ATE499615T1 - Direkte massenspektrometrische analyse von homoaggregaten therapeutischer proteine - Google Patents

Direkte massenspektrometrische analyse von homoaggregaten therapeutischer proteine

Info

Publication number
ATE499615T1
ATE499615T1 AT07857687T AT07857687T ATE499615T1 AT E499615 T1 ATE499615 T1 AT E499615T1 AT 07857687 T AT07857687 T AT 07857687T AT 07857687 T AT07857687 T AT 07857687T AT E499615 T1 ATE499615 T1 AT E499615T1
Authority
AT
Austria
Prior art keywords
therapeutic proteins
homoaggregates
mass spectrometric
spectrometric analysis
direct mass
Prior art date
Application number
AT07857687T
Other languages
English (en)
Inventor
Alexis Txomin Nazabal
Ryan Jay Wenzel
Original Assignee
Covalx Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Covalx Ag filed Critical Covalx Ag
Application granted granted Critical
Publication of ATE499615T1 publication Critical patent/ATE499615T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2525—Stabilizing or preserving

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Hematology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Peptides Or Proteins (AREA)
AT07857687T 2006-12-18 2007-12-17 Direkte massenspektrometrische analyse von homoaggregaten therapeutischer proteine ATE499615T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06126353 2006-12-18
PCT/EP2007/064056 WO2008074769A1 (en) 2006-12-18 2007-12-17 Direct mass spectrometric analysis of aggregates of therapeutic proteins

Publications (1)

Publication Number Publication Date
ATE499615T1 true ATE499615T1 (de) 2011-03-15

Family

ID=37945820

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07857687T ATE499615T1 (de) 2006-12-18 2007-12-17 Direkte massenspektrometrische analyse von homoaggregaten therapeutischer proteine

Country Status (6)

Country Link
US (1) US7943387B2 (de)
EP (1) EP2095129B1 (de)
JP (1) JP5302212B2 (de)
AT (1) ATE499615T1 (de)
DE (1) DE602007012759D1 (de)
WO (1) WO2008074769A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4976384B2 (ja) * 2005-05-04 2012-07-18 アイトゲネーシッシュ テヒニッシュ ホッホシュレ チューリッヒ 質量分析法
CN112125832B (zh) * 2020-08-12 2022-09-20 北京大学 刺突蛋白受体结合结构域纳米凝胶及其制备方法与应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6723564B2 (en) * 1998-05-07 2004-04-20 Sequenom, Inc. IR MALDI mass spectrometry of nucleic acids using liquid matrices
WO2000072004A2 (en) * 1999-05-26 2000-11-30 The Regents Of The University Of California Method of determining the three-dimensional shape of a macromolecule
CA2502413A1 (en) * 2002-11-01 2004-05-21 The Regents Of The University Of Colorado, A Body Corporate Quantitative analysis of protein isoforms using matrix-assisted laser desorption/ionization time of flight mass spectrometry
GB0325817D0 (en) * 2003-11-05 2003-12-10 Univ Cambridge Tech Method and apparatus for assessing polypeptide aggregation
WO2005101017A1 (en) * 2004-04-07 2005-10-27 Genentech, Inc. Mass spectrometry of antibody conjugates
JP4976384B2 (ja) * 2005-05-04 2012-07-18 アイトゲネーシッシュ テヒニッシュ ホッホシュレ チューリッヒ 質量分析法

Also Published As

Publication number Publication date
US7943387B2 (en) 2011-05-17
JP2010513890A (ja) 2010-04-30
WO2008074769A1 (en) 2008-06-26
DE602007012759D1 (en) 2011-04-07
EP2095129A1 (de) 2009-09-02
US20100022013A1 (en) 2010-01-28
EP2095129B1 (de) 2011-02-23
JP5302212B2 (ja) 2013-10-02

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