)	WO2000002857A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6589975B2 (en)	1998-07-08	2003-07-08	The Regents Of The University Of California	Synthetic compounds for treatment of inflammation
DE69920455T2 (de) *	1998-07-08	2005-01-20	Harbor Branch Oceanographic Institution Inc., Fort Pierce	Bis-indolederivate und ihre verwendung als entzündungshemmende mittel
EP1427413A2 (de)	2001-09-13	2004-06-16	Synta Pharmaceuticals Corporation	2-aroylimidazol-verbindungen zur behandlung von krebs
US6800655B2 (en) *	2002-08-20	2004-10-05	Sri International	Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents
US7074938B2 (en) *	2002-11-19	2006-07-11	The Regents Of The University Of California	Method for the synthesis of soritin compounds
US7592269B2 (en) *	2003-11-04	2009-09-22	Regents Of The University Of Minnesota	Method and apparatus for depositing charge and/or nanoparticles
US7232771B2 (en) *	2003-11-04	2007-06-19	Regents Of The University Of Minnesota	Method and apparatus for depositing charge and/or nanoparticles
WO2006083458A2 (en) *	2004-12-30	2006-08-10	Bioresponse Llc	Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associates conditions
EP1893576A4 (de) *	2005-05-27	2010-03-17	Univ Kingston	Behandlung von proteinfaltungsstörungen
UA95788C2 (en)	2005-12-15	2011-09-12	Ф. Хоффманн-Ля Рош Аг	Fused pyrrole derivatives
BRPI0717753B1 (pt)	2006-10-27	2022-04-12	Bioresponse, Llc	Uso de uma composição compreendendo 50-250 mg de um ou mais indóis relacionados com dim e um ou mais agentes anti-protozoários, e, composição
US20080220175A1 (en)	2007-01-22	2008-09-11	Lorenzo Mangolini	Nanoparticles wtih grafted organic molecules
US10799479B2 (en)	2015-04-10	2020-10-13	Bioresponse, L.L.C.	Self-emulsifying formulations of DIM-related indoles
CN108822116A (zh) *	2018-06-04	2018-11-16	南京中医药大学	具有抗肿瘤活性的吲哚生物碱及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1403617A (fr)	1962-04-02	1965-06-25	Rhone Poulenc Sa	Nouveaux dérivés de l'indole et leur préparation
US4866084A (en) *	1987-07-17	1989-09-12	Harbor Branch Oceanographic Institution, Inc.	Topsentin compounds effective against viruses and certain tumors
IL94274A0 (en)	1989-05-05	1991-03-10	Goedecke Ag	Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
US4970226A (en)	1989-10-03	1990-11-13	Harbor Branch Oceanographic Institution, Inc.	Bis-indole imidazole compounds which are useful antitumor and antimicrobial agents
CA2046801C (en)	1990-08-07	2002-02-26	Peter D. Davis	Substituted pyrroles
US5290777A (en)	1993-02-24	1994-03-01	Regents Of The Univ. Of California	Use for topsentin compounds and pharmaceutical compositions containing same
JP2001503414A (ja) *	1996-10-31	2001-03-13	ハーバーブランチオーシャノグラフィックインスティテューションインク．	抗神経性炎症化合物および組成物ならびにその使用法
EP0887348A1 (de) *	1997-06-25	1998-12-30	Boehringer Mannheim Italia S.p.A.	Bis-Indolderivative mit antimetastatischer Wirkung, Verfahren für deren Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
DE69920455T2 (de) *	1998-07-08	2005-01-20	Harbor Branch Oceanographic Institution Inc., Fort Pierce	Bis-indolederivate und ihre verwendung als entzündungshemmende mittel

1999
- 1999-07-08 DE DE69920455T patent/DE69920455T2/de not_active Expired - Fee Related
- 1999-07-08 EP EP99933759A patent/EP1093455B1/de not_active Expired - Lifetime
- 1999-07-08 CA CA002335254A patent/CA2335254A1/en not_active Abandoned
- 1999-07-08 AT AT99933759T patent/ATE277010T1/de not_active IP Right Cessation
- 1999-07-08 ES ES99933759T patent/ES2229736T3/es not_active Expired - Lifetime
- 1999-07-08 US US09/349,316 patent/US6323233B1/en not_active Expired - Lifetime
- 1999-07-08 WO PCT/US1999/015376 patent/WO2000002857A1/en not_active Ceased
- 1999-07-08 JP JP2000559088A patent/JP2002520315A/ja active Pending
2001
- 2001-07-27 US US09/916,470 patent/US6444697B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1093455A1 (de)	2001-04-25
ES2229736T3 (es)	2005-04-16
US6444697B2 (en)	2002-09-03
JP2002520315A (ja)	2002-07-09
EP1093455B1 (de)	2004-09-22
US6323233B1 (en)	2001-11-27
DE69920455D1 (de)	2004-10-28
DE69920455T2 (de)	2005-01-20
US20010056112A1 (en)	2001-12-27
WO2000002857A1 (en)	2000-01-20
CA2335254A1 (en)	2000-01-20
WO2000002857A9 (en)	2000-07-20

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Legal Events

Date	Code	Title	Description
2005-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties