ATE501248T1 - Stabile wässrige systeme mit proteinen - Google Patents
Stabile wässrige systeme mit proteinenInfo
- Publication number
- ATE501248T1 ATE501248T1 AT06764894T AT06764894T ATE501248T1 AT E501248 T1 ATE501248 T1 AT E501248T1 AT 06764894 T AT06764894 T AT 06764894T AT 06764894 T AT06764894 T AT 06764894T AT E501248 T1 ATE501248 T1 AT E501248T1
- Authority
- AT
- Austria
- Prior art keywords
- protein
- ionisable groups
- stabilising
- proteins
- aqueous systems
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 108090000623 proteins and genes Proteins 0.000 title abstract 5
- 239000003381 stabilizer Substances 0.000 abstract 5
- 150000001412 amines Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 238000010494 dissociation reaction Methods 0.000 abstract 1
- 230000005593 dissociations Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0513653.6A GB0513653D0 (en) | 2005-07-02 | 2005-07-02 | Protein stability |
| GBGB0610140.6A GB0610140D0 (en) | 2006-05-22 | 2006-05-22 | Protein stability |
| PCT/GB2006/002470 WO2007003936A1 (en) | 2005-07-02 | 2006-07-03 | Stable aqueous systems comprising proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE501248T1 true ATE501248T1 (de) | 2011-03-15 |
Family
ID=36940697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06764894T ATE501248T1 (de) | 2005-07-02 | 2006-07-03 | Stabile wässrige systeme mit proteinen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20090148406A1 (de) |
| EP (3) | EP2264161A1 (de) |
| JP (1) | JP5033798B2 (de) |
| AT (1) | ATE501248T1 (de) |
| CA (1) | CA2614006C (de) |
| DE (1) | DE602006020568D1 (de) |
| DK (1) | DK1899462T3 (de) |
| WO (1) | WO2007003936A1 (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0610140D0 (en) | 2006-05-22 | 2006-06-28 | Insense Ltd | Protein stability |
| GB2435510A (en) * | 2006-02-23 | 2007-08-29 | Mologic Ltd | Enzyme detection product and methods |
| US20090136538A1 (en) * | 2006-05-22 | 2009-05-28 | Jan Jezek | Stable vaccine formulation |
| GB0626021D0 (en) | 2006-12-29 | 2007-02-07 | Insense Ltd | The stabilisation of proteins |
| GB0700523D0 (en) * | 2007-01-11 | 2007-02-21 | Insense Ltd | The Stabilisation Of Proteins |
| NZ598881A (en) * | 2007-03-29 | 2013-11-29 | Abbvie Inc | Crystalline anti-human il-12 antibodies |
| JP5273438B2 (ja) * | 2007-11-22 | 2013-08-28 | 国立大学法人東京農工大学 | ペプチド付加生体分子の溶解度計算方法、及びそれを用いたペプチドタグの設計方法と封入体形成防止方法 |
| KR20210049186A (ko) * | 2007-11-30 | 2021-05-04 | 애브비 바이오테크놀로지 리미티드 | 단백질 제형 및 이의 제조방법 |
| US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
| US11197916B2 (en) | 2007-12-28 | 2021-12-14 | Takeda Pharmaceutical Company Limited | Lyophilized recombinant VWF formulations |
| WO2009086400A2 (en) * | 2007-12-28 | 2009-07-09 | Baxter International Inc. | Recombinant vwf formulations |
| WO2009133408A2 (en) | 2008-05-01 | 2009-11-05 | Arecor Limited | Protein formulation |
| EP2113564A1 (de) | 2008-05-01 | 2009-11-04 | Arecor Limited | Proteinformulierung |
| WO2010094906A1 (en) * | 2009-07-16 | 2010-08-26 | Arecor Limited | The stabilisation of proteins |
| EP2341940A1 (de) * | 2008-07-16 | 2011-07-13 | Arecor Limited | Stabilisierung von proteinen |
| EP2328607A1 (de) | 2008-07-16 | 2011-06-08 | Arecor Limited | Stabile formulierung eines therapeutischen proteins |
| DK2349314T3 (da) * | 2008-10-21 | 2013-05-27 | Baxter Int | Lyofiliserede præparater af rekombinant VWF |
| MX2011005672A (es) * | 2008-11-28 | 2011-06-20 | Abbott Lab | Composiciones de anticuerpo estables y metodos para estabilizar a las mismas. |
| NZ595694A (en) * | 2009-05-04 | 2013-09-27 | Abbvie Biotechnology Ltd | Stable high protein concentration formulations of human anti-tnf-alpha-antibodies |
| EP3409289B1 (de) | 2010-02-26 | 2020-09-30 | Novo Nordisk A/S | Stabile, antikörperhaltige zusammensetzungen |
| RS59830B1 (sr) | 2010-03-01 | 2020-02-28 | Bayer Healthcare Llc | Optimizovana monoklonska antitela protiv inhibitora puta faktora tkiva (tfpi) |
| RU2012153786A (ru) | 2010-05-28 | 2014-07-10 | Ново Нордиск А/С | Стабильные многодозовые композиции, содержащие антитело и консервант |
| CN103458926B (zh) | 2010-11-11 | 2016-10-26 | 艾伯维生物技术有限公司 | 改进的高浓度抗TNF α 抗体液体制剂 |
| GB201113880D0 (en) * | 2011-08-12 | 2011-09-28 | Archimed Llp | Novel compositions |
| US9592297B2 (en) | 2012-08-31 | 2017-03-14 | Bayer Healthcare Llc | Antibody and protein formulations |
| US8613919B1 (en) | 2012-08-31 | 2013-12-24 | Bayer Healthcare, Llc | High concentration antibody and protein formulations |
| WO2014125237A1 (en) | 2013-02-12 | 2014-08-21 | Microarray Limited | Novel biosensor |
| FR3014446B1 (fr) | 2013-12-10 | 2017-05-26 | Biomerieux Sa | Stabilisation de la gdh en solution aqueuse |
| CN104480095A (zh) * | 2014-11-27 | 2015-04-01 | 广西大学 | 一种酶活力稳定的液态木瓜蛋白酶制剂 |
| US11173197B2 (en) | 2015-07-07 | 2021-11-16 | Bluewillow Biologics, Inc. | Methods and compositions for nanoemulsion vaccine formulations |
| EP3319930A4 (de) * | 2015-07-07 | 2019-04-10 | NanoBio Corporation | Verfahren und zusammensetzungen zur stabilisierung von proteinen |
| WO2017044367A1 (en) | 2015-09-11 | 2017-03-16 | Dow Global Technologies Llc | A composition comprising a protein and a polyalkoxy fatty compound |
| BR112018004394B1 (pt) | 2015-09-11 | 2022-01-18 | Rohm And Haas Company | Composto graxo de polialcóxi, e, método para fabricação de um composto graxo de polialcóxi |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3051627A (en) | 1960-08-18 | 1962-08-28 | Armour Pharma | Stabilized chymotrypsin solution |
| US5981485A (en) * | 1997-07-14 | 1999-11-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
| DE3942141A1 (de) * | 1989-12-20 | 1991-06-27 | Boehringer Mannheim Gmbh | K2p pro-stabilisierung |
| EP0503583A1 (de) * | 1991-03-12 | 1992-09-16 | Takeda Chemical Industries, Ltd. | Erythropoietin enthaltendes Arzneimittel mit verzögerter Wirkstofffreigabe |
| DE4111393A1 (de) * | 1991-04-09 | 1992-10-15 | Behringwerke Ag | Stabilisierte faktor viii-praeparationen |
| IT1247946B (it) | 1991-05-17 | 1995-01-05 | Instrumentation Lab Srl | Stabilizzazione in forma liquida dell'enzima urato ossidasi |
| TW518219B (en) * | 1996-04-26 | 2003-01-21 | Chugai Pharmaceutical Co Ltd | Erythropoietin solution preparation |
| SI0948358T2 (sl) | 1996-12-24 | 2012-03-30 | Biogen Idec Inc | Stabilne tekoče formulacije interferona |
| JP5485489B2 (ja) * | 2000-08-11 | 2014-05-07 | 中外製薬株式会社 | 抗体含有安定化製剤 |
| JP2002125693A (ja) * | 2000-10-19 | 2002-05-08 | Toyobo Co Ltd | 無細胞タンパク質合成用細胞抽出液組成物 |
| EP1409013B1 (de) * | 2001-07-26 | 2009-11-18 | Novartis Vaccines and Diagnostics S.r.l. | Aluminiumadjuvans und histidin enthaltende impstoffe |
| JP2005502945A (ja) * | 2001-08-30 | 2005-01-27 | ボード オブ レジェンツ,ザ ユニバーシティー オブ テキサス システム | タンパク質安定性のpH依存性のアンサンブルに基づく分析 |
| EP1429739A1 (de) * | 2001-09-21 | 2004-06-23 | Egalet A/S | Polymer-freigabe-system |
| RU2357751C2 (ru) * | 2001-12-21 | 2009-06-10 | Ново Нордиск Хелт Кэр Аг | Жидкая композиция полипептидов фактора vii |
| GB0202633D0 (en) * | 2002-02-05 | 2002-03-20 | Delta Biotechnology Ltd | Stabilization of protein preparations |
| ES2615484T3 (es) * | 2002-05-21 | 2017-06-07 | Daiichi Sankyo Company, Limited | Composiciones medicinales que contienen grelina |
| JP2006523609A (ja) * | 2002-12-31 | 2006-10-19 | アルタス ファーマシューティカルズ インコーポレイテッド | タンパク質結晶およびイオン性ポリマーの複合体 |
| EP1643970A2 (de) * | 2003-06-09 | 2006-04-12 | Nastech Pharmaceutical Company Inc. | Zusammensetzungen und verfahren für die verbesserte schleimhautabgabe von wachstumshormon |
| DE10333317A1 (de) * | 2003-07-22 | 2005-02-17 | Biotecon Therapeutics Gmbh | Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA) |
| US20050281879A1 (en) * | 2003-11-14 | 2005-12-22 | Guohua Chen | Excipients in drug delivery vehicles |
| TW200806317A (en) * | 2006-03-20 | 2008-02-01 | Wyeth Corp | Methods for reducing protein aggregation |
-
2006
- 2006-07-03 AT AT06764894T patent/ATE501248T1/de active
- 2006-07-03 DE DE602006020568T patent/DE602006020568D1/de active Active
- 2006-07-03 EP EP10175575A patent/EP2264161A1/de not_active Withdrawn
- 2006-07-03 WO PCT/GB2006/002470 patent/WO2007003936A1/en not_active Ceased
- 2006-07-03 JP JP2008518976A patent/JP5033798B2/ja active Active
- 2006-07-03 EP EP20100175581 patent/EP2264162A1/de not_active Withdrawn
- 2006-07-03 EP EP06764894A patent/EP1899462B1/de not_active Revoked
- 2006-07-03 US US11/994,408 patent/US20090148406A1/en not_active Abandoned
- 2006-07-03 DK DK06764894.9T patent/DK1899462T3/da active
- 2006-07-03 CA CA2614006A patent/CA2614006C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20090148406A1 (en) | 2009-06-11 |
| CA2614006C (en) | 2014-11-04 |
| WO2007003936A1 (en) | 2007-01-11 |
| DE602006020568D1 (de) | 2011-04-21 |
| EP1899462A1 (de) | 2008-03-19 |
| CA2614006A1 (en) | 2007-01-11 |
| EP2264162A1 (de) | 2010-12-22 |
| JP2008544977A (ja) | 2008-12-11 |
| JP5033798B2 (ja) | 2012-09-26 |
| DK1899462T3 (da) | 2011-06-06 |
| EP1899462B1 (de) | 2011-03-09 |
| EP2264161A1 (de) | 2010-12-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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