ATE500245T1 - Pyridonamidderivate als fokale adhäsionskinase (fak)-inhibitoren und ihre verwendung zur behandlung von krebs - Google Patents
Pyridonamidderivate als fokale adhäsionskinase (fak)-inhibitoren und ihre verwendung zur behandlung von krebsInfo
- Publication number
- ATE500245T1 ATE500245T1 AT08785643T AT08785643T ATE500245T1 AT E500245 T1 ATE500245 T1 AT E500245T1 AT 08785643 T AT08785643 T AT 08785643T AT 08785643 T AT08785643 T AT 08785643T AT E500245 T1 ATE500245 T1 AT E500245T1
- Authority
- AT
- Austria
- Prior art keywords
- cancer
- pyridonamide
- fak
- inhibitors
- derivatives
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 102000016621 Focal Adhesion Protein-Tyrosine Kinases Human genes 0.000 title 2
- 108010067715 Focal Adhesion Protein-Tyrosine Kinases Proteins 0.000 title 2
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07016399A EP2065380A1 (de) | 2007-08-22 | 2007-08-22 | Pyridonamid-Derivate als Focal-Adhesion-Kinase (FAK) Hemmer und deren Verwendung zur Behandlung von Krebs |
| PCT/EP2008/006834 WO2009024332A1 (en) | 2007-08-22 | 2008-08-20 | Pyridoneamide derivatives as focal adhesion kinase (fak) inhibitors and their use for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE500245T1 true ATE500245T1 (de) | 2011-03-15 |
Family
ID=38924813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08785643T ATE500245T1 (de) | 2007-08-22 | 2008-08-20 | Pyridonamidderivate als fokale adhäsionskinase (fak)-inhibitoren und ihre verwendung zur behandlung von krebs |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20110218199A1 (de) |
| EP (2) | EP2065380A1 (de) |
| JP (1) | JP2010536813A (de) |
| CN (1) | CN101784538A (de) |
| AT (1) | ATE500245T1 (de) |
| CA (1) | CA2696197A1 (de) |
| DE (1) | DE602008005326D1 (de) |
| ES (1) | ES2360162T3 (de) |
| WO (1) | WO2009024332A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101150530B1 (ko) * | 2009-06-01 | 2012-06-01 | 연세대학교 산학협력단 | 신규한 피리돈 화합물 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 암 치료용 약학 조성물 |
| US20120244141A1 (en) | 2010-09-28 | 2012-09-27 | Boehringer Ingelheim International Gmbh | Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors |
| DK2675793T3 (en) | 2011-02-17 | 2018-11-12 | Cancer Therapeutics Crc Pty Ltd | FAK INHIBITORS |
| EP2675794B1 (de) | 2011-02-17 | 2019-02-13 | Cancer Therapeutics Crc Pty Limited | Selektive fak-inhibitoren |
| WO2015054477A1 (en) | 2013-10-09 | 2015-04-16 | The General Hospital Corporation | Methods of diagnosing and treating b cell acute lymphoblastic leukemia |
| US11589583B2 (en) | 2013-12-03 | 2023-02-28 | Fmc Corporation | Pyrrolidinones herbicides |
| HUE049827T2 (hu) | 2013-12-03 | 2020-10-28 | Fmc Corp | Pirrolidinonok mint herbicidek |
| KR102479858B1 (ko) | 2014-07-02 | 2022-12-21 | 에프엠씨 코포레이션 | 피페리디논계 제초제 |
| AU2015361018B2 (en) | 2014-12-08 | 2020-01-16 | Fmc Corporation | 3-oxo-3-(arylamino)propanoates, a process for their preparation, and their use in preparing pyrrolidinones |
| AU2016246410B2 (en) | 2015-04-10 | 2020-11-05 | Fmc Corporation | Substituted cyclic amides as herbicides |
| BR112017020094B1 (pt) | 2015-04-27 | 2022-01-11 | Fmc Corporation | Composto, composições herbicidas, mistura de herbicida e método para controlar o crescimento de vegetação indesejada |
| WO2016182780A1 (en) | 2015-05-12 | 2016-11-17 | E I Du Pont De Nemours And Company | Aryl substituted bicyclic compounds as herbicides |
| JP6869192B2 (ja) * | 2015-05-29 | 2021-05-12 | エフ エム シー コーポレーションＦｍｃ Ｃｏｒｐｏｒａｔｉｏｎ | 除草剤としての置換環状アミド |
| RU2017142979A (ru) | 2015-06-02 | 2019-07-15 | ЭфЭмСи Корпорейшн | Замещенные циклические амиды и их применение в качестве гербицидов |
| DK3325488T3 (da) * | 2015-07-21 | 2020-09-14 | Turning Point Therapeutics Inc | Chiral diaryl-makrocyklus og anvendelse deraf til behandling af cancer |
| CA2993000C (en) | 2015-07-31 | 2024-01-23 | E.I. Du Pont De Nemours & Company | Cyclic n-carboxamide compounds useful as herbicides |
| AU2017378640B2 (en) | 2016-12-21 | 2022-03-03 | Fmc Corporation | Nitrone herbicides |
| WO2018175231A1 (en) | 2017-03-21 | 2018-09-27 | Fmc Corporation | Herbicidal mixture, composition and method |
| JP7201609B2 (ja) | 2017-03-21 | 2023-01-10 | エフ エム シー コーポレーション | ピロリジノン及びこれらを調製するためのプロセス |
| AR111967A1 (es) | 2017-05-30 | 2019-09-04 | Fmc Corp | Amidas herbicidas |
| AR111839A1 (es) | 2017-05-30 | 2019-08-21 | Fmc Corp | Lactamas 3-sustituidas herbicidas |
| TW202428252A (zh) | 2022-11-15 | 2024-07-16 | 英商克拉德夫製藥有限公司 | 類Cdc激酶之雜環抑制劑 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0002320D0 (sv) * | 1999-10-25 | 2000-06-21 | Active Biotech Ab | Malignant tumors |
| CN1514833A (zh) * | 2001-03-28 | 2004-07-21 | ����˹�ж�-����˹˹������˾ | 新型酪氨酸激酶抑制剂 |
| WO2004063151A2 (en) * | 2003-01-03 | 2004-07-29 | Bristol-Myers Squibb Company | Novel tyrosine kinase inhibitors |
-
2007
- 2007-08-22 EP EP07016399A patent/EP2065380A1/de not_active Ceased
-
2008
- 2008-08-20 DE DE602008005326T patent/DE602008005326D1/de active Active
- 2008-08-20 CN CN200880103731A patent/CN101784538A/zh active Pending
- 2008-08-20 ES ES08785643T patent/ES2360162T3/es active Active
- 2008-08-20 JP JP2010521355A patent/JP2010536813A/ja active Pending
- 2008-08-20 AT AT08785643T patent/ATE500245T1/de not_active IP Right Cessation
- 2008-08-20 CA CA2696197A patent/CA2696197A1/en not_active Abandoned
- 2008-08-20 WO PCT/EP2008/006834 patent/WO2009024332A1/en not_active Ceased
- 2008-08-20 EP EP08785643A patent/EP2190834B1/de not_active Not-in-force
- 2008-08-20 US US12/672,332 patent/US20110218199A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20110218199A1 (en) | 2011-09-08 |
| DE602008005326D1 (de) | 2011-04-14 |
| EP2190834B1 (de) | 2011-03-02 |
| ES2360162T3 (es) | 2011-06-01 |
| JP2010536813A (ja) | 2010-12-02 |
| CN101784538A (zh) | 2010-07-21 |
| EP2065380A1 (de) | 2009-06-03 |
| CA2696197A1 (en) | 2009-02-26 |
| WO2009024332A1 (en) | 2009-02-26 |
| EP2190834A1 (de) | 2010-06-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |