ATE500251T1 - Benzimidazole und ihre verwendung zur behandlung von diabetes - Google Patents

Benzimidazole und ihre verwendung zur behandlung von diabetes

Info

Publication number: ATE500251T1
Authority: AT; Austria
Prior art keywords: phenyl; benzimidazoles; diabetes; treatment; dgat1
Prior art date: 2006-06-08

Application number

AT07733082T

Other languages

English (en)

Inventor

Alan Martin Birch

Roger John Butlin

Alleyn Plowright

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-06-08

Filing date

2007-06-06

Publication date

2011-03-15

2007-06-06 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2011-03-15 Application granted granted Critical

2011-03-15 Publication of ATE500251T1 publication Critical patent/ATE500251T1/de

Links

150000001556 benzimidazoles Chemical class 0.000 title 1
206010012601 diabetes mellitus Diseases 0.000 title 1
ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 abstract 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 1
108010001348 Diacylglycerol O-acyltransferase Proteins 0.000 abstract 1
102000002148 Diacylglycerol O-acyltransferase Human genes 0.000 abstract 1
102100036869 Diacylglycerol O-acyltransferase 1 Human genes 0.000 abstract 1
101000927974 Homo sapiens Diacylglycerol O-acyltransferase 1 Proteins 0.000 abstract 1
229940100228 acetyl coenzyme a Drugs 0.000 abstract 1
150000001602 bicycloalkyls Chemical group 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Cardiology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Neurology (AREA)
Obesity (AREA)
Hematology (AREA)
Rheumatology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Virology (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Dermatology (AREA)
Communicable Diseases (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Ophthalmology & Optometry (AREA)
Psychiatry (AREA)
Oncology (AREA)
Molecular Biology (AREA)

AT07733082T 2006-06-08 2007-06-06 Benzimidazole und ihre verwendung zur behandlung von diabetes ATE500251T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US81189506P	2006-06-08	2006-06-08
PCT/GB2007/002070 WO2007141517A1 (en)	2006-06-08	2007-06-06	Benzimidazoles and their use for the treatemnt of diabetes

Publications (1)

Publication Number	Publication Date
ATE500251T1 true ATE500251T1 (de)	2011-03-15

Family

ID=38510308

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07733082T ATE500251T1 (de)	2006-06-08	2007-06-06	Benzimidazole und ihre verwendung zur behandlung von diabetes

Country Status (16)

Country	Link
US (1)	US20090197926A1 (de)
EP (1)	EP2035417B1 (de)
JP (1)	JP2009539818A (de)
KR (1)	KR20090016629A (de)
CN (1)	CN101460492A (de)
AT (1)	ATE500251T1 (de)
AU (1)	AU2007255180B2 (de)
CA (1)	CA2655225A1 (de)
DE (1)	DE602007012875D1 (de)
ES (1)	ES2359653T3 (de)
IL (1)	IL195912A0 (de)
MX (1)	MX2008015725A (de)
NO (1)	NO20085216L (de)
NZ (1)	NZ573576A (de)
WO (1)	WO2007141517A1 (de)
ZA (1)	ZA200810643B (de)

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AU2005315430B2 (en) *	2004-12-14	2010-05-27	Astrazeneca Ab	Oxadiazole derivatives as DGAT inhibitors
JP2009520786A (ja) *	2005-12-22	2009-05-28	アストラゼネカアクチボラグ	Ｄｇａｔ阻害剤として使用するためのピリミド−［４，５−ｂ］−オキサジン
EP2402317B1 (de)	2006-03-31	2013-07-03	Novartis AG	DGAT Inhibitor
KR20090010092A (ko)	2006-05-30	2009-01-28	아스트라제네카 아베	Ｄｇａｔ1 억제제로서의 1,3,4-옥사디아졸 유도체
NZ572586A (en)	2006-05-30	2011-03-31	Astrazeneca Ab	Substituted 5-phenylamino-1,3,4-oxadiazol-2-ylcarbonylamino-4-phenoxy-cyclohexane carboxylic acid as inhibitors of acetyl coenzyme a diacylglycerol acyltransferase
MX2009011754A (es)	2007-04-30	2009-12-01	Abbott Lab	Inhibidores de enzima de diacilglicerol o-aciltransferasa tipo 1.
AR066169A1 (es)	2007-09-28	2009-07-29	Novartis Ag	Derivados de benzo-imidazoles, utiles para trastornos asociados con la actividad de dgat
JP5662803B2 (ja)	2007-12-20	2015-02-04	アストラゼネカアクチボラグ	Ｄｇａｔ１阻害剤としてのカルバモイル化合物１９０
WO2009112445A1 (en) *	2008-03-10	2009-09-17	Novartis Ag	Method of increasing cellular phosphatidyl choline by dgat1 inhibition
WO2010023609A1 (en) *	2008-08-25	2010-03-04	Piramal Life Sciences Limited	Oxazole, oxadiazole and thiazole derivatives as diacylglycerol acyltranferase inhibitors
RU2011121300A (ru) *	2008-12-19	2013-01-27	Астразенека Аб	Производные 1,3,4-оксадиазола и их применение для лечения диабета
EP2805951B1 (de)	2009-03-20	2018-03-14	Metabasis Therapeutics, Inc.	Inhibitoren von Diacylglycerin-O-acyltransferase 1 (DGAT-1) und Verwendungen davon
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MX2011014018A (es) *	2009-06-19	2012-02-22	Astrazeneca Ab	Pirazincarboxamidas como inhibidores de dgati.
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KR102900338B1 (ko) *	2022-03-04	2025-12-15	한국화학연구원	보호기가 도입된 폴리벤즈이미다졸, 이를 이용한 막의 제조방법 및 이의 용도
WO2023167545A1 (ko) *	2022-03-04	2023-09-07	한국화학연구원	보호기가 도입된 폴리벤즈이미다졸, 이를 이용한 막의 제조방법 및 이의 용도

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JP5076091B2 (ja) *	2005-11-28	2012-11-21	マドリガル・ファーマシューティカルズ・インコーポレーテッド	ジアシルグリセロールアシルトランスフェラーゼ（ｄｇａｔ）のインヒビター
JP2009520786A (ja) *	2005-12-22	2009-05-28	アストラゼネカアクチボラグ	Ｄｇａｔ阻害剤として使用するためのピリミド−［４，５−ｂ］−オキサジン
KR20090010092A (ko) *	2006-05-30	2009-01-28	아스트라제네카 아베	Ｄｇａｔ1 억제제로서의 1,3,4-옥사디아졸 유도체
NZ572586A (en) *	2006-05-30	2011-03-31	Astrazeneca Ab	Substituted 5-phenylamino-1,3,4-oxadiazol-2-ylcarbonylamino-4-phenoxy-cyclohexane carboxylic acid as inhibitors of acetyl coenzyme a diacylglycerol acyltransferase
EP2035397A1 (de) *	2006-06-06	2009-03-18	Astra Zeneca AB	Chemische verbindungen
GB0611506D0 (en) *	2006-06-10	2006-07-19	Astrazeneca Ab	Chemical compounds
GB0611507D0 (en) *	2006-06-10	2006-07-19	Astrazeneca Ab	Chemical compounds
US7569590B2 (en) *	2006-09-19	2009-08-04	Bristol-Myers Squibb Company	Use of thianecarboxamides as dgat inhibitors
JP5662803B2 (ja) *	2007-12-20	2015-02-04	アストラゼネカアクチボラグ	Ｄｇａｔ１阻害剤としてのカルバモイル化合物１９０
RU2011121300A (ru) *	2008-12-19	2013-01-27	Астразенека Аб	Производные 1,3,4-оксадиазола и их применение для лечения диабета
MX2011014018A (es) *	2009-06-19	2012-02-22	Astrazeneca Ab	Pirazincarboxamidas como inhibidores de dgati.

2007
- 2007-06-06 EP EP07733082A patent/EP2035417B1/de active Active
- 2007-06-06 MX MX2008015725A patent/MX2008015725A/es not_active Application Discontinuation
- 2007-06-06 ES ES07733082T patent/ES2359653T3/es active Active
- 2007-06-06 WO PCT/GB2007/002070 patent/WO2007141517A1/en not_active Ceased
- 2007-06-06 JP JP2009513759A patent/JP2009539818A/ja active Pending
- 2007-06-06 US US12/303,512 patent/US20090197926A1/en not_active Abandoned
- 2007-06-06 AU AU2007255180A patent/AU2007255180B2/en not_active Ceased
- 2007-06-06 CN CNA2007800210582A patent/CN101460492A/zh active Pending
- 2007-06-06 KR KR1020097000116A patent/KR20090016629A/ko not_active Withdrawn
- 2007-06-06 DE DE602007012875T patent/DE602007012875D1/de active Active
- 2007-06-06 AT AT07733082T patent/ATE500251T1/de not_active IP Right Cessation
- 2007-06-06 NZ NZ573576A patent/NZ573576A/en not_active IP Right Cessation
- 2007-06-06 CA CA002655225A patent/CA2655225A1/en not_active Abandoned
2008
- 2008-12-14 IL IL195912A patent/IL195912A0/en unknown
- 2008-12-15 NO NO20085216A patent/NO20085216L/no not_active Application Discontinuation
- 2008-12-17 ZA ZA200810643A patent/ZA200810643B/xx unknown

Also Published As

Publication number	Publication date
ZA200810643B (en)	2010-05-26
JP2009539818A (ja)	2009-11-19
EP2035417A1 (de)	2009-03-18
ES2359653T3 (es)	2011-05-25
DE602007012875D1 (de)	2011-04-14
NO20085216L (no)	2009-01-06
EP2035417B1 (de)	2011-03-02
AU2007255180B2 (en)	2011-02-03
WO2007141517A1 (en)	2007-12-13
CN101460492A (zh)	2009-06-17
KR20090016629A (ko)	2009-02-16
MX2008015725A (es)	2009-02-13
IL195912A0 (en)	2011-08-01
HK1129099A1 (en)	2009-11-20
US20090197926A1 (en)	2009-08-06
AU2007255180A1 (en)	2007-12-13
NZ573576A (en)	2011-01-28
CA2655225A1 (en)	2007-12-13

Legal Events

Date	Code	Title	Description
2011-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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