ATE499359T1 - Azotierte tetrahydropyridyl-alkyl-heterozyklen mit tnf-wirkung - Google Patents

Azotierte tetrahydropyridyl-alkyl-heterozyklen mit tnf-wirkung

Info

Publication number: ATE499359T1
Authority: AT; Austria
Prior art keywords: tetrahydropyridyl; alkyl; azotated; alkyl heterocycles; tnf action
Prior art date: 2001-11-19

Application number

AT02803433T

Other languages

English (en)

Inventor

Marco Baroni

Bernard Bourrie

Pierre Casellas

Letizia Puleo

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-19

Filing date

2002-11-18

Publication date

2011-03-15

2002-11-18 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2011-03-15 Application granted granted Critical

2011-03-15 Publication of ATE499359T1 publication Critical patent/ATE499359T1/de

Links

229910052757 nitrogen Inorganic materials 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 3
150000001204 N-oxides Chemical class 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
239000012453 solvate Substances 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Physical Education & Sports Medicine (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Obesity (AREA)
Psychology (AREA)
Virology (AREA)
Tropical Medicine & Parasitology (AREA)
Emergency Medicine (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)

AT02803433T 2001-11-19 2002-11-18 Azotierte tetrahydropyridyl-alkyl-heterozyklen mit tnf-wirkung ATE499359T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0114897A FR2832405B1 (fr)	2001-11-19	2001-11-19	Tetrahydropyridyl-alkyl-heterocycles azotes, procede pour leur preparation et compositions pharmaceutiques les contenant
PCT/FR2002/003929 WO2003044010A1 (fr)	2001-11-19	2002-11-18	Tetrahydropyridyl-alkyl-heterocycles azotes avec une activity du tnf______

Publications (1)

Publication Number	Publication Date
ATE499359T1 true ATE499359T1 (de)	2011-03-15

Family

ID=8869506

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02803433T ATE499359T1 (de)	2001-11-19	2002-11-18	Azotierte tetrahydropyridyl-alkyl-heterozyklen mit tnf-wirkung

Country Status (12)

Country	Link
US (1)	US7211578B2 (de)
EP (1)	EP1448550B1 (de)
JP (1)	JP4603794B2 (de)
AT (1)	ATE499359T1 (de)
AU (1)	AU2002356244B2 (de)
CA (1)	CA2464721C (de)
DE (1)	DE60239284D1 (de)
FR (1)	FR2832405B1 (de)
HU (1)	HUP0402229A3 (de)
MX (1)	MXPA04004760A (de)
PL (1)	PL208647B1 (de)
WO (1)	WO2003044010A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200840566A (en) *	2006-12-22	2008-10-16	Esteve Labor Dr	Heterocyclyl-substituted-ethylamino-phenyl derivatives, their preparation and use as medicaments

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS4885572A (de) *	1972-02-17	1973-11-13
JPS49100090A (de) *	1973-01-30	1974-09-20
JPS49100089A (de) *	1973-01-30	1974-09-20
JPS5236B2 (de) *	1973-03-28	1977-01-05
JPS5046669A (de) *	1973-03-28	1975-04-25
DE19517851A1 (de) *	1995-05-16	1996-11-21	Hoechst Ag	Organometallverbindung
FR2757160B1 (fr) *	1996-12-13	1999-03-12	Sanofi Sa	1-phenylalkyl-1,2,3,6-tetrahydropyridines
US6316466B1 (en) *	1998-05-05	2001-11-13	Syntex (U.S.A.) Llc	Pyrazole derivatives P-38 MAP kinase inhibitors
DZ2796A1 (fr) *	1998-05-21	2003-12-01	Smithkline Beecham Corp	Composés à fonction bis-aminométhyl-carbonyle nouveaux, procédé pour leur préparation et compositions pharmaceutiques les contenant.
IL149250A0 (en) *	1999-10-22	2002-11-10	Sanofi Synthelabo	Phenyl-and pyridyl-tetrahydro-pyridines having tnf inhibiting activity
FR2803593B1 (fr) *	2000-01-06	2002-02-15	Sanofi Synthelabo	Nouvelles tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant
SI1283839T1 (de) *	2000-05-26	2005-08-31	Schering Corp

2001
- 2001-11-19 FR FR0114897A patent/FR2832405B1/fr not_active Expired - Fee Related
2002
- 2002-11-18 JP JP2003545647A patent/JP4603794B2/ja not_active Expired - Fee Related
- 2002-11-18 WO PCT/FR2002/003929 patent/WO2003044010A1/fr not_active Ceased
- 2002-11-18 DE DE60239284T patent/DE60239284D1/de not_active Expired - Lifetime
- 2002-11-18 EP EP02803433A patent/EP1448550B1/de not_active Expired - Lifetime
- 2002-11-18 US US10/495,890 patent/US7211578B2/en not_active Expired - Fee Related
- 2002-11-18 AT AT02803433T patent/ATE499359T1/de not_active IP Right Cessation
- 2002-11-18 CA CA2464721A patent/CA2464721C/en not_active Expired - Fee Related
- 2002-11-18 AU AU2002356244A patent/AU2002356244B2/en not_active Ceased
- 2002-11-18 PL PL370832A patent/PL208647B1/pl not_active IP Right Cessation
- 2002-11-18 MX MXPA04004760A patent/MXPA04004760A/es active IP Right Grant
- 2002-11-18 HU HU0402229A patent/HUP0402229A3/hu unknown

Also Published As

Publication number	Publication date
PL208647B1 (pl)	2011-05-31
AU2002356244A1 (en)	2003-06-10
CA2464721C (en)	2011-03-08
HUP0402229A2 (hu)	2005-02-28
MXPA04004760A (es)	2004-07-30
WO2003044010A1 (fr)	2003-05-30
JP4603794B2 (ja)	2010-12-22
EP1448550B1 (de)	2011-02-23
FR2832405B1 (fr)	2004-12-10
AU2002356244B2 (en)	2008-07-24
HUP0402229A3 (en)	2009-07-28
DE60239284D1 (de)	2011-04-07
JP2005509678A (ja)	2005-04-14
EP1448550A1 (de)	2004-08-25
PL370832A1 (en)	2005-05-30
US7211578B2 (en)	2007-05-01
CA2464721A1 (en)	2003-05-30
FR2832405A1 (fr)	2003-05-23
US20050004132A1 (en)	2005-01-06

Legal Events

Date	Code	Title	Description
2011-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ZA958647B (en)	1996-04-15	Aroyl-piperidine derivatives
DK1382604T3 (da)	2006-04-18	Quinolinderivater med en azolylgruppe og quinazolinderivater
ATE219077T1 (de)	2002-06-15	Endothelin antagoniste
NZ238714A (en)	1994-07-26	O-benzyloxime ether derivatives; fungicidal compositions thereof
CY1113054T1 (el)	2016-04-13	Παραγωγα διαμινης
ATE72436T1 (de)	1992-02-15	2-(methyl(4-piperidinyl)>-1,2,3,4-tetrahydro-9h pyrido(3,4-b>indolderivate, ihre herstellung und therapeutische verwendung.
EP1535910A4 (de)	2007-03-14	Chinolinderivate und chinazolinderivate, die die autophosphorilierung des macrophage colony stimulating factor receptors inhibieren
AR021533A1 (es)	2002-07-24	Derivados de 2,5-diazabiciclo[2.2.1]heptano, su preparacion y su aplicacion en terapeutica
SE0101579D0 (sv)	2001-05-04	New compounds
DE69407407D1 (de)	1998-01-29	Ampa antagonisten und behandlungsmethode
DE60239284D1 (de)	2011-04-07	Azotierte tetrahydropyridyl-alkyl-heterozyklen mit tnf-wirkung
MXPA03011032A (es)	2004-03-19	Activadores de derivados de oxazol/tiazol del receptor hppar-alfa.
IL158641A0 (en)	2004-05-12	Process for preparing a thiazole ppar-ligand and polymorphs thereof
DK1023287T3 (da)	2002-10-14	Derivater af 3-oxo-(2H)-1,2,4-triazin som ligander for 5HT1a-receptorer
EP1020426A4 (de)	2003-02-05	Aminderivate und verfahren zu ihrer herstellung
NO308472B1 (no)	2000-09-18	Akronycinanaloger
DE3774176D1 (de)	1991-12-05	Substituierte n-phenylpyridazon-derivate.
PL338944A1 (en)	2000-09-11	Method of obtaining n-[5-(diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-n-methylmethanesulphonamide
HRP20080501T3 (en)	2008-11-30	Beta-lactams for the treatment of cns disorders
FR2840304A1 (fr)	2003-12-05	Derives d'oxophenyl-cyclohexyl-propanolamine, leur preparation et leur application en therapeutique
ECSP951529A (es)	1997-05-16	Compuestos farmaceuticos
TR200401359T4 (tr)	2004-08-23	İkame edilmiş piridinlerin hazırlanmasına yönelik işlem
ATE192146T1 (de)	2000-05-15	Enolether und ihre verwendung als fungizide