PL2097423T3 - Aminotiazolowe związki makrocykliczne, ich zastosowanie jako związków przeciwbakteryjnych i sposoby ich wytwarzania - Google Patents

Aminotiazolowe związki makrocykliczne, ich zastosowanie jako związków przeciwbakteryjnych i sposoby ich wytwarzania

Info

Publication number
PL2097423T3
PL2097423T3 PL07863118T PL07863118T PL2097423T3 PL 2097423 T3 PL2097423 T3 PL 2097423T3 PL 07863118 T PL07863118 T PL 07863118T PL 07863118 T PL07863118 T PL 07863118T PL 2097423 T3 PL2097423 T3 PL 2097423T3
Authority
PL
Poland
Prior art keywords
macrocycles
aminothiazole
processes
production
antibacterial compounds
Prior art date
Application number
PL07863118T
Other languages
English (en)
Inventor
Matthew J Lamarche
Jennifer A Leeds
Philipp Krastel
Hans-Ulrich Naegeli
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PL2097423T3 publication Critical patent/PL2097423T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/185—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PL07863118T 2006-12-20 2007-12-19 Aminotiazolowe związki makrocykliczne, ich zastosowanie jako związków przeciwbakteryjnych i sposoby ich wytwarzania PL2097423T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US87105106P 2006-12-20 2006-12-20
US88959107P 2007-02-13 2007-02-13
US89298807P 2007-03-05 2007-03-05
EP07863118A EP2097423B1 (en) 2006-12-20 2007-12-19 Aminothiazole macrocycles, their use as antibacterial compounds and processes for their production
PCT/US2007/025955 WO2008082562A2 (en) 2006-12-20 2007-12-19 Aminothiazole macrocycles, their use as antibacterial compounds and processes for their production

Publications (1)

Publication Number Publication Date
PL2097423T3 true PL2097423T3 (pl) 2011-07-29

Family

ID=39166701

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07863118T PL2097423T3 (pl) 2006-12-20 2007-12-19 Aminotiazolowe związki makrocykliczne, ich zastosowanie jako związków przeciwbakteryjnych i sposoby ich wytwarzania

Country Status (15)

Country Link
US (1) US8183341B2 (pl)
EP (1) EP2097423B1 (pl)
JP (1) JP5230647B2 (pl)
KR (1) KR20090082504A (pl)
CN (1) CN101563353B (pl)
AT (1) ATE500259T1 (pl)
AU (1) AU2007339279A1 (pl)
BR (1) BRPI0720542A2 (pl)
CA (1) CA2673506A1 (pl)
DE (1) DE602007012935D1 (pl)
EA (1) EA200900816A1 (pl)
MX (1) MX2009006745A (pl)
PL (1) PL2097423T3 (pl)
PT (1) PT2097423E (pl)
WO (1) WO2008082562A2 (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101772506B (zh) * 2007-06-04 2014-02-12 诺华股份有限公司 大环化合物及其用途
EP2229386B1 (en) 2007-12-12 2015-06-03 Novartis AG An aminothiazole derivative as antibacterial agent
JP2011116662A (ja) * 2008-03-26 2011-06-16 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 新規抗生物質ｓｆ２８７６物質、その製造法および医薬組成物
EP2699584B1 (en) 2011-04-18 2016-04-13 Myongji University Industry and Academia Cooperation Foundation Cyclic peptide from nonomuraea sp., process for the production thereof, and pharmaceutical composition for the prevention or treatment of mycobacteria related disease comprising the same
WO2014027821A1 (ko) * 2012-08-14 2014-02-20 한국화학연구원 스트랩토마이세스 스코풀리리디스 kr-001 균주, 또는 이의 배양액을 유효성분으로 포함하는 잡초 방제용 조성물

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4740299A (en) * 1985-05-14 1988-04-26 Parker Hannifin Corporation Filter assembly with threaded collection bowl
US5202241A (en) * 1988-09-09 1993-04-13 Gruppo Lepetit S.P.A. Antibiotic GE 2270
DE69016284T2 (de) * 1989-07-04 1995-05-24 Lepetit Spa Antibiotikum GE 22270, Faktoren A1,A2,A3 und H.
ES2071143T3 (es) * 1990-03-08 1995-06-16 Lepetit Spa Factores b1, b2, c1, c2, d1, d2, e y t del antibiotico ge 2270.
IL100572A (en) 1991-01-03 1997-01-10 Lepetit Spa Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them
DK0529410T3 (da) * 1991-08-30 1998-05-11 Biosearch Italia Spa Antibiotikum GE 2270 faktor C2a
US5882900A (en) * 1992-09-10 1999-03-16 Gruppo Lepetit S.P.A. Process for the selective increase of production of antibiotic GE 2270 factor a by adding vitamin B12 to nutrient medium
KR960703410A (ko) 1992-12-22 1996-08-17 프란세스코 마체타 항생물질 GE 37468 A, B 및 C(Antibiotics GE 37468 A, B and C)
US5547686A (en) 1994-08-15 1996-08-20 Clemson University Feed supplements for ruminants and method for using same
JPH10508476A (ja) 1994-11-08 1998-08-25 グルポ・レペチツト・エス・ピー・エイ 抗生物質ｇｅ２２７０因子ｄ▲下２▼を得るための微生物変換法
DE69600244T2 (de) * 1995-02-07 1998-10-01 Biosearch Italia Spa Basische prolinamid derivate von ge2270 und ge2270-ahnlichten antibiotika
WO1996024608A1 (en) * 1995-02-07 1996-08-15 Biosearch Italia S.P.A. Basic oxazoline-amide derivatives of ge 2270 and ge 2270-like antibiotics
ES2186866T3 (es) * 1996-02-14 2003-05-16 Biosearch Italia Spa Derivados de factores del antibiotico ge2270.
DE10160497A1 (de) * 2001-12-08 2003-06-12 Mann & Hummel Filter Verfahren und Vorrichtung zum Speichern von aus Kraftstoff ausgefiltertem Wasser
KR20050026401A (ko) 2002-06-17 2005-03-15 비큐론 파마세티컬스 인코포레이티드 여드름 치료를 위한 ｇｅ 2270 인자 ａ3의 아미드유도체의 용도
CA2580882A1 (en) 2004-09-22 2006-08-17 Merck & Co., Inc. Antibiotic compound
AR060977A1 (es) 2006-05-31 2008-07-23 Novartis Ag Aminotiazoles y sus usos

Also Published As

Publication number Publication date
EP2097423B1 (en) 2011-03-02
DE602007012935D1 (de) 2011-04-14
KR20090082504A (ko) 2009-07-30
WO2008082562A3 (en) 2008-11-13
MX2009006745A (es) 2009-08-19
CA2673506A1 (en) 2008-07-10
JP2010513512A (ja) 2010-04-30
ATE500259T1 (de) 2011-03-15
PT2097423E (pt) 2011-06-01
US8183341B2 (en) 2012-05-22
EP2097423A2 (en) 2009-09-09
US20100093615A1 (en) 2010-04-15
BRPI0720542A2 (pt) 2014-01-21
WO2008082562A2 (en) 2008-07-10
CN101563353A (zh) 2009-10-21
JP5230647B2 (ja) 2013-07-10
EA200900816A1 (ru) 2009-12-30
CN101563353B (zh) 2012-06-27
AU2007339279A1 (en) 2008-07-10

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