ATE500847T1 - Pegylierte g-csf-polypeptide und herstellungsverfahren dafür - Google Patents
Pegylierte g-csf-polypeptide und herstellungsverfahren dafürInfo
- Publication number
- ATE500847T1 ATE500847T1 AT06722962T AT06722962T ATE500847T1 AT E500847 T1 ATE500847 T1 AT E500847T1 AT 06722962 T AT06722962 T AT 06722962T AT 06722962 T AT06722962 T AT 06722962T AT E500847 T1 ATE500847 T1 AT E500847T1
- Authority
- AT
- Austria
- Prior art keywords
- pegylated
- csf polypeptides
- csf
- production method
- polypeptide
- Prior art date
Links
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 title abstract 4
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
- 210000000440 neutrophil Anatomy 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68672605P | 2005-06-01 | 2005-06-01 | |
| PCT/DK2006/000292 WO2006128460A2 (en) | 2005-06-01 | 2006-05-26 | Pegylated g-csf polypeptides and methods of producing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE500847T1 true ATE500847T1 (de) | 2011-03-15 |
Family
ID=37308965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06722962T ATE500847T1 (de) | 2005-06-01 | 2006-05-26 | Pegylierte g-csf-polypeptide und herstellungsverfahren dafür |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US7381805B2 (de) |
| EP (1) | EP1888119B1 (de) |
| JP (2) | JP5137821B2 (de) |
| KR (1) | KR20080027291A (de) |
| CN (1) | CN101193658B (de) |
| AT (1) | ATE500847T1 (de) |
| AU (1) | AU2006254543A1 (de) |
| BR (1) | BRPI0611221A2 (de) |
| CA (1) | CA2607844C (de) |
| DE (1) | DE602006020562D1 (de) |
| IL (1) | IL187009A0 (de) |
| MX (1) | MX2007015156A (de) |
| NO (1) | NO20075708L (de) |
| RU (1) | RU2007149238A (de) |
| WO (1) | WO2006128460A2 (de) |
| ZA (1) | ZA200709704B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080027291A (ko) * | 2005-06-01 | 2008-03-26 | 맥시겐 홀딩스 엘티디 | 피이지화된 지-씨에스에프 폴리펩타이드 및 그 제조방법 |
| US8546328B2 (en) * | 2007-08-27 | 2013-10-01 | Biogenerix Ag | Liquid formulation of G-CSF conjugate |
| CA2737756A1 (en) * | 2008-09-19 | 2010-03-25 | Grant Yonehiro | Method for the treatment of radiation-induced neutropenia by administration of a multi-pegylated granulocyte colony stimulating factor (g-csf) variant |
| US7914828B2 (en) * | 2008-10-17 | 2011-03-29 | Levine Brian M | Combination herbal product to benefit respiratory tract |
| TW201138831A (en) * | 2009-09-30 | 2011-11-16 | Prolong Pharmaceuticals Inc | Modified granulocyte colony stimulating factor (G-CSF) |
| EP2494050A4 (de) * | 2009-10-30 | 2013-10-30 | Merck Sharp & Dohme | In glycoengineerter pichia pastoris hergestellter granulozytenkolonienstimulierender faktor |
| TWI480288B (zh) | 2010-09-23 | 2015-04-11 | Lilly Co Eli | 牛顆粒細胞群落刺激因子及其變體之調配物 |
| WO2012064845A2 (en) * | 2010-11-09 | 2012-05-18 | Nektar Therapeutics | G-csf polymer conjugates having a releasable linkage |
| US20140187488A1 (en) * | 2011-05-17 | 2014-07-03 | Bristol-Myers Squibb Company | Methods for maintaining pegylation of polypeptides |
| CN104109199B (zh) * | 2013-04-16 | 2019-04-30 | 深圳未名新鹏生物医药有限公司 | 一种聚乙二醇单修饰的人粒细胞集落刺激因子的制备方法及其产品 |
| CA2988988A1 (en) * | 2015-06-11 | 2016-12-15 | Ambio Pharmaceuticals, Llc | Pegylated granulocyte colony stimulating factor (gcsf) |
| KR102020995B1 (ko) * | 2017-10-30 | 2019-09-16 | 한국코러스 주식회사 | 콜로니자극인자와 폴리올이 접합된 접합물을 고수율로 제조하는 방법 |
| US20210386680A1 (en) * | 2018-12-06 | 2021-12-16 | Board Of Regents, The University Of Texas System | Selectively cleavable therapeutic nanoparticles |
| CN114853872B (zh) * | 2022-04-27 | 2023-11-17 | 山东新时代药业有限公司 | 一种聚乙二醇修饰rhG-CSF的制备方法 |
Family Cites Families (99)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US588025A (en) * | 1897-08-10 | Furnace-door-operating device | ||
| AU631312B (en) | 1912-09-04 | 1913-09-16 | Aage Philip Heyman | Improvements in and relating; to milking; machines |
| WO1985000817A1 (en) | 1983-08-10 | 1985-02-28 | Amgen | Microbial expression of interleukin ii |
| JPS61227526A (ja) | 1984-07-25 | 1986-10-09 | Chugai Pharmaceut Co Ltd | 新規なコロニー刺激因子 |
| EP0215126B1 (de) | 1985-02-08 | 1991-07-31 | Chugai Seiyaku Kabushiki Kaisha | Menschlicher granuloxcyt-kolonie-stimulierungsfaktor |
| US4810643A (en) | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
| JPS63500636A (ja) | 1985-08-23 | 1988-03-10 | 麒麟麦酒株式会社 | 多分化能性顆粒球コロニー刺激因子をコードするｄｎａ |
| US6004548A (en) | 1985-08-23 | 1999-12-21 | Amgen, Inc. | Analogs of pluripotent granulocyte colony-stimulating factor |
| JPS6263335A (ja) | 1985-09-13 | 1987-03-20 | Fuji Photo Film Co Ltd | 化学反応情報の処理方法 |
| DE3681551D1 (de) | 1985-09-30 | 1991-10-24 | Chugai Pharmaceutical Co Ltd | Menschlicher granulozyten-colony stimulierender faktor. |
| ES2039209T5 (es) | 1986-01-22 | 1996-07-16 | Chugai Pharmaceutical Co Ltd | Compuesto farmaceutico que promueve el restablecimiento de la capacidad hemopoyetica. |
| US4908773A (en) | 1987-04-06 | 1990-03-13 | Genex Corporation | Computer designed stabilized proteins and method for producing same |
| DK203187A (da) | 1986-04-22 | 1987-10-23 | Immunex Corp | Human g-csf proteinekspression |
| AU7675487A (en) | 1986-08-11 | 1988-05-19 | Cetus Corporation | Expression of granulocyte colony-stimulating factor |
| US4704692A (en) | 1986-09-02 | 1987-11-03 | Ladner Robert C | Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides |
| US5681720A (en) | 1986-12-23 | 1997-10-28 | Kyowa Hakko Co., Ltd. | DNA encoding human granulocyte colony stimulating factor plasmids and host cells comprising same, and methods of expressing the encoded polypeptide |
| US5214132A (en) | 1986-12-23 | 1993-05-25 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
| US5362853A (en) | 1986-12-23 | 1994-11-08 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
| NO176799C (no) | 1986-12-23 | 1995-05-31 | Kyowa Hakko Kogyo Kk | DNA som koder for et polypeptid, rekombinant plasmid som koder for og kan uttrykke et polypeptid og fremgangsmåte for fremstilling av dette polypeptid |
| US4853871A (en) | 1987-04-06 | 1989-08-01 | Genex Corporation | Computer-based method for designing stablized proteins |
| US4904584A (en) | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
| GB2213821B (en) | 1987-12-23 | 1992-01-02 | British Bio Technology | Synthetic human granulocyte colony stimulating factor gene |
| CA1340810C (en) | 1988-03-31 | 1999-11-02 | Motoo Yamasaki | Polypeptide derivatives of human granulocyte colony stimulating factor |
| EP0719860B1 (de) | 1988-05-13 | 2009-12-16 | Amgen Inc. | Verfahren zur Isolierung und Reinigung von G-CSF |
| EP0344796B1 (de) | 1988-06-03 | 1994-09-21 | Chugai Seiyaku Kabushiki Kaisha | Menschlicher kristallinischer Granulocyt-Koloniestimulierungsfaktor und dessen Herstellung |
| US5025388A (en) | 1988-08-26 | 1991-06-18 | Cramer Richard D Iii | Comparative molecular field analysis (CoMFA) |
| US5218092A (en) | 1988-09-29 | 1993-06-08 | Kyowa Hakko Kogyo Co., Ltd. | Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains |
| US5349052A (en) | 1988-10-20 | 1994-09-20 | Royal Free Hospital School Of Medicine | Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct for PEG and granulocyte-macrophage colony stimulating factor |
| US5104651A (en) | 1988-12-16 | 1992-04-14 | Amgen Inc. | Stabilized hydrophobic protein formulations of g-csf |
| US6166183A (en) | 1992-11-30 | 2000-12-26 | Kirin-Amgen, Inc. | Chemically-modified G-CSF |
| US20020177688A1 (en) * | 1988-12-22 | 2002-11-28 | Kirin-Amgen, Inc., | Chemically-modified G-CSF |
| EP0401384B1 (de) | 1988-12-22 | 1996-03-13 | Kirin-Amgen, Inc. | Chemisch modifizierte granulocytenkolonie erregender faktor |
| US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
| US5109119A (en) | 1989-06-06 | 1992-04-28 | Schering Corporation | Crystalline r-h-gm-csf and method |
| IE66494B1 (en) | 1989-09-26 | 1996-01-10 | Immunex Corp | Granulocyte-colony stimulating factor receptors |
| JPH04502164A (ja) | 1989-10-10 | 1992-04-16 | アムジエン・インコーポレーテツド | 犬科・猫科動物における感染の治療または予防のための化学組成物及び方法 |
| US5265030A (en) | 1990-04-24 | 1993-11-23 | Scripps Clinic And Research Foundation | System and method for determining three-dimensional structures of proteins |
| GB9107846D0 (en) | 1990-04-30 | 1991-05-29 | Ici Plc | Polypeptides |
| US5399345A (en) | 1990-05-08 | 1995-03-21 | Boehringer Mannheim, Gmbh | Muteins of the granulocyte colony stimulating factor |
| DE4014750A1 (de) | 1990-05-08 | 1991-11-14 | Boehringer Mannheim Gmbh | Muteine des granulozyten-stimulierenden faktors (g-csf) |
| JP3249147B2 (ja) | 1990-06-01 | 2002-01-21 | キリン−アムジエン・インコーポレーテツド | 生理活性蛋白含有経口製剤 |
| IE912365A1 (en) | 1990-07-23 | 1992-01-29 | Zeneca Ltd | Continuous release pharmaceutical compositions |
| AU651152B2 (en) | 1990-08-29 | 1994-07-14 | Genetics Institute, Llc | Multidomain hematopoiesis stimulators |
| US5124297A (en) | 1990-12-07 | 1992-06-23 | Amoco Corporation | Olefin polymerization and copolymerization catalyst |
| DE4105480A1 (de) | 1991-02-21 | 1992-08-27 | Boehringer Mannheim Gmbh | Verbesserte aktivierung von rekombinanten proteinen |
| US6565841B1 (en) | 1991-03-15 | 2003-05-20 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| US5157736A (en) | 1991-04-19 | 1992-10-20 | International Business Machines Corporation | Apparatus and method for optical recognition of chemical graphics |
| ATE196548T1 (de) | 1991-05-10 | 2000-10-15 | Genentech Inc | Auswählen von agonisten und antagonisten von liganden |
| US5386507A (en) | 1991-07-18 | 1995-01-31 | Teig; Steven L. | Computer graphics system for selectively modelling molecules and investigating the chemical and physical properties thereof |
| US5281698A (en) | 1991-07-23 | 1994-01-25 | Cetus Oncology Corporation | Preparation of an activated polymer ester for protein conjugation |
| AU666866B2 (en) | 1991-08-30 | 1996-02-29 | Fred Hutchinson Cancer Research Center | Hybrid cytokines |
| JP2638359B2 (ja) | 1991-11-26 | 1997-08-06 | 富士通株式会社 | 分子動力学法の拘束条件作成装置 |
| JPH08507916A (ja) | 1992-06-09 | 1996-08-27 | カイロン コーポレイション | Ｍ−ｃｓｆの結晶化 |
| ZA933926B (en) | 1992-06-17 | 1994-01-03 | Amgen Inc | Polyoxymethylene-oxyethylene copolymers in conjuction with blomolecules |
