ATE500247T1 - Verfahren zur herstellung von 3-(1,3- dihydroimidazol-2-thion-1-yl)-chromanen und thiochromanen als dopamin-beta-hydroxylase inhibitor - Google Patents

Verfahren zur herstellung von 3-(1,3- dihydroimidazol-2-thion-1-yl)-chromanen und thiochromanen als dopamin-beta-hydroxylase inhibitor

Info

Publication number: ATE500247T1
Authority: AT; Austria
Prior art keywords: thiochromanes; chromanes; thion; dihydroimidazole; producing
Prior art date: 2002-10-11

Application number

AT07076124T

Other languages

English (en)

Inventor

David Alexander Learmonth

Da Silva Patricio Manuel Vieira Soares

Alexander Beliaev

Original Assignee

Portela & Ca Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-10-11

Filing date

2003-10-10

Publication date

2011-03-15

2003-10-10 Application filed by Portela & Ca Sa filed Critical Portela & Ca Sa

2011-03-15 Application granted granted Critical

2011-03-15 Publication of ATE500247T1 publication Critical patent/ATE500247T1/de

Links

108010015720 Dopamine beta-Hydroxylase Proteins 0.000 title 1
102100033156 Dopamine beta-hydroxylase Human genes 0.000 title 1
229940122439 Hydroxylase inhibitor Drugs 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Hospice & Palliative Care (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT07076124T 2002-10-11 2003-10-10 Verfahren zur herstellung von 3-(1,3- dihydroimidazol-2-thion-1-yl)-chromanen und thiochromanen als dopamin-beta-hydroxylase inhibitor ATE500247T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB0223719A GB2393958A (en)	2002-10-11	2002-10-11	Peripherally-selective imidazole inhibitors of dopamine-beta-hydroxylase
GB0224306A GB2394223B (en)	2002-10-11	2002-10-18	Peripherally-selective inhibitors of dopamine-beta-hydroxylase and method of their preparation

Publications (1)

Publication Number	Publication Date
ATE500247T1 true ATE500247T1 (de)	2011-03-15

Family

ID=9945777

Family Applications (5)

Application Number	Title	Priority Date	Filing Date
AT07076125T ATE505465T1 (de)	2002-10-11	2003-10-10	Chroman- und thiochroman-3-yl-1,3- dihydroimidazole als hemmer der dopamin-beta- hydroxylase und verfahren zu ihrer herstellung
AT03256420T ATE403652T1 (de)	2002-10-11	2003-10-10	Imidazolderivate und deren verwendung als peripheral-selektive inhibitoren von dopamin-beta-hydroxylasen
AT07076124T ATE500247T1 (de)	2002-10-11	2003-10-10	Verfahren zur herstellung von 3-(1,3- dihydroimidazol-2-thion-1-yl)-chromanen und thiochromanen als dopamin-beta-hydroxylase inhibitor
AT07076123T ATE550335T1 (de)	2002-10-11	2003-10-10	3,4-dihydro-3-amino-2h-1-benzopyran und - benzothiopyran derivate als dopamine-beta- hydroxylase inhibitoren und verfahren zu ihrer herstellung
AT07076122T ATE500248T1 (de)	2002-10-11	2003-10-10	Silyl-geschützte hydroxymethyl-carbamoylalkyl- ketone als intermediate in der herstellung von dopamine-beta-hydroxylase inhibitoren

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
AT07076125T ATE505465T1 (de)	2002-10-11	2003-10-10	Chroman- und thiochroman-3-yl-1,3- dihydroimidazole als hemmer der dopamin-beta- hydroxylase und verfahren zu ihrer herstellung
AT03256420T ATE403652T1 (de)	2002-10-11	2003-10-10	Imidazolderivate und deren verwendung als peripheral-selektive inhibitoren von dopamin-beta-hydroxylasen

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
AT07076123T ATE550335T1 (de)	2002-10-11	2003-10-10	3,4-dihydro-3-amino-2h-1-benzopyran und - benzothiopyran derivate als dopamine-beta- hydroxylase inhibitoren und verfahren zu ihrer herstellung
AT07076122T ATE500248T1 (de)	2002-10-11	2003-10-10	Silyl-geschützte hydroxymethyl-carbamoylalkyl- ketone als intermediate in der herstellung von dopamine-beta-hydroxylase inhibitoren

Country Status (10)

Country	Link
KR (1)	KR101350741B1 (de)
CN (1)	CN100393715C (de)
AR (2)	AR041589A1 (de)
AT (5)	ATE505465T1 (de)
CY (2)	CY1108452T1 (de)
DE (4)	DE60336275D1 (de)
DK (2)	DK1408038T3 (de)
ES (5)	ES2309279T3 (de)
GB (2)	GB2393958A (de)
SI (2)	SI1408038T1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0708818D0 (en) *	2007-05-08	2007-06-13	Portela & Ca Sa	Compounds
PT2655363T (pt) *	2010-12-22	2017-07-13	Bial-Portela & Ca S A	Formas cristalinas e processos para a sua preparação
GB201316410D0 (en)	2013-09-13	2013-10-30	Bial Portela & Ca Sa	Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL82401A0 (en) *	1986-05-06	1987-11-30	Merrell Dow Pharma	Dopamine beta hydroxy-lase inhibiting imidazole derivatives and pharmaceutical compositions containing them
US4868210A (en)	1988-03-30	1989-09-19	Warner-Lambert Company	Antihyperlipidemic and antiatherosclerotic compounds and compositions
ES2201104T3 (es) *	1994-04-26	2004-03-16	Roche Palo Alto Llc	Derivados de benzociclohexilimidazoltiona.

2002
- 2002-10-11 GB GB0223719A patent/GB2393958A/en not_active Withdrawn
- 2002-10-18 GB GB0224306A patent/GB2394223B/en not_active Expired - Lifetime
2003
- 2003-10-10 ES ES03256420T patent/ES2309279T3/es not_active Expired - Lifetime
- 2003-10-10 SI SI200331309T patent/SI1408038T1/sl unknown
- 2003-10-10 AT AT07076125T patent/ATE505465T1/de active
- 2003-10-10 DE DE60336275T patent/DE60336275D1/de not_active Expired - Lifetime
- 2003-10-10 DE DE60336276T patent/DE60336276D1/de not_active Expired - Lifetime
- 2003-10-10 AT AT03256420T patent/ATE403652T1/de active
- 2003-10-10 DK DK03256420T patent/DK1408038T3/da active
- 2003-10-10 AT AT07076124T patent/ATE500247T1/de not_active IP Right Cessation
- 2003-10-10 KR KR1020127005102A patent/KR101350741B1/ko not_active Expired - Fee Related
- 2003-10-10 DE DE60336772T patent/DE60336772D1/de not_active Expired - Lifetime
- 2003-10-10 ES ES07076123T patent/ES2384118T3/es not_active Expired - Lifetime
- 2003-10-10 CN CNB2003801059426A patent/CN100393715C/zh not_active Expired - Fee Related
- 2003-10-10 SI SI200331986T patent/SI1908760T1/sl unknown
- 2003-10-10 ES ES07076122T patent/ES2361938T3/es not_active Expired - Lifetime
- 2003-10-10 ES ES07076125T patent/ES2364919T3/es not_active Expired - Lifetime
- 2003-10-10 DK DK07076125.9T patent/DK1908760T3/da active
- 2003-10-10 AT AT07076123T patent/ATE550335T1/de active
- 2003-10-10 AR ARP030103711A patent/AR041589A1/es active IP Right Grant
- 2003-10-10 DE DE60322642T patent/DE60322642D1/de not_active Expired - Lifetime
- 2003-10-10 ES ES07076124T patent/ES2361939T3/es not_active Expired - Lifetime
- 2003-10-10 AT AT07076122T patent/ATE500248T1/de not_active IP Right Cessation
2008
- 2008-10-24 CY CY20081101204T patent/CY1108452T1/el unknown
2011
- 2011-07-01 CY CY20111100639T patent/CY1112457T1/el unknown
2014
- 2014-03-18 AR ARP140101283A patent/AR095674A2/es unknown

Also Published As

Publication number	Publication date
GB2394223A (en)	2004-04-21
CN100393715C (zh)	2008-06-11
CN1726211A (zh)	2006-01-25
ATE500248T1 (de)	2011-03-15
KR101350741B1 (ko)	2014-01-10
ES2361939T3 (es)	2011-06-24
AR041589A1 (es)	2005-05-26
ES2384118T3 (es)	2012-06-29
DE60336275D1 (de)	2011-04-14
CY1108452T1 (el)	2014-04-09
DE60322642D1 (de)	2008-09-18
GB2393958A (en)	2004-04-14
ES2364919T3 (es)	2011-09-16
GB0223719D0 (en)	2002-11-20
ATE550335T1 (de)	2012-04-15
ATE505465T1 (de)	2011-04-15
SI1908760T1 (sl)	2011-05-31
ES2361938T3 (es)	2011-06-24
CY1112457T1 (el)	2015-12-09
SI1408038T1 (sl)	2008-10-31
DE60336772D1 (de)	2011-05-26
DK1908760T3 (da)	2011-07-25
GB2394223B (en)	2007-05-16
KR20120038014A (ko)	2012-04-20
DK1408038T3 (da)	2008-11-24
ATE403652T1 (de)	2008-08-15
AR095674A2 (es)	2015-11-04
ES2309279T3 (es)	2008-12-16
DE60336276D1 (de)	2011-04-14
GB0224306D0 (en)	2002-11-27
HK1116188A1 (en)	2008-12-19

Legal Events

Date	Code	Title	Description
2011-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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