ATE497776T1 - Nicht-hypertensive pegylierte hämoglobine und deren herstellungsverfahren - Google Patents

Nicht-hypertensive pegylierte hämoglobine und deren herstellungsverfahren

Info

Publication number: ATE497776T1
Authority: AT; Austria
Prior art keywords: hypertensive; production; peg chains; reacting; bound
Prior art date: 2002-12-23

Application number

AT03799982T

Other languages

English (en)

Inventor

Seetharama Acharya

Belur Manjula

Original Assignee

Einstein Coll Med

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-23

Filing date

2003-12-18

Publication date

2011-02-15

2003-12-18 Application filed by Einstein Coll Med filed Critical Einstein Coll Med

2011-02-15 Application granted granted Critical

2011-02-15 Publication of ATE497776T1 publication Critical patent/ATE497776T1/de

Links

102000001554 Hemoglobins Human genes 0.000 title abstract 3
108010054147 Hemoglobins Proteins 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title abstract 2
INGWEZCOABYORO-UHFFFAOYSA-N 2-(furan-2-yl)-7-methyl-1h-1,8-naphthyridin-4-one Chemical compound N=1C2=NC(C)=CC=C2C(O)=CC=1C1=CC=CO1 INGWEZCOABYORO-UHFFFAOYSA-N 0.000 title 1
206010020772 Hypertension Diseases 0.000 title 1
125000005439 maleimidyl group Chemical group C1(C=CC(N1*)=O)=O 0.000 abstract 1
125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
CNHYKKNIIGEXAY-UHFFFAOYSA-N thiolan-2-imine Chemical compound N=C1CCCS1 CNHYKKNIIGEXAY-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/105831—Protein or peptide standard or control [e.g., hemoglobin, etc.]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

AT03799982T 2002-12-23 2003-12-18 Nicht-hypertensive pegylierte hämoglobine und deren herstellungsverfahren ATE497776T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US43614902P	2002-12-23	2002-12-23
PCT/US2003/040407 WO2004058291A1 (en)	2002-12-23	2003-12-18	Modified hemoglobin and methods of making same

Publications (1)

Publication Number	Publication Date
ATE497776T1 true ATE497776T1 (de)	2011-02-15

Family

ID=32682349

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03799982T ATE497776T1 (de)	2002-12-23	2003-12-18	Nicht-hypertensive pegylierte hämoglobine und deren herstellungsverfahren

Country Status (16)

Country	Link
US (1)	US7501499B2 (de)
EP (1)	EP1585538B1 (de)
JP (1)	JP2006514652A (de)
KR (1)	KR101086138B1 (de)
CN (1)	CN1741812B (de)
AT (1)	ATE497776T1 (de)
AU (1)	AU2003299700B2 (de)
BR (1)	BR0317721A (de)
CA (1)	CA2511494A1 (de)
DE (1)	DE60336018D1 (de)
ES (1)	ES2360215T3 (de)
MX (1)	MXPA05006702A (de)
MY (1)	MY135256A (de)
SA (1)	SA04250032B1 (de)
TW (1)	TW200505941A (de)
WO (1)	WO2004058291A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030153491A1 (en) *	2002-01-11	2003-08-14	Winslow Robert M.	Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
EP1894573A3 (de) *	2002-01-11	2013-06-12	Sangart, Inc.	Verfahren und Zusammensetzungen für den Sauerstofftransport mit hoher Sauerstoffaffinität
US7144989B2 (en)	2002-03-25	2006-12-05	Albert Einstein College Of Medicine Of Yeshiva University	Pegylated non-hypertensive hemoglobins, methods of preparing same, and uses thereof
US7521174B2 (en) *	2003-12-05	2009-04-21	Albert Einstein College Of Medicine Of Yeshiva University	Universal red blood cells, methods of preparing same, and uses thereof
KR20070069154A (ko) *	2004-08-31	2007-07-02	생가트, 인코포레이티드	산소 운반 조성물을 사용하여 혈역학적 안정성을향상시키는 방법
US20060134694A1 (en) *	2004-12-22	2006-06-22	Intel Corporation	Methods of protein profiling by thiolation
CA2600927C (en)	2005-03-07	2017-04-18	Sangart, Inc.	Compositions and methods for delivering carbon monoxide (co) and nitric oxide (no) to tissue using heme proteins as carriers
WO2007050121A2 (en) *	2005-05-11	2007-05-03	Albert Einstein College Of Medicine Of Yeshiva University	Site specific pegylated hemoglobin, method of preparing same, and uses thereof
WO2006135740A1 (en) *	2005-06-10	2006-12-21	Albert Einstein College Of Medicine Of Yeshiva University	Pegylated hemoglobin and albumin and uses thereof
WO2007058678A2 (en)	2005-06-10	2007-05-24	Albert Einstein College Of Medicine Of Yeshiva University	Uses of pegylated albumin
US7795401B2 (en) *	2006-09-06	2010-09-14	National Chung Cheng University	Modified hemoglobin with allosteric effector conjugated
US8697645B2 (en) *	2007-03-13	2014-04-15	Albert Einstein College Of Medicine Of Yeshiva University	Second generation low oxygen affinity pegylated hemoglobins as oxygen-carrying plasma expanders
CN101306196B (zh) *	2008-07-03	2011-05-11	中国科学院长春应用化学研究所	一种生物降解的键合了血红蛋白分子的纳米粒子及制法
US10172950B2 (en)	2009-06-09	2019-01-08	Prolong Pharmaceuticals, LLC	Hemoglobin compositions
US10172949B2 (en)	2009-06-09	2019-01-08	Prolong Pharmaceuticals, LLC	Hemoglobin compositions
ES2966234T3 (es)	2009-06-09	2024-04-18	Prolong Pharmaceuticals Llc	Composiciones de hemoglobina
AU2011220885A1 (en) *	2010-02-25	2012-09-06	Sangart, Inc.	Methods for preparing PEG-hemoglobin conjugates using reduced reactant ratios
US7989593B1 (en)	2010-05-27	2011-08-02	Bing Lou Wong	Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof
US7932356B1 (en)	2010-06-23	2011-04-26	Bing Lou Wong	Method for the preparation of a heat stable oxygen carrier-containing pharmaceutical composition
US8048856B1 (en)	2010-06-23	2011-11-01	Billion King, Ltd.	Treatment methods using a heat stable oxygen carrier-containing pharmaceutical composition
US8084581B1 (en)	2011-04-29	2011-12-27	Bing Lou Wong	Method for removing unmodified hemoglobin from cross-linked hemoglobin solutions including polymeric hemoglobin with a high temperature short time heat treatment apparatus
US20130052232A1 (en)	2011-08-31	2013-02-28	Bing Lou Wong	Method for the preparation of a heat stable oxygen carrier-containing composition facilating beta-beta cross-linking
CN104379160A (zh)	2012-03-29	2015-02-25	桑加特公司	双阿司匹林交联聚乙二醇化血红蛋白
JP2015514718A (ja)	2012-04-03	2015-05-21	サンガート，インコーポレイテッド	スクシンイミド活性化されたニトロキシル化合物およびタンパク質のニトロキシル化のためのその使用のための方法
US10821158B2 (en)	2013-03-15	2020-11-03	William Schindler	Polyalkylene oxide valerate hemoglobin conjugates

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5234903A (en) *	1989-11-22	1993-08-10	Enzon, Inc.	Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute
US5585484A (en) *	1995-04-19	1996-12-17	Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University	Hemoglobin crosslinkers
US5900402A (en) *	1997-05-29	1999-05-04	Enzon, Inc.	Method of reducing side effects associated with administration of oxygen-carrying proteins
US6773613B1 (en) *	1998-10-15	2004-08-10	Sangart, Inc.	Method for production of stroma-free hemoglobin
US7019117B2 (en) *	2001-07-19	2006-03-28	Albert Einstein College Of Medicine Of Yeshiva University	Size enhanced hemoglobins: surface decoration and crosslinking of the protein with polyoxy alkylene glycols
EP1469811A4 (de) *	2002-01-11	2006-01-04	Sangart Inc	Verfahren und zusammensetzungen für den sauerstofftransport mit modifiziertem hämoglobin in plasma
US20030153491A1 (en) *	2002-01-11	2003-08-14	Winslow Robert M.	Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US7144989B2 (en) *	2002-03-25	2006-12-05	Albert Einstein College Of Medicine Of Yeshiva University	Pegylated non-hypertensive hemoglobins, methods of preparing same, and uses thereof
US7521174B2 (en) *	2003-12-05	2009-04-21	Albert Einstein College Of Medicine Of Yeshiva University	Universal red blood cells, methods of preparing same, and uses thereof
WO2007050121A2 (en)	2005-05-11	2007-05-03	Albert Einstein College Of Medicine Of Yeshiva University	Site specific pegylated hemoglobin, method of preparing same, and uses thereof

2003
- 2003-12-18 KR KR1020057011737A patent/KR101086138B1/ko not_active Expired - Fee Related
- 2003-12-18 AU AU2003299700A patent/AU2003299700B2/en not_active Ceased
- 2003-12-18 MX MXPA05006702A patent/MXPA05006702A/es active IP Right Grant
- 2003-12-18 ES ES03799982T patent/ES2360215T3/es not_active Expired - Lifetime
- 2003-12-18 JP JP2004563778A patent/JP2006514652A/ja active Pending
- 2003-12-18 EP EP03799982A patent/EP1585538B1/de not_active Expired - Lifetime
- 2003-12-18 US US10/538,976 patent/US7501499B2/en not_active Expired - Fee Related
- 2003-12-18 BR BR0317721-1A patent/BR0317721A/pt not_active IP Right Cessation
- 2003-12-18 CN CN2003801091578A patent/CN1741812B/zh not_active Expired - Fee Related
- 2003-12-18 DE DE60336018T patent/DE60336018D1/de not_active Expired - Lifetime
- 2003-12-18 CA CA002511494A patent/CA2511494A1/en not_active Abandoned
- 2003-12-18 WO PCT/US2003/040407 patent/WO2004058291A1/en not_active Ceased
- 2003-12-18 AT AT03799982T patent/ATE497776T1/de not_active IP Right Cessation
- 2003-12-22 MY MYPI20034947A patent/MY135256A/en unknown
- 2003-12-23 TW TW092136572A patent/TW200505941A/zh unknown
2004
- 2004-03-09 SA SA04250032A patent/SA04250032B1/ar unknown

Also Published As

Publication number	Publication date
JP2006514652A (ja)	2006-05-11
CN1741812A (zh)	2006-03-01
US7501499B2 (en)	2009-03-10
MY135256A (en)	2008-03-31
US20060135753A1 (en)	2006-06-22
ES2360215T3 (es)	2011-06-01
SA04250032B1 (ar)	2007-07-31
CN1741812B (zh)	2013-04-24
WO2004058291A1 (en)	2004-07-15
DE60336018D1 (de)	2011-03-24
KR101086138B1 (ko)	2011-11-25
AU2003299700B2 (en)	2009-03-26
EP1585538A4 (de)	2007-11-21
AU2003299700A1 (en)	2004-07-22
BR0317721A (pt)	2005-12-06
MXPA05006702A (es)	2005-09-30
KR20050084460A (ko)	2005-08-26
EP1585538B1 (de)	2011-02-09
TW200505941A (en)	2005-02-16
CA2511494A1 (en)	2004-07-15
EP1585538A1 (de)	2005-10-19

Legal Events

Date	Code	Title	Description
2011-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE497776T1 (de)	2011-02-15	Nicht-hypertensive pegylierte hämoglobine und deren herstellungsverfahren
ATE369878T1 (de)	2007-09-15	Träger-pharmaka-konjugate
WO1998001158A3 (de)	1998-03-19	Hämoglobin-hydroxyethylstärke-konjugate als sauerstoff-transport-mittel
ZA200606237B (en)	2007-12-27	Bicycloester derivative
MXPA03009840A (es)	2004-04-02	Derivados de fenilurea sustituidos con carboxamida y metodo para la produccion de los mismos como farmacos.
CY1114922T1 (el)	2016-12-14	Κυτταροτοξικοι παραγοντες οι οποιοι περιλαμβανουν νεα παραγωγα τομαϋμυκινης και τη θεραπευτικη τους χρηση
EP2292636A3 (de)	2013-05-01	Prozess, um Antikörper und therapeutische Produkte zu konzentrieren
EA200800657A1 (ru)	2008-08-29	Способ приготовления очищенных конъюгатов лекарственных средств
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