| US5772992A (en) | 1992-11-24 | 1998-06-30 | G.D. Searle & Co. | Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors |
| US6153183A (en) | 1992-11-24 | 2000-11-28 | G. D. Searle & Company | Co-administration of interleukin-3 mutant polypeptides with CSF's or cytokines for multi-lineage hematopoietic cell production |
| DK0672145T3 (da) | 1992-11-24 | 2003-08-11 | Searle & Co | Interleukin-3-(IL-3)-polypeptider med flere mutationer |
| US6057133A (en) | 1992-11-24 | 2000-05-02 | G. D. Searle | Multivariant human IL-3 fusion proteins and their recombinant production |
| US5738849A (en) | 1992-11-24 | 1998-04-14 | G. D. Searle & Co. | Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them |
| US5424963A (en) | 1992-11-25 | 1995-06-13 | Photon Research Associates, Inc. | Molecular dynamics simulation method and apparatus |
| US5581476A (en) | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
| DE69521880T2 (de) | 1994-02-08 | 2002-01-03 | Amgen Inc., Thousand Oaks | Orales verabreichungssystem von chemischmodifizierten proteinen g-csf |
| EP0744409B9 (de) | 1994-02-23 | 2009-08-19 | Kyowa Hakko Kogyo Co., Ltd | Beschleuniger des plättchenwachstums |
| US5635599A (en) | 1994-04-08 | 1997-06-03 | The United States Of America As Represented By The Department Of Health And Human Services | Fusion proteins comprising circularly permuted ligands |
| US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| WO1996023888A1 (en) | 1995-02-03 | 1996-08-08 | G.D. Searle & Co. | NOVEL c-MPL LIGANDS |
| US6017523A (en) | 1995-06-06 | 2000-01-25 | G.D. Searle & Co. | Therapeutic methods employing mutant human interleukin-3 (IL-3) polypeptides |
| US6100070A (en) | 1995-10-05 | 2000-08-08 | G. D. Searle & Co. | G-CSF receptor agonists |
| US6066318A (en) | 1995-10-05 | 2000-05-23 | G.D. Searle & Co. | Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors |
| EP0870027A1 (de) | 1995-10-05 | 1998-10-14 | G.D. Searle & Co. | C-mpl rezeptoragonisten |
| CA2234042A1 (en) | 1995-10-05 | 1997-04-10 | G.D. Searle & Co. | Novel g-csf receptor agonists |
| BRPI9610977A2 (pt) | 1995-10-05 | 2019-09-17 | Searle & Co | agonistas receptores hematopoiéticos multi-funcionais |
| US5969105A (en) | 1996-10-25 | 1999-10-19 | Feng; Yiqing | Stem cell factor receptor agonists |
| US6660257B1 (en) | 1996-10-25 | 2003-12-09 | Pharmacia Corporation | Circular permuteins of flt3 ligand |
| RO120919B1 (ro) | 1996-10-25 | 2006-09-29 | G.D. Searle & Co. | Proteină hematopoietină, moleculă de acid nucleiccare o codifică, compoziţie farmaceutică şi utilizarea proteinei |
| AU751498B2 (en) | 1997-04-11 | 2002-08-15 | G.D. Searle & Co. | flt3 ligand chimeric proteins |
| KR100241257B1 (ko) | 1997-05-22 | 2000-02-01 | 한승수 | 인체 과립구 콜로니 자극 인자 활성물질 및 그것의 제조방법 |
| ATE469166T1 (de) | 1997-06-06 | 2010-06-15 | Kyowa Hakko Kirin Co Ltd | Chemisch modifizierte polypeptide |
| ATE375363T1 (de) | 1997-07-14 | 2007-10-15 | Bolder Biotechnology Inc | Derivate des wachstumshormons und verwandte proteine |
| US5985263A (en) | 1997-12-19 | 1999-11-16 | Enzon, Inc. | Substantially pure histidine-linked protein polymer conjugates |
| US6451986B1 (en) | 1998-06-22 | 2002-09-17 | Immunex Corporation | Site specific protein modification |
| AU6246599A (en) | 1998-09-25 | 2000-04-17 | G.D. Searle & Co. | Method of producing permuteins by scanning permutagenesis |
