BR0201237A - Processo de obtenção de lignanas dibenzilbutirolactÈnicas, processo de obtenção de derivados sintéticos de lignanas ostentando atividades quimioprofilática e terapêutica antichagásica - Google Patents

Processo de obtenção de lignanas dibenzilbutirolactÈnicas, processo de obtenção de derivados sintéticos de lignanas ostentando atividades quimioprofilática e terapêutica antichagásica

Info

Publication number
BR0201237A
BR0201237A BR0201237-5A BR0201237A BR0201237A BR 0201237 A BR0201237 A BR 0201237A BR 0201237 A BR0201237 A BR 0201237A BR 0201237 A BR0201237 A BR 0201237A
Authority
BR
Brazil
Prior art keywords
obtaining
lignans
cubebin
derivatives
dibenzylbutyrolactinic
Prior art date
Application number
BR0201237-5A
Other languages
English (en)
Inventor
Marcio Luis Andrade E Silva
Sergio De Albuquerque
Gustavo Henrique Bianco Souza
Jairo Kenupp Bastos
Original Assignee
Fundacao De Amparo A Pesquisa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundacao De Amparo A Pesquisa filed Critical Fundacao De Amparo A Pesquisa
Priority to BR0201237-5A priority Critical patent/BR0201237A/pt
Priority to EP03709465A priority patent/EP1487825B1/en
Priority to US10/508,875 priority patent/US7317114B2/en
Priority to PCT/BR2003/000045 priority patent/WO2003080600A1/en
Priority to JP2003578354A priority patent/JP2005532277A/ja
Priority to ES03709465T priority patent/ES2362260T3/es
Priority to DE60335980T priority patent/DE60335980D1/de
Priority to AT03709465T priority patent/ATE497958T1/de
Priority to AU2003213896A priority patent/AU2003213896A1/en
Publication of BR0201237A publication Critical patent/BR0201237A/pt
Priority to US11/951,460 priority patent/US7521569B2/en
Priority to JP2010275582A priority patent/JP2011098968A/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

"PROCESSO DE OBTENçãO DE LIGNANAS DIBENZILBUTIROLACTÈNICAS; PROCESSO DE OBTENçãO DE DERIVADOS SINTéTICOS DE LIGNANAS OSTENTANDO ATIVIDADES QUIMIOPROFILáTICA E TERAPêUTICA ANTICHAGáSICA". A presente invenção se refere a um processo para obtenção de lignanas dibenzilbutirolactónicas, em especial, obtenção de cubebina e metilpluviatolido, a partir de folhas de Zanthoxylum naranjillo ou sementes Piper cubeba. Refere-se também a um processo de obtenção dos derivados semi-sintéticos de cubebina, lignana dibenzilbutirolactónica, tais como: hinoquinina, cubebina O-acetil, cubebina O-metil, 6,6'-dinitroinoquinina e cubebina O-dimetiletilamina e outros derivados que venham a ser obtidos através de processos ora descritos, os quais são utilizados na fabricação de medicamentos que proporcionarão atividade de no mínimo cinco vezes maior do que aquela observada para violeta de genciana e demais compostos utilizados, até então no tratamento de sangue, para a profilaxia da doença de Chagas.,
BR0201237-5A 2002-03-25 2002-03-25 Processo de obtenção de lignanas dibenzilbutirolactÈnicas, processo de obtenção de derivados sintéticos de lignanas ostentando atividades quimioprofilática e terapêutica antichagásica BR0201237A (pt)

Priority Applications (11)

Application Number Priority Date Filing Date Title
BR0201237-5A BR0201237A (pt) 2002-03-25 2002-03-25 Processo de obtenção de lignanas dibenzilbutirolactÈnicas, processo de obtenção de derivados sintéticos de lignanas ostentando atividades quimioprofilática e terapêutica antichagásica
ES03709465T ES2362260T3 (es) 2002-03-25 2003-03-25 Procedimientos para la preparación de derivados sintéticos de los lignanos dibencilbutirolactónicos que presentan propiedades antichagas.
US10/508,875 US7317114B2 (en) 2002-03-25 2003-03-25 Process to obtain dibenzylbutyrolactonic lignans, process to obtain synthetic derivatives from lignans bearing anti-Chagas chemoprophylactic and therapeutical activities
PCT/BR2003/000045 WO2003080600A1 (en) 2002-03-25 2003-03-25 Process to obtain dibenzylbutyrolactonic lignans; process to obtain synthetic derivatives from lignanes bearing anti-chagas chemoprophylactic and therapeutical activities
JP2003578354A JP2005532277A (ja) 2002-03-25 2003-03-25 ジベンジルブチロラクトニックリグナンを得るための方法；抗−シャーガスの化学的予防活性及び治療的活性を有する、リグナンからの合成誘導体を得る方法。
EP03709465A EP1487825B1 (en) 2002-03-25 2003-03-25 Processes for the preparation of synthetic derivatives of dibenzylbutyrolactonic lignans having anti-chagas properties
DE60335980T DE60335980D1 (de) 2002-03-25 2003-03-25 Verfahren zur herstellung von synthetischen derivaten von dibenzylbutyrolacton-lignanen mit antichagas eigenschaften
AT03709465T ATE497958T1 (de) 2002-03-25 2003-03-25 Verfahren zur herstellung von synthetischen derivaten von dibenzylbutyrolacton-lignanen mit antichagas eigenschaften
AU2003213896A AU2003213896A1 (en) 2002-03-25 2003-03-25 Process to obtain dibenzylbutyrolactonic lignans; process to obtain synthetic derivatives from lignanes bearing anti-chagas chemoprophylactic and therapeutical activities
US11/951,460 US7521569B2 (en) 2002-03-25 2007-12-06 Process to obtain dibenzylbutyrolactonic lignans, process to obtain synthetic derivatives from lignans bearing anti-Chagas chemoprophylactic and therapeutical activities
JP2010275582A JP2011098968A (ja) 2002-03-25 2010-12-10 ジベンジルブチロラクトニックリグナンを得るための方法；抗−シャーガスの化学的予防活性及び治療的活性を有する、リグナンからの合成誘導体を得る方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BR0201237-5A BR0201237A (pt) 2002-03-25 2002-03-25 Processo de obtenção de lignanas dibenzilbutirolactÈnicas, processo de obtenção de derivados sintéticos de lignanas ostentando atividades quimioprofilática e terapêutica antichagásica

