ATE500268T1 - Peptide mit neuropeptide-2 rezeptor agonist aktivität - Google Patents

Peptide mit neuropeptide-2 rezeptor agonist aktivität

Info

Publication number
ATE500268T1
ATE500268T1 AT06700451T AT06700451T ATE500268T1 AT E500268 T1 ATE500268 T1 AT E500268T1 AT 06700451 T AT06700451 T AT 06700451T AT 06700451 T AT06700451 T AT 06700451T AT E500268 T1 ATE500268 T1 AT E500268T1
Authority
AT
Austria
Prior art keywords
neuropeptide
peptides
receptor agonist
agonist activity
activity
Prior art date
Application number
AT06700451T
Other languages
English (en)
Inventor
Waleed Danho
George Ehrlich
David Fry
Wajiha Khan
Joseph Swistok
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE500268T1 publication Critical patent/ATE500268T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57545—Neuropeptide Y
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT06700451T 2005-01-18 2006-01-11 Peptide mit neuropeptide-2 rezeptor agonist aktivität ATE500268T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64484005P 2005-01-18 2005-01-18
PCT/EP2006/000161 WO2006077035A1 (en) 2005-01-18 2006-01-11 Peptides with neuropeptide-2 receptor (y2r) agonist activity

Publications (1)

Publication Number Publication Date
ATE500268T1 true ATE500268T1 (de) 2011-03-15

Family

ID=36118121

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06700451T ATE500268T1 (de) 2005-01-18 2006-01-11 Peptide mit neuropeptide-2 rezeptor agonist aktivität

Country Status (22)

Country Link
US (1) US7410949B2 (de)
EP (1) EP1844070B1 (de)
JP (1) JP4633804B2 (de)
KR (1) KR100905380B1 (de)
CN (1) CN101107266A (de)
AR (1) AR051904A1 (de)
AT (1) ATE500268T1 (de)
AU (1) AU2006207659B2 (de)
BR (1) BRPI0606675A2 (de)
CA (1) CA2594423A1 (de)
DE (1) DE602006020407D1 (de)
DK (1) DK1844070T3 (de)
ES (1) ES2359850T3 (de)
IL (1) IL184428A0 (de)
MX (1) MX2007008614A (de)
NO (1) NO20073664L (de)
PL (1) PL1844070T3 (de)
PT (1) PT1844070E (de)
RU (1) RU2383553C2 (de)
TW (1) TWI309653B (de)
WO (1) WO2006077035A1 (de)
ZA (1) ZA200705674B (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007065808A2 (en) * 2005-12-07 2007-06-14 F. Hoffmann-La Roche Ag Neuropeptide-2 receptor-agonists
US8299023B2 (en) * 2008-09-17 2012-10-30 Hoffmann-La Roche Inc. Neuropeptide-2 receptor (Y-2R) agonists
CA2741921A1 (en) * 2008-11-05 2010-05-14 F. Hoffmann-La Roche Ag Neuropeptide-2-receptor (y-2r) agonists and uses thereof
US9260500B2 (en) 2009-07-02 2016-02-16 Takeda Pharmaceutical Company Limited Peptide and use thereof
EP2477643A1 (de) * 2009-09-18 2012-07-25 Novo Nordisk A/S V2-rezeptoragonisten mit langzeitwirkung
CA2776302A1 (en) * 2009-10-13 2011-04-21 F. Hoffmann-La Roche Ag Neuropeptide-2 receptor (y-2r) agonists
MX345501B (es) 2010-12-16 2017-02-02 Novo Nordisk As Composiciones solidas que comprenden agonista de glp-1 y sal del acido n-(8-(2-hidroxibenzoil)amino)caprilico.
EP2827885B1 (de) 2012-03-22 2018-08-15 Novo Nordisk A/S Zusammensetzungen von glp-1-peptiden und ihre herstellung
HRP20161774T1 (hr) 2012-06-13 2017-02-24 F. Hoffmann - La Roche Ag Novi diazaspirocikloalkan i azaspirocikloalkan
BR112015004111A2 (pt) 2012-09-25 2017-07-04 Hoffmann La Roche novos derivados bicíclicos
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
SMT201800492T1 (it) 2013-05-02 2018-11-09 Novo Nordisk As Dosaggio orale di composti di glp-1
AU2014350197B2 (en) 2013-11-15 2018-10-04 Novo Nordisk A/S Selective PYY compounds and uses thereof
EP3068795B1 (de) 2013-11-15 2019-03-06 Novo Nordisk A/S Beta-homoarginin substitution an position 35 von hpyy(1-36)
KR20160087900A (ko) 2013-11-26 2016-07-22 에프. 호프만-라 로슈 아게 신규한 옥타하이드로-사이클로부타[1,2-c；3,4-c'']다이피롤-2-일
SI3122750T1 (sl) 2014-03-26 2019-12-31 F. Hoffmann-La Roche Ag Biciklične spojine kot zaviralci proizvodnje avtotaksina (ATX) in lizofosfatidne kisline (LPA)
KR20160128428A (ko) 2014-03-26 2016-11-07 에프. 호프만-라 로슈 아게 오토탁신(atx) 및 리소포스파티드산(lpa) 생성 억제제로서의 축합형 [1,4]다이아제핀 화합물
MA41898A (fr) * 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
AU2016275735B2 (en) 2015-06-12 2020-02-06 Novo Nordisk A/S Selective PYY compounds and uses thereof
JP6886967B2 (ja) 2015-09-04 2021-06-16 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ フェノキシメチル誘導体
JP6877413B2 (ja) 2015-09-24 2021-05-26 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 二重ａｔｘ／ｃａ阻害剤としての新規な二環式化合物
AU2016328365B2 (en) 2015-09-24 2020-04-23 F. Hoffmann-La Roche Ag New bicyclic compounds as dual ATX/CA inhibitors
CN107635995B (zh) 2015-09-24 2022-08-19 豪夫迈·罗氏有限公司 作为atx抑制剂的二环化合物
RU2018112230A (ru) 2015-09-24 2019-10-30 Ф. Хоффманн-Ля Рош Аг Бициклические соединения в качестве ингибиторов atx
WO2018167113A1 (en) 2017-03-16 2018-09-20 F. Hoffmann-La Roche Ag New bicyclic compounds as atx inhibitors
EP3596059B1 (de) 2017-03-16 2024-04-24 F. Hoffmann-La Roche AG Als duale atx/ca-inhibitoren nützliche heterocyclische verbindungen
US20210171598A1 (en) 2017-12-01 2021-06-10 University Of Copenhagen Peptide hormone with one or more o-glycans
EP4299118A3 (de) 2018-02-02 2024-04-10 Novo Nordisk A/S Feste zusammensetzungen mit einem glp-1-agonisten, einem salz aus n-(8-(2-hydroxybenzoyl)amino)caprylsäure und einem schmierstoff
EP3800195A1 (de) * 2019-10-03 2021-04-07 Universitat de Barcelona Peptidverbindungen zur reduzierung der nebenwirkungen von cb1-rezeptoragonisten

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5080891A (en) 1987-08-03 1992-01-14 Ddi Pharmaceuticals, Inc. Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
EP0692971A4 (de) 1993-03-29 1997-11-12 Univ Cincinnati Peptid yy-analogen und verwendungen dafür
US6017879A (en) * 1998-04-03 2000-01-25 B.M.R.A. Corporation B.V. Template associated NPY Y2-receptor agonists
MXPA02000927A (es) * 1999-07-28 2003-07-14 Johnson & Johnson Amina y derivados de amida como ligandos para el receptor del neuropeptido y y5 utiles en el tratamiento de obesidad y otros trastornos.
EP1583549A4 (de) * 2003-01-17 2006-10-04 Sod Conseils Rech Applic Yy-peptid-analoga
US20090105122A1 (en) * 2003-11-25 2009-04-23 Bayer Pharmaceuticals Corporation Selective neuropeptide y2 receptor agonists
US8603969B2 (en) * 2004-02-11 2013-12-10 Amylin Pharmaceuticals, Llc Pancreatic polypeptide family motifs and polypeptides comprising the same

Also Published As

Publication number Publication date
US20060160742A1 (en) 2006-07-20
EP1844070A1 (de) 2007-10-17
AU2006207659A1 (en) 2006-07-27
JP2008527017A (ja) 2008-07-24
DK1844070T3 (da) 2011-06-14
CN101107266A (zh) 2008-01-16
WO2006077035A1 (en) 2006-07-27
KR100905380B1 (ko) 2009-06-30
KR20070095422A (ko) 2007-09-28
DE602006020407D1 (de) 2011-04-14
TW200637874A (en) 2006-11-01
AR051904A1 (es) 2007-02-14
ZA200705674B (en) 2009-08-26
BRPI0606675A2 (pt) 2009-07-07
ES2359850T3 (es) 2011-05-27
JP4633804B2 (ja) 2011-02-16
EP1844070B1 (de) 2011-03-02
CA2594423A1 (en) 2006-07-27
RU2383553C2 (ru) 2010-03-10
NO20073664L (no) 2007-09-28
US7410949B2 (en) 2008-08-12
RU2007131504A (ru) 2009-02-27
AU2006207659B2 (en) 2009-10-29
WO2006077035A9 (en) 2006-10-26
IL184428A0 (en) 2007-10-31
PT1844070E (pt) 2011-05-04
PL1844070T3 (pl) 2011-07-29
MX2007008614A (es) 2007-09-11
TWI309653B (en) 2009-05-11

Similar Documents

Publication Publication Date Title
ATE500268T1 (de) Peptide mit neuropeptide-2 rezeptor agonist aktivität
FR22C1054I2 (fr) Amides peptidiques synthetiques
ATE480555T1 (de) Antimykotische polypeptide
CU23872B1 (es) Anticuerpos antagonistas dirigidos contra el péptido relacionado con el gen de calcitonina
DK2035447T3 (da) Polypeptid
DK2602263T3 (da) Polypeptider omfattende en isbindende aktivitet
DE602006007563D1 (de) Agonisten
EP2151236A4 (de) G-protein-konjugierter rezeptoragonist
DE602005015131D1 (de) Interleukin-15-antagonistisches peptid
EP2382311A4 (de) Polypeptide mit xylanaseaktivität
IL189922A0 (en) Selective vpac2 receptor peptide agonists
IL184284A0 (en) Modified beta thymosin peptides
ATE549350T1 (de) Neuropeptid-2-rezeptor-agonisten
DK2468292T3 (da) Nyt peptid med antisekretorisk aktivitet
DK1711465T3 (da) Hydroisoindolin-tachykinikreceptorantagonister
IS8482A (is) Kalsítóníngen-skyldir peptíðviðtaka antagónistar
DK1973886T3 (da) Prokineticin-1-receptor-antagonister
EP1735335A4 (de) Zellabtötende peptide
DK1776133T3 (da) Peptid-vasopressin-receptor-agonister
EP1858914A4 (de) Peptidnetze
DK2207790T3 (da) Biologisk aktive C-terminalt argininholdige peptider
ATE397618T1 (de) Peptidcyclisierung
DK1809660T3 (da) Thymus-specifikt protein
EP2326176A4 (de) Nicht-amidische binder mit verzweigten enden als cgrp-rezeptorantagonisten
DK1968623T3 (da) Bacteriocin-inducer-peptider

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1844070

Country of ref document: EP