ATE500259T1 - Aminothiazolmakrocyclen, ihre verwendung als antibakterielle verbindungen und verfahren zu ihrer herstellung - Google Patents

Aminothiazolmakrocyclen, ihre verwendung als antibakterielle verbindungen und verfahren zu ihrer herstellung

Info

Publication number
ATE500259T1
ATE500259T1 AT07863118T AT07863118T ATE500259T1 AT E500259 T1 ATE500259 T1 AT E500259T1 AT 07863118 T AT07863118 T AT 07863118T AT 07863118 T AT07863118 T AT 07863118T AT E500259 T1 ATE500259 T1 AT E500259T1
Authority
AT
Austria
Prior art keywords
macrocycles
aminothiazole
production
antibacterial compounds
compounds
Prior art date
Application number
AT07863118T
Other languages
English (en)
Inventor
Matthew J Lamarche
Jennifer A Leeds
Philipp Krastel
Hans-Ulrich Naegeli
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of ATE500259T1 publication Critical patent/ATE500259T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/185—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT07863118T 2006-12-20 2007-12-19 Aminothiazolmakrocyclen, ihre verwendung als antibakterielle verbindungen und verfahren zu ihrer herstellung ATE500259T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US87105106P 2006-12-20 2006-12-20
US88959107P 2007-02-13 2007-02-13
US89298807P 2007-03-05 2007-03-05
PCT/US2007/025955 WO2008082562A2 (en) 2006-12-20 2007-12-19 Aminothiazole macrocycles, their use as antibacterial compounds and processes for their production

Publications (1)

Publication Number Publication Date
ATE500259T1 true ATE500259T1 (de) 2011-03-15

Family

ID=39166701

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07863118T ATE500259T1 (de) 2006-12-20 2007-12-19 Aminothiazolmakrocyclen, ihre verwendung als antibakterielle verbindungen und verfahren zu ihrer herstellung

Country Status (15)

Country Link
US (1) US8183341B2 (de)
EP (1) EP2097423B1 (de)
JP (1) JP5230647B2 (de)
KR (1) KR20090082504A (de)
CN (1) CN101563353B (de)
AT (1) ATE500259T1 (de)
AU (1) AU2007339279A1 (de)
BR (1) BRPI0720542A2 (de)
CA (1) CA2673506A1 (de)
DE (1) DE602007012935D1 (de)
EA (1) EA200900816A1 (de)
MX (1) MX2009006745A (de)
PL (1) PL2097423T3 (de)
PT (1) PT2097423E (de)
WO (1) WO2008082562A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008258639B2 (en) 2007-06-04 2012-07-05 Novartis Ag Macrocycles and their uses
CA2708793C (en) 2007-12-12 2016-06-21 Novartis Ag Aminothiazoles and their uses
JP2011116662A (ja) * 2008-03-26 2011-06-16 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 新規抗生物質ｓｆ２８７６物質、その製造法および医薬組成物
KR101599982B1 (ko) * 2011-04-18 2016-03-09 명지대학교 산학협력단 노노무라에아 종으로부터의 고리형 펩티드, 그에 대한 생산 프로세스 및 이를 포함하는 마이코박테리아 관련 질병의 치료 혹은 예방을 위한 약학적 조성물
JP6273279B2 (ja) * 2012-08-14 2018-01-31 コーリア リサーチ インスティテュート オブ ケミカル テクノロジー ストレプトマイセス・スコプリリディスｋｒ−００１株またはその培養液を活性成分として含む雑草防除用組成物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4740299A (en) * 1985-05-14 1988-04-26 Parker Hannifin Corporation Filter assembly with threaded collection bowl
US5202241A (en) * 1988-09-09 1993-04-13 Gruppo Lepetit S.P.A. Antibiotic GE 2270
ES2066914T3 (es) * 1989-07-04 1995-03-16 Lepetit Spa Factores a1, a2, a3 y h del antibiotico ge 2270.
DK0451486T3 (da) * 1990-03-08 1995-05-08 Lepetit Spa Antibiotikum GE 2270 faktorer B1, B2, C1, C2, D1, D2, E og T
IL100572A (en) * 1991-01-03 1997-01-10 Lepetit Spa Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them
DE69224497T2 (de) * 1991-08-30 1998-07-02 Biosearch Italia Spa Faktor C2a des Antibiotikums CE 2270
US5882900A (en) * 1992-09-10 1999-03-16 Gruppo Lepetit S.P.A. Process for the selective increase of production of antibiotic GE 2270 factor a by adding vitamin B12 to nutrient medium
DE69317058T2 (de) 1992-12-22 1998-06-10 Biosearch Italia Spa Die antibiotika ge 37468 a, b und c
US5547686A (en) 1994-08-15 1996-08-20 Clemson University Feed supplements for ruminants and method for using same
WO1996014427A1 (en) 1994-11-08 1996-05-17 Gruppo Lepetit S.P.A. Microbial transformation process for obtaining antibiotic ge 2270 factor d¿2?
ATE165101T1 (de) * 1995-02-07 1998-05-15 Biosearch Italia Spa Basische prolinamid derivate von ge2270 und ge2270-ahnlichten antibiotika
JP3518606B2 (ja) * 1995-02-07 2004-04-12 バイオサーチ・イタリア・ソチエタ・ペル・アチオニ Ｇｅ２２７０及びｇｅ２２７０−様抗生物質の塩基性オキサゾリン−アミド誘導体
EP0880541B1 (de) * 1996-02-14 2003-01-15 Biosearch Italia S.p.A. Derivate des antibiotisch wirkenden faktors ge2270
DE10160497A1 (de) * 2001-12-08 2003-06-12 Mann & Hummel Filter Verfahren und Vorrichtung zum Speichern von aus Kraftstoff ausgefiltertem Wasser
DK1553967T3 (da) 2002-06-17 2011-08-29 Naicons S C A R L Anvendelse af et amidderivat af GE 2270 faktor A3 til behandling af acne
AU2005327139A1 (en) * 2004-09-22 2006-08-17 Merck & Co., Inc. Antibiotic compound
PE20080103A1 (es) * 2006-05-31 2008-04-03 Novartis Ag AMINOTIAZOLES COMO MODULADORES DEL FACTOR DE ELONGACION EF-Tu

Also Published As

Publication number Publication date
CN101563353B (zh) 2012-06-27
DE602007012935D1 (de) 2011-04-14
EA200900816A1 (ru) 2009-12-30
WO2008082562A3 (en) 2008-11-13
BRPI0720542A2 (pt) 2014-01-21
PT2097423E (pt) 2011-06-01
JP2010513512A (ja) 2010-04-30
KR20090082504A (ko) 2009-07-30
PL2097423T3 (pl) 2011-07-29
WO2008082562A2 (en) 2008-07-10
EP2097423B1 (de) 2011-03-02
EP2097423A2 (de) 2009-09-09
AU2007339279A1 (en) 2008-07-10
US8183341B2 (en) 2012-05-22
US20100093615A1 (en) 2010-04-15
MX2009006745A (es) 2009-08-19
JP5230647B2 (ja) 2013-07-10
CN101563353A (zh) 2009-10-21
CA2673506A1 (en) 2008-07-10

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