ATE497958T1 - Verfahren zur herstellung von synthetischen derivaten von dibenzylbutyrolacton-lignanen mit antichagas eigenschaften - Google Patents
Verfahren zur herstellung von synthetischen derivaten von dibenzylbutyrolacton-lignanen mit antichagas eigenschaftenInfo
- Publication number
- ATE497958T1 ATE497958T1 AT03709465T AT03709465T ATE497958T1 AT E497958 T1 ATE497958 T1 AT E497958T1 AT 03709465 T AT03709465 T AT 03709465T AT 03709465 T AT03709465 T AT 03709465T AT E497958 T1 ATE497958 T1 AT E497958T1
- Authority
- AT
- Austria
- Prior art keywords
- cubebin
- lignans
- derivatives
- antichagas
- properties
- Prior art date
Links
- 229930013686 lignan Natural products 0.000 title abstract 3
- 235000009408 lignans Nutrition 0.000 title abstract 3
- -1 DERIVATIVES OF DIBENZYLBUTYROLACTONE LIGNANS Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- DIYWRNLYKJKHAM-MDOVXXIYSA-N (-)-cubebin Chemical compound C1=C2OCOC2=CC(C[C@@H]2[C@@H](CC=3C=C4OCOC4=CC=3)CO[C@@H]2O)=C1 DIYWRNLYKJKHAM-MDOVXXIYSA-N 0.000 abstract 3
- XUEHVOLRMXNRKQ-KHMAMNHCSA-N alpha cubebene Natural products CC(C)[C@@H]([C@H]12)CC[C@@H](C)[C@]32[C@@H]1C(C)=CC3 XUEHVOLRMXNRKQ-KHMAMNHCSA-N 0.000 abstract 3
- DDWGQGZPYDSYEL-UHFFFAOYSA-N Cubebinolide Natural products C1=C2OCOC2=CC(CC2C(CC=3C=C4OCOC4=CC=3)COC2=O)=C1 DDWGQGZPYDSYEL-UHFFFAOYSA-N 0.000 abstract 2
- DDWGQGZPYDSYEL-LSDHHAIUSA-N hinokinin Chemical compound C1=C2OCOC2=CC(C[C@@H]2[C@@H](CC=3C=C4OCOC4=CC=3)COC2=O)=C1 DDWGQGZPYDSYEL-LSDHHAIUSA-N 0.000 abstract 2
- 150000005692 lignans Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- IYBDDRJHJMFFBB-UHFFFAOYSA-N methylpluviatolide Natural products C1=C(OC)C(OC)=CC=C1CC1C(=O)OCC1CC1=CC=C(OCO2)C2=C1 IYBDDRJHJMFFBB-UHFFFAOYSA-N 0.000 abstract 2
- 206010001935 American trypanosomiasis Diseases 0.000 abstract 1
- 208000024699 Chagas disease Diseases 0.000 abstract 1
- 240000003731 Piper cubeba Species 0.000 abstract 1
- 235000002711 Piper cubeba Nutrition 0.000 abstract 1
- 241000949456 Zanthoxylum Species 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- ZXJXZNDDNMQXFV-UHFFFAOYSA-M crystal violet Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1[C+](C=1C=CC(=CC=1)N(C)C)C1=CC=C(N(C)C)C=C1 ZXJXZNDDNMQXFV-UHFFFAOYSA-M 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229960001235 gentian violet Drugs 0.000 abstract 1
- 244000077696 naranjillo Species 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR0201237-5A BR0201237A (pt) | 2002-03-25 | 2002-03-25 | Processo de obtenção de lignanas dibenzilbutirolactÈnicas, processo de obtenção de derivados sintéticos de lignanas ostentando atividades quimioprofilática e terapêutica antichagásica |
| PCT/BR2003/000045 WO2003080600A1 (en) | 2002-03-25 | 2003-03-25 | Process to obtain dibenzylbutyrolactonic lignans; process to obtain synthetic derivatives from lignanes bearing anti-chagas chemoprophylactic and therapeutical activities |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE497958T1 true ATE497958T1 (de) | 2011-02-15 |
Family
ID=39303809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03709465T ATE497958T1 (de) | 2002-03-25 | 2003-03-25 | Verfahren zur herstellung von synthetischen derivaten von dibenzylbutyrolacton-lignanen mit antichagas eigenschaften |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7317114B2 (de) |
| EP (1) | EP1487825B1 (de) |
| JP (2) | JP2005532277A (de) |
| AT (1) | ATE497958T1 (de) |
| AU (1) | AU2003213896A1 (de) |
| BR (1) | BR0201237A (de) |
| DE (1) | DE60335980D1 (de) |
| ES (1) | ES2362260T3 (de) |
| WO (1) | WO2003080600A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0501542A (pt) * | 2005-04-28 | 2006-12-12 | Fundacao De Amparo A Pesquisa | processo de obtenção de lignanas dibenzilbutirolactÈnicas, tetrahidrofuránicas e de seus derivados sintéticos e semi-sintéticos, suas atividades analgésica e antiinflamatória, formulações tópicas e/ou sistêmicas contendo tais lignanas e respectivo método terapêutico |
| BRPI0503951A (pt) * | 2005-07-15 | 2007-03-06 | Fundacao De Amparo A Pesquisa | processo de obtenção de derivados sintéticos e semi-sintéticos de lignanas, suas atividades antiparasitárias e respectivas formulações farmacêuticas, englobando o método terapêutico utilizando tais lignanas no tratamento de parasitoses |
| CH698627B1 (de) * | 2007-08-16 | 2009-09-15 | Alpinia Laudanum Inst Of Phytopharmaceutical | Herstellung und Verwendung von Extrakten oder Extraktivstoffen aus Piper cubeba L. als wirksame Bestandteile in einem Medikament zur Behandlung von Krebserkrankungen. |
| US8829049B2 (en) | 2009-12-21 | 2014-09-09 | Acef S.A. | Medicinal composition intended for the treatment of erectile dysfunction in mammals and use of the composition |
| CN102603754B (zh) * | 2012-04-06 | 2015-06-17 | 苏州大学 | 一种两面针喹诺酮类生物碱的制备及应用 |
| WO2014086379A1 (en) | 2012-12-03 | 2014-06-12 | Alpinia Laudanum Institute Of Phytopharmaceutical Sciences Ag | Lignan compositions |
| JP7197908B2 (ja) * | 2019-03-04 | 2022-12-28 | 株式会社ナチュファルマ琉球 | 骨減少性疾患の予防及び／又は治療用組成物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK346987D0 (da) * | 1987-07-06 | 1987-07-06 | Hans Goeran Magnusson | Fremgangsmaade til fremstilling af tetrahydrofuranforbindelser |
-
2002
- 2002-03-25 BR BR0201237-5A patent/BR0201237A/pt active Search and Examination
-
2003
- 2003-03-25 WO PCT/BR2003/000045 patent/WO2003080600A1/en not_active Ceased
- 2003-03-25 DE DE60335980T patent/DE60335980D1/de not_active Expired - Lifetime
- 2003-03-25 EP EP03709465A patent/EP1487825B1/de not_active Expired - Lifetime
- 2003-03-25 US US10/508,875 patent/US7317114B2/en not_active Expired - Fee Related
- 2003-03-25 JP JP2003578354A patent/JP2005532277A/ja active Pending
- 2003-03-25 AT AT03709465T patent/ATE497958T1/de not_active IP Right Cessation
- 2003-03-25 AU AU2003213896A patent/AU2003213896A1/en not_active Abandoned
- 2003-03-25 ES ES03709465T patent/ES2362260T3/es not_active Expired - Lifetime
-
2007
- 2007-12-06 US US11/951,460 patent/US7521569B2/en not_active Expired - Fee Related
-
2010
