ATE500847T1 - Pegylierte g-csf-polypeptide und herstellungsverfahren dafür - Google Patents
Pegylierte g-csf-polypeptide und herstellungsverfahren dafürInfo
- Publication number
- ATE500847T1 ATE500847T1 AT06722962T AT06722962T ATE500847T1 AT E500847 T1 ATE500847 T1 AT E500847T1 AT 06722962 T AT06722962 T AT 06722962T AT 06722962 T AT06722962 T AT 06722962T AT E500847 T1 ATE500847 T1 AT E500847T1
- Authority
- AT
- Austria
- Prior art keywords
- pegylated
- csf polypeptides
- csf
- production method
- polypeptide
- Prior art date
Links
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 title abstract 4
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
- 210000000440 neutrophil Anatomy 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68672605P | 2005-06-01 | 2005-06-01 | |
| PCT/DK2006/000292 WO2006128460A2 (en) | 2005-06-01 | 2006-05-26 | Pegylated g-csf polypeptides and methods of producing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE500847T1 true ATE500847T1 (de) | 2011-03-15 |
Family
ID=37308965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06722962T ATE500847T1 (de) | 2005-06-01 | 2006-05-26 | Pegylierte g-csf-polypeptide und herstellungsverfahren dafür |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US7381805B2 (de) |
| EP (1) | EP1888119B1 (de) |
| JP (2) | JP5137821B2 (de) |
| KR (1) | KR20080027291A (de) |
| CN (1) | CN101193658B (de) |
| AT (1) | ATE500847T1 (de) |
| AU (1) | AU2006254543A1 (de) |
| BR (1) | BRPI0611221A2 (de) |
| CA (1) | CA2607844C (de) |
| DE (1) | DE602006020562D1 (de) |
| IL (1) | IL187009A0 (de) |
| MX (1) | MX2007015156A (de) |
| NO (1) | NO20075708L (de) |
| RU (1) | RU2007149238A (de) |
| WO (1) | WO2006128460A2 (de) |
| ZA (1) | ZA200709704B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7381805B2 (en) | 2005-06-01 | 2008-06-03 | Maxygen Holdings, Ltd. | Compositions comprising mixtures of positional PEG isomers of PEGylated G-CSF |
| DK2197919T3 (da) * | 2007-08-27 | 2014-07-07 | Ratiopharm Gmbh | Flydende formulering af g-csf-konjugat |
| RU2011115187A (ru) * | 2008-09-19 | 2012-10-27 | Максиджен, Инк. (Us) | Способ лечения индуцированной радиацией нейтропении путем введения множественно конъюгированного с полиэтиленгликолем варианта гранулоцитарного колониестимулирущего фактора (г-ксф) |
| US7914828B2 (en) * | 2008-10-17 | 2011-03-29 | Levine Brian M | Combination herbal product to benefit respiratory tract |
| WO2011041376A1 (en) * | 2009-09-30 | 2011-04-07 | Prolong Pharmaceuticals | Modified granulocyte colony stimulating factor (g-csf) |
| US20120213728A1 (en) * | 2009-10-30 | 2012-08-23 | Merck | Granulocyte-colony stimulating factor produced in glycoengineered pichia pastoris |
| TWI480288B (zh) * | 2010-09-23 | 2015-04-11 | Lilly Co Eli | 牛顆粒細胞群落刺激因子及其變體之調配物 |
| WO2012064845A2 (en) * | 2010-11-09 | 2012-05-18 | Nektar Therapeutics | G-csf polymer conjugates having a releasable linkage |
| US20140187488A1 (en) * | 2011-05-17 | 2014-07-03 | Bristol-Myers Squibb Company | Methods for maintaining pegylation of polypeptides |
| CN104109199B (zh) * | 2013-04-16 | 2019-04-30 | 深圳未名新鹏生物医药有限公司 | 一种聚乙二醇单修饰的人粒细胞集落刺激因子的制备方法及其产品 |