| US6420339B1 (en) | 1998-10-14 | 2002-07-16 | Amgen Inc. | Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility |
| AU770131B2 (en) | 1999-01-06 | 2004-02-12 | Xencor, Inc. | Nucleic acids and proteins corresponding to mutants of G-CSF with granulopoietic activity |
| WO2000044785A1 (en) | 1999-01-29 | 2000-08-03 | F. Hoffmann-La Roche Ag | Gcsf conjugates |
| JP2000319298A (ja) | 1999-03-04 | 2000-11-21 | Seibutsu Bunshi Kogaku Kenkyusho:Kk | 蛋白質複合体の結晶、構造座標、及び構造座標の使用 |
| KR100356140B1 (ko) | 1999-07-08 | 2002-10-19 | 한미약품공업 주식회사 | 인간 과립구 콜로니 자극인자 변이체 및 이의 생산 방법 |
| US6831158B2 (en) | 2000-01-10 | 2004-12-14 | Maxygen Holdings Ltd. | G-CSF conjugates |
| HUP0203751A3 (en) * | 2000-01-10 | 2005-01-28 | Maxygen Holdings Ltd Redwood C | G-csf conjugates |
| US6646110B2 (en) | 2000-01-10 | 2003-11-11 | Maxygen Holdings Ltd. | G-CSF polypeptides and conjugates |
| US6555660B2 (en) | 2000-01-10 | 2003-04-29 | Maxygen Holdings Ltd. | G-CSF conjugates |
| AU2001288220A1 (en) | 2000-09-07 | 2002-03-22 | Eli Lilly And Company | Hyperglycosylated polypeptides |
| AU9084601A (en) | 2000-09-08 | 2002-03-22 | Massachusetts Inst Technology | G-csf analog compositions and methods |
| GB0022877D0 (en) | 2000-09-18 | 2000-11-01 | Isis Innovation | Analogues |
| WO2002036626A1 (en) | 2000-11-02 | 2002-05-10 | Maxygen Aps | Single-chain multimeric polypeptides |
| US20020142964A1 (en) | 2000-11-02 | 2002-10-03 | Nissen Torben Lauesgaard | Single-chain polypeptides |
| EP1346282A1 (de) * | 2000-12-11 | 2003-09-24 | Koninklijke Philips Electronics N.V. | Signalverarbeitungseinrichtung und verfahren zum zuführen eines signalverarbeitungsergebnisses zu mehreren registern |
| KR100961859B1 (ko) | 2001-07-11 | 2010-06-09 | 맥시겐 홀딩스 엘티디 | 지-씨에스에프 접합체 |
| KR20080027291A (ko) | 2005-06-01 | 2008-03-26 | 맥시겐 홀딩스 엘티디 | 피이지화된 지-씨에스에프 폴리펩타이드 및 그 제조방법 |
-
2006
- 2006-05-26 KR KR1020077030982A patent/KR20080027291A/ko not_active Abandoned
- 2006-05-26 AU AU2006254543A patent/AU2006254543A1/en not_active Abandoned
- 2006-05-26 CN CN2006800195588A patent/CN101193658B/zh not_active Expired - Fee Related
- 2006-05-26 WO PCT/DK2006/000292 patent/WO2006128460A2/en not_active Ceased
- 2006-05-26 AT AT06722962T patent/ATE500847T1/de not_active IP Right Cessation
- 2006-05-26 RU RU2007149238/13A patent/RU2007149238A/ru not_active Application Discontinuation
- 2006-05-26 EP EP06722962A patent/EP1888119B1/de not_active Expired - Lifetime
- 2006-05-26 US US11/420,546 patent/US7381805B2/en not_active Expired - Fee Related
- 2006-05-26 CA CA2607844A patent/CA2607844C/en not_active Expired - Fee Related
- 2006-05-26 MX MX2007015156A patent/MX2007015156A/es unknown
- 2006-05-26 JP JP2008513928A patent/JP5137821B2/ja not_active Expired - Fee Related
- 2006-05-26 BR BRPI0611221-8A patent/BRPI0611221A2/pt not_active IP Right Cessation
- 2006-05-26 DE DE602006020562T patent/DE602006020562D1/de not_active Expired - Lifetime
- 2006-09-18 US US11/532,818 patent/US20070014763A1/en not_active Abandoned
- 2006-09-18 US US11/532,808 patent/US20070014762A1/en not_active Abandoned
-
2007
- 2007-04-30 US US11/742,551 patent/US20080167218A1/en not_active Abandoned
- 2007-04-30 US US11/742,445 patent/US7655766B2/en not_active Expired - Fee Related
- 2007-10-30 IL IL187009A patent/IL187009A0/en unknown
