ATE499598T1 - Markierungsfreier einzelzelltest - Google Patents

Markierungsfreier einzelzelltest

Info

Publication number
ATE499598T1
ATE499598T1 AT08836091T AT08836091T ATE499598T1 AT E499598 T1 ATE499598 T1 AT E499598T1 AT 08836091 T AT08836091 T AT 08836091T AT 08836091 T AT08836091 T AT 08836091T AT E499598 T1 ATE499598 T1 AT E499598T1
Authority
AT
Austria
Prior art keywords
marker
cell test
free single
biosensor
cell
Prior art date
Application number
AT08836091T
Other languages
English (en)
Inventor
Ye Fang
Ann Ferrie
Qi Wu
Original Assignee
Corning Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corning Inc filed Critical Corning Inc
Application granted granted Critical
Publication of ATE499598T1 publication Critical patent/ATE499598T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/21—Polarisation-affecting properties
    • G01N21/211—Ellipsometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G01N21/553—Attenuated total reflection and using surface plasmons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G01N21/553—Attenuated total reflection and using surface plasmons
    • G01N21/554—Attenuated total reflection and using surface plasmons detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT08836091T 2007-10-06 2008-10-02 Markierungsfreier einzelzelltest ATE499598T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99790807P 2007-10-06 2007-10-06
US12/128,267 US8703428B2 (en) 2007-10-06 2008-05-28 Single-cell label-free assay
PCT/US2008/011404 WO2009045465A1 (en) 2007-10-06 2008-10-02 Single-cell label-free assay

Publications (1)

Publication Number Publication Date
ATE499598T1 true ATE499598T1 (de) 2011-03-15

Family

ID=40523597

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08836091T ATE499598T1 (de) 2007-10-06 2008-10-02 Markierungsfreier einzelzelltest

Country Status (6)

Country Link
US (1) US8703428B2 (de)
EP (1) EP2195639B1 (de)
JP (1) JP2010540963A (de)
AT (1) ATE499598T1 (de)
DE (1) DE602008005172D1 (de)
WO (1) WO2009045465A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10203320B2 (en) 2008-11-11 2019-02-12 Corning Incorporated Label free method for assessing chemical cardiotoxicity
JP2010154847A (ja) * 2008-11-25 2010-07-15 Corning Inc パルス刺激下の細胞信号伝達を調べる方法及び装置
WO2013019714A1 (en) 2011-07-29 2013-02-07 The Trustees Of Columbia University In The City Of New York Mems affinity sensor for continuous monitoring of analytes
FR2983213B1 (fr) * 2011-11-30 2015-03-06 Commissariat Energie Atomique Procede de mesure en temps reel des secretions individuelles d'une cellule
WO2017033113A1 (en) 2015-08-21 2017-03-02 Acerta Pharma B.V. Therapeutic combinations of a mek inhibitor and a btk inhibitor
WO2021150686A1 (en) 2020-01-22 2021-07-29 Firmenich Incorporated High-sensitivity detection of gpcr activity and uses thereof

