ATE500336T1 - Expression von schutzantigenen in transgenen chloroplasten und herstellung verbesserter impfstoffe - Google Patents
Expression von schutzantigenen in transgenen chloroplasten und herstellung verbesserter impfstoffeInfo
- Publication number
- ATE500336T1 ATE500336T1 AT02792531T AT02792531T ATE500336T1 AT E500336 T1 ATE500336 T1 AT E500336T1 AT 02792531 T AT02792531 T AT 02792531T AT 02792531 T AT02792531 T AT 02792531T AT E500336 T1 ATE500336 T1 AT E500336T1
- Authority
- AT
- Austria
- Prior art keywords
- vaccines
- well
- plants
- protective antigens
- expression
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title abstract 4
- 239000000427 antigen Substances 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 210000003763 chloroplast Anatomy 0.000 title abstract 2
- 230000001681 protective effect Effects 0.000 title abstract 2
- 230000009261 transgenic effect Effects 0.000 title 1
- 241000196324 Embryophyta Species 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 2
- 230000036039 immunity Effects 0.000 abstract 2
- 210000002706 plastid Anatomy 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 241000209510 Liliopsida Species 0.000 abstract 1
- 229940126576 edible vaccine Drugs 0.000 abstract 1
- 241001233957 eudicotyledons Species 0.000 abstract 1
- 230000001524 infective effect Effects 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/056—Transvascular endocardial electrode systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8214—Plastid transformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/056—Transvascular endocardial electrode systems
- A61N1/0565—Electrode heads
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cell Biology (AREA)
- Radiology & Medical Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34470401P | 2001-12-26 | 2001-12-26 | |
| US39365102P | 2002-07-03 | 2002-07-03 | |
| US40081602P | 2002-08-02 | 2002-08-02 | |
| PCT/US2002/041503 WO2003057834A2 (en) | 2001-12-26 | 2002-12-26 | Expression of protective antigens in transgenic chloroplasts and the production of improved vaccines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE500336T1 true ATE500336T1 (de) | 2011-03-15 |
Family
ID=27407646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02792531T ATE500336T1 (de) | 2001-12-26 | 2002-12-26 | Expression von schutzantigenen in transgenen chloroplasten und herstellung verbesserter impfstoffe |
Country Status (6)
| Country | Link |
|---|---|
| EP (2) | EP2284274B1 (de) |
| AT (1) | ATE500336T1 (de) |
| AU (1) | AU2002358292B2 (de) |
| CA (1) | CA2471737C (de) |
| DE (1) | DE60239355D1 (de) |
| WO (1) | WO2003057834A2 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110179530A1 (en) * | 2001-01-23 | 2011-07-21 | University Of Central Florida Research Foundation, Inc. | Pharmaceutical Proteins, Human Therapeutics, Human Serum Albumin Insulin, Native Cholera Toxin B Subunit on Transgenic Plastids |
| US20100251425A9 (en) | 1998-05-15 | 2010-09-30 | University Of Central Florida | Expression of human interferon in transgenic chloroplasts |
| EP1274846A4 (de) | 2000-03-01 | 2004-09-29 | Univ Auburn | Plastidentransformationsvektoren für die expression von menschlichen proteinen in pflanzen |
| EP2308985B1 (de) | 2002-07-03 | 2018-06-06 | The Trustees of the University of Pennsylvania | Gentechnische Manipulation von Plastiden über somatische Embryogenese |
| WO2005026375A2 (en) | 2003-05-22 | 2005-03-24 | Fraunhofer Usa, Inc. | Recombinant carrier molecule for expression, delivery and purification of target polypeptides |
| WO2007053182A2 (en) * | 2005-05-27 | 2007-05-10 | University Of Central Florida Research Foundation, Inc. | Plant produced vaccine for amebiasis |
| US7928290B2 (en) * | 2004-02-27 | 2011-04-19 | Dow Agrosciences Llc | Viral capsid fusion peptide expressing plant cells |
| US20180371485A1 (en) * | 2005-05-27 | 2018-12-27 | The Trustees Of The University Of Pennsylvania | Chloroplasts engineered to express pharmaceutical proteins |
| US20080274143A1 (en) | 2005-05-27 | 2008-11-06 | Henry Daniell | Chloroplasts Engineering to Express Pharmaceutical Proteins |
| JP2009502207A (ja) | 2005-08-03 | 2009-01-29 | フラウンホーファー ユーエスエー， インコーポレイテッド | イムノグロブリンの産生のための組成物および方法 |
| GB2447416B (en) * | 2006-12-15 | 2010-08-25 | Uni I Stavanger | Methods and vectors for transformation of plastids and marker excision using site-specific recombination |
| US10752909B2 (en) | 2007-03-30 | 2020-08-25 | The Trustees Of The University Of Pennsylvania | Chloroplasts engineered to express pharmaceutical proteins in edible plants |
| WO2009009759A2 (en) | 2007-07-11 | 2009-01-15 | Fraunhofer Usa, Inc. | Yersinia pestis antigens, vaccine compositions, and related methods |
| US20090297550A1 (en) * | 2007-10-31 | 2009-12-03 | Henry Daniell | Chloroplast-derived human vaccine antigens against malaria |
| US20100266640A1 (en) * | 2009-04-20 | 2010-10-21 | Henry Daniell | Plant-Derived Cholera and Malaria Vaccine |
| US10689633B2 (en) | 2008-02-29 | 2020-06-23 | The Trustees Of The University Of Pennsylvania | Expression of β-mannanase in chloroplasts and its utilization in lignocellulosic woody biomass hydrolysis |
| US8734803B2 (en) | 2008-09-28 | 2014-05-27 | Ibio Inc. | Humanized neuraminidase antibody and methods of use thereof |
| US8784819B2 (en) | 2009-09-29 | 2014-07-22 | Ibio Inc. | Influenza hemagglutinin antibodies, compositions and related methods |
| WO2011057243A2 (en) | 2009-11-09 | 2011-05-12 | University Of Central Florida Research Foundation, Inc. | Administration of plant expressed oral tolerance agents |
| US10865419B2 (en) | 2011-10-24 | 2020-12-15 | The Trustees Of The University Of Pennsylvania | Orally administered plastid expressed cholera toxin B subunit-exendin 4 as treatment for type 2 diabetes |
| WO2013063059A1 (en) * | 2011-10-24 | 2013-05-02 | University Of Central Florida Research Foundation, Inc. | Plastid-expressed mycobacterium tuberculosis vaccine antigens esat-6 and mtb72f fused to cholera toxin b subunit |
| CN104004696A (zh) * | 2013-02-27 | 2014-08-27 | 中国人民解放军军事医学科学院生物工程研究所 | 一株ba5641基因缺失的炭疽杆菌及其构建方法 |
| WO2015058214A1 (en) | 2013-10-18 | 2015-04-23 | Trustees Of The University Of Pennsylvania | Oral delivery of angiotensin converting enzyme 2 (ace2) or angiotensin-(1-7) bioencapsulated in plant cells |
| PT3068869T (pt) | 2013-11-15 | 2020-10-08 | Univ Pennsylvania | Composições para supressão da formação de inibidores contra fator viii em pacientes de hemofilia a |
| AU2016355563A1 (en) | 2015-11-16 | 2018-06-21 | The Trustees Of The University Of Pennsylvania | Targeted delivery of therapeutic proteins bioencapsulated in plant cells to cell types of interest for the treatment of disease |
| US20230126093A1 (en) * | 2020-03-16 | 2023-04-27 | Vrije Universiteit Brussel | Synthetic dna template for in vitro mrna transcription |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5932479A (en) | 1988-09-26 | 1999-08-03 | Auburn University | Genetic engineering of plant chloroplasts |
| US5693507A (en) | 1988-09-26 | 1997-12-02 | Auburn University | Genetic engineering of plant chloroplasts |
| US5612487A (en) * | 1991-08-26 | 1997-03-18 | Edible Vaccines, Inc. | Anti-viral vaccines expressed in plants |
| NZ502742A (en) | 1997-08-07 | 2004-04-30 | Univ Auburn | Universal chloroplast integration and expression vectors, transformed plants and products thereof |
| WO2000003022A2 (en) * | 1998-07-10 | 2000-01-20 | Calgene Llc | Expression of herbicide tolerance genes in plant plastids |
| WO2001064024A1 (en) | 2000-02-29 | 2001-09-07 | Auburn University | Multiple gene expression for engineering novel pathways and hyperexpression of foreign proteins in plants |
| EP1274846A4 (de) | 2000-03-01 | 2004-09-29 | Univ Auburn | Plastidentransformationsvektoren für die expression von menschlichen proteinen in pflanzen |
| AU2001245359A1 (en) | 2000-03-02 | 2001-09-12 | Auburn University | Marker free transgenic plants: engineering the chloroplast genome without the use of antibiotic selection |
-
2002
- 2002-12-26 AT AT02792531T patent/ATE500336T1/de not_active IP Right Cessation
- 2002-12-26 EP EP10171735.3A patent/EP2284274B1/de not_active Expired - Lifetime
- 2002-12-26 EP EP02792531A patent/EP1456390B1/de not_active Expired - Lifetime
- 2002-12-26 WO PCT/US2002/041503 patent/WO2003057834A2/en not_active Ceased
- 2002-12-26 DE DE60239355T patent/DE60239355D1/de not_active Expired - Lifetime
- 2002-12-26 AU AU2002358292A patent/AU2002358292B2/en not_active Expired
- 2002-12-26 CA CA2471737A patent/CA2471737C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003057834A2 (en) | 2003-07-17 |
| WO2003057834A3 (en) | 2003-12-31 |
| EP1456390B1 (de) | 2011-03-02 |
| AU2002358292B2 (en) | 2008-12-18 |
| EP1456390A4 (de) | 2005-12-21 |
| DE60239355D1 (de) | 2011-04-14 |
| CA2471737C (en) | 2016-01-26 |
| EP2284274A1 (de) | 2011-02-16 |
| EP2284274B1 (de) | 2015-08-26 |
| EP1456390A2 (de) | 2004-09-15 |
| CA2471737A1 (en) | 2003-07-17 |
| AU2002358292A1 (en) | 2003-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |