ATE502031T1 - Carbamatverbindungen, die die durch vla-4 vermittelte leukozytenadhäsion inhibieren - Google Patents

Carbamatverbindungen, die die durch vla-4 vermittelte leukozytenadhäsion inhibieren

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Publication number
ATE502031T1
ATE502031T1 AT06804266T AT06804266T ATE502031T1 AT E502031 T1 ATE502031 T1 AT E502031T1 AT 06804266 T AT06804266 T AT 06804266T AT 06804266 T AT06804266 T AT 06804266T AT E502031 T1 ATE502031 T1 AT E502031T1
Authority
AT
Austria
Prior art keywords
compounds
vla
leukocyte adhesion
carbamat
adhesion mediated
Prior art date
Application number
AT06804266T
Other languages
English (en)
Inventor
Christopher Semko
Ying-Zi Xu
Frank Stappenbeck
Jenifer Lea Smith
Kassandra Inez Rossiter
Juri Y Fukuda
Andrei W Konradi
Original Assignee
Elan Pharm Inc
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc, Wyeth Llc filed Critical Elan Pharm Inc
Application granted granted Critical
Publication of ATE502031T1 publication Critical patent/ATE502031T1/de

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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AT06804266T 2005-09-29 2006-09-28 Carbamatverbindungen, die die durch vla-4 vermittelte leukozytenadhäsion inhibieren ATE502031T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72235505P 2005-09-29 2005-09-29
PCT/US2006/038113 WO2007041324A1 (en) 2005-09-29 2006-09-28 Carbamate compounds which inhibit leukocyte adhesion mediated by vla-4

Publications (1)

Publication Number Publication Date
ATE502031T1 true ATE502031T1 (de) 2011-04-15

Family

ID=37591849

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06804266T ATE502031T1 (de) 2005-09-29 2006-09-28 Carbamatverbindungen, die die durch vla-4 vermittelte leukozytenadhäsion inhibieren

Country Status (11)

Country Link
US (3) US7727996B2 (de)
EP (1) EP1940827B1 (de)
JP (2) JP5081828B2 (de)
CN (1) CN101273035A (de)
AT (1) ATE502031T1 (de)
AU (1) AU2006297180A1 (de)
BR (1) BRPI0616643A2 (de)
CA (2) CA2851103A1 (de)
DE (1) DE602006020754D1 (de)
WO (1) WO2007041324A1 (de)
ZA (1) ZA200803016B (de)

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EP2424841A1 (de) * 2009-04-27 2012-03-07 Elan Pharmaceuticals Inc. Pyridinonantagonisten von alpha-4-integrinen
US20120258093A1 (en) 2009-08-20 2012-10-11 Institut National De La Sante Et De La Recherche Medicale (Inserm) Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy
EP3430053A1 (de) * 2016-03-14 2019-01-23 Millennium Pharmaceuticals, Inc. Verfahren zur behandlung oder prävention von transplantatabstossung
US10590136B2 (en) * 2017-10-04 2020-03-17 Celgene Corporation Processes for the preparation of cis-4-[2-{[(3S,4R)-3-fluorooxan-4-yl]amino}-8-(2,4,6-trichloroanilino)-9H-purin-9-yl]-1-methylcyclohexane-1-carboxamide
CN114302881B (zh) * 2019-08-16 2025-03-25 沃尔克·亚当斯 适用于治疗和预防肌肉萎缩和其他状况的化合物
US20240301512A1 (en) 2021-01-29 2024-09-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of assessing the risk of developing progressive multifocal leukoencephalopathy in patients treated with vla-4 antagonists

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