ATE501134T1 - Indazole mit analgetischer aktivität - Google Patents

Indazole mit analgetischer aktivität

Info

Publication number
ATE501134T1
ATE501134T1 AT04729106T AT04729106T ATE501134T1 AT E501134 T1 ATE501134 T1 AT E501134T1 AT 04729106 T AT04729106 T AT 04729106T AT 04729106 T AT04729106 T AT 04729106T AT E501134 T1 ATE501134 T1 AT E501134T1
Authority
AT
Austria
Prior art keywords
indazoles
analgesic activity
analgesic
activity
Prior art date
Application number
AT04729106T
Other languages
English (en)
Inventor
Maria Alisi
Nicola Cazzolla
Guido Furlotti
Angelo Guglielmotti
Lorenzo Polenzani
Original Assignee
Acraf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acraf filed Critical Acraf
Application granted granted Critical
Publication of ATE501134T1 publication Critical patent/ATE501134T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT04729106T 2003-05-15 2004-04-23 Indazole mit analgetischer aktivität ATE501134T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000972A ITMI20030972A1 (it) 2003-05-15 2003-05-15 Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende.
PCT/EP2004/004390 WO2004101548A1 (en) 2003-05-15 2004-04-23 Indazole having analgesic activity ,

Publications (1)

Publication Number Publication Date
ATE501134T1 true ATE501134T1 (de) 2011-03-15

Family

ID=33446432

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04729106T ATE501134T1 (de) 2003-05-15 2004-04-23 Indazole mit analgetischer aktivität

Country Status (21)

Country Link
US (2) US7662836B2 (de)
EP (1) EP1622892B1 (de)
JP (1) JP4865559B2 (de)
KR (1) KR101093048B1 (de)
CN (1) CN100364988C (de)
AR (1) AR044317A1 (de)
AT (1) ATE501134T1 (de)
AU (1) AU2004238449B2 (de)
CA (1) CA2519733C (de)
DE (1) DE602004031726D1 (de)
DK (1) DK1622892T3 (de)
EA (1) EA008499B1 (de)
ES (1) ES2359242T3 (de)
GE (1) GEP20074183B (de)
IL (1) IL170769A (de)
IT (1) ITMI20030972A1 (de)
MX (1) MXPA05012297A (de)
PL (1) PL1622892T3 (de)
SI (1) SI1622892T1 (de)
UA (1) UA80605C2 (de)
WO (1) WO2004101548A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20031468A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
ITMI20062230A1 (it) * 2006-11-22 2008-05-23 Acraf Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende
UA99927C2 (uk) * 2007-11-12 2012-10-25 Ацьенде Кимике Риуните Анджелини Франческо А.Чи.Р.А.Ф. С.П.А. Медикамент, який є активним при невропатичному болі
KR101646093B1 (ko) 2008-07-29 2016-08-05 아지엔드 키미쉐 리유나이트 안젤리니 프란체스코 에이.씨.알.에이.에프. 에스.피.에이 세로토닌 활성을 가진 화합물, 이의 제조 방법 및 이를 포함하는 약학적 조성물
EA024939B1 (ru) 2012-02-21 2016-11-30 Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А. 1h-индазол-3-карбоксамидные соединения в качестве ингибиторов гликогенсинтазы киназы 3-бета
WO2013124169A1 (en) * 2012-02-21 2013-08-29 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Use of 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
ES2913975T3 (es) 2018-05-07 2022-06-07 Acraf Compuestos de 1H-indazol-3-carboxamida como inhibidores de la glucógeno sintasa cinasa-3 beta

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6017931A (en) 1994-03-01 2000-01-25 Fmc Corporation Insecticidal compositions containing n-(substituted phenylmethyl)-4-[bis(substituted phenyl)methyl]piperidines
US5654320A (en) * 1995-03-16 1997-08-05 Eli Lilly And Company Indazolecarboxamides
WO1996038420A1 (en) * 1995-05-31 1996-12-05 Nisshin Flour Milling Co., Ltd. Indazole derivatives having monocyclic amino group
CN1093801C (zh) * 1995-11-08 2002-11-06 东丽株式会社 直接成像型无水平版印刷版原版
WO1998007728A1 (en) 1996-08-16 1998-02-26 Smithkline Beecham Plc PROCESS FOR THE PREPARATION OF N-[(1-nBUTYL-4-PIPERIDYL)METHYL] -3,4-DIHYDRO -2H-[1,3] OXAZINO[3,2-a] INDOLE-10-CARBOXAMIDE AND SALTS AND INTERMEDIATES IN THE PROCESS
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
US6339087B1 (en) * 1997-08-18 2002-01-15 Syntex (U.S.A.) Llc Cyclic amine derivatives-CCR-3 receptor antagonists
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
DE10132746A1 (de) * 2001-07-05 2003-02-06 Gruenenthal Gmbh Substituierte 1-Phenethylpiperidinverbindungen
AU2002353186A1 (en) * 2001-12-19 2003-06-30 Smithkline Beecham P.L.C. (1-h-indazol-3-yl) -amide derivatives as gsk-3 inhibitors

Also Published As

Publication number Publication date
IL170769A0 (en) 2009-02-11
AU2004238449A1 (en) 2004-11-25
IL170769A (en) 2012-05-31
JP2006528212A (ja) 2006-12-14
ES2359242T3 (es) 2011-05-19
EP1622892B1 (de) 2011-03-09
DE602004031726D1 (de) 2011-04-21
CN1777597A (zh) 2006-05-24
DK1622892T3 (da) 2011-06-27
EA200501818A1 (ru) 2006-06-30
CN100364988C (zh) 2008-01-30
PL1622892T3 (pl) 2011-08-31
US20100094015A1 (en) 2010-04-15
US8415476B2 (en) 2013-04-09
EA008499B1 (ru) 2007-06-29
HK1087705A1 (en) 2006-10-20
US20070010555A1 (en) 2007-01-11
WO2004101548A1 (en) 2004-11-25
JP4865559B2 (ja) 2012-02-01
GEP20074183B (en) 2007-08-10
AU2004238449B2 (en) 2010-09-02
CA2519733C (en) 2011-11-29
EP1622892A1 (de) 2006-02-08
MXPA05012297A (es) 2006-01-30
KR20060009937A (ko) 2006-02-01
UA80605C2 (en) 2007-10-10
CA2519733A1 (en) 2004-11-25
SI1622892T1 (sl) 2011-06-30
US7662836B2 (en) 2010-02-16
KR101093048B1 (ko) 2011-12-13
AR044317A1 (es) 2005-09-07
ITMI20030972A1 (it) 2004-11-16

Similar Documents

Publication Publication Date Title
IS2672B (is) Asíþrómýsín lyfjaskammtaform með minni hliðarverkanir
FI7658U1 (fi) Otorinologinen antolaite
EP1691718A4 (de) Therapeutische mikroteilchen
EP1597276A4 (de) Therapeutische moleküle
IL182397A0 (en) Thiazolyl-dihydro indazoles
DE60329912D1 (de) Ausgabe-behälter
DE602004016590D1 (de) Einspritzventil
EP1612795A4 (de) Editionseinrichtung
DK1597171T3 (da) Terapeutisk mikroskum
FI20040855A0 (fi) Tuloilmalaite
DE50304722D1 (de) Fungizide Wirkstoffkombinationen
DK1594859T3 (da) Indazolamider med analgetisk aktivitet
DK1622892T3 (da) Indazoler med analgetisk aktivitet
DE602005019913D1 (de) Therapeutische pyrazoloä3,4-büpyridine und -indazole
DE502004005095D1 (de) Einspritzdüse
DE502004009781D1 (de) Einspritzventil
DE50313605D1 (de) Versorgungsleitungsstruktur
FI20040569A0 (fi) Tuloilmalaite
DE502004005873D1 (de) Einspritzdüse
DE502004004640D1 (de) Verschwenkvorrichtung
DE602004030419D1 (de) Flüssigkeitsinjektor
SE0403119D0 (sv) Therapeutic agents
SE0400718D0 (sv) Therapeutic agents
ATA862002A (de) Schraubverschluss
NO20030754D0 (no) Nöd-slepeline

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1622892

Country of ref document: EP