ATE502050T1 - Von dd 3b6/22 abgeleitete humanisierte antikörper mit spezifität für das d-dimer fragment von fibrin - Google Patents

Von dd 3b6/22 abgeleitete humanisierte antikörper mit spezifität für das d-dimer fragment von fibrin

Info

Publication number
ATE502050T1
ATE502050T1 AT02748417T AT02748417T ATE502050T1 AT E502050 T1 ATE502050 T1 AT E502050T1 AT 02748417 T AT02748417 T AT 02748417T AT 02748417 T AT02748417 T AT 02748417T AT E502050 T1 ATE502050 T1 AT E502050T1
Authority
AT
Austria
Prior art keywords
fibrin
specificity
humanized antibodies
antibodies derived
dimer fragment
Prior art date
Application number
AT02748417T
Other languages
English (en)
Inventor
Francis J Carr
Anita A Hamilton
Original Assignee
Agen Biomedical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agen Biomedical Ltd filed Critical Agen Biomedical Ltd
Application granted granted Critical
Publication of ATE502050T1 publication Critical patent/ATE502050T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
AT02748417T 2001-06-26 2002-06-26 Von dd 3b6/22 abgeleitete humanisierte antikörper mit spezifität für das d-dimer fragment von fibrin ATE502050T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30115401P 2001-06-26 2001-06-26
US30094701P 2001-06-27 2001-06-27
PCT/AU2002/000827 WO2003000736A1 (en) 2001-06-26 2002-06-26 Humanized antibodies derived from dd-3b6/22, specific for the d-dimer fragment of fibrin

Publications (1)

Publication Number Publication Date
ATE502050T1 true ATE502050T1 (de) 2011-04-15

Family

ID=26972062

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02748417T ATE502050T1 (de) 2001-06-26 2002-06-26 Von dd 3b6/22 abgeleitete humanisierte antikörper mit spezifität für das d-dimer fragment von fibrin

Country Status (12)

Country Link
US (4) US7087724B2 (de)
EP (1) EP1412388B1 (de)
JP (2) JP5006504B2 (de)
CN (2) CN1531554A (de)
AT (1) ATE502050T1 (de)
AU (1) AU2002318960B2 (de)
BR (1) BR0210648A (de)
CA (1) CA2450828C (de)
DE (1) DE60239467D1 (de)
MX (1) MXPA03012030A (de)
NZ (1) NZ530122A (de)
WO (1) WO2003000736A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1531554A (zh) * 2001-06-26 2004-09-22 ��������ҽѧ���޹�˾ 血纤维蛋白d-二聚体片段特异性的、来源于dd-3b6/22的人源化抗体
KR100842121B1 (ko) * 2004-02-09 2008-07-01 (주)바이오버드 Ｄ-다이머에 대한 단일클론 항체와 이를 이용한 ｄ-다이머및 교차결합성 피브린 또는 이를 포함하는 피브린 분해물검사용 진단시약
JP4471867B2 (ja) * 2005-02-25 2010-06-02 シスメックス株式会社 Ｄダイマー測定用標準物質
WO2007013709A1 (en) * 2005-07-29 2007-02-01 Biobud Co., Ltd. Monoclonal antibody against d-dimer and diagnosis agent for detecting d-dimer, crosslinked fibrin and its derivatives containing d-dimer by using the antibody
US20080280310A1 (en) * 2007-05-09 2008-11-13 Louis Panagopoulos Testing for Blood Group Immunological Reaction Without the Use of Anti-Human Globulin
WO2009014835A2 (en) * 2007-06-21 2009-01-29 Angelica Therapeutics, Inc. Modified toxins
AU2008287427B2 (en) * 2007-08-13 2014-10-09 Vasgene Therapeutics, Inc. Cancer treatment using humanized antibodies that bind to EphB4
EP2268297A4 (de) * 2008-02-29 2011-11-16 Angelica Therapeutics Inc Modifizierte toxine
US20100143890A1 (en) * 2008-12-08 2010-06-10 Electronics And Telecommunications Research Institute Peptide compounds for capturing or inhibiting avian influenza virus and application thereof
JP2012000072A (ja) * 2010-06-18 2012-01-05 Japan Health Science Foundation 新規な抗フィブリン抗体
JP6490574B2 (ja) 2013-02-28 2019-03-27 国立研究開発法人国立がん研究センター 不溶性フィブリンに対する抗体
HK1220376A1 (zh) 2013-03-15 2017-05-05 Angelica Therapeutics, Inc. 修饰的毒素
CN103468644B (zh) * 2013-09-26 2016-01-20 重庆探生科技有限公司 产生抗人d-二聚体的单克隆抗体的杂交瘤细胞株及制备方法和应用
CN104062436B (zh) * 2014-06-06 2016-02-10 上海良润生物医药科技有限公司 Fxyd在制备诊断和预示肺癌标志物中的应用及fxyd双抗夹心elisa检测试剂盒
CN110582514B (zh) 2017-05-02 2024-03-01 国立研究开发法人国立癌症研究中心 纤溶酶可切割的抗不溶性纤维蛋白的抗体与药物的偶联物
CN109053893B (zh) * 2018-08-15 2021-03-30 智享生物(苏州)有限公司 一种抗d-二聚体单克隆抗体及其制备方法
CN112851818B (zh) * 2019-11-28 2022-12-27 东莞市朋志生物科技有限公司 针对d-二聚体的结合蛋白及其应用和检测d-二聚体的方法
WO2022159776A1 (en) * 2021-01-21 2022-07-28 Therini Bio, Inc. Antibodies which bind human fibrin and methods of use

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU572125B2 (en) * 1983-03-17 1988-05-05 Mabco Limited Monoclonal antibodies with specificity for crosslinked fibrin and their diagnotic uses
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US4946778A (en) * 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5091513A (en) * 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
IE67430B1 (en) * 1988-06-24 1996-04-03 Res Corp Technologies Inc Assay for soluble crosslinked fibrin polymers
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
CA2065362A1 (en) 1989-08-24 1991-02-25 Fook-Thean Lee Radio-labelled antibodies for imaging
US5859205A (en) * 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
ZA937553B (en) * 1992-10-12 1994-05-03 Agen Ltd Clot directed anticoagulant process for making same and methods of use
WO1994009817A1 (en) * 1992-11-04 1994-05-11 City Of Hope Novel antibody construct
US6180377B1 (en) * 1993-06-16 2001-01-30 Celltech Therapeutics Limited Humanized antibodies
US6056957A (en) * 1994-08-04 2000-05-02 Schering Corporation Humanized monoclonal antibodies against human interleukin-5
JP3889084B2 (ja) * 1996-05-15 2007-03-07 株式会社三菱化学ヤトロン 新規なモノクローナル抗体並びにｅ−Ｄダイマー及びｅ−ＤＤ／Ｅ複合体の免疫学的測定法
WO1998052976A1 (en) * 1997-05-21 1998-11-26 Biovation Limited Method for the production of non-immunogenic proteins
EP1051432B1 (de) 1998-12-08 2007-01-24 Biovation Limited Verfahren zur verminderung der immunogenität von proteinen
CN1531554A (zh) * 2001-06-26 2004-09-22 ��������ҽѧ���޹�˾ 血纤维蛋白d-二聚体片段特异性的、来源于dd-3b6/22的人源化抗体

Also Published As

Publication number Publication date
CN102206276A (zh) 2011-10-05
WO2003000736A1 (en) 2003-01-03
US20060239912A1 (en) 2006-10-26
DE60239467D1 (de) 2011-04-28
JP2005502610A (ja) 2005-01-27
JP5006504B2 (ja) 2012-08-22
US20090092546A1 (en) 2009-04-09
CN1531554A (zh) 2004-09-22
MXPA03012030A (es) 2005-07-01
BR0210648A (pt) 2004-10-05
CN102206276B (zh) 2013-07-17
US20100286375A1 (en) 2010-11-11
AU2002318960B2 (en) 2008-05-15
CA2450828A1 (en) 2003-01-03
US20030124056A1 (en) 2003-07-03
NZ530122A (en) 2008-03-28
EP1412388B1 (de) 2011-03-16
EP1412388A1 (de) 2004-04-28
JP2009149686A (ja) 2009-07-09
EP1412388A4 (de) 2006-08-09
US7459143B2 (en) 2008-12-02
US7087724B2 (en) 2006-08-08
CA2450828C (en) 2013-11-26

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