- 2010-12-10 JP JP2010275582A patent/JP2011098968A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1487825B1 (de) | 2011-02-09 |
| AU2003213896A1 (en) | 2003-10-08 |
| ES2362260T3 (es) | 2011-06-30 |
| JP2011098968A (ja) | 2011-05-19 |
| US7317114B2 (en) | 2008-01-08 |
| US20050154215A1 (en) | 2005-07-14 |
| EP1487825A1 (de) | 2004-12-22 |
| US20080090901A1 (en) | 2008-04-17 |
| WO2003080600A1 (en) | 2003-10-02 |
| JP2005532277A (ja) | 2005-10-27 |
| BR0201237A (pt) | 2003-12-02 |
| US7521569B2 (en) | 2009-04-21 |
| DE60335980D1 (de) | 2011-03-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NL300933I2 (nl) | Letermovir | |
| CY1107074T1 (el) | Συνθεση εναντιομερων 4-αμινο-θαλιδομιδης | |
| WO2004043954A3 (en) | Trans-9,10-dehydroepothilone c and d, analogs thereof and methos of making the same | |
| SE0102299D0 (sv) | Compounds | |
| BR0310106A (pt) | Composto, processo para a produção de um composto, composição farmacêutica, uso do composto e método para o tratamento de um sujeito em sofrimento de uma condição ou doença patalógica | |
| YU71901A (sh) | NOVE VRSTE LEKOVITIH KOMPOZICIJA NA BAZI JEDINJENJA KOJA DELUJU ANTIHOLINERGIJSKI I beta-MIMETIKA | |
| MXPA04001500A (es) | Compuestos que tienen un efecto sobre la glucocinasa. | |
| WO2002076976A3 (en) | Rho-kinase inhibitors | |
| WO2002076977A3 (en) | Rho-kinase inhibitors | |
| WO2004029045A3 (en) | Process for preparing quinazoline rho-kinase inhibitors and intermediates thereof | |
| EA200401365A1 (ru) | Способы лечения илеуса | |
| PT1606288E (pt) | Derivados de benzenossulfonamida, processo para a sua preparação e a sua utilização para tratamento da dor | |
| ATE372114T1 (de) | Verfahren zur erhöhung des testosteronspiegels | |
| ATE497958T1 (de) | Verfahren zur herstellung von synthetischen derivaten von dibenzylbutyrolacton-lignanen mit antichagas eigenschaften | |
| ATE417856T1 (de) | Motilidverbindungen | |
| ATE339202T1 (de) | Verwendung von alpha-halogenacryloyl-distamycin derivaten zur herstellung eines medikaments zur behandlung von krebs | |
| DE60222806D1 (de) | Verfahren zur herstellung von (1,4,5)-oxadiazepinderivaten | |
| ATE424892T1 (de) | Verfahren zur herstellung von derivaten des 4a,5, 9,10,11,12-hexahydrobenzofuro ä3a,3,2üä 2 ü- benzazepins | |
| CY1105275T1 (el) | Ενωσεις υποκατεστημενης γ-λακτονης ως ανταγωνισται - νμda | |
| CY1110156T1 (el) | Υποκατεστημενες ενωσεις 4,5,6,7-τετραϋδρο-βενζοθειαζολ-2-υλαμινης | |
| ATE437855T1 (de) | (4,5,6,7-tetrahydro-1h-indol-7- yl)essigsäurederivate zur behandlung von alzheimer-krankheit | |
| DE50210322D1 (de) | Verfahren zur herstellung von extrakten aus pelargonium sidoides und/oder pelargonium reniforme | |
| MXPA04000272A (es) | Derivados de 4-aminociclohexanol sustituidos. | |
| BR0210407A (pt) | Composto, composição farmacêutica, uso de um composto e método de tratamento de um distúrbio ou de uma doença de corpo animal vivo, incluindo um humano | |
| ATE265418T1 (de) | Neue substituierte 3-phenoxy- und 3- phenylalkyloxy-2-phenyl-propylamine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |