ITMI20062230A1 - Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende - Google Patents

Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende

Info

Publication number
ITMI20062230A1
ITMI20062230A1 IT002230A ITMI20062230A ITMI20062230A1 IT MI20062230 A1 ITMI20062230 A1 IT MI20062230A1 IT 002230 A IT002230 A IT 002230A IT MI20062230 A ITMI20062230 A IT MI20062230A IT MI20062230 A1 ITMI20062230 A1 IT MI20062230A1
Authority
IT
Italy
Prior art keywords
indazolic
alchil
preparation
pharmaceutical composition
compound procedure
Prior art date
Application number
IT002230A
Other languages
English (en)
Inventor
Maria Alessandra Alisi
Nicola Cazzolla
Guido Furlotti
Caterina Maugeri
Rosella Ombrato
Lorenzo Polenzani
Original Assignee
Acraf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acraf filed Critical Acraf
Priority to IT002230A priority Critical patent/ITMI20062230A1/it
Priority to SG2011085891A priority patent/SG176504A1/en
Priority to PCT/EP2007/010000 priority patent/WO2008061688A1/en
Priority to JP2009537521A priority patent/JP5551443B2/ja
Priority to EA200970496A priority patent/EA019217B1/ru
Priority to PL07846673T priority patent/PL2099780T3/pl
Priority to AU2007323368A priority patent/AU2007323368B2/en
Priority to MX2009005250A priority patent/MX2009005250A/es
Priority to KR1020097012960A priority patent/KR101471987B1/ko
Priority to CA2668205A priority patent/CA2668205C/en
Priority to US12/516,091 priority patent/US8507528B2/en
Priority to BRPI0718976-1A priority patent/BRPI0718976A2/pt
Priority to GEAP200711320A priority patent/GEP20125414B/en
Priority to SI200731154T priority patent/SI2099780T1/sl
Priority to PT78466737T priority patent/PT2099780E/pt
Priority to ES07846673T priority patent/ES2401199T3/es
Priority to HK09108893.2A priority patent/HK1129112B/en
Priority to EP07846673A priority patent/EP2099780B1/en
Priority to DK07846673.7T priority patent/DK2099780T3/da
Priority to UAA200905092A priority patent/UA98311C2/ru
Priority to CN2007800433966A priority patent/CN101558057B/zh
Priority to ARP070105165A priority patent/AR063881A1/es
Publication of ITMI20062230A1 publication Critical patent/ITMI20062230A1/it
Priority to IL198432A priority patent/IL198432A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
IT002230A 2006-11-22 2006-11-22 Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende ITMI20062230A1 (it)

Priority Applications (23)

Application Number Priority Date Filing Date Title
IT002230A ITMI20062230A1 (it) 2006-11-22 2006-11-22 Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende
GEAP200711320A GEP20125414B (en) 2006-11-22 2007-11-19 2 -alkyl- indazole compounds for the treatment of certain cns-related disorders
BRPI0718976-1A BRPI0718976A2 (pt) 2006-11-22 2007-11-19 Composto de 2-alquil-indazol, método para preparar o mesmo, intermediário, composição farmacêutica, e, uso de uma composição farmacêutica
JP2009537521A JP5551443B2 (ja) 2006-11-22 2007-11-19 特定のｃｎｓに関係した障害を治療するための２−アルキル−インダゾール化合物
EA200970496A EA019217B1 (ru) 2006-11-22 2007-11-19 Соединения 2-алкилиндазола для лечения некоторых расстройств цнс
PL07846673T PL2099780T3 (pl) 2006-11-22 2007-11-19 Związki 2-alkiloindazolu do leczenia określonych zaburzeń związanych z ośrodkowym układem nerwowym
AU2007323368A AU2007323368B2 (en) 2006-11-22 2007-11-19 2 -Alkyl- indazole compounds for the treatment of certain CNS-related disorders
MX2009005250A MX2009005250A (es) 2006-11-22 2007-11-19 Compuestos 2-alquil-indazol para el tratamiento de ciertas enfermedades relacionadas con el sistema nervioso central (cns).
SI200731154T SI2099780T1 (sl) 2006-11-22 2007-11-19 2-alkil-indazolne spojine za zdravljenje določenih motenj, povezanih s CŽS
PCT/EP2007/010000 WO2008061688A1 (en) 2006-11-22 2007-11-19 2 -alkyl- indazole compounds for the treatment of certain cns-related disorders
US12/516,091 US8507528B2 (en) 2006-11-22 2007-11-19 2-alkyl-indazole compounds for the treatment of certain cns-related disorders
SG2011085891A SG176504A1 (en) 2006-11-22 2007-11-19 2 -alkyl- indazole compounds for the treatment of certain cns-related disorders
CA2668205A CA2668205C (en) 2006-11-22 2007-11-19 2-alkyl-indazole compounds for the treatment of certain cns-related disorders
KR1020097012960A KR101471987B1 (ko) 2006-11-22 2007-11-19 일정한 ｃｎｓ-관련 질환을 치료하기 위한 2-알킬-인다졸 화합물
PT78466737T PT2099780E (pt) 2006-11-22 2007-11-19 Compostos de 2-alquilo-indazol para o tratamento de certas desordens relacionadas com o snc
ES07846673T ES2401199T3 (es) 2006-11-22 2007-11-19 Compuestos de 2-alquil-indazol para el tratamiento de determinados trastornos relacionados con el SNC
HK09108893.2A HK1129112B (en) 2006-11-22 2007-11-19 2 -alkyl- indazole compounds for the treatment of certain cns-related disorders
EP07846673A EP2099780B1 (en) 2006-11-22 2007-11-19 2 -alkyl- indazole compounds for the treatment of certain cns-related disorders
DK07846673.7T DK2099780T3 (da) 2006-11-22 2007-11-19 2-alkyl-indazol forbindelser til behandling af visse CNS-relaterede lidelser
UAA200905092A UA98311C2 (ru) 2006-11-22 2007-11-19 Соединение 2-алкилиндазола для лечения определенных расстройств, связанных с цнс, способ его получения (варианты) и фармацевтическая композиция на его основе
CN2007800433966A CN101558057B (zh) 2006-11-22 2007-11-19 用于治疗某些cns-相关病症的2-烷基-吲唑化合物
ARP070105165A AR063881A1 (es) 2006-11-22 2007-11-21 Compuesto de 2-alquil-indazol, procedimiento de preparacion y composicion farmaceutica que lo contiene
IL198432A IL198432A (en) 2006-11-22 2009-04-28 2-alkyl-indazole compounds and pharmaceutical compositions comprising them for the treatment of certain cns-related disorders

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT002230A ITMI20062230A1 (it) 2006-11-22 2006-11-22 Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende

Publications (1)

Publication Number Publication Date
ITMI20062230A1 true ITMI20062230A1 (it) 2008-05-23

Family

ID=38474157

Family Applications (1)

Application Number Title Priority Date Filing Date
IT002230A ITMI20062230A1 (it) 2006-11-22 2006-11-22 Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende

Country Status (22)

Country Link
US (1) US8507528B2 (it)
EP (1) EP2099780B1 (it)
JP (1) JP5551443B2 (it)
KR (1) KR101471987B1 (it)
CN (1) CN101558057B (it)
AR (1) AR063881A1 (it)
AU (1) AU2007323368B2 (it)
BR (1) BRPI0718976A2 (it)
CA (1) CA2668205C (it)
DK (1) DK2099780T3 (it)
EA (1) EA019217B1 (it)
ES (1) ES2401199T3 (it)
GE (1) GEP20125414B (it)
IL (1) IL198432A (it)
IT (1) ITMI20062230A1 (it)
MX (1) MX2009005250A (it)
PL (1) PL2099780T3 (it)
PT (1) PT2099780E (it)
SG (1) SG176504A1 (it)
SI (1) SI2099780T1 (it)
UA (1) UA98311C2 (it)
WO (1) WO2008061688A1 (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA021417B1 (ru) * 2010-04-08 2015-06-30 Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А. Трициклическое индазольное соединение, способ его получения и содержащая его фармацевтическая композиция
AU2012230503B2 (en) 2011-03-18 2016-07-07 Bayer Intellectual Property Gmbh N-(3-carbamoylphenyl)-1H-pyrazole-5-carboxamide derivatives and the use thereof for controlling animal pests
CN114391013B (zh) 2019-09-24 2024-01-26 上海美悦生物科技发展有限公司 一种irak抑制剂及其制备方法和用途

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4436913A (en) * 1980-09-05 1984-03-13 Siegfried Aktiengesellschaft 1H- and 2H- indazole derivatives
GB8623142D0 (en) * 1986-09-26 1986-10-29 Beecham Group Plc Compounds
DE3650772T2 (de) * 1985-04-27 2003-04-03 F. Hoffmann-La Roche Ag, Basel Derivate von Indazole-3-carboxamide und -3-carboxylsäure
JPH02215779A (ja) * 1989-02-14 1990-08-28 Kuraray Co Ltd カルボン酸アミド誘導体類及びその医薬用途
US5246947A (en) * 1991-09-23 1993-09-21 Hoechst-Roussel Pharmaceuticals Incorporated Substituted pyridinylamino-1,2-benzisothiazoles and their use for treating depression
WO1994005642A1 (en) 1992-08-28 1994-03-17 Ciba-Geigy Ag Indazole derivatives
JPH08277287A (ja) * 1995-02-09 1996-10-22 Mitsubishi Chem Corp インダゾール類およびその用途
KR19990022096A (ko) * 1995-05-31 1999-03-25 쇼다 오사무 모노시클릭 아미노기를 갖는 인다졸 유도체
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
US6218390B1 (en) * 1998-12-17 2001-04-17 Synaptic Pharmaceutical Corporation Morpholinone and morpholine derivatives and uses thereof
MXPA05005794A (es) 2002-12-02 2005-08-16 Hoffmann La Roche Derivados de indazol como antagonistas del factor de liberacion de corticotropina.
ITMI20030972A1 (it) * 2003-05-15 2004-11-16 Acraf Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende.
ITMI20031468A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
FR2857966A1 (fr) * 2003-07-24 2005-01-28 Aventis Pharma Sa Produits aryl-heteroaromatiques, compositions les contenant et utilisation
DE602004025508D1 (de) * 2003-12-23 2010-03-25 Serodus As Modulatoren von peripheren 5-ht-rezeptoren
WO2005066163A2 (en) * 2004-01-05 2005-07-21 Astrazeneca Ab Thiophene derivatives as chk 1 inihibitors
AU2005271737A1 (en) * 2004-08-03 2006-02-16 Wyeth Indazoles useful in treating cardiovascular diseases
TW200621237A (en) * 2004-11-01 2006-07-01 Wyeth Corp [(1-h-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1h-indazol-3-yl)methanones
PE20061130A1 (es) * 2004-11-19 2007-01-05 Arena Pharm Inc Derivados de 3-fenil-pirazol como moduladores del receptor de serotonina 5-ht2a
WO2008054748A2 (en) * 2006-10-31 2008-05-08 Arena Pharmaceuticals, Inc. Indazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto

Also Published As

Publication number Publication date
PT2099780E (pt) 2013-03-11
PL2099780T3 (pl) 2013-05-31
BRPI0718976A2 (pt) 2014-02-04
DK2099780T3 (da) 2013-04-15
AU2007323368B2 (en) 2013-02-07
UA98311C2 (ru) 2012-05-10
KR20090089880A (ko) 2009-08-24
AU2007323368A1 (en) 2008-05-29
US20100056573A1 (en) 2010-03-04
EP2099780A1 (en) 2009-09-16
IL198432A (en) 2013-03-24
HK1129112A1 (en) 2009-11-20
KR101471987B1 (ko) 2014-12-12
SI2099780T1 (sl) 2013-03-29
AR063881A1 (es) 2009-02-25
US8507528B2 (en) 2013-08-13
GEP20125414B (en) 2012-03-12
SG176504A1 (en) 2011-12-29
JP5551443B2 (ja) 2014-07-16
CN101558057A (zh) 2009-10-14
EA019217B1 (ru) 2014-02-28
EA200970496A1 (ru) 2009-10-30
JP2010510265A (ja) 2010-04-02
MX2009005250A (es) 2009-05-28
CN101558057B (zh) 2013-05-01
CA2668205A1 (en) 2008-05-29
WO2008061688A1 (en) 2008-05-29
ES2401199T3 (es) 2013-04-17
EP2099780B1 (en) 2013-01-09
CA2668205C (en) 2014-10-21
IL198432A0 (en) 2010-02-17

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