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4631605A (en) * 1984-09-20 1986-12-23 Ampex Corporation Multiple speed scanner servo system for protecting the heads and tape of helical recorders
JPH0627703B2 (ja) 1985-05-29 1994-04-13 アーティフィシャル センシング インスツルメンツ エイエスアイ アクチェンゲゼルシャフト 物質の選択的検出および測定物質内の屈折率変化検知を行なう光学センサ
US5830766A (en) 1990-05-23 1998-11-03 Ares-Serono Research & Development Ltd. Partnership Enhanced signal-to-noise ratio and sensitivity optical immunoassay
US5305074A (en) 1992-07-17 1994-04-19 The United States Of America As Represented By The United States Department Of Energy Achromatic self-referencing interferometer
US5512492A (en) 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
GB9314991D0 (en) 1993-07-20 1993-09-01 Sandoz Ltd Mechanical device
US5847892A (en) * 1995-11-13 1998-12-08 Seagate Technology, Inc. Servoing and formatting magnetic recording tape in an arcuate scanner system
US6130792A (en) * 1995-11-13 2000-10-10 Seagate Technology, Inc. Flat servo bursts for arcuate track scanner
US6727071B1 (en) 1997-02-27 2004-04-27 Cellomics, Inc. System for cell-based screening
WO1999005962A1 (en) * 1997-07-31 1999-02-11 Case Western Reserve University A system and method for non-invasive electrocardiographic imaging
DK1077636T3 (da) 1998-05-13 2004-05-24 Cygnus Therapeutic Systems Signalbehandling til måling af fysiologiske analytter
DK1192448T3 (da) 1999-07-05 2007-01-15 Novartis Ag Fremgangsmåde til anvendelse af en sensorplatform
US6771376B2 (en) 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
AU2001233276A1 (en) 2000-02-03 2001-08-14 Immunomatrix Inc. Method and apparatus for signal transduction pathway profiling
AU2001243656B2 (en) 2000-03-17 2005-09-29 President And Fellows Of Harvard College Cell patterning technique
AU2001226796A1 (en) 2000-05-06 2001-11-26 Zeptosens Ag Grating optical waveguide structure for multi-analyte determinations and the usethereof
AU2001271937A1 (en) 2000-07-21 2002-02-05 Thaumdx, Llc Apparatus and method for evanescent light fluoroassays
US6818886B2 (en) 2000-08-09 2004-11-16 Artificial Sensing Instruments Asi Ag Detection method
JP3795312B2 (ja) 2000-09-06 2006-07-12 独立行政法人科学技術振興機構 細胞活性の評価方法
US7175980B2 (en) 2000-10-30 2007-02-13 Sru Biosystems, Inc. Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities
US20030113766A1 (en) 2000-10-30 2003-06-19 Sru Biosystems, Llc Amine activated colorimetric resonant biosensor
US7153702B2 (en) 2000-10-30 2006-12-26 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7217574B2 (en) 2000-10-30 2007-05-15 Sru Biosystems, Inc. Method and apparatus for biosensor spectral shift detection
US7202076B2 (en) 2000-10-30 2007-04-10 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7142296B2 (en) 2000-10-30 2006-11-28 Sru Biosystems, Inc. Method and apparatus for detecting biomolecular interactions
US7023544B2 (en) 2000-10-30 2006-04-04 Sru Biosystems, Inc. Method and instrument for detecting biomolecular interactions
US7264973B2 (en) 2000-10-30 2007-09-04 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant optical biosensor
US7094595B2 (en) 2000-10-30 2006-08-22 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7101660B2 (en) 2000-10-30 2006-09-05 Sru Biosystems, Inc. Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US7070987B2 (en) 2000-10-30 2006-07-04 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US6951715B2 (en) 2000-10-30 2005-10-04 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7306827B2 (en) 2000-10-30 2007-12-11 Sru Biosystems, Inc. Method and machine for replicating holographic gratings on a substrate
US20030092075A1 (en) 2000-10-30 2003-05-15 Sru Biosystems, Llc Aldehyde chemical surface activation processes and test methods for colorimetric resonant sensors
US20020164824A1 (en) 2001-02-16 2002-11-07 Jianming Xiao Method and apparatus based on bundled capillaries for high throughput screening
US20040009540A1 (en) 2001-04-27 2004-01-15 Genoptix, Inc Detection and evaluation of cancer cells using optophoretic analysis
US20030124516A1 (en) 2001-04-27 2003-07-03 Genoptix, Inc. Method of using optical interrogation to determine a biological property of a cell or population of cells
US20030194755A1 (en) 2001-04-27 2003-10-16 Genoptix, Inc. Early detection of apoptotic events and apoptosis using optophoretic analysis
US20040023310A1 (en) 2001-04-27 2004-02-05 Genoptix, Inc Quantitative determination of protein kinase C activation using optophoretic analysis
EP1262764B1 (de) 2001-05-25 2007-04-11 Corning Incorporated Verfahren zur Bestimmung der Reaktionen und der Metabolischen Aktivitat mit Fluoreszentem temperaturempfindlichem Material
US6893705B2 (en) 2001-05-25 2005-05-17 Massachusetts Institute Of Technology Large area orientation of block copolymer microdomains in thin films
US6762571B2 (en) * 2001-09-21 2004-07-13 Seagate Technology Llc Sinusoidal feed-forward seek with adaptive acoustic level constraint
US20030211461A1 (en) 2002-05-01 2003-11-13 Genoptix, Inc Optophoretic detection of durgs exhibiting inhibitory effect on Bcr-Abl positive tumor cells
US20040033539A1 (en) 2002-05-01 2004-02-19 Genoptix, Inc Method of using optical interrogation to determine a biological property of a cell or population of cells
US7105347B2 (en) 2002-07-30 2006-09-12 Corning Incorporated Method and device for protein delivery into cells
AU2003276870A1 (en) 2002-09-07 2004-03-29 Lightwave Bioapplications Bioanalysis systems including optical integrated circuit
US20040053209A1 (en) 2002-09-12 2004-03-18 Genoptix, Inc Detection and evaluation of topoisomerase inhibitors using optophoretic analysis
US20040091397A1 (en) 2002-11-07 2004-05-13 Corning Incorporated Multiwell insert device that enables label free detection of cells and other objects
EP1570271A2 (de) 2002-11-13 2005-09-07 David R. Wulfman Wellenleitersystem zur erkennung von fluoreszierendgekennzeichneten nukleinsäuresequenzen
WO2004067191A2 (en) 2003-01-29 2004-08-12 President And Fellows Of Harward College Alteration of surface affinities
US7566531B2 (en) 2003-03-03 2009-07-28 University Of Massachusetts Selective whole cell quartz crystal microbalance biosensors
JP2004271337A (ja) * 2003-03-07 2004-09-30 Hiroo Iwata 表面プラズモン共鳴現象を利用した細胞の多検体同時解析装置
US20060246043A1 (en) * 2003-04-16 2006-11-02 Kazutomo Inoue Cellular preparation
US7497992B2 (en) 2003-05-08 2009-03-03 Sru Biosystems, Inc. Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers
US7057720B2 (en) 2003-06-24 2006-06-06 Corning Incorporated Optical interrogation system and method for using same
US7292333B2 (en) 2003-06-24 2007-11-06 Corning Incorporated Optical interrogation system and method for 2-D sensor arrays
WO2005005979A1 (en) 2003-07-14 2005-01-20 Mds Inc. , Doing Business As Mds Sciex Label-free method for classification and characterization of cellular events
US20050018944A1 (en) 2003-07-25 2005-01-27 Mozdy Eric J. Polarization modulation interrogation of grating-coupled waveguide sensors
US6985664B2 (en) 2003-08-01 2006-01-10 Corning Incorporated Substrate index modification for increasing the sensitivity of grating-coupled waveguides
US20050070027A1 (en) 2003-09-30 2005-03-31 Jacques Gollier Double resonance interrogation of grating-coupled waveguides
US7604984B2 (en) 2004-12-29 2009-10-20 Corning Incorporated Spatially scanned optical reader system and method for using same
US20060223051A1 (en) 2005-04-05 2006-10-05 Ye Fang System and method for performing G protein coupled receptor (GPCR) cell assays using waveguide-grating sensors
JP5129119B2 (ja) * 2005-04-05 2013-01-23 コーニング インコーポレイテッド 標識フリーバイオセンサおよび細胞
WO2007018872A1 (en) 2005-07-20 2007-02-15 Corning Incorporated Label-free high throughput biomolecular screening system and method
WO2007015878A2 (en) 2005-07-20 2007-02-08 University Of Louisville Research Foundation, Inc. Method for measuring cytopathic effect in cells using electric cell-substrate impedance sensing

Also Published As

Publication number Publication date
US8703428B2 (en) 2014-04-22
EP2195639A1 (de) 2010-06-16
DE602008005172D1 (de) 2011-04-07
JP2010540963A (ja) 2010-12-24
EP2195639B1 (de) 2011-02-23
WO2009045465A1 (en) 2009-04-09
US20090093013A1 (en) 2009-04-09

Similar Documents

Publication Publication Date Title
BR112012016119A2 (pt) detecção de carga biológica viva com o uso de micropartículas
BR112013017632A2 (pt) meio de cultura celular
EP1815244A4 (de) Zellkulturvorrichtung
BRPI1013896A2 (pt) Célula de levedura, e, métodos para produzir um composto isoprenóide e para detectar em uma amostra biológica a presença ou ausência de uma célula microbiana geneticamente.
BRPI0922572A2 (pt) método para cultivar células pluripotentes, cultura de células de mamífero pluripotentes, meio de cultura de célula, célula animal pluripotente isolada, e, método para aumentar a pluripotência de uma célula de mamífero.
DK2132562T3 (da) Fremgangsmåder til at vurdere celler og cellekulturer
EP2344632A4 (de) Verfahren zur herbeiführung von pluripotenzen in zellen
EP3948276A4 (de) Vorhersage des zellkulturverhaltens in bioreaktoren
EP2128242A4 (de) Zellkulturmodul
EP2352197A4 (de) Brennstoffzellensystem
WO2009085573A3 (en) Quality control cell device for immunohistochemistry assay and methods of use thereof
EP3495799A3 (de) Verfahren zur messung eines komponenten in zellen
WO2010019439A3 (en) A predictor of when to harvest cells grown in a bioreactor
PL2634243T3 (pl) Ulepszony sposób hodowli komórkowej
WO2009070767A3 (en) Systemic instigation systems to study tumor growth or metastasis
DK2499236T3 (da) Dyrkningsmedier, cellekulturer og metoder til dyrkning af pluripotente stamceller i en udifferentieret tilstand
BRPI0812882A2 (pt) Sacarificação e fermentação concorrentes de biomassa fibrosa
DE602008006086D1 (de) Zellenneuauswahl in einem drahtlosen kommunikationssystem
WO2008118392A3 (en) Synthetic cell platforms and methods of use thereof
ATE499598T1 (de) Markierungsfreier einzelzelltest
EP2343361A4 (de) Zellkulturkit, prüfverfahren und herstellungsverfahren für das zellkulturkit
EP4257203A3 (de) Verfahren zum erhalten von stromastammzellen
GB201307298D0 (en) Pixel sensor cell with hold node for leakage cancellation and methods of manufacture and design structure
WO2012082742A3 (en) Detecting cancer with anti-ccl25 and anti-ccr9 antibodies
DK1989544T3 (da) T-celle-testmetode

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties