DK1908760T3 - Chroman- og thiochroman-3-yl-1,3-dihydroimidazoler som inhibitorer af dopamin-beta-hydroxylase og fremgangsmåder til deres fremstilling - Google Patents
Chroman- og thiochroman-3-yl-1,3-dihydroimidazoler som inhibitorer af dopamin-beta-hydroxylase og fremgangsmåder til deres fremstillingInfo
- Publication number
- DK1908760T3 DK1908760T3 DK07076125.9T DK07076125T DK1908760T3 DK 1908760 T3 DK1908760 T3 DK 1908760T3 DK 07076125 T DK07076125 T DK 07076125T DK 1908760 T3 DK1908760 T3 DK 1908760T3
- Authority
- DK
- Denmark
- Prior art keywords
- dihydroimidazoles
- thiochroman
- hydroxylase
- chromatic
- inhibitors
- Prior art date
Links
- FVVJXNLMRXNHCY-UHFFFAOYSA-N 3-(3,4-dihydro-2h-thiochromen-3-yl)-1,2-dihydroimidazole Chemical class C1NC=CN1C1CC2=CC=CC=C2SC1 FVVJXNLMRXNHCY-UHFFFAOYSA-N 0.000 title 1
- 108010015720 Dopamine beta-Hydroxylase Proteins 0.000 title 1
- 102100033156 Dopamine beta-hydroxylase Human genes 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0223719A GB2393958A (en) | 2002-10-11 | 2002-10-11 | Peripherally-selective imidazole inhibitors of dopamine-beta-hydroxylase |
| GB0224306A GB2394223B (en) | 2002-10-11 | 2002-10-18 | Peripherally-selective inhibitors of dopamine-beta-hydroxylase and method of their preparation |
| EP03256420A EP1408038B1 (en) | 2002-10-11 | 2003-10-10 | Imidazole deriviatives and their use as peripherally-selective inhibitors of dopamine-beta-hydroxylase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1908760T3 true DK1908760T3 (da) | 2011-07-25 |
Family
ID=9945777
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07076125.9T DK1908760T3 (da) | 2002-10-11 | 2003-10-10 | Chroman- og thiochroman-3-yl-1,3-dihydroimidazoler som inhibitorer af dopamin-beta-hydroxylase og fremgangsmåder til deres fremstilling |
| DK03256420T DK1408038T3 (da) | 2002-10-11 | 2003-10-10 | Imidazolderivater samt deres anvendelse som perifert selektive inhibitorer dopamin-beta-hydroxylase |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03256420T DK1408038T3 (da) | 2002-10-11 | 2003-10-10 | Imidazolderivater samt deres anvendelse som perifert selektive inhibitorer dopamin-beta-hydroxylase |
Country Status (10)
| Country | Link |
|---|---|
| KR (1) | KR101350741B1 (da) |
| CN (1) | CN100393715C (da) |
| AR (2) | AR041589A1 (da) |
| AT (5) | ATE500247T1 (da) |
| CY (2) | CY1108452T1 (da) |
| DE (4) | DE60336276D1 (da) |
| DK (2) | DK1908760T3 (da) |
| ES (5) | ES2364919T3 (da) |
| GB (2) | GB2393958A (da) |
| SI (2) | SI1408038T1 (da) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0708818D0 (en) * | 2007-05-08 | 2007-06-13 | Portela & Ca Sa | Compounds |
| JP6161538B2 (ja) * | 2010-12-22 | 2017-07-12 | バイアル−ポルテラ アンド シーエー，エス．エー． | 結晶形及びその製造方法 |
| GB201316410D0 (en) * | 2013-09-13 | 2013-10-30 | Bial Portela & Ca Sa | Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2581556B2 (ja) * | 1986-05-06 | 1997-02-12 | メレルダウファーマスーティカルズ インコーポレーテッド | 新規なドパミンベ−タヒドロキシラ−ゼ抑制剤 |
| US4868210A (en) | 1988-03-30 | 1989-09-19 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
| WO1995029165A2 (en) * | 1994-04-26 | 1995-11-02 | Syntex (U.S.A.) Inc. | Benzocycloalkylaz0lethione derivatives as dopamin beta-hydroxylase inhibitors |
-
2002
- 2002-10-11 GB GB0223719A patent/GB2393958A/en not_active Withdrawn
- 2002-10-18 GB GB0224306A patent/GB2394223B/en not_active Expired - Lifetime
-
2003
- 2003-10-10 SI SI200331309T patent/SI1408038T1/sl unknown
- 2003-10-10 DE DE60336276T patent/DE60336276D1/de not_active Expired - Lifetime
- 2003-10-10 ES ES07076125T patent/ES2364919T3/es not_active Expired - Lifetime
- 2003-10-10 DK DK07076125.9T patent/DK1908760T3/da active
- 2003-10-10 SI SI200331986T patent/SI1908760T1/sl unknown
- 2003-10-10 AR ARP030103711A patent/AR041589A1/es active IP Right Grant
- 2003-10-10 ES ES07076124T patent/ES2361939T3/es not_active Expired - Lifetime
- 2003-10-10 AT AT07076124T patent/ATE500247T1/de not_active IP Right Cessation
- 2003-10-10 CN CNB2003801059426A patent/CN100393715C/zh not_active Expired - Fee Related
- 2003-10-10 ES ES03256420T patent/ES2309279T3/es not_active Expired - Lifetime
- 2003-10-10 DE DE60336275T patent/DE60336275D1/de not_active Expired - Lifetime
- 2003-10-10 DE DE60322642T patent/DE60322642D1/de not_active Expired - Lifetime
- 2003-10-10 DK DK03256420T patent/DK1408038T3/da active
- 2003-10-10 ES ES07076122T patent/ES2361938T3/es not_active Expired - Lifetime
- 2003-10-10 KR KR1020127005102A patent/KR101350741B1/ko not_active Expired - Fee Related
- 2003-10-10 AT AT03256420T patent/ATE403652T1/de active
- 2003-10-10 AT AT07076123T patent/ATE550335T1/de active
- 2003-10-10 AT AT07076125T patent/ATE505465T1/de active
- 2003-10-10 AT AT07076122T patent/ATE500248T1/de not_active IP Right Cessation
- 2003-10-10 DE DE60336772T patent/DE60336772D1/de not_active Expired - Lifetime
- 2003-10-10 ES ES07076123T patent/ES2384118T3/es not_active Expired - Lifetime
-
2008
- 2008-10-24 CY CY20081101204T patent/CY1108452T1/el unknown
-
2011
- 2011-07-01 CY CY20111100639T patent/CY1112457T1/el unknown
-
2014
- 2014-03-18 AR ARP140101283A patent/AR095674A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1108452T1 (el) | 2014-04-09 |
| DE60336772D1 (de) | 2011-05-26 |
| GB2393958A (en) | 2004-04-14 |
| ATE550335T1 (de) | 2012-04-15 |
| DE60336276D1 (de) | 2011-04-14 |
| ES2364919T3 (es) | 2011-09-16 |
| ATE500248T1 (de) | 2011-03-15 |
| KR20120038014A (ko) | 2012-04-20 |
| CN1726211A (zh) | 2006-01-25 |
| ATE500247T1 (de) | 2011-03-15 |
| AR095674A2 (es) | 2015-11-04 |
| GB2394223B (en) | 2007-05-16 |
| ATE505465T1 (de) | 2011-04-15 |
| DE60336275D1 (de) | 2011-04-14 |
| SI1908760T1 (sl) | 2011-05-31 |
| ES2361938T3 (es) | 2011-06-24 |
| SI1408038T1 (sl) | 2008-10-31 |
| DE60322642D1 (de) | 2008-09-18 |
| ES2309279T3 (es) | 2008-12-16 |
| GB2394223A (en) | 2004-04-21 |
| DK1408038T3 (da) | 2008-11-24 |
| ATE403652T1 (de) | 2008-08-15 |
| CY1112457T1 (el) | 2015-12-09 |
| ES2361939T3 (es) | 2011-06-24 |
| CN100393715C (zh) | 2008-06-11 |
| HK1116188A1 (en) | 2008-12-19 |
| GB0224306D0 (en) | 2002-11-27 |
| AR041589A1 (es) | 2005-05-26 |
| ES2384118T3 (es) | 2012-06-29 |
| GB0223719D0 (en) | 2002-11-20 |
| KR101350741B1 (ko) | 2014-01-10 |
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