- 2007-11-08 NO NO20075708A patent/NO20075708L/no not_active Application Discontinuation
- 2007-11-12 ZA ZA200709704A patent/ZA200709704B/xx unknown
-
2012
- 2012-08-06 JP JP2012173959A patent/JP2013010765A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006128460A2 (en) | 2006-12-07 |
| US20080090764A1 (en) | 2008-04-17 |
| WO2006128460A3 (en) | 2007-03-01 |
| JP2008542311A (ja) | 2008-11-27 |
| IL187009A0 (en) | 2008-02-09 |
| US20070014762A1 (en) | 2007-01-18 |
| EP1888119B1 (de) | 2011-03-09 |
| NO20075708L (no) | 2008-02-27 |
| CN101193658A (zh) | 2008-06-04 |
| US7655766B2 (en) | 2010-02-02 |
| US20070014763A1 (en) | 2007-01-18 |
| CA2607844A1 (en) | 2006-12-07 |
| US20080167218A1 (en) | 2008-07-10 |
| MX2007015156A (es) | 2008-02-15 |
| CN101193658B (zh) | 2011-08-31 |
| BRPI0611221A2 (pt) | 2010-08-24 |
| US20070009478A1 (en) | 2007-01-11 |
| RU2007149238A (ru) | 2009-07-20 |
| KR20080027291A (ko) | 2008-03-26 |
| CA2607844C (en) | 2012-07-10 |
| DE602006020562D1 (de) | 2011-04-21 |
| US7381805B2 (en) | 2008-06-03 |
| JP5137821B2 (ja) | 2013-02-06 |
| AU2006254543A1 (en) | 2006-12-07 |
| EP1888119A2 (de) | 2008-02-20 |
| JP2013010765A (ja) | 2013-01-17 |
| ZA200709704B (en) | 2008-11-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20075708L (no) | Pegylert G-CSF-polypeptider og fremgangsmater for fremstilling av samme | |
| ATE448686T1 (de) | Actriib-fusionspolypeptide und verwendungen dafür | |
| DE60125381D1 (de) | Zusammensetzungen und verfahren mit analogen von g-csf | |
| IL226857A (en) | Recombinant proteins that underwent glycosylation at site n correspond to prokaryotes | |
| DK1638586T3 (da) | Synergistisk sammensætning til behandling af diabetes mellitus | |
| ATE540973T1 (de) | Zusammensetzungen und verfahren zur verwendung von mgd-cdf zur krankheitsbehandlung | |
| SG131109A1 (en) | Muteins of tear lipocalin | |
| MX2009005455A (es) | (r)-n-estereoisomeros de analogos de 7,8-saturados-4,5 epoxi-morfinano. | |
| IN2015DN02553A (de) | ||
| MX336807B (es) | Composiciones y metodos para producir una composicion. | |
| WO2006031811A3 (en) | Glycopegylated interferon alpha | |
| EP2402369A3 (de) | Peptidfragmente zur Induzierung der Synthese extrazellulärer Matrixproteine | |
| MXPA05014082A (es) | Acidos biariloximetilarenocarboxilicos. | |
| MX2008012748A (es) | Un proceso para la concentracion de un polipeptido. | |
| EP1505990A4 (de) | Verfahren zur behandlung von hepatitis | |
| BRPI0811320A2 (pt) | Surfactantes reconstituídos com propriedades melhoradas | |
| RU2013126581A (ru) | Мутанты стрептокиназы и их ковалентно модифицированные формы | |
| TW200505939A (en) | Process for production of cyclic peptides | |
| WO2003029418A3 (en) | Proliferation and differentiation of stem cells using extracellular matrix and other molecules | |
| DE602005001688D1 (de) | Aufbereitung von Aldesleukin zur pharmazeutischen Verwendung | |
| WO2007013358A3 (en) | Vivit polypeptides, therapeutic agent comprising the same, and method of screening for anti-cancer agent | |
| ATE554793T1 (de) | Konjugat | |
| WO2005040210A3 (en) | Novel cxcl8 antagonists | |
| ZA200507966B (en) | A method for oxygen regulated production of recombinant staphylokinase | |
| NZ593774A (en) | Systems and methods for identifying Replikin scaffolds and uses of said Replikin scaffolds |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |