ATE498693T1 - Marker zur prognose der reaktion auf therapie bzw. der überlebensrate von brustkrebspatienten - Google Patents

Marker zur prognose der reaktion auf therapie bzw. der überlebensrate von brustkrebspatienten

Info

Publication number
ATE498693T1
ATE498693T1 AT04029486T AT04029486T ATE498693T1 AT E498693 T1 ATE498693 T1 AT E498693T1 AT 04029486 T AT04029486 T AT 04029486T AT 04029486 T AT04029486 T AT 04029486T AT E498693 T1 ATE498693 T1 AT E498693T1
Authority
AT
Austria
Prior art keywords
predicting
response
markers
therapy
breast cancer
Prior art date
Application number
AT04029486T
Other languages
English (en)
Inventor
John Foekens
Nadia Harbeck
Thomas Koenig
Sabine Maier
John Martens
Fabian Model
Inko Nimmrich
Tamas Rujan
Manfred Schmitt
Ralf Lesche
Dimo Dietrich
Volkmar Mueller
Antje Kluth
Ina Schwope
Oliver Hartmann
Heinz Hoefler
Peter Adorjan
Original Assignee
Epigenomics Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epigenomics Ag filed Critical Epigenomics Ag
Application granted granted Critical
Publication of ATE498693T1 publication Critical patent/ATE498693T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT04029486T 2003-12-11 2004-12-13 Marker zur prognose der reaktion auf therapie bzw. der überlebensrate von brustkrebspatienten ATE498693T1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP03090432 2003-12-11
EP04090041 2004-02-10
EP04090127 2004-04-01
EP04013328 2004-06-05
EP04090380 2004-09-30
EP04027213 2004-11-16

Publications (1)

Publication Number Publication Date
ATE498693T1 true ATE498693T1 (de) 2011-03-15

Family

ID=34637445

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04029486T ATE498693T1 (de) 2003-12-11 2004-12-13 Marker zur prognose der reaktion auf therapie bzw. der überlebensrate von brustkrebspatienten

Country Status (8)

Country Link
US (1) US9017944B2 (de)
EP (1) EP1692316A2 (de)
JP (2) JP2007513621A (de)
AT (1) ATE498693T1 (de)
AU (3) AU2004237861B2 (de)
CA (2) CA2549852A1 (de)
DE (1) DE602004031405D1 (de)
WO (1) WO2005059172A2 (de)

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EP1961827A3 (de) * 2004-07-18 2008-09-17 Epigenomics AG Epigenetische Verfahren und Nukleinsäuren für den Nachweis von proliferativen Erkrankungen von Mammazellen
ES2534139T3 (es) 2004-12-02 2015-04-17 Epigenomics Ag Métodos y ácidos nucleicos para el análisis de la expresión génica asociada con el pronóstico de trastornos proliferativos de células de próstata
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WO2006131391A1 (en) * 2005-06-10 2006-12-14 Epigenomics Ag Prognostic assay for prediction of treatment response and/or survival of breast cell proliferative disorder patients
WO2007003397A2 (en) * 2005-07-01 2007-01-11 Epigenomics Ag Method and nucleic acids for the improved treatment of cancers
WO2007047699A1 (en) * 2005-10-17 2007-04-26 Epigenomics Ag Method and nucleic acids for the improved treatment of breast cancers
WO2007085497A2 (en) * 2006-01-30 2007-08-02 Epigenomics Ag Markers for the prediction of outcome of anthracycline treatment
US8068994B2 (en) * 2007-07-27 2011-11-29 Wayne State University Method for analyzing biological networks
EP2193209B1 (de) * 2007-09-17 2014-11-12 Koninklijke Philips N.V. Verfahren zur analyse von brustkrebserkrankungen
BRPI0818780A2 (pt) * 2007-10-19 2015-04-22 Genentech Inc Anticorpo anti-tenb2 planejados por cisteína e conjugados de medicamento com anticorpos
EP3048176B1 (de) * 2009-04-20 2019-03-06 Erasmus University Medical Center Rotterdam Verfahren zur diagnose von blasenkrebs
US20120190024A1 (en) * 2009-06-30 2012-07-26 Sysmex Corporation Method for determining presence or absence of epithelial cancer-origin cell in biological sample, and molecular marker and kit therefor
US20110282043A1 (en) * 2010-03-12 2011-11-17 Cenetron Diagnostics Llc Methods and compositions comprising nucleic acid polymerization enhancers
EP2505665A1 (de) * 2011-03-31 2012-10-03 Queen Mary And Westfield College, University Of London Krebsmarker
JP2014519319A (ja) * 2011-05-12 2014-08-14 ザ・ジョンズ・ホプキンス・ユニバーシティー エピジェネティックドメインの安定性の全般的な損失を通して癌を検出する方法およびその組成物
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US10316361B2 (en) 2011-07-15 2019-06-11 The John Hopkins University Genome-wide methylation analysis and use to identify genes specific to breast cancer hormone receptor status and risk of recurrence
GB201204785D0 (en) * 2012-03-19 2012-05-02 Queen Mary & Westfield College Method for determining prognosis of prostate cancer in a subject
EP2971179B1 (de) 2013-03-14 2019-01-09 Mayo Foundation for Medical Education and Research Neoplasma-erkennung
WO2016160454A1 (en) 2015-03-27 2016-10-06 Exact Sciences Corporation Detecting esophageal disorders
US20170211035A1 (en) 2016-01-25 2017-07-27 American Sterilizer Company Biological indicators
EP3421609B1 (de) * 2016-02-24 2022-03-02 FUJIFILM Corporation Verfahren zur quantifizierung der chromosomenzahl
EP4528275A3 (de) 2016-08-10 2025-05-14 Grail, Inc. Verfahren zur herstellung von dual-indexierten dna-bibliotheken für bisulfitumwandlungssequenzierung
WO2019012544A1 (en) * 2017-07-13 2019-01-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. STRATEGY FOR DOUBLE PROBE DROPLETS FOR SPECIFIC DETECTION OF CIRCULATING DNA MOLECULES SPECIFIC TO A TISSUE
WO2019190908A1 (en) * 2018-03-26 2019-10-03 Rush University Medical Center Method of treatment utilizing a gene expression signature predicting the response of her2-directed therapies
US12544472B2 (en) 2018-12-27 2026-02-10 Solventum Intellectual Properties Company Multilayer test pack for sterilization monitoring
AU2020254760B2 (en) * 2019-04-03 2025-10-23 Exact Sciences Corporation Detecting pancreatic ductal adenocarcinoma in plasma
WO2020252721A1 (en) * 2019-06-20 2020-12-24 The Johns Hopkins University Dna methylation markers and their use in differentiation of suspected cancerous lymph node biopsy samples
KR102923870B1 (ko) 2019-09-02 2026-02-06 주식회사 시선바이오머티리얼스 신규한 pna 올리고머, 이의 dna 메틸화 검출용도 및 이를 이용한 dna 메틸화 검출방법
CN115910365B (zh) * 2022-11-16 2024-02-13 华中科技大学同济医学院附属同济医院 Eos-CRSwNP术前难治性评估模型的构建方法及预测系统
WO2024258948A1 (en) * 2023-06-12 2024-12-19 Tru Diagnostics, Inc. Method for predicting health of a human subject
CN117070633A (zh) * 2023-10-05 2023-11-17 上海奕谱生物科技有限公司 DNA甲基化标志物TAGMe-4及其在肿瘤检测中的用途

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Also Published As

Publication number Publication date
JP2007513621A (ja) 2007-05-31
WO2005059172A3 (en) 2005-12-08
US9017944B2 (en) 2015-04-28
AU2010201017A1 (en) 2010-04-08
CA2549852A1 (en) 2005-06-30
US20080254447A1 (en) 2008-10-16
WO2005059172A2 (en) 2005-06-30
EP1692316A2 (de) 2006-08-23
AU2004237861A1 (en) 2005-06-30
CA2487578A1 (en) 2005-06-11
DE602004031405D1 (de) 2011-03-31
AU2004237861B2 (en) 2010-04-29
JP2005204651A (ja) 2005-08-04
AU2004298537A1 (en) 2005-06-30

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