| JP2018519359A (ja) * | 2015-06-11 | 2018-07-19 | アンビオ ファーマシューティカルズ，エルエルシー | Ｐｅｇ化顆粒球コロニー刺激因子（ｇｃｓｆ） |
| KR102020995B1 (ko) * | 2017-10-30 | 2019-09-16 | 한국코러스 주식회사 | 콜로니자극인자와 폴리올이 접합된 접합물을 고수율로 제조하는 방법 |
| US20210386680A1 (en) * | 2018-12-06 | 2021-12-16 | Board Of Regents, The University Of Texas System | Selectively cleavable therapeutic nanoparticles |
| CN114853872B (zh) * | 2022-04-27 | 2023-11-17 | 山东新时代药业有限公司 | 一种聚乙二醇修饰rhG-CSF的制备方法 |
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-
2006
- 2006-05-26 US US11/420,546 patent/US7381805B2/en not_active Expired - Fee Related
- 2006-05-26 BR BRPI0611221-8A patent/BRPI0611221A2/pt not_active IP Right Cessation
- 2006-05-26 MX MX2007015156A patent/MX2007015156A/es unknown
- 2006-05-26 JP JP2008513928A patent/JP5137821B2/ja not_active Expired - Fee Related
- 2006-05-26 AT AT06722962T patent/ATE500847T1/de not_active IP Right Cessation
- 2006-05-26 AU AU2006254543A patent/AU2006254543A1/en not_active Abandoned
- 2006-05-26 EP EP06722962A patent/EP1888119B1/de not_active Not-in-force
- 2006-05-26 CA CA2607844A patent/CA2607844C/en not_active Expired - Fee Related
- 2006-05-26 CN CN2006800195588A patent/CN101193658B/zh not_active Expired - Fee Related
- 2006-05-26 KR KR1020077030982A patent/KR20080027291A/ko not_active Abandoned
- 2006-05-26 DE DE602006020562T patent/DE602006020562D1/de active Active
- 2006-05-26 WO PCT/DK2006/000292 patent/WO2006128460A2/en not_active Ceased
- 2006-05-26 RU RU2007149238/13A patent/RU2007149238A/ru not_active Application Discontinuation
- 2006-09-18 US US11/532,818 patent/US20070014763A1/en not_active Abandoned
- 2006-09-18 US US11/532,808 patent/US20070014762A1/en not_active Abandoned
-
2007
- 2007-04-30 US US11/742,551 patent/US20080167218A1/en not_active Abandoned
- 2007-04-30 US US11/742,445 patent/US7655766B2/en not_active Expired - Fee Related
- 2007-10-30 IL IL187009A patent/IL187009A0/en unknown
- 2007-11-08 NO NO20075708A patent/NO20075708L/no not_active Application Discontinuation
- 2007-11-12 ZA ZA200709704A patent/ZA200709704B/xx unknown
-
2012
- 2012-08-06 JP JP2012173959A patent/JP2013010765A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20080090764A1 (en) | 2008-04-17 |
| JP2013010765A (ja) | 2013-01-17 |
| KR20080027291A (ko) | 2008-03-26 |
| US20070009478A1 (en) | 2007-01-11 |
| CN101193658A (zh) | 2008-06-04 |
| BRPI0611221A2 (pt) | 2010-08-24 |
| US7655766B2 (en) | 2010-02-02 |
| AU2006254543A1 (en) | 2006-12-07 |
| NO20075708L (no) | 2008-02-27 |
| JP2008542311A (ja) | 2008-11-27 |
| US7381805B2 (en) | 2008-06-03 |
| JP5137821B2 (ja) | 2013-02-06 |
| ZA200709704B (en) | 2008-11-26 |
| EP1888119A2 (de) | 2008-02-20 |
| US20070014762A1 (en) | 2007-01-18 |
| MX2007015156A (es) | 2008-02-15 |
| CA2607844C (en) | 2012-07-10 |
| IL187009A0 (en) | 2008-02-09 |
| US20070014763A1 (en) | 2007-01-18 |
| WO2006128460A2 (en) | 2006-12-07 |
| CA2607844A1 (en) | 2006-12-07 |
| RU2007149238A (ru) | 2009-07-20 |
| DE602006020562D1 (de) | 2011-04-21 |
| WO2006128460A3 (en) | 2007-03-01 |
| US20080167218A1 (en) | 2008-07-10 |
| CN101193658B (zh) | 2011-08-31 |
| EP1888119B1 (de) | 2011-03-09 |
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