Publications (1)

Publication Number Publication Date
BR0201237A true BR0201237A (pt) 2003-12-02

Family

ID=39303809

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0201237-5A BR0201237A (pt) 2002-03-25 2002-03-25 Processo de obtenção de lignanas dibenzilbutirolactÈnicas, processo de obtenção de derivados sintéticos de lignanas ostentando atividades quimioprofilática e terapêutica antichagásica

Country Status (9)

Country Link
US (2) US7317114B2 (pt)
EP (1) EP1487825B1 (pt)
JP (2) JP2005532277A (pt)
AT (1) ATE497958T1 (pt)
AU (1) AU2003213896A1 (pt)
BR (1) BR0201237A (pt)
DE (1) DE60335980D1 (pt)
ES (1) ES2362260T3 (pt)
WO (1) WO2003080600A1 (pt)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011075801A1 (pt) 2009-12-21 2011-06-30 Acef S.A. Cubebina, lignana dibenzilbutirolactólica, seus derivados semi-sintéticos e sintéticos, bem como outras lignanas e neolignanas como agente vasodilatador na terapia da disfunção erétil

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0501542A (pt) * 2005-04-28 2006-12-12 Fundacao De Amparo A Pesquisa processo de obtenção de lignanas dibenzilbutirolactÈnicas, tetrahidrofuránicas e de seus derivados sintéticos e semi-sintéticos, suas atividades analgésica e antiinflamatória, formulações tópicas e/ou sistêmicas contendo tais lignanas e respectivo método terapêutico
BRPI0503951A (pt) * 2005-07-15 2007-03-06 Fundacao De Amparo A Pesquisa processo de obtenção de derivados sintéticos e semi-sintéticos de lignanas, suas atividades antiparasitárias e respectivas formulações farmacêuticas, englobando o método terapêutico utilizando tais lignanas no tratamento de parasitoses
CH698627B1 (de) * 2007-08-16 2009-09-15 Alpinia Laudanum Inst Of Phytopharmaceutical Herstellung und Verwendung von Extrakten oder Extraktivstoffen aus Piper cubeba L. als wirksame Bestandteile in einem Medikament zur Behandlung von Krebserkrankungen.
CN102603754B (zh) * 2012-04-06 2015-06-17 苏州大学 一种两面针喹诺酮类生物碱的制备及应用
WO2014086379A1 (en) 2012-12-03 2014-06-12 Alpinia Laudanum Institute Of Phytopharmaceutical Sciences Ag Lignan compositions
JP7197908B2 (ja) * 2019-03-04 2022-12-28 株式会社ナチュファルマ琉球 骨減少性疾患の予防及び／又は治療用組成物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK346987D0 (da) * 1987-07-06 1987-07-06 Hans Goeran Magnusson Fremgangsmaade til fremstilling af tetrahydrofuranforbindelser

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011075801A1 (pt) 2009-12-21 2011-06-30 Acef S.A. Cubebina, lignana dibenzilbutirolactólica, seus derivados semi-sintéticos e sintéticos, bem como outras lignanas e neolignanas como agente vasodilatador na terapia da disfunção erétil

Also Published As

Publication number Publication date
EP1487825A1 (en) 2004-12-22
JP2005532277A (ja) 2005-10-27
US7317114B2 (en) 2008-01-08
ATE497958T1 (de) 2011-02-15
EP1487825B1 (en) 2011-02-09
WO2003080600A1 (en) 2003-10-02
US7521569B2 (en) 2009-04-21
US20050154215A1 (en) 2005-07-14
ES2362260T3 (es) 2011-06-30
US20080090901A1 (en) 2008-04-17
DE60335980D1 (de) 2011-03-24
AU2003213896A1 (en) 2003-10-08
JP2011098968A (ja) 2011-05-19

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Free format text: REFERENTE A RPI 1717 DE 02/12/2003, QUANTO AO ITEM (72).

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08G Application fees: restoration [chapter 8.7 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B07F Notification of approval that there is no relation to art. 229 of lpi (pipeline patents) [chapter 7.6 patent gazette]