BG101024A - Моноклонално антитяло срещу сd44v6 - Google Patents

Моноклонално антитяло срещу сd44v6

Info

Publication number
BG101024A
BG101024A BG101024A BG10102496A BG101024A BG 101024 A BG101024 A BG 101024A BG 101024 A BG101024 A BG 101024A BG 10102496 A BG10102496 A BG 10102496A BG 101024 A BG101024 A BG 101024A
Authority
BG
Bulgaria
Prior art keywords
antibody against
sd44v6
monoclinal antibody
monoclinal
antibody
Prior art date
Application number
BG101024A
Other languages
English (en)
Other versions
BG64181B1 (bg
Inventor
Guenther Adolf
Erik Patzelt
Original Assignee
Boehringer Ingelheim International Gmbh
Forschungszentrum Karlsruhe Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19944431297 external-priority patent/DE4431297A1/de
Application filed by Boehringer Ingelheim International Gmbh, Forschungszentrum Karlsruhe Gmbh filed Critical Boehringer Ingelheim International Gmbh
Publication of BG101024A publication Critical patent/BG101024A/bg
Publication of BG64181B1 publication Critical patent/BG64181B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70585—CD44
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2884—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD44
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Изобретението се отнася до антитяло срещу епитоп,който се кодира от вариантния екзон v6 на гена заCD44. Антитялото е с подобрени свойства в сравнение с известните досега антитела и може да се използва в терапията и диагностиката.
BG101024A 1994-06-08 1996-12-03 Моноклонално антитяло срещу cd44v6 BG64181B1 (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4419913 1994-06-08
DE19944431297 DE4431297A1 (de) 1994-09-02 1994-09-02 Monoklonaler Antikörper gegen CD44v6
PCT/EP1995/002126 WO1995033771A1 (de) 1994-06-08 1995-06-02 MONOKLONALER ANTIKÖRPER GEGEN CD44v6

Publications (2)

Publication Number Publication Date
BG101024A true BG101024A (bg) 1997-09-30
BG64181B1 BG64181B1 (bg) 2004-03-31

Family

ID=25937246

Family Applications (1)

Application Number Title Priority Date Filing Date
BG101024A BG64181B1 (bg) 1994-06-08 1996-12-03 Моноклонално антитяло срещу cd44v6

Country Status (27)

Country Link
US (1) US5916561A (bg)
EP (1) EP0765343B1 (bg)
JP (2) JP3387929B2 (bg)
KR (2) KR100379217B1 (bg)
CN (1) CN1125083C (bg)
AT (1) ATE197592T1 (bg)
BG (1) BG64181B1 (bg)
BR (1) BR9507964A (bg)
CA (1) CA2192370A1 (bg)
CO (1) CO4410258A1 (bg)
CZ (1) CZ291274B6 (bg)
DE (1) DE59508864D1 (bg)
DK (1) DK0765343T3 (bg)
ES (1) ES2151603T3 (bg)
FI (1) FI964845L (bg)
GR (1) GR3035388T3 (bg)
HU (1) HU220168B (bg)
NO (1) NO317948B1 (bg)
NZ (1) NZ288224A (bg)
PL (1) PL190897B1 (bg)
PT (1) PT765343E (bg)
RO (1) RO118753B1 (bg)
RU (1) RU2204606C2 (bg)
SI (1) SI0765343T1 (bg)
SK (1) SK282649B6 (bg)
UA (1) UA58482C2 (bg)
WO (1) WO1995033771A1 (bg)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY24389A1 (es) * 1995-12-06 2001-10-25 Karlsruhe Forschzent Composición farmacéutica para el tratamiento de carcinoma de epitelio plano
WO1997030173A1 (en) 1996-02-15 1997-08-21 Chugai Seiyaku Kabushiki Kaisha Monoclonal antibody that recognizes antigens present on the surface of endothelial cell of tumor vessel
DE19648209A1 (de) * 1996-11-21 1998-05-28 Boehringer Ingelheim Int Verfahren zur Tumorzelldepletion CD34-positiver Zellen
DE19708713C2 (de) * 1997-03-04 2002-11-28 Boehringer Ingelheim Int Verwendung von anti-CD44 Antikörpern enthaltenden Präparationen zur Behandlung bestimmter Tumore und zur Unterdrückung von Immunreaktionen
CA2329776C (en) 1998-06-08 2009-02-10 Fuso Pharmaceutical Industries, Ltd. Antibody against lar phosphatase subunit
US6933135B1 (en) * 1998-07-10 2005-08-23 Fuso Pharmaceutical Industries Ltd. Antibodies specific for intracellular domain of protein tyrosine phosphatase
US20090004103A1 (en) * 1999-10-08 2009-01-01 Young David S F Cytotoxicity mediation of cells evidencing surface expression of CD44
US7189397B2 (en) * 1999-10-08 2007-03-13 Arius Research Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US20050100542A1 (en) * 1999-10-08 2005-05-12 Young David S. Cytotoxicity mediation of cells evidencing surface expression of CD44
US8048416B2 (en) 1999-10-08 2011-11-01 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US7947496B2 (en) * 1999-10-08 2011-05-24 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US20080124327A1 (en) * 1999-10-08 2008-05-29 Arius Research, Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US8071072B2 (en) * 1999-10-08 2011-12-06 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
CA2443437A1 (en) * 2001-05-18 2002-11-28 Boehringer Ingelheim International Gmbh Antibodies specific for cd44v6
US20030103985A1 (en) * 2001-05-18 2003-06-05 Boehringer Ingelheim International Gmbh Cytotoxic CD44 antibody immunoconjugates
US6972324B2 (en) * 2001-05-18 2005-12-06 Boehringer Ingelheim Pharmaceuticals, Inc. Antibodies specific for CD44v6
ATE399017T1 (de) * 2001-08-24 2008-07-15 Celecure As Neue angiogenese-inhibitoren basierend auf löslicher hyaluronsäure-bindedomäne des cd44- rezeptors
US20040126379A1 (en) * 2002-08-21 2004-07-01 Boehringer Ingelheim International Gmbh Compositions and methods for treating cancer using cytotoxic CD44 antibody immunoconjugates and chemotherapeutic agents
US20040110933A1 (en) * 2002-09-13 2004-06-10 Dyax Corporation CD44-binding ligands
US20040120949A1 (en) * 2002-11-08 2004-06-24 Boehringer Ingelheim International Gmbh Compositions and methods for treating cancer using cytotoxic CD44 antibody immunoconjugates and radiotherapy
US20060140963A1 (en) * 2003-04-14 2006-06-29 Arius Research, Inc. Cytotoxicity mediation of cells evidencing surface expression of CD59
EP1806365A1 (en) 2006-01-05 2007-07-11 Boehringer Ingelheim International GmbH Antibody molecules specific for fibroblast activation protein and immunoconjugates containing them
EP2266593A1 (en) * 2009-06-24 2010-12-29 Karlsruher Institut für Technologie Use of CD44v6 in the treatment of ophthalmic diseases
ES2622487T3 (es) * 2009-08-19 2017-07-06 Merck Patent Gmbh Anticuerpos para la detección de complejos de integrina en material FFPE
CN102337298B (zh) * 2011-08-19 2013-11-06 黄开红 一种输送siRNA的免疫纳米载体及其制备方法和应用
DK2886126T3 (en) 2013-12-23 2017-09-18 Exchange Imaging Tech Gmbh Nanoparticle conjugated to CD44-binding peptides
EP3755717A4 (en) * 2018-02-22 2022-01-26 Multitude Inc. THERAPEUTIC ANTIBODY AND USES THEREOF
CN109593125A (zh) * 2018-12-12 2019-04-09 深圳市龙华区人民医院 基于前列腺癌干细胞标志物cd44的抗原表位多肽cd44-p1及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08506801A (ja) * 1992-11-20 1996-07-23 アイシス・イノベーション・リミテッド Ｃｄ４４エキソン６に対応するペプチド、そのペプチドに特異的な抗体、および、腫瘍診断にそれらの抗体を使用する方法
EP0703989B1 (en) * 1993-06-18 1997-11-05 Oy Biotie Therapies COMPOSITIONS AND DIAGNOSTIC METHODS USING MONOCLONAL ANTIBODIES AGAINST CD44v6
EP0767378A1 (de) * 1993-06-22 1997-04-09 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Verfahren zur Diagnose und Analyse von Magenkarzinomen

Also Published As

Publication number Publication date
CO4410258A1 (es) 1997-01-09
HK1011697A1 (en) 1999-07-16
RO118753B1 (ro) 2003-10-30
EP0765343A1 (de) 1997-04-02
CZ291274B6 (cs) 2003-01-15
SK282649B6 (sk) 2002-10-08
FI964845A0 (fi) 1996-12-04
KR970703368A (ko) 1997-07-03
DK0765343T3 (da) 2000-12-27
SK154896A3 (en) 1997-08-06
UA58482C2 (uk) 2003-08-15
DE59508864D1 (de) 2000-12-21
PL190897B1 (pl) 2006-02-28
CA2192370A1 (en) 1995-12-14
JP3387929B2 (ja) 2003-03-17
WO1995033771A1 (de) 1995-12-14
GR3035388T3 (en) 2001-05-31
CN1125083C (zh) 2003-10-22
NZ288224A (en) 1999-04-29
NO317948B1 (no) 2005-01-10
CN1152925A (zh) 1997-06-25
RU2204606C2 (ru) 2003-05-20
HU220168B (hu) 2001-11-28
AU701885B2 (en) 1999-02-11
NO965239L (no) 1996-12-06
CZ359196A3 (en) 1997-11-12
HU9603387D0 (en) 1997-01-28
JP2003034700A (ja) 2003-02-07
FI964845A7 (fi) 1996-12-04
FI964845L (fi) 1996-12-04
BG64181B1 (bg) 2004-03-31
ES2151603T3 (es) 2001-01-01
PL317536A1 (en) 1997-04-14
HUT76260A (en) 1997-07-28
EP0765343B1 (de) 2000-11-15
AU2737095A (en) 1996-01-04
SI0765343T1 (en) 2001-02-28
PT765343E (pt) 2001-02-28
ATE197592T1 (de) 2000-12-15
BR9507964A (pt) 1997-09-02
US5916561A (en) 1999-06-29
NO965239D0 (no) 1996-12-06
JPH10501797A (ja) 1998-02-17
KR100379217B1 (ko) 2003-06-11

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