WO2002008190A3 - Neue heteroaryl-derivate und deren verwendung als antitumormittel - Google Patents

Neue heteroaryl-derivate und deren verwendung als antitumormittel Download PDF

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Publication number
WO2002008190A3
WO2002008190A3 PCT/EP2001/008262 EP0108262W WO0208190A3 WO 2002008190 A3 WO2002008190 A3 WO 2002008190A3 EP 0108262 W EP0108262 W EP 0108262W WO 0208190 A3 WO0208190 A3 WO 0208190A3
Authority
WO
WIPO (PCT)
Prior art keywords
tumour agents
heteroaryl derivatives
novel heteroaryl
novel
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/008262
Other languages
English (en)
French (fr)
Other versions
WO2002008190A2 (de
Inventor
Peter Emig
Eckhard Guenther
Juergen Schmidt
Bernhard Kutscher
Bernd Nickel
Anita Storch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aeterna Zentaris GmbH
Original Assignee
Zentaris AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to PL36135401A priority Critical patent/PL361354A1/xx
Priority to AU8198901A priority patent/AU8198901A/xx
Priority to NZ524156A priority patent/NZ524156A/en
Priority to BR0112711-0A priority patent/BR0112711A/pt
Priority to EP01960509A priority patent/EP1305289A2/de
Priority to AU2001281989A priority patent/AU2001281989B2/en
Priority to IL15393101A priority patent/IL153931A0/xx
Priority to SK194-2003A priority patent/SK1942003A3/sk
Priority to HU0300743A priority patent/HUP0300743A2/hu
Application filed by Zentaris AG filed Critical Zentaris AG
Priority to KR10-2003-7000880A priority patent/KR20030015894A/ko
Priority to JP2002514097A priority patent/JP2004516243A/ja
Priority to MXPA03000596A priority patent/MXPA03000596A/es
Publication of WO2002008190A2 publication Critical patent/WO2002008190A2/de
Publication of WO2002008190A3 publication Critical patent/WO2002008190A3/de
Priority to NO20030302A priority patent/NO20030302L/no
Anticipated expiration legal-status Critical
Priority to BG107506A priority patent/BG107506A/bg
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Die Erfindung betrifft neue Pyridin-Derivate der allgemeinen Formel (1), deren Herstellung und Verwendung als Arzneimittel, insbesondere zur Behandlung von Tumoren.
PCT/EP2001/008262 2000-07-21 2001-07-18 Neue heteroaryl-derivate und deren verwendung als antitumormittel Ceased WO2002008190A2 (de)

Priority Applications (14)

Application Number Priority Date Filing Date Title
HU0300743A HUP0300743A2 (hu) 2000-07-21 2001-07-18 Heteroarilszármazékok és alkalmazásuk gyógyszerként
NZ524156A NZ524156A (en) 2000-07-21 2001-07-18 Novel heteroaryl derivatives and their use as medicaments
KR10-2003-7000880A KR20030015894A (ko) 2000-07-21 2001-07-18 신규한 헤테로아릴 유도체 및 약물로서의 이의 용도
EP01960509A EP1305289A2 (de) 2000-07-21 2001-07-18 Neue heteroaryl-derivate und deren verwendung als antitumormittel
AU2001281989A AU2001281989B2 (en) 2000-07-21 2001-07-18 Novel heteroaryl derivatives and use thereof as anti-tumour agents
IL15393101A IL153931A0 (en) 2000-07-21 2001-07-18 Novel heteroaryl derivatives and use thereof as anti-tumour agents
SK194-2003A SK1942003A3 (en) 2000-07-21 2001-07-18 Novel heteroaryl derivatives and use thereof as anti-tumour agents
PL36135401A PL361354A1 (en) 2000-07-21 2001-07-18 Novel heteroaryl derivatives and use thereof as anti-tumour agents
BR0112711-0A BR0112711A (pt) 2000-07-21 2001-07-18 Derivados de heteroarila e seus usos como medicamentos
AU8198901A AU8198901A (en) 2000-07-21 2001-07-18 Novel heteroaryl derivatives and use thereof as medicaments
JP2002514097A JP2004516243A (ja) 2000-07-21 2001-07-18 新規のヘテロアリール誘導体および該化合物の医薬品としての使用
MXPA03000596A MXPA03000596A (es) 2000-07-21 2001-07-18 Nuevos derivasdos de heteroarilo y su uso como agentes antitumorales.
NO20030302A NO20030302L (no) 2000-07-21 2003-01-20 Nye heteroarylderivater og deres anvendelse som medikamenter
BG107506A BG107506A (bg) 2000-07-21 2003-01-30 Нови хетероарилови производни и тяхното използване като лекарствени средства

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10035908A DE10035908A1 (de) 2000-07-21 2000-07-21 Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
DE10035908.6 2000-07-21

Publications (2)

Publication Number Publication Date
WO2002008190A2 WO2002008190A2 (de) 2002-01-31
WO2002008190A3 true WO2002008190A3 (de) 2002-08-01

Family

ID=7649970

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/008262 Ceased WO2002008190A2 (de) 2000-07-21 2001-07-18 Neue heteroaryl-derivate und deren verwendung als antitumormittel

Country Status (21)

Country Link
US (1) US6638935B2 (de)
EP (1) EP1305289A2 (de)
JP (1) JP2004516243A (de)
KR (1) KR20030015894A (de)
CN (1) CN1447796A (de)
AR (1) AR032467A1 (de)
AU (2) AU8198901A (de)
BG (1) BG107506A (de)
BR (1) BR0112711A (de)
CA (1) CA2353353A1 (de)
DE (1) DE10035908A1 (de)
HU (1) HUP0300743A2 (de)
IL (1) IL153931A0 (de)
MX (1) MXPA03000596A (de)
NO (1) NO20030302L (de)
NZ (1) NZ524156A (de)
PL (1) PL361354A1 (de)
RU (1) RU2003105238A (de)
SK (1) SK1942003A3 (de)
WO (1) WO2002008190A2 (de)
ZA (1) ZA200300545B (de)

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AU2004218260A1 (en) * 2003-01-28 2004-09-16 Aventis Pharma S.A. N-aryl heteroaromatic products, compositions containing same and use thereof
FR2855825B1 (fr) * 2003-06-04 2008-08-22 Aventis Pharma Sa Produits aryl-heteroaromatiques, compositions les contenant et utilisation
PE20050226A1 (es) * 2003-06-04 2005-05-18 Aventis Pharma Sa Productos aril-heteroaromaticos y composiciones que los contienen
US7592466B2 (en) 2003-10-09 2009-09-22 Abbott Laboratories Ureas having antiangiogenic activity
FR2871157A1 (fr) * 2004-06-04 2005-12-09 Aventis Pharma Sa Produits biaryl aromatiques, compositions les contenant et utilisation
EP1645556A1 (de) * 2004-10-07 2006-04-12 Boehringer Ingelheim International GmbH Arylpiperazin-Benzoylamidderivate geeignet als Arzneimittelwirkstoffe
EP2121613A2 (de) * 2007-01-31 2009-11-25 Vertex Pharmaceuticals, Inc. 2-aminopyridinderivate als kinaseinhibitoren
US8835426B2 (en) * 2007-02-26 2014-09-16 Vitae Pharmaceuticals, Inc. Cyclic urea and carbamate inhibitors of 11β-hydroxysteroid dehydrogenase 1
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US8173635B2 (en) 2007-11-02 2012-05-08 Vertex Pharmaceuticals Incorporated Kinase inhibitors
AR069207A1 (es) * 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
CA2708303A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
TW200934490A (en) * 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
WO2009094169A1 (en) 2008-01-24 2009-07-30 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2714532A1 (en) * 2008-02-11 2009-08-20 Vitae Pharmaceuticals, Inc. 1,3-oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
US8598160B2 (en) * 2008-02-15 2013-12-03 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
CA2718264A1 (en) * 2008-03-18 2009-09-24 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
CA2723032A1 (en) * 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2291370B1 (de) 2008-05-01 2013-11-27 Vitae Pharmaceuticals, Inc. Cyclische inhibitoren von 11beta-hydroxysteroiddehydrogenase 1
KR20110002492A (ko) 2008-05-01 2011-01-07 비타이 파마슈티컬즈, 인코포레이티드 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제
TW201004945A (en) 2008-05-01 2010-02-01 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8569337B2 (en) 2008-07-23 2013-10-29 Vertex Pharmaceuticals Incorporated Tri-cyclic pyrazolopyridine kinase inhibitors
NZ590784A (en) 2008-07-23 2012-12-21 Vertex Pharma Pyrazolopyridine kinase inhibitors
MX2011000837A (es) 2008-07-23 2011-04-05 Vertex Pharma Inhibidores de pirazolpiridina cinasa triciclica.
WO2010011314A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1
US8846668B2 (en) 2008-07-25 2014-09-30 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
MX2011001319A (es) 2008-08-06 2011-04-05 Vertex Pharma Inhibidores de aminopiridina cinasa.
JP5679997B2 (ja) 2009-02-04 2015-03-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
TW201039034A (en) * 2009-04-27 2010-11-01 Chunghwa Picture Tubes Ltd Pixel structure and the method of forming the same
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EP2528917B1 (de) 2010-01-27 2016-10-19 Vertex Pharmaceuticals Incorporated Zur behandlung von autoimmun-, entzündlichen oder (hyper)proliferativen erkrankungen geeignete pyrazolopyridine
EP2582702A1 (de) 2010-01-27 2013-04-24 Vertex Pharmaceuticals Incorporated Pyrazolopyrimidinkinasehemmer
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DE2828888A1 (de) * 1977-06-30 1979-01-18 Egyt Gyogyszervegyeszeti Gyar Verfahren zur herstellung von pyridincarbonsaeureamiden
EP0040793A1 (de) * 1980-05-22 1981-12-02 Masayuki Ishikawa Chinazolindion-Verbindungen, Verfahren zu deren Herstellung und deren pharmazeutische Verwendung
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EP0350448A1 (de) * 1988-07-07 1990-01-10 Ciba-Geigy Ag Biarylverbindungen
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WO1996028427A1 (en) * 1995-03-10 1996-09-19 Berlex Laboratories, Inc. Benzamidine derivatives their preparation and their use as anti-coagulants
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Also Published As

Publication number Publication date
EP1305289A2 (de) 2003-05-02
RU2003105238A (ru) 2004-08-10
AU8198901A (en) 2002-02-05
KR20030015894A (ko) 2003-02-25
NO20030302D0 (no) 2003-01-20
MXPA03000596A (es) 2003-05-14
AR032467A1 (es) 2003-11-12
WO2002008190A2 (de) 2002-01-31
CN1447796A (zh) 2003-10-08
BR0112711A (pt) 2003-05-20
US20020111354A1 (en) 2002-08-15
US6638935B2 (en) 2003-10-28
JP2004516243A (ja) 2004-06-03
PL361354A1 (en) 2004-10-04
SK1942003A3 (en) 2003-12-02
IL153931A0 (en) 2003-07-31
CA2353353A1 (en) 2002-01-21
NO20030302L (no) 2003-02-07
DE10035908A1 (de) 2002-03-07
NZ524156A (en) 2005-10-28
HUP0300743A2 (hu) 2003-10-28
ZA200300545B (en) 2003-02-12
BG107506A (bg) 2003-09-30
AU2001281989B2 (en) 2005-05-12

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