ATE499372T1 - Azabenzimidalzolderivate, ihre herstellung und ihre verwendung als antikrebsmittel - Google Patents

Azabenzimidalzolderivate, ihre herstellung und ihre verwendung als antikrebsmittel

Info

Publication number
ATE499372T1
ATE499372T1 AT06762868T AT06762868T ATE499372T1 AT E499372 T1 ATE499372 T1 AT E499372T1 AT 06762868 T AT06762868 T AT 06762868T AT 06762868 T AT06762868 T AT 06762868T AT E499372 T1 ATE499372 T1 AT E499372T1
Authority
AT
Austria
Prior art keywords
preparation
azabenzimidalzol
derivatives
anticancer agents
compounds
Prior art date
Application number
AT06762868T
Other languages
English (en)
Inventor
Richard Engh
Hubert Hertenberger
Konrad Honold
Birgit Masjost
Petra Rueger
Wolfgang Schaefer
Stefan Scheiblich
Manfred Schwaiger
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE499372T1 publication Critical patent/ATE499372T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT06762868T 2005-07-29 2006-07-28 Azabenzimidalzolderivate, ihre herstellung und ihre verwendung als antikrebsmittel ATE499372T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05016607 2005-07-29
PCT/EP2006/007478 WO2007017143A1 (en) 2005-07-29 2006-07-28 Azabenzimidazole derivatives, their manufacture and use as anti-cancer agents

Publications (1)

Publication Number Publication Date
ATE499372T1 true ATE499372T1 (de) 2011-03-15

Family

ID=34979704

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06762868T ATE499372T1 (de) 2005-07-29 2006-07-28 Azabenzimidalzolderivate, ihre herstellung und ihre verwendung als antikrebsmittel

Country Status (9)

Country Link
US (1) US20090227578A1 (de)
EP (1) EP1919910B1 (de)
JP (1) JP2009502843A (de)
CN (1) CN101208338B (de)
AT (1) ATE499372T1 (de)
CA (1) CA2614156A1 (de)
DE (1) DE602006020295D1 (de)
SG (1) SG148192A1 (de)
WO (1) WO2007017143A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101104666B1 (ko) * 2006-09-06 2012-01-13 에프. 호프만-라 로슈 아게 단백질 키나제 억제제로서의 헤테로아릴 유도체
WO2008144253A1 (en) * 2007-05-14 2008-11-27 Irm Llc Protein kinase inhibitors and methods for using thereof
MX2009013332A (es) 2007-06-08 2010-01-25 Mannkind Corp Inhibidores de ire-1 alfa.
CA2716947A1 (en) * 2008-02-29 2009-09-11 Array Biopharma Inc. Imidazo [4,5-b] pyridine derivatives used as raf inhibitors
KR20100122505A (ko) 2008-02-29 2010-11-22 어레이 바이오파마 인크. Ｒａｆ 저해물질 화합물 및 이들의 이용 방법
JP2011513331A (ja) * 2008-02-29 2011-04-28 アレイ バイオファーマ、インコーポレイテッド ピラゾール［３，４−ｂ］ピリジンＲＡＦ阻害剤
US8883819B2 (en) * 2011-09-01 2014-11-11 Irm Llc Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
FR3000493A1 (fr) * 2012-12-28 2014-07-04 Oribase Pharma Nouveaux inhibiteurs de proteines kinases
FR3000494B1 (fr) 2012-12-28 2015-08-21 Oribase Pharma Nouveaux derives d'azaindoles en tant qu'inhibiteurs de proteines kinases
FR3000492B1 (fr) * 2012-12-28 2015-09-11 Oribase Pharma Nouveaux derives azaindole en tant qu'inhibiteurs multikinases
US9296754B2 (en) 2013-03-15 2016-03-29 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
WO2014151630A2 (en) 2013-03-15 2014-09-25 Irm Llc Compounds and compositions for the treatment of parasitic diseases
WO2014151729A1 (en) 2013-03-15 2014-09-25 Irm Llc Compounds and compositions for the treatment of parasitic diseases
BR112016014004B1 (pt) 2013-12-19 2022-11-01 Novartis Ag Compostos para tratamento de doenças parasíticas, seus usos, e composições farmacêuticas
BR112020017159A2 (pt) * 2018-02-23 2020-12-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Inibidores de glutaminil ciclases bacterianas para uso no tratamento de doenças periodontais e relacionadas

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0213562A (pt) * 2001-10-26 2004-08-31 Aventis Pharma Inc Benzimidazóis e análogos e seu uso como inibidores de cinases de proteìna

Also Published As

Publication number Publication date
WO2007017143A1 (en) 2007-02-15
SG148192A1 (en) 2008-12-31
DE602006020295D1 (de) 2011-04-07
EP1919910B1 (de) 2011-02-23
JP2009502843A (ja) 2009-01-29
EP1919910A1 (de) 2008-05-14
CN101208338B (zh) 2010-12-29
US20090227578A1 (en) 2009-09-10
CA2614156A1 (en) 2007-02-15
CN101208338A (zh) 2008-06-25

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties